Global Health Epidemiology and Genomics最新文献_第7页

Hyak mortality monitoring system: innovative sampling and estimation methods - proof of concept by simulation. Hyak死亡率监测系统:创新的抽样和估计方法-通过模拟验证概念。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2018-02-05 eCollection Date: 2018-01-01 DOI: 10.1017/gheg.2017.15

S J Clark, J Wakefield, T McCormick, M Ross

{"title":"Hyak mortality monitoring system: innovative sampling and estimation methods - proof of concept by simulation.","authors":"S J Clark, J Wakefield, T McCormick, M Ross","doi":"10.1017/gheg.2017.15","DOIUrl":"10.1017/gheg.2017.15","url":null,"abstract":"Traditionally health statistics are derived from civil and/or vital registration. Civil registration in low- to middle-income countries varies from partial coverage to essentially nothing at all. Consequently the state of the art for public health information in low- to middle-income countries is efforts to combine or triangulate data from different sources to produce a more complete picture across both time and space - data amalgamation. Data sources amenable to this approach include sample surveys, sample registration systems, health and demographic surveillance systems, administrative records, census records, health facility records and others. We propose a new statistical framework for gathering health and population data - Hyak - that leverages the benefits of sampling and longitudinal, prospective surveillance to create a cheap, accurate, sustainable monitoring platform. Hyak has three fundamental components: Data amalgamation: A sampling and surveillance component that organizes two or more data collection systems to work together: (1) data from HDSS with frequent, intense, linked, prospective follow-up and (2) data from sample surveys conducted in large areas surrounding the Health and Demographic Surveillance System (HDSS) sites using informed sampling so as to capture as many events as possible;Cause of death: Verbal autopsy to characterize the distribution of deaths by cause at the population level; andSocioeconomic status (SES): Measurement of SES in order to characterize poverty and wealth. We conduct a simulation study of the informed sampling component of Hyak based on the Agincourt HDSS site in South Africa. Compared with traditional cluster sampling, Hyak's informed sampling captures more deaths, and when combined with an estimation model that includes spatial smoothing, produces estimates of both mortality counts and mortality rates that have lower variance and small bias.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"3 ","pages":"e3"},"PeriodicalIF":1.9,"publicationDate":"2018-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2017.15","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Design and content validation of a set of SMS to promote seeking of specialized mental health care within the Allillanchu Project. 设计并验证一套短信内容，以促进在阿利兰楚项目内寻求专门的心理保健服务。

IF 1.1

Global Health Epidemiology and Genomics Pub Date : 2018-01-31 eCollection Date: 2018-01-01 DOI: 10.1017/gheg.2017.18

M Toyama, F Diez-Canseco, P Busse, I Del Mastro, J J Miranda

{"title":"Design and content validation of a set of SMS to promote seeking of specialized mental health care within the Allillanchu Project.","authors":"M Toyama, F Diez-Canseco, P Busse, I Del Mastro, J J Miranda","doi":"10.1017/gheg.2017.18","DOIUrl":"10.1017/gheg.2017.18","url":null,"abstract":"Background: The aim of this study was to design and develop a set of, short message service (SMS) to promote specialized mental health care seeking within the framework of the Allillanchu Project.Methods: The design phase consisted of 39 interviews with potential recipients of the SMS, about use of cellphones, and perceptions and motivations towards seeking mental health care. After the data collection, the research team developed a set of seven SMS for validation. The content validation phase consisted of 24 interviews. The participants answered questions regarding their understanding of the SMS contents and rated its appeal.Results: The seven SMS subjected to content validation were tailored to the recipient using their name. The reminder message included the working hours of the psychology service at the patient's health center. The motivational messages addressed perceived barriers and benefits when seeking mental health services. The average appeal score of the seven SMS was 9.0 (SD±0.4) of 10 points. Participants did not make significant suggestions to change the wording of the messages.Conclusions: Five SMS were chosen to be used. This approach is likely to be applicable to other similar low-resource settings, and the methodology used can be adapted to develop SMS for other chronic conditions.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"3 ","pages":"e2"},"PeriodicalIF":1.1,"publicationDate":"2018-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel polymorphisms in TICAM2 and NOD1 associated with tuberculosis progression phenotypes in Ethiopian populations. 埃塞俄比亚人群中与结核病进展表型相关的TICAM2和NOD1新多态性

IF 1.1

Global Health Epidemiology and Genomics Pub Date : 2018-01-23 eCollection Date: 2018-01-01 DOI: 10.1017/gheg.2017.17

