How interactions between oxidized DNA and the NLRP3 inflammasome fuel inflammatory disease

IF 11 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2025-10-01 DOI:10.1016/j.tibs.2025.07.007

Angela Lackner , Lemuel Leonidas , Alijah Macapagal , Hannah Lee , Reginald McNulty

引用次数: 0

Abstract

Recent discoveries have emphasized the critical role of oxidized DNA (ox-DNA) in inflammation and immune regulation. Produced during oxidative stress from infection or tissue damage, ox-DNA activates signaling pathways that drive the release of proinflammatory cytokines, specifically engaging the NLRP3 inflammasome, a key player in cytokine maturation and host defense. NLRP3 is increasingly implicated in inflammatory and autoimmune diseases, with ox-DNA recognized as a central activator of this inflammasome. This review examines the role of ox-DNA in inflammasome activation, its broader impact on inflammatory processes, and promising therapeutic approaches targeting ox-DNA through both immunological and structural lenses. These insights highlight ox-DNA’s relevance in inflammation and offer potential avenues for the treatment of a range of immune-related disorders.

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氧化DNA和NLRP3炎性体之间的相互作用如何促进炎症性疾病。

最近的发现强调了氧化DNA （ox-DNA）在炎症和免疫调节中的关键作用。在感染或组织损伤引起的氧化应激过程中产生的ox-DNA激活了驱动促炎细胞因子释放的信号通路，特别是参与细胞因子成熟和宿主防御的关键角色NLRP3炎症小体。NLRP3越来越多地与炎症和自身免疫性疾病有关，ox-DNA被认为是这种炎症小体的中心激活剂。本文综述了ox-DNA在炎性小体激活中的作用，其对炎症过程的广泛影响，以及通过免疫和结构透镜靶向ox-DNA的有前途的治疗方法。这些见解突出了ox-DNA在炎症中的相关性，并为治疗一系列免疫相关疾病提供了潜在的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

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