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Eph receptor signaling complexes in the plasma membrane 质膜中的 Eph 受体信号复合体
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-12-01 DOI: 10.1016/j.tibs.2024.10.002
Elena B. Pasquale
{"title":"Eph receptor signaling complexes in the plasma membrane","authors":"Elena B. Pasquale","doi":"10.1016/j.tibs.2024.10.002","DOIUrl":"10.1016/j.tibs.2024.10.002","url":null,"abstract":"<div><div>Eph receptor tyrosine kinases, together with their cell surface-anchored ephrin ligands, constitute an important cell–cell communication system that regulates physiological and pathological processes in most cell types. This review focuses on the multiple mechanisms by which Eph receptors initiate signaling via the formation of protein complexes in the plasma membrane. Upon ephrin binding, Eph receptors assemble into oligomers that can further aggregate into large complexes. Eph receptors also mediate ephrin-independent signaling through interplay with intracellular kinases or other cell-surface receptors. The distinct characteristics of Eph receptor family members, as well as their conserved domain structure, provide a framework for understanding their functional differences and redundancies. Possible areas of interest for future investigations of Eph receptor signaling complexes are also highlighted.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 12","pages":"Pages 1079-1096"},"PeriodicalIF":11.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Constructive neutral evolution of homodimer to heterodimer transition 同源二聚体向异源二聚体过渡的建设性中性进化。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-12-01 DOI: 10.1016/j.tibs.2024.10.003
Lin Chou , Carly J. Houghton , Aaron Wacholder , Anne-Ruxandra Carvunis
{"title":"Constructive neutral evolution of homodimer to heterodimer transition","authors":"Lin Chou ,&nbsp;Carly J. Houghton ,&nbsp;Aaron Wacholder ,&nbsp;Anne-Ruxandra Carvunis","doi":"10.1016/j.tibs.2024.10.003","DOIUrl":"10.1016/j.tibs.2024.10.003","url":null,"abstract":"<div><div>Complexification of macrobiomolecules, such as homodimer to heterodimer transitions, are common during evolution. Is such complexification always adaptive? Using large-scale experiments and in-depth biochemical analyses, <span><span>Després <em>et al.</em></span><svg><path></path></svg></span> recently demonstrated that an obligate heterodimer can evolve from a homodimer through neutral, nonadaptive events, and quantified key parameters required for such transitions.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 12","pages":"Pages 1036-1038"},"PeriodicalIF":11.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅及版权资料
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-12-01 DOI: 10.1016/S0968-0004(24)00264-0
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/S0968-0004(24)00264-0","DOIUrl":"10.1016/S0968-0004(24)00264-0","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 12","pages":"Page e1"},"PeriodicalIF":11.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functionalized DNA secondary structures and nanostructures for specific protein modifications 用于特定蛋白质修饰的功能化 DNA 二级结构和纳米结构。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-12-01 DOI: 10.1016/j.tibs.2024.09.003
Bauke Albada
{"title":"Functionalized DNA secondary structures and nanostructures for specific protein modifications","authors":"Bauke Albada","doi":"10.1016/j.tibs.2024.09.003","DOIUrl":"10.1016/j.tibs.2024.09.003","url":null,"abstract":"<div><div>The development of non-biological applications of DNA has not only resulted in delicately shaped DNA-based nano-objects with complex functions but also spawned their use for novel catalytic applications. From the multitude of applications of DNAzymes that operate on a relatively simple substrate, we have witnessed the emergence of multifunctional catalytically active DNA-based nanostructures for one of the most challenging tasks known to a chemist: the controlled and precise modification of a wild-type protein in its natural environment. By incorporating various elements associated with post-translational modification (PTM) writer enzymes into complex nanostructures, it is now possible to chemically modify a specific protein in cell lysates under the influence of an externally added trigger, clearly illustrating the promising future for this approach.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 12","pages":"Pages 1124-1135"},"PeriodicalIF":11.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A two-way relationship between histone acetylation and metabolism 组蛋白乙酰化与新陈代谢之间的双向关系
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-12-01 DOI: 10.1016/j.tibs.2024.10.005
Evelina Charidemou , Antonis Kirmizis
