东南亚社区观察站卫生和人口监测系统生物标志物可行性研究。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2018-08-22 eCollection Date: 2018-01-01 DOI:10.1017/gheg.2018.13
U Partap, E H Young, P Allotey, M S Sandhu, D D Reidpath
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引用次数: 0

摘要

背景:生物标志物数据与健康和生活方式信息的整合为提高健康研究的科学价值提供了强有力的工具。现有的卫生和人口监测系统(HDSSs)为为此目的创建新的生物数据资源提供了机会,但数据和生物样本收集往往面临挑战。我们概述了开发这些资源的一些挑战,并介绍了东南亚共同体观测站(SEACO) HDSS中嵌入的生物标志物可行性研究的结果。方法:我们评估了与研究相关的记录,以确定数据收集的速度、潜在参与者的反应以及数据和样本收集后的反馈。总结了数据和样本可用性的总体和分层措施。检查了主要危险因素的粗略流行率。结果:大约一半(49.5%)被邀请的个人同意参加这项研究,最终样本量为203人(161名成人和42名儿童)。与男性相比,女性更有可能同意参与,而儿童、年轻人和马来人则不太可能同意与老年人或任何其他种族的人相比。成功地从所有参与者中收集了至少一种生物样本(所有参与者的血液-手指刺破和静脉[血清、血浆和全血样本],仅成人的头发或尿液),并从90%以上的个体中获得了血液检测数据。在成年人中,最常采集的是尿液样本(97.5%),其次是血液样本(91.9%)和头发样本(83.2%)。心脏代谢危险因素负担高(成人HbA1c升高患病率:23.8%;成人甘油三酯升高:38.1%;儿童总胆固醇升高:19.5%)。结论:在这项研究中,我们表明利用现有的HDSS框架创建生物数据资源是可行的,并确定了需要在该人群中进一步评估的潜在高负担心脏代谢危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A biomarker feasibility study in the South East Asia Community Observatory health and demographic surveillance system.

A biomarker feasibility study in the South East Asia Community Observatory health and demographic surveillance system.

A biomarker feasibility study in the South East Asia Community Observatory health and demographic surveillance system.

A biomarker feasibility study in the South East Asia Community Observatory health and demographic surveillance system.

Background: Integration of biomarker data with information on health and lifestyle provides a powerful tool to enhance the scientific value of health research. Existing health and demographic surveillance systems (HDSSs) present an opportunity to create novel biodata resources for this purpose, but data and biological sample collection often presents challenges. We outline some of the challenges in developing these resources and present the outcomes of a biomarker feasibility study embedded within the South East Asia Community Observatory (SEACO) HDSS.

Methods: We assessed study-related records to determine the pace of data collection, response from potential participants, and feedback following data and sample collection. Overall and stratified measures of data and sample availability were summarised. Crude prevalence of key risk factors was examined.

Results: Approximately half (49.5%) of invited individuals consented to participate in this study, for a final sample size of 203 (161 adults and 42 children). Women were more likely to consent to participate compared with men, whereas children, young adults and individuals of Malay ethnicity were less likely to consent compared with older individuals or those of any other ethnicity. At least one biological sample (blood from all participants - finger-prick and venous [for serum, plasma and whole blood samples], hair or urine for adults only) was successfully collected from all participants, with blood test data available from over 90% of individuals. Among adults, urine samples were most commonly collected (97.5%), followed by any blood samples (91.9%) and hair samples (83.2%). Cardiometabolic risk factor burden was high (prevalence of elevated HbA1c among adults: 23.8%; of elevated triglycerides among adults: 38.1%; of elevated total cholesterol among children: 19.5%).

Conclusions: In this study, we show that it is feasible to create biodata resources using existing HDSS frameworks, and identify a potentially high burden of cardiometabolic risk factors that requires further evaluation in this population.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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