Genetics of breast cancer in African populations: a literature review.

IF 1.1 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Global Health Epidemiology and Genomics Pub Date : 2018-05-11 eCollection Date: 2018-01-01 DOI:10.1017/gheg.2018.8
A Abbad, H Baba, H Dehbi, M Elmessaoudi-Idrissi, Z Elyazghi, O Abidi, F Radouani
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引用次数: 23

Abstract

Breast cancer (BC) is one of the most complex, diverse and leading cause of death in women worldwide. The present investigation aims to explore genes panel associated with BC in different African regions, and compare them to those studied worldwide. We extracted relevant information from 43 studies performed in Africa using the following criteria: case-control study, association between genetic variations and BC risk. Data were provided on mutations and polymorphisms associated with BC without fixing a specific date. Case-only studies and clinical trials were excluded. Our study revealed that the majority of African BC genetic studies remain restricted to the investigation of BRCA1 and BRCA2 genes and differences in their mutations spectrum. Therefore, it is necessary to encourage African researchers to characterize more genes involved in BC using methods generating global information such as next-generation sequencing in order to guide specific and more effective therapeutic strategies for the African community.

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非洲人群乳腺癌的遗传学:文献综述。
乳腺癌(BC)是世界范围内最复杂、最多样化和最主要的妇女死亡原因之一。本研究旨在探索不同非洲地区与BC相关的基因面板,并将其与世界范围内的研究进行比较。我们从在非洲进行的43项研究中提取相关信息,使用以下标准:病例对照研究,遗传变异与BC风险之间的关联。提供了与BC相关的突变和多态性的数据,但没有确定具体日期。排除病例研究和临床试验。我们的研究表明,大多数非洲BC基因研究仍然局限于BRCA1和BRCA2基因的研究及其突变谱的差异。因此,有必要鼓励非洲研究人员利用下一代测序等产生全球信息的方法来描述更多与BC相关的基因,以便为非洲社区指导具体和更有效的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Global Health Epidemiology and Genomics
Global Health Epidemiology and Genomics PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
1.40
自引率
0.00%
发文量
10
审稿时长
20 weeks
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