发布求助
文献互助 智能选刊 最新文献

Trends in Biochemical Sciences最新文献

筛选
英文 中文
The Leishmania ribosome: more than passive mRNA translating machinery 利什曼原虫核糖体：不只是被动的 mRNA 翻译机器。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/j.tibs.2024.06.008
{"title":"The Leishmania ribosome: more than passive mRNA translating machinery","authors":"","doi":"10.1016/j.tibs.2024.06.008","DOIUrl":"10.1016/j.tibs.2024.06.008","url":null,"abstract":"<div><p><span><span>While the central dogma of molecular biology describes how </span>genetic<span> information flows, gene expression is also affected by epigenetic and epitranscriptomic processes. A recent report by </span></span><span><span>Rajan <em>et al</em></span><svg><path></path></svg></span><em>.</em> demonstrates how pseudouridylation of a <span><span>Leishmania</span></span><span> ribosomal rRNA affects the expression of particular proteins: an example of epitranslatomic control.</span></p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":null,"pages":null},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Migrasome biogenesis: when biochemistry meets biophysics on membranes 移行体的生物发生：当生物化学与生物物理学在膜上相遇。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/j.tibs.2024.06.004
{"title":"Migrasome biogenesis: when biochemistry meets biophysics on membranes","authors":"","doi":"10.1016/j.tibs.2024.06.004","DOIUrl":"10.1016/j.tibs.2024.06.004","url":null,"abstract":"<div><p>Migrasomes, newly identified organelles, play crucial roles in intercellular communication, contributing to organ development and angiogenesis. These vesicles, forming on retraction fibers of migrating cells, showcase a sophisticated architecture. Recent research reveals that migrasome biogenesis is a complicated and highly regulated process. This review summarizes the mechanisms governing migrasome formation, proposing a model in which biogenesis is understood through the lens of membrane microdomain assembly. It underscores the critical interplay between biochemistry and biophysics. The biogenesis unfolds in three distinct stages: nucleation, maturation, and expansion, each characterized by unique morphological, biochemical, and biophysical features. We also explore the broader implications of migrasome research in membrane biology and outline key unanswered questions that represent important directions for future investigation.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":null,"pages":null},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellular oxidants and the proteostasis network: balance between activation and destruction 细胞氧化剂与蛋白稳态网络：激活与破坏之间的平衡。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/j.tibs.2024.07.001
{"title":"Cellular oxidants and the proteostasis network: balance between activation and destruction","authors":"","doi":"10.1016/j.tibs.2024.07.001","DOIUrl":"10.1016/j.tibs.2024.07.001","url":null,"abstract":"<div><p>Loss of protein homeostasis (proteostasis) is a common hallmark of aging and age-associated diseases. Considered as the guardian of proteostasis, the proteostasis network (PN) acts to preserve the functionality of proteins during their lifetime. However, its activity declines with age, leading to disease manifestation. While reactive oxygen species (ROS) were traditionally considered culprits in this process, recent research challenges this view. While harmful at high concentrations, moderate ROS levels protect the cell against age-mediated onset of proteotoxicity by activating molecular chaperones, stress response pathways, and autophagy. This review explores the nuanced roles of ROS in proteostasis and discusses the most recent findings regarding the redox regulation of the PN and its potential in extending healthspan and delaying age-related pathologies.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":null,"pages":null},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0968000424001646/pdfft?md5=e438983700d0e46168c3bfae96cab77d&pid=1-s2.0-S0968000424001646-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142015999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IUBMB Trainee Initiative: supporting emerging biochemists and molecular biologists around the world 国际生物化学和分子生物学联合会受训人员计划：支持世界各地的新兴生物化学家和分子生物学家。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/j.tibs.2024.07.004
{"title":"IUBMB Trainee Initiative: supporting emerging biochemists and molecular biologists around the world","authors":"","doi":"10.1016/j.tibs.2024.07.004","DOIUrl":"10.1016/j.tibs.2024.07.004","url":null,"abstract":"<div><p>The International Union of Biochemistry and Molecular Biology (IUBMB) Trainee Initiative aims to identify challenges experienced by biochemistry and molecular biology trainees and create programming to foster their growth and development as the next generation of scientists. Here, we highlight resources and events developed by the Trainee Initiative in their endeavor to support trainees around the world.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":null,"pages":null},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0968000424001816/pdfft?md5=1766f2b5945a5294a72bfa46625178ac&pid=1-s2.0-S0968000424001816-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142144854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural transitions modulate the chaperone activities of Grp94 结构转变调节了 Grp94 的伴侣活性。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/j.tibs.2024.06.007
