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Post-translational modifications as key regulators of proline metabolism 翻译后修饰作为脯氨酸代谢的关键调节因子。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-07-01 Epub Date: 2026-05-14 DOI: 10.1016/j.tibs.2026.04.009
Nina Durand, Arnould Savouré, Sandrine Lebreton
{"title":"Post-translational modifications as key regulators of proline metabolism","authors":"Nina Durand,&nbsp;Arnould Savouré,&nbsp;Sandrine Lebreton","doi":"10.1016/j.tibs.2026.04.009","DOIUrl":"10.1016/j.tibs.2026.04.009","url":null,"abstract":"<div><div>Post-translational modifications (PTMs) are emerging as crucial regulators of proline metabolism, a pathway central to redox homeostasis, stress adaptation, and disease progression conserved across species. Beyond transcriptional regulation, PTMs such as phosphorylation, acetylation, and ubiquitination fine-tune the activity, stability, and localization of proline metabolic enzymes, including those involved in its biosynthesis and catabolism. Advances in proteomics and structural biology now provide insights into how these reversible modifications modulate enzyme oligomerization and metabolic flux, with involvement in plant stress tolerance and cancer cell survival. Here, we synthesize recent observations across kingdoms, discuss how PTMs integrate into metabolic control, and highlight future directions for exploiting PTM-based regulation in agriculture and human health.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 7","pages":"Pages 717-731"},"PeriodicalIF":14.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147939349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transglutaminase 2 drives histone monoaminylation as an epigenetic mechanism in health and disease 转谷氨酰胺酶2驱动组蛋白单胺化作为健康和疾病的表观遗传机制。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-07-01 Epub Date: 2026-04-20 DOI: 10.1016/j.tibs.2026.04.003
Anne A. Leaman, Zeng Lin (林曾), Qingfei Zheng (郑庆飞)
{"title":"Transglutaminase 2 drives histone monoaminylation as an epigenetic mechanism in health and disease","authors":"Anne A. Leaman,&nbsp;Zeng Lin (林曾),&nbsp;Qingfei Zheng (郑庆飞)","doi":"10.1016/j.tibs.2026.04.003","DOIUrl":"10.1016/j.tibs.2026.04.003","url":null,"abstract":"<div><div>Transglutaminases (TGs) were originally discovered to catalyze protein–protein crosslinking by forming isopeptide bonds between the side chains of lysine and glutamine. Recently, TGs have been found to mediate the bioconjugation between protein glutamines and monoamine metabolites (such as serotonin, dopamine, and histamine), which is termed ‘monoaminylation’. Monoaminylation on core histones, installed by human transglutaminase 2 (TG2), is an emerging epigenetic mark that plays a significant role in regulating cellular gene transcription. Unlike other histone post-translational modifications, the dynamics of monoaminylation (including its installation, removal, and replacement) are solely regulated by TG2. Here, we review the most recent advances in TG2-mediated histone monoaminylation (including serotonylation, dopaminylation, and histaminylation), focusing on its novel biochemical basis and epigenetic functions in pathophysiology.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 7","pages":"Pages 673-684"},"PeriodicalIF":14.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Better call chaperone 最好叫监护人来。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-07-01 Epub Date: 2026-07-02 DOI: 10.1016/j.tibs.2026.05.003
Yunxing ‘Stella’ Li
{"title":"Better call chaperone","authors":"Yunxing ‘Stella’ Li","doi":"10.1016/j.tibs.2026.05.003","DOIUrl":"10.1016/j.tibs.2026.05.003","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 7","pages":"Page 748"},"PeriodicalIF":14.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会及内容
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-07-01 Epub Date: 2026-07-02 DOI: 10.1016/S0968-0004(26)00185-4
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/S0968-0004(26)00185-4","DOIUrl":"10.1016/S0968-0004(26)00185-4","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 7","pages":"Pages i-ii"},"PeriodicalIF":14.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148429252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stimulus-responsive nuclear moonlighting of plant metabolic enzymes rewires chromatin 植物代谢酶的刺激响应核月光重新连接染色质。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-07-01 Epub Date: 2026-05-29 DOI: 10.1016/j.tibs.2026.05.002
Guiyu Xiao , Jisen Zhang , Qiutao Xu
{"title":"Stimulus-responsive nuclear moonlighting of plant metabolic enzymes rewires chromatin","authors":"Guiyu Xiao ,&nbsp;Jisen Zhang ,&nbsp;Qiutao Xu","doi":"10.1016/j.tibs.2026.05.002","DOIUrl":"10.1016/j.tibs.2026.05.002","url":null,"abstract":"<div><div>Traditionally viewed as cytoplasmic catalysts, plant metabolic enzymes are now known to moonlight in the nucleus. This forum article highlights emerging mechanisms by which nuclear-localized metabolic enzymes couple plant metabolic status to development and stress responses via chromatin regulation, providing a conceptual framework for metabolic–epigenetic crosstalk and future crop improvement.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 7","pages":"Pages 657-660"},"PeriodicalIF":14.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148051788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of inflammatory gene transcription by ubiquitination and deubiquitination 泛素化和去泛素化对炎症基因转录的调控。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-03-09 DOI: 10.1016/j.tibs.2026.01.008
