Conserved signaling gears that sustain circadian clock robustness.

IF 11 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2025-07-10 DOI:10.1016/j.tibs.2025.06.013

Felipe Muñoz-Guzmán, Luis F Larrondo

引用次数: 0

Abstract

Circadian clocks maintain the correct period despite nutritional fluctuations, a property known as metabolic compensation (MC). In a recent report, Sárkány et al. reveal a conserved role for Ras guanine nucleotide exchange factor (RasGEF) signaling in MC from fungi to human cells. Their findings highlight how this pathway buffers circadian function under glucose deprivation, integrating metabolic cues into clock dynamic robustness.

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维持生物钟稳健性的保守信号装置。

尽管营养波动，生物钟仍保持正确的周期，这一特性被称为代谢补偿（MC）。在最近的一份报告中，Sárkány等人揭示了Ras鸟嘌呤核苷酸交换因子（Ras guine nucleotide exchange factor, RasGEF）信号在从真菌到人类细胞的MC中的保守作用。他们的发现强调了这一途径如何在葡萄糖剥夺下缓冲昼夜节律功能，将代谢线索整合到时钟动态稳健性中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.