{"title":"Structural transitions modulate the chaperone activities of Grp94","authors":"","doi":"10.1016/j.tibs.2024.06.007","DOIUrl":"10.1016/j.tibs.2024.06.007","url":null,"abstract":"<div><p>A recent study by <span><span>Amankwah <em>et al.</em></span><svg><path></path></svg></span><span> reports how co-chaperone proteins and ATP hydrolysis<span><span> fine-tune the function of endoplasmic reticulum (ER)-resident Hsp90 </span>paralog Grp94.</span></span></p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":null,"pages":null},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the bench: motivations and aspirations of the IUBMB Trainee Initiative Leadership Committee 工作台之外：国际生物化学和分子生物学联合会受训人员倡议领导委员会的动机和愿望。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/j.tibs.2024.07.003
{"title":"Beyond the bench: motivations and aspirations of the IUBMB Trainee Initiative Leadership Committee","authors":"","doi":"10.1016/j.tibs.2024.07.003","DOIUrl":"10.1016/j.tibs.2024.07.003","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":null,"pages":null},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0968000424001804/pdfft?md5=7afd34d52e497ed766019a7d1d8b0473&pid=1-s2.0-S0968000424001804-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142144853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Versatile JMJD proteins: juggling histones and much more 多用途 JMJD 蛋白：组蛋白和更多杂耍。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/j.tibs.2024.06.009
{"title":"Versatile JMJD proteins: juggling histones and much more","authors":"","doi":"10.1016/j.tibs.2024.06.009","DOIUrl":"10.1016/j.tibs.2024.06.009","url":null,"abstract":"<div><p>Jumonji C domain-containing (JMJD) proteins are found in bacteria, fungi, animals, and plants. They belong to the 2-oxoglutarate-dependent oxygenase superfamily and are endowed with various enzymatic activities, including demethylation of histones and hydroxylation of non-histone proteins. Many JMJD proteins are involved in the epigenetic control of gene expression, yet they also modulate a myriad other cellular processes. In this review we focus on the 33 human JMJD proteins and their established and controversial catalytic properties, survey their epigenetic and non-epigenetic functions, emphasize their contribution to sex-specific disease differences, and highlight how they sense metabolic changes. All this underlines not only their key roles in development and homeostasis, but also that JMJD proteins are destined to become drug targets in multiple diseases.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":null,"pages":null},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/S0968-0004(24)00200-7
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/S0968-0004(24)00200-7","DOIUrl":"10.1016/S0968-0004(24)00200-7","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":null,"pages":null},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/S0968-0004(24)00197-X
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/S0968-0004(24)00197-X","DOIUrl":"10.1016/S0968-0004(24)00197-X","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":null,"pages":null},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S096800042400197X/pdfft?md5=4cf0e61b464c1e32c0d7234ffa2149e3&pid=1-s2.0-S096800042400197X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional implications of fumarate-induced cysteine succination 富马酸诱导半胱氨酸琥珀酸化的功能影响
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/j.tibs.2024.05.003
{"title":"Functional implications of fumarate-induced cysteine succination","authors":"","doi":"10.1016/j.tibs.2024.05.003","DOIUrl":"10.1016/j.tibs.2024.05.003","url":null,"abstract":"<div><p>Mutations in metabolic enzymes are associated with hereditary and sporadic forms of cancer. For example, loss-of-function mutations affecting fumarate hydratase (FH), the tricarboxylic acid (TCA) cycle enzyme, result in the accumulation of millimolar levels of fumarate that cause an aggressive form of kidney cancer. A distinct feature of fumarate is its ability to spontaneously react with thiol groups of cysteines in a chemical reaction termed succination. Although succination of a few proteins has been causally implicated in the molecular features of FH-deficient cancers, the stoichiometry, wider functional consequences, and contribution of succination to disease development remain largely unexplored. We discuss the functional implications of fumarate-induced succination in FH-deficient cells, the available methodologies, and the current challenges in studying this post-translational modification.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":null,"pages":null},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0968000424001130/pdfft?md5=df3dc6aac16d13e59cc8af993548abc8&pid=1-s2.0-S0968000424001130-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141320369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信