酵母中的Crabtree效应：发酵与呼吸之间的磷酸盐拔河。

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2025-02-01 DOI:10.1016/j.tibs.2024.12.001

Ananda Krishnan Manoj , Aswathy Valsalakumari Saradanandan , Vijay Jayaraman

引用次数: 0

摘要

酵母中的Crabtree效应与线粒体抑制有关，酵母细胞在高葡萄糖环境中更喜欢发酵而不是呼吸作用，但分子机制此前尚不清楚。最近，Vengayil等人发现敲除编码去泛素酶的ubp3基因可以通过增加线粒体磷酸盐水平来减轻Crabtree效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Crabtree effect in yeast: a phosphate tug-of-war between fermentation and respiration

The Crabtree effect in yeast, where cells prefer fermentation over respiration in high -glucose environments, is associated with mitochondrial repression, but the molecular mechanisms were previously unclear. Recently, Vengayil et al. revealed that knocking out the ubp3 gene, encoding a deubiquitinase enzyme, mitigates the Crabtree effect by increasing mitochondrial phosphate levels.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.