KRAS 突变癌症中 ERK 依赖性蛋白磷酸化：意料之中与意料之外的混合。

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2024-11-16 DOI:10.1016/j.tibs.2024.10.011

Kevin Huang, Yubao Wang, Thomas M Roberts

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引用次数: 0

摘要

最近开发的 KRAS 抑制剂为临床带来了益处，但其抗肿瘤疗效仍然有限。Klomp 等人的最新研究报告前所未有地全面剖析了依赖于 KRAS 通路的蛋白质磷酸化，为提高 KRAS 靶向疗法的疗效提供了新的见解和方向。

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ERK-dependent protein phosphorylation in KRAS-mutant cancer: a mix of the expected and surprising.

Recently developed KRAS inhibitors have delivered clinical benefits but their antitumor efficacy remains limited. A recent study by Klomp et al. reports an unprecedentedly comprehensive profiling of protein phosphorylation dependent on the KRAS pathway and generates new insights and directions to improve the efficacy of KRAS-targeted therapies.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.