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Mass spectrometry-based single-cell proteomics technologies, trends, and biological insights 基于质谱的单细胞蛋白质组学技术、趋势和生物学见解。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-05-07 DOI: 10.1016/j.tibs.2026.04.011
Rui Hu (胡锐) , Christian Montes , Justin W. Walley
{"title":"Mass spectrometry-based single-cell proteomics technologies, trends, and biological insights","authors":"Rui Hu (胡锐) ,&nbsp;Christian Montes ,&nbsp;Justin W. Walley","doi":"10.1016/j.tibs.2026.04.011","DOIUrl":"10.1016/j.tibs.2026.04.011","url":null,"abstract":"<div><div>Single-cell proteomics (SCP) has emerged as a transformative approach for characterizing cellular heterogeneity at the protein level. Recent advances in mass spectrometry workflows, with improvements spanning sample preparation, peptide separation, data acquisition, and data interpretation, have enabled unprecedented proteome depth and throughput at single-cell resolution. Beyond technological innovations, SCP is now addressing complex biological questions in oncology, developmental biology, and neuroscience, revealing dynamic cellular states and regulatory mechanisms. Integration with other single-cell omics is bridging the gap between genotype–phenotype relationships and uncovering multilayered regulation. In this review, we summarize recent progress in SCP technologies and highlight emerging applications and integrative strategies that mark a transition from technological development to broad biological understanding.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 6","pages":"Pages 542-557"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FAOBMB: Asian and Oceanian regional organisation of IUBMB FAOBMB: IUBMB亚洲和大洋洲区域组织
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-06-04 DOI: 10.1016/j.tibs.2026.02.013
Phillip Nagley , Joon Kim
{"title":"FAOBMB: Asian and Oceanian regional organisation of IUBMB","authors":"Phillip Nagley ,&nbsp;Joon Kim","doi":"10.1016/j.tibs.2026.02.013","DOIUrl":"10.1016/j.tibs.2026.02.013","url":null,"abstract":"<div><div>The Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) encompasses 20 national societies. The Federation’s primary purpose is the development of biochemistry and molecular biology in the region. FAOBMB fosters research and education, organises annual scientific meetings, recognises high achievement, and places emphasis on young scientists and equal opportunities.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 6","pages":"Pages 529-532"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148153850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅及版权资料
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-06-04 DOI: 10.1016/S0968-0004(26)00150-7
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/S0968-0004(26)00150-7","DOIUrl":"10.1016/S0968-0004(26)00150-7","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 6","pages":"Page e1"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148153851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanisms and therapeutic potential of proton-sensing GPCRs 质子传感gpcr的分子机制和治疗潜力。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-04-03 DOI: 10.1016/j.tibs.2026.02.015
Xiaolei Yue , Shenyuan Gao , Zhi-Jie Liu , Tian Hua
{"title":"Molecular mechanisms and therapeutic potential of proton-sensing GPCRs","authors":"Xiaolei Yue ,&nbsp;Shenyuan Gao ,&nbsp;Zhi-Jie Liu ,&nbsp;Tian Hua","doi":"10.1016/j.tibs.2026.02.015","DOIUrl":"10.1016/j.tibs.2026.02.015","url":null,"abstract":"<div><div>Extracellular acidification is a defining feature of many pathological microenvironments and is sensed by G protein-coupled receptors (GPCRs)—GPR4, GPR65, and GPR68. These proton-sensing receptors regulate vascular, immune, and neural responses and are increasingly implicated in inflammation, cancer, fibrosis, and ischemic injury. Recent cryo-electron microscopy structures have revealed the molecular basis of proton detection, highlighting dynamic extracellular loop rearrangements, pH-sensitive histidine networks, and a stepwise activation mechanism that tunes G protein coupling and signaling bias. Emerging structural evidence also shows lipid modulation and species-specific adaptations that shape receptor responsiveness. These advances provide a structural and mechanistic framework for developing selective modulators of proton-sensing GPCRs as therapeutic targets in acidic disease environments.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 6","pages":"Pages 558-572"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic secrets in a ubiquitous enzyme 一种无处不在的酶的代谢秘密。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-04-16 DOI: 10.1016/j.tibs.2026.04.002
Dan Kehila , Paola Laurino
{"title":"Metabolic secrets in a ubiquitous enzyme","authors":"Dan Kehila ,&nbsp;Paola Laurino","doi":"10.1016/j.tibs.2026.04.002","DOIUrl":"10.1016/j.tibs.2026.04.002","url":null,"abstract":"<div><div>Recent work by <span><span>Sakuma <em>et al.</em></span><svg><path></path></svg></span> shows that the ubiquitous enzyme alkaline phosphatase (PhoA) can oxidize phosphite, revealing a new metabolic role for a classic catalytic generalist. Despite its relatively low efficiency, PhoA’s global distribution and conservation indicate that it may substantially influence phosphite turnover and highlight the significance of enzymatic multifunctionality.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 6","pages":"Pages 536-537"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The evolving landscape of protein structure and molecular recognition 蛋白质结构和分子识别的进化景观
