可编程的蛋白质编辑。

IF 11 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2025-10-01 DOI:10.1016/j.tibs.2025.06.008

Carly K. Schissel

引用次数: 0

摘要

将非自然的化学基序和结构安装到活细胞的蛋白质中是具有挑战性的。Beyer等人最近的工作展示了可编程的蛋白质编辑，他们将两个分裂的内部蛋白对安装到感兴趣的蛋白质中，在哺乳动物细胞内以完全合成的肽序列拼接。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Programmable protein editing

Installation of unnatural chemical motifs and structures into proteins in living cells is challenging. Recent work by Beyer et al. demonstrated programmable protein editing by installing two split intein pairs into a protein of interest, which splice in a fully synthetic peptide sequence inside mammalian cells.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.