{"title":"Zn<sup>2+</sup> transients and signaling in mammalian systems.","authors":"Ananya Rakshit, Amy E Palmer","doi":"10.1016/j.tibs.2025.09.002","DOIUrl":null,"url":null,"abstract":"<p><p>Labile zinc (Zn<sup>2+</sup>) represents an important fraction of the total intracellular zinc pool that is readily available for binding. The signaling function of labile Zn<sup>2+</sup> lies in its dynamic nature. Fluctuations in labile Zn<sup>2+</sup> concentrations caused by either endogenous or exogenous stimuli can transiently influence cellular microenvironments, leading to modulation of signaling pathways. In this review, we focus on recent findings of zinc transients that influence cellular processes in mammalian systems. We highlight different types of zinc transients and how cellular zinc status plays regulatory roles in early development, gene expression, and kinase or neuronal signaling. Although the molecular mechanism behind how zinc transients activate signaling cascades is not clear in all cases, charting these interactions is the first step in the process.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.0000,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Biochemical Sciences","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.tibs.2025.09.002","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Labile zinc (Zn2+) represents an important fraction of the total intracellular zinc pool that is readily available for binding. The signaling function of labile Zn2+ lies in its dynamic nature. Fluctuations in labile Zn2+ concentrations caused by either endogenous or exogenous stimuli can transiently influence cellular microenvironments, leading to modulation of signaling pathways. In this review, we focus on recent findings of zinc transients that influence cellular processes in mammalian systems. We highlight different types of zinc transients and how cellular zinc status plays regulatory roles in early development, gene expression, and kinase or neuronal signaling. Although the molecular mechanism behind how zinc transients activate signaling cascades is not clear in all cases, charting these interactions is the first step in the process.
期刊介绍：
For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.
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