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-06-04 DOI: 10.1016/j.tibs.2026.05.001
Ylva Ivarsson , Gregory A. Petsko
{"title":"The evolving landscape of protein structure and molecular recognition","authors":"Ylva Ivarsson ,&nbsp;Gregory A. Petsko","doi":"10.1016/j.tibs.2026.05.001","DOIUrl":"10.1016/j.tibs.2026.05.001","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 6","pages":"Pages 525-528"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148153849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PhD journey 博士的旅程
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-06-04 DOI: 10.1016/j.tibs.2026.02.012
Dominika Dobosz
{"title":"PhD journey","authors":"Dominika Dobosz","doi":"10.1016/j.tibs.2026.02.012","DOIUrl":"10.1016/j.tibs.2026.02.012","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 6","pages":"Page 637"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148153852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AMPK as a regulatory node in cell death AMPK作为细胞死亡的调控节点。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-03-20 DOI: 10.1016/j.tibs.2026.02.006
Dade Rong (容达德) , Shuai You (尤帅) , Han-Ming Shen (沈汉明)
{"title":"AMPK as a regulatory node in cell death","authors":"Dade Rong (容达德) ,&nbsp;Shuai You (尤帅) ,&nbsp;Han-Ming Shen (沈汉明)","doi":"10.1016/j.tibs.2026.02.006","DOIUrl":"10.1016/j.tibs.2026.02.006","url":null,"abstract":"<div><div>Adenosine Monophosphate (AMP)-activated protein kinase (AMPK) is a critical kinase in the control of cellular metabolism, and in recent years, accumulating evidence has demonstrated that AMPK plays a critical role in the regulation of various types of regulated cell death (RCD) pathways, including apoptosis, necroptosis, pyroptosis, and ferroptosis. In this review, we will first discuss the regulatory roles of AMPK in these forms of RCD. Then, we will examine the implications of AMPK in diseases such as cancer, diabetes complications, ischemia–reperfusion injury, and infectious diseases, focusing on the therapeutic potential of AMPK activators and inhibitors through the regulation of different types of RCD.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 6","pages":"Pages 601-619"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Principles for the design of multispecific proteins 多特异性蛋白的设计原则。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-05-02 DOI: 10.1016/j.tibs.2026.04.007
Shankar Raj Devkota , Pramod Aryal , Mikaela Bell , Surendra Kunwar , Martin J. Stone , Ram Prasad Bhusal
{"title":"Principles for the design of multispecific proteins","authors":"Shankar Raj Devkota ,&nbsp;Pramod Aryal ,&nbsp;Mikaela Bell ,&nbsp;Surendra Kunwar ,&nbsp;Martin J. Stone ,&nbsp;Ram Prasad Bhusal","doi":"10.1016/j.tibs.2026.04.007","DOIUrl":"10.1016/j.tibs.2026.04.007","url":null,"abstract":"<div><div>Multispecificity involves high-affinity binding to multiple related ligands while preserving discrimination against other ligands. The binding of tick evasins to human CC chemokines exemplifies key principles of multispecific binding: a rigid core recognising conserved features of all targets, with flexible peripheral regions enabling discrimination within the target family.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 6","pages":"Pages 538-541"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic encoding of multiple distinct noncanonical amino acids 多种不同的非规范氨基酸的遗传编码。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-04-25 DOI: 10.1016/j.tibs.2026.03.006
Wei Yu (于微) , Yu Fang (方誉) , Shixian Lin (林世贤) , Wenlong Ding (丁文龙)
{"title":"Genetic encoding of multiple distinct noncanonical amino acids","authors":"Wei Yu (于微) ,&nbsp;Yu Fang (方誉) ,&nbsp;Shixian Lin (林世贤) ,&nbsp;Wenlong Ding (丁文龙)","doi":"10.1016/j.tibs.2026.03.006","DOIUrl":"10.1016/j.tibs.2026.03.006","url":null,"abstract":"<div><div>The site-specific incorporation of noncanonical amino acids (ncAAs) has revolutionized protein research. However, synthesizing multifunctional biopolymers demands moving beyond single-type ncAA incorporation to simultaneously encoding multiple distinct ncAAs. This review summarizes transformative progress in the genetic encoding of multiple distinct ncAAs, including the development of mutually orthogonal translation systems and the expansion of codon repertoires. We highlight recent breakthroughs that have achieved the incorporation of multiple distinct ncAAs. Notably, integrating rare codon recoding with stop codon suppression in mammalian systems has recently enabled the genetic encoding of five distinct ncAAs. These innovations establish a robust platform for advanced biosensors, next-generation therapeutics, and synthetic biology with expanded chemical repertoires.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 6","pages":"Pages 620-634"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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