E Mekonnen, E Bekele, C M Stein

{"title":"Novel polymorphisms in TICAM2 and NOD1 associated with tuberculosis progression phenotypes in Ethiopian populations.","authors":"E Mekonnen, E Bekele, C M Stein","doi":"10.1017/gheg.2017.17","DOIUrl":"10.1017/gheg.2017.17","url":null,"abstract":"Background: Infection by Mycobacterium tuberculosis (Mtb) is a necessary but not sufficient cause for tuberculosis (TB). Although numerous studies suggest human genetic variation may influence TB pathogenesis, there is a conspicuous lack of replication, likely due to imprecise phenotype definition. We aimed to replicate novel findings from a Ugandan cohort in Ethiopian populations.Method: We ascertained TB cases and household controls (n = 292) from three different ethnic groups. Latent Mtb infection was determined using Quantiferon to develop reliable TB progression phenotypes. We sequenced exonic regions of TICAM2 and NOD1.Result: Significant novel associations were observed between two variants in NOD1 and TB: rs751770147 [unadjusted p = 7.28 × 10-5] and chr7:30477156(T), a novel variant, [unadjusted p = 1.04 × 10-4]. Two SNPs in TICAM2 were nominally associated with TB, including rs2288384 [unadjusted p = 0.003]. Haplotype-based association tests supported the SNP-based results.Conclusion: We replicated the association of TICAM2 and NOD1 with TB and identified novel genetic associations with TB in Ethiopian populations.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"3 ","pages":"e1"},"PeriodicalIF":1.1,"publicationDate":"2018-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV treatment is associated with a two-fold higher probability of raised triglycerides: Pooled Analyses in 21 023 individuals in sub-Saharan Africa. 艾滋病毒治疗与甘油三酯升高的概率增加两倍有关：对撒哈拉以南非洲 21 023 人的汇总分析。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2018-01-01 Epub Date: 2018-05-08 DOI: 10.1017/gheg.2018.7

Kenneth Ekoru, Elizabeth H Young, David G Dillon, Deepti Gurdasani, Nathan Stehouwer, Daniel Faurholt-Jepsen, Naomi S Levitt, Nigel J Crowther, Moffat Nyirenda, Marina A Njelekela, Kaushik Ramaiya, Ousman Nyan, Olanisun O Adewole, Kathryn Anastos, Caterina Compostella, Joel A Dave, Carla M Fourie, Henrik Friis, Iolanthe M Kruger, Chris T Longenecker, Dermot P Maher, Eugene Mutimura, Chiratidzo E Ndhlovu, George Praygod, Eric W Pefura Yone, Mar Pujades-Rodriguez, Nyagosya Range, Mahmoud U Sani, Muhammad Sanusi, Aletta E Schutte, Karen Sliwa, Phyllis C Tien, Este H Vorster, Corinna Walsh, Dickman Gareta, Fredirick Mashili, Eugene Sobngwi, Clement Adebamowo, Anatoli Kamali, Janet Seeley, Liam Smeeth, Deenan Pillay, Ayesha A Motala, Pontiano Kaleebu, Manjinder S Sandhu

{"title":"HIV treatment is associated with a two-fold higher probability of raised triglycerides: Pooled Analyses in 21 023 individuals in sub-Saharan Africa.","authors":"Kenneth Ekoru, Elizabeth H Young, David G Dillon, Deepti Gurdasani, Nathan Stehouwer, Daniel Faurholt-Jepsen, Naomi S Levitt, Nigel J Crowther, Moffat Nyirenda, Marina A Njelekela, Kaushik Ramaiya, Ousman Nyan, Olanisun O Adewole, Kathryn Anastos, Caterina Compostella, Joel A Dave, Carla M Fourie, Henrik Friis, Iolanthe M Kruger, Chris T Longenecker, Dermot P Maher, Eugene Mutimura, Chiratidzo E Ndhlovu, George Praygod, Eric W Pefura Yone, Mar Pujades-Rodriguez, Nyagosya Range, Mahmoud U Sani, Muhammad Sanusi, Aletta E Schutte, Karen Sliwa, Phyllis C Tien, Este H Vorster, Corinna Walsh, Dickman Gareta, Fredirick Mashili, Eugene Sobngwi, Clement Adebamowo, Anatoli Kamali, Janet Seeley, Liam Smeeth, Deenan Pillay, Ayesha A Motala, Pontiano Kaleebu, Manjinder S Sandhu","doi":"10.1017/gheg.2018.7","DOIUrl":"10.1017/gheg.2018.7","url":null,"abstract":"Background: Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TG) in western populations. However, there are limited data on the impact of ART on cardiometabolic risk in sub-Saharan African (SSA) populations.Methods: Pooled analyses of 14 studies comprising 21 023 individuals, on whom relevant cardiometabolic risk factors (including TG), HIV and ART status were assessed between 2003 and 2014, in SSA. The association between ART and raised TG (>2.3 mmol/L) was analysed using regression models.Findings: Among 10 615 individuals, ART was associated with a two-fold higher probability of raised TG (RR 2.05, 95% CI 1.51-2.77, I2=45.2%). The associations between ART and raised blood pressure, glucose, HbA1c, and other lipids were inconsistent across studies.Interpretation: Evidence from this study confirms the association of ART with raised TG in SSA populations. Given the possible causal effect of raised TG on cardiovascular disease (CVD), the evidence highlights the need for prospective studies to clarify the impact of long term ART on CVD outcomes in SSA.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"3 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36205100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole-genome association study of antibody response to Epstein-Barr virus in an African population: a pilot. 非洲人群对 Epstein-Barr 病毒抗体反应的全基因组关联研究：一项试验。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2017-11-27 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.16