{"title":"A two-way relationship between histone acetylation and metabolism","authors":"Evelina Charidemou ,&nbsp;Antonis Kirmizis","doi":"10.1016/j.tibs.2024.10.005","DOIUrl":"10.1016/j.tibs.2024.10.005","url":null,"abstract":"<div><div>A link between epigenetics and metabolism was initially recognized because the cellular metabolic state is communicated to the genome through the concentration of intermediary metabolites that are cofactors of chromatin-modifying enzymes. Recently, an additional interaction was postulated due to the capacity of the epigenome to store substantial amounts of metabolites that could become available again to cellular metabolite pools. Here, we focus on histone acetylation and review recent evidence illustrating this reciprocal relationship: in one direction, signaling-induced acetyl-coenzyme A (acetyl-CoA) changes influence histone acetylation levels to regulate genomic functions, and in the opposite direction histone acetylation acts as an acetate reservoir to directly affect downstream acetyl-CoA-mediated metabolism. This review highlights the current understanding, experimental challenges, and future perspectives of this bidirectional interplay.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 12","pages":"Pages 1046-1062"},"PeriodicalIF":11.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会及内容
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-12-01 DOI: 10.1016/S0968-0004(24)00261-5
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/S0968-0004(24)00261-5","DOIUrl":"10.1016/S0968-0004(24)00261-5","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 12","pages":"Pages i-ii"},"PeriodicalIF":11.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clues into Wnt cell surface signalosomes and its biogenesis Wnt 细胞表面信号体及其生物生成的线索。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-12-01 DOI: 10.1016/j.tibs.2024.09.007
Philip Schmiege , Xiaochun Li
{"title":"Clues into Wnt cell surface signalosomes and its biogenesis","authors":"Philip Schmiege ,&nbsp;Xiaochun Li","doi":"10.1016/j.tibs.2024.09.007","DOIUrl":"10.1016/j.tibs.2024.09.007","url":null,"abstract":"<div><div>Wnt morphogens induce signaling via binding their extracellular receptors. Here, we discuss several recent structural studies showing how Wnts engage their receptors frizzled (FZD) and low-density lipoprotein receptor-related protein 5/6 (LRP5/6), how Cachd1 has been shown as an alternative initiator of Wnt signaling, and how lipidated Wnt may be produced and secreted from the cell.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 12","pages":"Pages 1042-1045"},"PeriodicalIF":11.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of hydrolysis in perceiving and degrading the plant hormone strigolactones 水解作用在感知和降解植物激素绞股蓝内酯中的作用。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-12-01 DOI: 10.1016/j.tibs.2024.09.006
Kawthar F. Alashoor , Jian You Wang , Salim Al-Babili
{"title":"The role of hydrolysis in perceiving and degrading the plant hormone strigolactones","authors":"Kawthar F. Alashoor ,&nbsp;Jian You Wang ,&nbsp;Salim Al-Babili","doi":"10.1016/j.tibs.2024.09.006","DOIUrl":"10.1016/j.tibs.2024.09.006","url":null,"abstract":"<div><div>Strigolactones (SLs) perform versatile functions in plants. The different members of the α/β-hydrolase superfamily bind and hydrolyze SLs at varying rates to transduce their signal or maintain SL homeostasis. Recent work by <span><span>Palayam <em>et al.</em></span><svg><path></path></svg></span> on SL-degrading carboxylesterases (CXEs) uncovers structural elements that determine the mechanism, efficiency of SL hydrolysis, and biological functions.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 12","pages":"Pages 1039-1041"},"PeriodicalIF":11.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-01 DOI: 10.1016/S0968-0004(24)00241-X
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/S0968-0004(24)00241-X","DOIUrl":"10.1016/S0968-0004(24)00241-X","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 11","pages":"Page e1"},"PeriodicalIF":11.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two hearts beat as one: the debate over RAS dimers continues 两心相印：关于 RAS 二聚体的争论仍在继续。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-01 DOI: 10.1016/j.tibs.2024.09.005
Andrew G. Stephen
{"title":"Two hearts beat as one: the debate over RAS dimers continues","authors":"Andrew G. Stephen","doi":"10.1016/j.tibs.2024.09.005","DOIUrl":"10.1016/j.tibs.2024.09.005","url":null,"abstract":"<div><div>A recent report by <span><span>Yun <em>et al.</em></span><svg><path></path></svg></span> describes the detection of RAS dimers using intact mass spectrometry and investigates the role that membrane lipids, nucleotide state, and binding partners have in their formation.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 11","pages":"Pages 933-935"},"PeriodicalIF":11.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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