FN3K: the (un)sweetest kinase.

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2025-04-04 DOI:10.1016/j.tibs.2025.03.009

Joyce Ogidigo, Reena Kumari, Viraj R Sanghvi

引用次数: 0

Abstract

Fructosamine 3-kinase (FN3K) mitigates excessive protein glycation by phosphorylating and destabilizing fructosamines, preventing irreversible advanced glycation end-products (AGEs). Recent high-resolution structures of FN3K by Garg and On et al. reveal key active-site features, highlighting unique regulatory mechanisms and potential druggable sites and providing a foundation for structure-guided drug development against this target.

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果糖胺 3 激酶（FN3K）通过磷酸化和破坏果糖胺的稳定性，防止不可逆转的高级糖化终产物（AGEs），从而减轻蛋白质的过度糖化。Garg 和 On 等人最近对 FN3K 的高分辨率结构进行了研究，揭示了关键的活性位点特征，突出了独特的调控机制和潜在的可用药位点，为针对这一靶点的结构引导药物开发奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

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