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Diseases caused by altered specificity of a protein kinase for its allosteric activators 蛋白激酶对其异位激活剂的特异性改变导致的疾病。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.tibs.2024.10.008
Philip Cohen , Tom Snelling
{"title":"Diseases caused by altered specificity of a protein kinase for its allosteric activators","authors":"Philip Cohen ,&nbsp;Tom Snelling","doi":"10.1016/j.tibs.2024.10.008","DOIUrl":"10.1016/j.tibs.2024.10.008","url":null,"abstract":"<div><div>Protein kinases regulate many intracellular processes, and their dysregulation causes cancers and other diseases. This review focuses on the atypical alpha-kinase 1 (ALPK1), which is activated in mammalian cells by nucleoside diphosphate heptoses (ADP-heptose, UDP-heptose, and CDP-heptose) produced by microbial pathogens but not by mammalian cells. Mutations in human ALPK1 cause ROSAH syndrome and spiradenoma, which result from an alteration in its specificity for nucleoside diphosphate heptoses, causing aberrant activation by mammalian nucleoside diphosphate sugars without microbial infection. These may be the first diseases caused by altered specificity of an enzyme for its allosteric activators and has suggested ways in which selective drugs could be developed to treat them without compromising the innate immune system.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 1","pages":"Pages 61-70"},"PeriodicalIF":11.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅及版权资料
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-01-01 DOI: 10.1016/S0968-0004(24)00289-5
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/S0968-0004(24)00289-5","DOIUrl":"10.1016/S0968-0004(24)00289-5","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 1","pages":"Page e1"},"PeriodicalIF":11.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143136580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TEX264-mediated selective autophagy directs DNA damage repair TEX264 介导的选择性自噬可引导 DNA 损伤修复。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.tibs.2024.10.012
Yuxia Qi , Sho W. Suzuki
{"title":"TEX264-mediated selective autophagy directs DNA damage repair","authors":"Yuxia Qi ,&nbsp;Sho W. Suzuki","doi":"10.1016/j.tibs.2024.10.012","DOIUrl":"10.1016/j.tibs.2024.10.012","url":null,"abstract":"<div><div>DNA is constantly subject to damage from endogenous and exogenous factors, leading to mutations and disease. While DNA is traditionally repaired in the nucleus, <span><span>Lascaux <em>et al.</em></span><svg><path></path></svg></span> reveal a novel role for the lysosome in DNA repair, demonstrating that topoisomerase 1 (TOP1) cleavage complex (TOP1cc) DNA lesions are degraded via TEX264-mediated selective autophagy.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 1","pages":"Pages 4-5"},"PeriodicalIF":11.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inventories invite independence 清单会带来独立性。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.tibs.2024.11.003
Kayleigh Robichaux , Taylor Billings , Christina Marie Termini
{"title":"Inventories invite independence","authors":"Kayleigh Robichaux ,&nbsp;Taylor Billings ,&nbsp;Christina Marie Termini","doi":"10.1016/j.tibs.2024.11.003","DOIUrl":"10.1016/j.tibs.2024.11.003","url":null,"abstract":"<div><div>In this piece, we use an antibody inventory system to exemplify the potential benefits of laboratory organization in research environments. We highlight how inventories can support resource accessibility and strengthen a sense of independence for scientists, especially those new to research environments.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 1","pages":"Pages 1-3"},"PeriodicalIF":11.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How does p53 work? Regulation by the intrinsically disordered domains p53 如何工作？内在无序结构域的调控。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-01-01 DOI: 10.1016/j.tibs.2024.10.009
H. Jane Dyson , Peter E. Wright
{"title":"How does p53 work? Regulation by the intrinsically disordered domains","authors":"H. Jane Dyson ,&nbsp;Peter E. Wright","doi":"10.1016/j.tibs.2024.10.009","DOIUrl":"10.1016/j.tibs.2024.10.009","url":null,"abstract":"<div><div>Defects in the tumor suppressor protein p53 are found in the majority of cancers. The p53 protein (393 amino acids long) contains the folded DNA-binding domain (DBD) and tetramerization domain (TET), with the remainder of the sequence being intrinsically disordered. Since cancer-causing mutations occur primarily in the DBD, this has been the focus of most of the research on p53. However, recent reports show that the disordered N-terminal activation domain (NTAD) and C-terminal regulatory domain (CTD) function synergistically with the DBD to regulate p53 activity. We propose a mechanistic model in which intermolecular and intramolecular interactions of the disordered regions, modulated by post-translational modifications, perform a central role in the regulation and activation of p53 in response to cellular stress.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 1","pages":"Pages 9-17"},"PeriodicalIF":11.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会及内容
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-01-01 DOI: 10.1016/S0968-0004(24)00286-X
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/S0968-0004(24)00286-X","DOIUrl":"10.1016/S0968-0004(24)00286-X","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 1","pages":"Pages i-ii"},"PeriodicalIF":11.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143136579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring cross-α amyloids: from functional roles to design innovations 探索交叉α淀粉样蛋白：从功能作用到设计创新。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-12-01 DOI: 10.1016/j.tibs.2024.10.004