N Sallah, T Carstensen, K Wakeham, R Bagni, N Labo, M O Pollard, D Gurdasani, K Ekoru, C Pomilla, E H Young, S Fatumo, G Asiki, A Kamali, M Sandhu, P Kellam, D Whitby, I Barroso, R Newton

{"title":"Whole-genome association study of antibody response to Epstein-Barr virus in an African population: a pilot.","authors":"N Sallah, T Carstensen, K Wakeham, R Bagni, N Labo, M O Pollard, D Gurdasani, K Ekoru, C Pomilla, E H Young, S Fatumo, G Asiki, A Kamali, M Sandhu, P Kellam, D Whitby, I Barroso, R Newton","doi":"10.1017/gheg.2017.16","DOIUrl":"10.1017/gheg.2017.16","url":null,"abstract":"Epstein Barr virus (EBV) infects 95% of the global population and is associated with up to 2% of cancers globally. Immunoglobulin G (IgG) antibody levels to EBV have been shown to be heritable and associated with developing malignancies. We, therefore, performed a pilot genome-wide association analysis of anti-EBV IgG traits in an African population, using a combined approach including array genotyping, whole-genome sequencing and imputation to a panel with African sequence data. In 1562 Ugandans, we identify a variant in human leukocyte antigen (HLA)-DQA1, rs9272371 (p = 2.6 × 10-17) associated with anti-EBV nuclear antigen-1 responses. Trans-ancestry meta-analysis and fine-mapping with European-ancestry individuals suggest the presence of distinct HLA class II variants driving associations in Uganda. In addition, we identify four putative, novel, very rare African-specific loci with preliminary evidence for association with anti-viral capsid antigen IgG responses which will require replication for validation. These findings reinforce the need for the expansion of such studies in African populations with relevant datasets to capture genetic diversity.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"2 ","pages":"e18"},"PeriodicalIF":1.9,"publicationDate":"2017-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10661052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: Antimicrobial resistance in human populations: challenges and opportunities - ERRATUM. 勘误:人类抗菌素耐药性:挑战和机遇-勘误。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2017-01-01 DOI: 10.1017/gheg.2017.12

S Allcock, E H Young, M Holmes, D Gurdasani, G Dougan, M S Sandhu, L Solomon, M E Török

引用次数: 9

The need for an integrated approach for chronic disease research and care in Africa. 非洲慢性病研究和护理需要综合方法。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2016-11-29 eCollection Date: 2016-01-01 DOI: 10.1017/gheg.2016.16

A L Barr, E H Young, L Smeeth, R Newton, J Seeley, K Ripullone, T R Hird, J R M Thornton, M J Nyirenda, S Kapiga, C A Adebamowo, A G Amoah, N Wareham, C N Rotimi, N S Levitt, K Ramaiya, B J Hennig, J C Mbanya, S Tollman, A A Motala, P Kaleebu, M S Sandhu

引用次数: 0

Diabetes, pre-diabetes and their risk factors in Malta: a study profile of national cross-sectional prevalence study. 马耳他的糖尿病、糖尿病前期及其危险因素:国家横断面患病率研究概况。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2016-11-23 eCollection Date: 2016-01-01 DOI: 10.1017/gheg.2016.18