Zixu Liu
{"title":"Regulation of inflammatory gene transcription by ubiquitination and deubiquitination","authors":"Zixu Liu","doi":"10.1016/j.tibs.2026.01.008","DOIUrl":"10.1016/j.tibs.2026.01.008","url":null,"abstract":"<div><div>Transcriptional responses are initiated immediately after the recognition of pathogen-associated molecular patterns by pattern recognition receptors, enabling host cells to deal with inflammatory stimuli, including microbial infections. In turn, these inflammatory transcriptional programs must be tightly controlled to prevent potential detrimental consequences, such as immunopathological or even fatal outcomes. To date, many well-defined mechanisms have been reported that contribute to the transcriptional control of inflammatory gene expression at multiple levels. Here, I mainly focus on reviewing recent progress in post-translational modifications, in particular, how the ubiquitination–deubiquitination cycle controls inflammatory gene transcription mediated by nuclear factor kappa-light-chain-enhancer of activated B cells and interferon signaling pathways. Lastly, I will emphasize the importance of understanding gene-specific mechanisms in controlling inflammatory gene transcription.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 6","pages":"Pages 587-600"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mobile peptide and receptor complex mediates systemic stomatal immunity 移动肽和受体复合物介导全身气孔免疫。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-03-30 DOI: 10.1016/j.tibs.2026.02.019
Huizhen Liang , Xiaoyu Su , Zheng Qing Fu , Zhengwei Tan
{"title":"Mobile peptide and receptor complex mediates systemic stomatal immunity","authors":"Huizhen Liang ,&nbsp;Xiaoyu Su ,&nbsp;Zheng Qing Fu ,&nbsp;Zhengwei Tan","doi":"10.1016/j.tibs.2026.02.019","DOIUrl":"10.1016/j.tibs.2026.02.019","url":null,"abstract":"<div><div>While pathogen-induced local leaf stomatal closure is known to be crucial for plant immunity, whether local infection triggers stomatal closure in distant leaves has remained unknown. Recently, <span><span>Liu <em>et al</em>.</span><svg><path></path></svg></span> discovered that an upstream open reading frame-encoded mobile peptide and its receptor–coreceptor pair activate systemic stomatal immunity.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 6","pages":"Pages 533-535"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The multifunctional, stress-sensitive ribonuclease angiogenin cross-regulates different gene expression processes 多功能，应激敏感核糖核酸酶血管生成素交叉调节不同的基因表达过程。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-04-23 DOI: 10.1016/j.tibs.2026.03.005
Ana C. de A.P. Schwarzer , Markus T. Bohnsack , Katherine E. Bohnsack
{"title":"The multifunctional, stress-sensitive ribonuclease angiogenin cross-regulates different gene expression processes","authors":"Ana C. de A.P. Schwarzer ,&nbsp;Markus T. Bohnsack ,&nbsp;Katherine E. Bohnsack","doi":"10.1016/j.tibs.2026.03.005","DOIUrl":"10.1016/j.tibs.2026.03.005","url":null,"abstract":"<div><div>Ribonucleases shape gene expression by mediating RNA processing and degradation. Angiogenin (ANG) is a prominent ribonuclease implicated in several pathophysiologies that contributes to multiple cellular processes by targeting different RNA substrates in a context-dependent manner. ANG has emerged as a key regulator of ribosomal DNA transcription and a direct modulator of translation. Upon cellular stress, ANG is responsible for the cleavage of tRNAs into fragments that are now recognized as important regulators of different aspects of gene expression, including mRNA stability and translation. In this review, we provide updated perspectives on the mechanisms of gene expression regulation by ANG and highlight the potential of multifunctional ribonucleases for mediating crosstalk between different aspects of gene expression.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 6","pages":"Pages 573-586"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repurposing nanopore sequencing platforms for high-throughput peptide profiling 利用纳米孔测序平台进行高通量肽谱分析。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-04-22 DOI: 10.1016/j.tibs.2026.04.005
Ji Wang (王冀) , Junyi Chen (陈俊毅) , Xun Xu (徐讯)
{"title":"Repurposing nanopore sequencing platforms for high-throughput peptide profiling","authors":"Ji Wang (王冀) ,&nbsp;Junyi Chen (陈俊毅) ,&nbsp;Xun Xu (徐讯)","doi":"10.1016/j.tibs.2026.04.005","DOIUrl":"10.1016/j.tibs.2026.04.005","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 6","pages":"Pages 635-636"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会及内容
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-06-04 DOI: 10.1016/S0968-0004(26)00147-7
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/S0968-0004(26)00147-7","DOIUrl":"10.1016/S0968-0004(26)00147-7","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 6","pages":"Pages i-ii"},"PeriodicalIF":11.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148153299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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