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Decapping NAD-RNAs: TIR domain-containing proteins stand out for specificity 为 NAD-RNA 解旋：含 TIR 结构域的蛋白质具有突出的特异性。
IF 13.8 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-06-01 DOI: 10.1016/j.tibs.2024.04.004
Dechang Cao
{"title":"Decapping NAD-RNAs: TIR domain-containing proteins stand out for specificity","authors":"Dechang Cao","doi":"10.1016/j.tibs.2024.04.004","DOIUrl":"10.1016/j.tibs.2024.04.004","url":null,"abstract":"<div><p>A recently characterized RNA modification is NAD<sup>+</sup>-modified RNAs (NAD-RNAs). Various enzymes decap NAD-RNAs, and <span>Wang and Yu <em>et al.</em></span><svg><path></path></svg> now describe another, namely Toll/interleukin-1 receptor (TIR) domain-containing proteins of bacteria and Archaea. TIR decapping products are a specific variant of cyclic ADP ribose (ADPR)-RNAs (v-cADPR-RNAs), opening a new window to the NAD-RNA world.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 6","pages":"Pages 477-479"},"PeriodicalIF":13.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 13.8 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-06-01 DOI: 10.1016/S0968-0004(24)00126-9
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/S0968-0004(24)00126-9","DOIUrl":"https://doi.org/10.1016/S0968-0004(24)00126-9","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 6","pages":"Page e1"},"PeriodicalIF":13.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141264087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promoting a MOSAIC future in science 促进科学领域的 MOSAIC 未来。
IF 13.8 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-06-01 DOI: 10.1016/j.tibs.2024.03.001
Ruma Banerjee , Kirsten F. Block
{"title":"Promoting a MOSAIC future in science","authors":"Ruma Banerjee ,&nbsp;Kirsten F. Block","doi":"10.1016/j.tibs.2024.03.001","DOIUrl":"10.1016/j.tibs.2024.03.001","url":null,"abstract":"<div><p>Discoveries at the frontiers of science and finding solutions to pressing biomedical problems will be accelerated when talent, which is widely distributed, is better aligned with opportunities. Strategies to enhance a MOSAIC (Maximizing Opportunities for Scientific and Academic Independent Careers) professoriate and diversify the biomedical landscape are discussed.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 6","pages":"Pages 471-474"},"PeriodicalIF":13.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140183411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determining intracellular protein physical microenvironment using fluorescence lifetime imaging microscopy 利用荧光寿命成像显微镜确定细胞内蛋白质的物理微环境。
IF 13.8 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-06-01 DOI: 10.1016/j.tibs.2024.04.006
Yu Xiao , Baoxing Shen , He Huang
{"title":"Determining intracellular protein physical microenvironment using fluorescence lifetime imaging microscopy","authors":"Yu Xiao ,&nbsp;Baoxing Shen ,&nbsp;He Huang","doi":"10.1016/j.tibs.2024.04.006","DOIUrl":"10.1016/j.tibs.2024.04.006","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 6","pages":"Pages 557-558"},"PeriodicalIF":13.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain 控制神经元活动：α-突触核蛋白丝氨酸-129磷酸化在健康大脑中的新作用。
IF 13.8 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-05-01 DOI: 10.1016/j.tibs.2024.02.006
Danielle E. Mor
{"title":"Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain","authors":"Danielle E. Mor","doi":"10.1016/j.tibs.2024.02.006","DOIUrl":"10.1016/j.tibs.2024.02.006","url":null,"abstract":"<div><p>Phosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by <span>Parra-Rivas, Madhivanan <em>et al</em>.,</span><svg><path></path></svg> Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 5","pages":"Pages 382-383"},"PeriodicalIF":13.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 13.8 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-05-01 DOI: 10.1016/S0968-0004(24)00092-6
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/S0968-0004(24)00092-6","DOIUrl":"https://doi.org/10.1016/S0968-0004(24)00092-6","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 5","pages":"Page e1"},"PeriodicalIF":13.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140822652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitotic bookmarking by transcription factors: be aware of redundancy 转录因子的有丝分裂标记：注意冗余。
IF 13.8 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-05-01 DOI: 10.1016/j.tibs.2024.03.003
Miguel V. Silva , Diogo S. Castro
