Mps1 激酶在有丝分裂纺锤体组装和纠错中的功能

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2025-05-01 DOI:10.1016/j.tibs.2025.02.005

Victor M. Bolanos-Garcia

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引用次数: 0

摘要

蛋白激酶Mps1（也称为TTK）是有丝分裂纺锤体组装检查点（SAC）的核心组成部分，SAC是真核细胞周期的重要自我监测系统，通过延迟后期的开始，直到所有染色体在有丝分裂纺锤体上正确定位，确保准确的染色体分离。Mps1激酶是SAC的重要上游调控因子，其向着丝点的募集对启动SAC信号传导至关重要。本文讨论了目前对Mps1在SAC中的基本功能的理解，Mps1在维护基因组稳定性的纠错中作用的新细节，以及Mps1抑制治疗与异常SAC信号传导和染色体分离缺陷相关的癌症类型的治疗潜力。

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Mps1 kinase functions in mitotic spindle assembly and error correction

The protein kinase Mps1 (also known as TTK) is a central component of the mitotic spindle assembly checkpoint (SAC), an essential self-monitoring system of the eukaryotic cell cycle that ensures accurate chromosome segregation by delaying the onset of anaphase until all chromosomes are properly bioriented on the mitotic spindle. Mps1 kinase is an important upstream regulator of the SAC and its recruitment to kinetochores critical for initiating SAC signaling. This review discusses the current understanding of Mps1 essential functions in the SAC, the emerging details of Mps1 role in error correction to safeguard genome stability, and the therapeutic potential of Mps1 inhibition for the treatment of cancer types associated with aberrant SAC signaling and chromosome segregation defects.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.