Sukantha Dey , Rohit Kumar , Rajkumar Mishra , Santu Bera
{"title":"Exploring cross-α amyloids: from functional roles to design innovations","authors":"Sukantha Dey ,&nbsp;Rohit Kumar ,&nbsp;Rajkumar Mishra ,&nbsp;Santu Bera","doi":"10.1016/j.tibs.2024.10.004","DOIUrl":"10.1016/j.tibs.2024.10.004","url":null,"abstract":"<div><div>Amyloids are filamentous protein aggregates that have traditionally been associated with neurodegenerative diseases, although they are also known to play pivotal functional roles across diverse forms of life. Although the cross-β structure has represented the hallmark of amyloidal assemblies, a cross-α structure was recently characterized as a functional microbial amyloid, and further work has shown that <em>de novo</em> designed sequences also assemble into cross-α amyloids, emphasizing cross-α as an alternative paradigm for self-assembly into ordered aggregates. In this review, we summarize recent discoveries of cross-α amyloids both in nature and artificially designed systems, and we describe their fundamental structural organization, self-assembly mechanisms, and biological functions. Finally, we outline the future opportunities for research and development in this potential field.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 12","pages":"Pages 1097-1110"},"PeriodicalIF":11.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catchers of folding gone awry: a tale of small heat shock proteins 折叠出错的捕手：小型热休克蛋白的故事。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-12-01 DOI: 10.1016/j.tibs.2024.08.003
Carsten Peters , Martin Haslbeck , Johannes Buchner
{"title":"Catchers of folding gone awry: a tale of small heat shock proteins","authors":"Carsten Peters ,&nbsp;Martin Haslbeck ,&nbsp;Johannes Buchner","doi":"10.1016/j.tibs.2024.08.003","DOIUrl":"10.1016/j.tibs.2024.08.003","url":null,"abstract":"<div><div>Small heat shock proteins (sHsps) are an important part of the cellular system maintaining protein homeostasis under physiological and stress conditions. As molecular chaperones, they form complexes with different non-native proteins in an ATP-independent manner. Many sHsps populate ensembles of energetically similar but different-sized oligomers. Regulation of chaperone activity occurs by changing the equilibrium of these ensembles. This makes sHsps a versatile and adaptive system for trapping non-native proteins in complexes, allowing recycling with the help of ATP-dependent chaperones. In this review, we discuss progress in our understanding of the structural principles of sHsp oligomers and their functional principles, as well as their roles in aging and eye lens transparency.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 12","pages":"Pages 1063-1078"},"PeriodicalIF":11.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses 细菌中解除宿主泛素防御的 CE 族蛋白酶的结构多样性。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-12-01 DOI: 10.1016/j.tibs.2024.09.001
Lucía Sánchez-Alba , Helena Borràs-Gas , Ge Huang , Nathalia Varejão , David Reverter
{"title":"Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses","authors":"Lucía Sánchez-Alba ,&nbsp;Helena Borràs-Gas ,&nbsp;Ge Huang ,&nbsp;Nathalia Varejão ,&nbsp;David Reverter","doi":"10.1016/j.tibs.2024.09.001","DOIUrl":"10.1016/j.tibs.2024.09.001","url":null,"abstract":"<div><div>Ubiquitin (Ub) and ubiquitin-like (UbL) modifications are critical regulators of multiple cellular processes in eukaryotes. These modifications are dynamically controlled by proteases that balance conjugation and deconjugation. In eukaryotes, these proteases include deubiquitinases (DUBs), mostly belonging to the CA-clan of cysteine proteases, and ubiquitin-like proteases (ULPs), belonging to the CE-clan proteases. Intriguingly, infectious bacteria exploit the CE-clan protease fold to generate deubiquitinating activities to disarm the immune system and degradation defenses of the host during infection. In this review, we explore the substrate preferences encoded within the CE-clan proteases and the structural determinants in the protease fold behind its selectivity, in particular those from infectious bacteria and viruses. Understanding this protease family provides crucial insights into the molecular mechanisms underlying infection and transmission of pathogenic organisms.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 12","pages":"Pages 1111-1123"},"PeriodicalIF":11.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anything you can do, glycans do better: deglycosylation and noncanonical ubiquitination vie to rule the proteasome 你能做的任何事情，聚糖都能做得更好：脱糖基化和非经典泛素化争夺蛋白酶体的统治权。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-12-01 DOI: 10.1016/j.tibs.2024.10.001
Nicolas Lehrbach
{"title":"Anything you can do, glycans do better: deglycosylation and noncanonical ubiquitination vie to rule the proteasome","authors":"Nicolas Lehrbach","doi":"10.1016/j.tibs.2024.10.001","DOIUrl":"10.1016/j.tibs.2024.10.001","url":null,"abstract":"<div><div>The Nrf1/Nfe2L1 transcription factor is a master regulator of proteasome biogenesis. New work by <span><span>Yoshida and colleagues</span><svg><path></path></svg></span> reveals a surprising mechanism by which ubiquitination of <em>N</em>-glycosylated Nrf1 controls its function.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 12","pages":"Pages 1033-1035"},"PeriodicalIF":11.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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