S Cuschieri, J Vassallo, N Calleja, N Pace, J Mamo

{"title":"Diabetes, pre-diabetes and their risk factors in Malta: a study profile of national cross-sectional prevalence study.","authors":"S Cuschieri, J Vassallo, N Calleja, N Pace, J Mamo","doi":"10.1017/gheg.2016.18","DOIUrl":"https://doi.org/10.1017/gheg.2016.18","url":null,"abstract":"Background: Type 2 diabetes mellitus constitutes a global epidemic and a major burden on health care systems across the world. Prevention of this disease is essential, and the development of effective prevention strategies requires validated information on the disease burden and the risk factors. Embarking on a nationally representative cross-sectional study is challenging and costly. Few countries undertake this process regularly, if at all.Method: This paper sets out the evidence-based protocol of a recent cross-sectional study that was conducted in Malta. Data collection took place from November 2014 to January 2016.Results: This study presents up-to-date national data on diabetes and its risk factors (such as obesity, smoking, physical activity and alcohol intake) that will soon be publicly available.Conclusion: This protocol was compiled so that the study can be replicated in other countries. The protocol contains step-by-step descriptions of the study design, including details on the population sampling, the permissions required and the validated measurement tools used.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"1 ","pages":"e21"},"PeriodicalIF":1.9,"publicationDate":"2016-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2016.18","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

H3Africa AWI-Gen Collaborative Centre: a resource to study the interplay between genomic and environmental risk factors for cardiometabolic diseases in four sub-Saharan African countries. H3Africa AWI-Gen协作中心:研究撒哈拉以南非洲四个国家心脏代谢疾病的基因组和环境风险因素之间相互作用的资源。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2016-11-22 eCollection Date: 2016-01-01 DOI: 10.1017/gheg.2016.17

M Ramsay, N Crowther, E Tambo, G Agongo, V Baloyi, S Dikotope, X Gómez-Olivé, N Jaff, H Sorgho, R Wagner, C Khayeka-Wandabwa, A Choudhury, S Hazelhurst, K Kahn, Z Lombard, F Mukomana, C Soo, H Soodyall, A Wade, S Afolabi, I Agorinya, L Amenga-Etego, S A Ali, J D Bognini, R P Boua, C Debpuur, S Diallo, E Fato, A Kazienga, S Z Konkobo, P M Kouraogo, F Mashinya, L Micklesfield, S Nakanabo-Diallo, B Njamwea, E Nonterah, S Ouedraogo, V Pillay, A M Somande, P Tindana, R Twine, M Alberts, C Kyobutungi, S A Norris, A R Oduro, H Tinto, S Tollman, O Sankoh

{"title":"H3Africa AWI-Gen Collaborative Centre: a resource to study the interplay between genomic and environmental risk factors for cardiometabolic diseases in four sub-Saharan African countries.","authors":"M Ramsay, N Crowther, E Tambo, G Agongo, V Baloyi, S Dikotope, X Gómez-Olivé, N Jaff, H Sorgho, R Wagner, C Khayeka-Wandabwa, A Choudhury, S Hazelhurst, K Kahn, Z Lombard, F Mukomana, C Soo, H Soodyall, A Wade, S Afolabi, I Agorinya, L Amenga-Etego, S A Ali, J D Bognini, R P Boua, C Debpuur, S Diallo, E Fato, A Kazienga, S Z Konkobo, P M Kouraogo, F Mashinya, L Micklesfield, S Nakanabo-Diallo, B Njamwea, E Nonterah, S Ouedraogo, V Pillay, A M Somande, P Tindana, R Twine, M Alberts, C Kyobutungi, S A Norris, A R Oduro, H Tinto, S Tollman, O Sankoh","doi":"10.1017/gheg.2016.17","DOIUrl":"https://doi.org/10.1017/gheg.2016.17","url":null,"abstract":"Africa is experiencing a rapid increase in adult obesity and associated cardiometabolic diseases (CMDs). The H3Africa AWI-Gen Collaborative Centre was established to examine genomic and environmental factors that influence body composition, body fat distribution and CMD risk, with the aim to provide insights towards effective treatment and intervention strategies. It provides a research platform of over 10 500 participants, 40-60 years old, from Burkina Faso, Ghana, Kenya and South Africa. Following a process that involved community engagement, training of project staff and participant informed consent, participants were administered detailed questionnaires, anthropometric measurements were taken and biospecimens collected. This generated a wealth of demographic, health history, environmental, behavioural and biomarker data. The H3Africa SNP array will be used for genome-wide association studies. AWI-Gen is building capacity to perform large epidemiological, genomic and epigenomic studies across several African counties and strives to become a valuable resource for research collaborations in Africa.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"1 ","pages":"e20"},"PeriodicalIF":1.9,"publicationDate":"2016-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2016.17","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35687824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 90

Body composition and the monitoring of non-communicable chronic disease risk. 身体构成和非传染性慢性疾病风险监测。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2016-10-21 eCollection Date: 2016-01-01 DOI: 10.1017/gheg.2016.9

J C K Wells, M K Shirley

引用次数: 25