{"title":"Mitotic bookmarking by transcription factors: be aware of redundancy","authors":"Miguel V. Silva ,&nbsp;Diogo S. Castro","doi":"10.1016/j.tibs.2024.03.003","DOIUrl":"10.1016/j.tibs.2024.03.003","url":null,"abstract":"<div><p>A recent report by <span>Chervova, Molliex, <em>et al.</em></span><svg><path></path></svg> shows redundant functions for the transcription factors (TFs) ESRRB and NR5A2 as mitotic bookmarkers in mouse embryonic stem (ES) cells. These occupy some of their target sites in mitotic chromatin, ensuring their robust reactivation after cell division, including markers and regulators of pluripotency.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 5","pages":"Pages 384-386"},"PeriodicalIF":13.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computationally guided AAV engineering for enhanced gene delivery 计算引导的 AAV 工程，用于增强基因递送。
IF 13.8 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-05-01 DOI: 10.1016/j.tibs.2024.03.002
Jingxuan Guo , Li F. Lin , Sydney V. Oraskovich , Julio A. Rivera de Jesús , Jennifer Listgarten , David V. Schaffer
{"title":"Computationally guided AAV engineering for enhanced gene delivery","authors":"Jingxuan Guo ,&nbsp;Li F. Lin ,&nbsp;Sydney V. Oraskovich ,&nbsp;Julio A. Rivera de Jesús ,&nbsp;Jennifer Listgarten ,&nbsp;David V. Schaffer","doi":"10.1016/j.tibs.2024.03.002","DOIUrl":"10.1016/j.tibs.2024.03.002","url":null,"abstract":"<div><p>Gene delivery vehicles based on adeno-associated viruses (AAVs) are enabling increasing success in human clinical trials, and they offer the promise of treating a broad spectrum of both genetic and non-genetic disorders. However, delivery efficiency and targeting must be improved to enable safe and effective therapies. In recent years, considerable effort has been invested in creating AAV variants with improved delivery, and computational approaches have been increasingly harnessed for AAV engineering. In this review, we discuss how computationally designed AAV libraries are enabling directed evolution. Specifically, we highlight approaches that harness sequences outputted by next-generation sequencing (NGS) coupled with machine learning (ML) to generate new functional AAV capsids and related regulatory elements, pushing the frontier of what vector engineering and gene therapy may achieve.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 5","pages":"Pages 457-469"},"PeriodicalIF":13.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Team science: building, nurturing, and expanding research collaborations 团队科学:建立、培育和扩大研究合作。
IF 13.8 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-05-01 DOI: 10.1016/j.tibs.2023.10.010
Arun K. Shukla
{"title":"Team science: building, nurturing, and expanding research collaborations","authors":"Arun K. Shukla","doi":"10.1016/j.tibs.2023.10.010","DOIUrl":"10.1016/j.tibs.2023.10.010","url":null,"abstract":"<div><p>Science is a collaborative endeavor, and the importance of collaborations across disciplines and boundaries is becoming clearer with the advent of new technologies. This article focuses on key aspects of initiating and sustaining new collaborations, and expanding from bilateral to multilateral efforts to create major impact through team science.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 5","pages":"Pages 379-381"},"PeriodicalIF":13.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89716446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A left-handed RNA quadruplex directs gene silencing 左手 RNA 四重链引导基因沉默。
IF 13.8 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-05-01 DOI: 10.1016/j.tibs.2024.01.009
Samuel E. Butcher
{"title":"A left-handed RNA quadruplex directs gene silencing","authors":"Samuel E. Butcher","doi":"10.1016/j.tibs.2024.01.009","DOIUrl":"10.1016/j.tibs.2024.01.009","url":null,"abstract":"<div><p>Poly(UG) or ‘pUG’ dinucleotide repeats direct gene silencing in <em>Caenorhabditis elegans</em> by adopting an unusual quadruplex structure. Humans have thousands of pUG sequences and proteins that interact with them. The pUG fold reveals new aspects of gene regulation and RNA folding, highlighting how a simple sequence can encode a complex structure.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 5","pages":"Pages 387-390"},"PeriodicalIF":13.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139897830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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