Clinical Optometry最新文献

{"title":"Corneal Variables in Children: A Literature Review.","authors":"Nonkazimulo Shabalala, Velibanti Sukati, Nishanee Rampersad","doi":"10.2147/OPTO.S603654","DOIUrl":"10.2147/OPTO.S603654","url":null,"abstract":"<p><strong>Background: </strong>Corneal variables such as thickness, curvature and diameter are important for ocular assessments in children. Despite this, there is limited normative data relevant to children for these corneal variables. Developmental changes, together with potential demographic differences, complicate the direct extrapolation of adult reference values to paediatric populations.</p><p><strong>Purpose: </strong>To map literature related to corneal thickness, curvature, and diameter in healthy children.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across different electronic databases to identify articles published from January 2000 to December 2024 reporting on these corneal variables in healthy children aged less than 18 years.</p><p><strong>Results: </strong>Twenty-eight articles with data from more than 46,000 healthy children were included. The majority of articles originated from Asia. Central corneal thickness was the most commonly reported corneal variable compared with corneal curvature and diameter. Overall, the articles showed that the corneal variables showed lesser variation in early childhood and highlighted age, gender, ethnicity, and geographical variations.</p><p><strong>Conclusion: </strong>Currently available literature on corneal variables shows a predominant focus on central corneal thickness measurements, with limited research on corneal curvature and diameter. The currently available literature was predominantly from studies conducted on Asian populations, with an underrepresentation of African and other geographical regions. As corneal variables differ by geographical location, this skewed distribution limits the applicability of current normative values to diverse paediatric populations. Additionally, the differences in study methodologies and reporting limit the integration of the normative data available in current literature, thus limiting their clinical applicability when diagnosing and managing paediatric ocular conditions. Future research would benefit from a more standardised approach and a comprehensive assessment of corneal variables in diverse paediatric populations.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"603654"},"PeriodicalIF":2.4,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Influence of Two Types of Silicone Hydrogel Daily Disposable Contact Lenses on Clinical Signs of Allergic Conjunctivitis Symptoms.","authors":"Tatsuya Mimura, Ryota Nakagomi, Hidetaka Noma","doi":"10.2147/OPTO.S652435","DOIUrl":"10.2147/OPTO.S652435","url":null,"abstract":"<p><strong>Purpose: </strong>Contact lens (CL) wear can exacerbate allergic conjunctivitis. This study compared the effects of narafilcon A and verofilcon A on clinical signs of allergic conjunctivitis in CL wearers. Our previous studies using the same crossover cohort examined subjective CL comfort and related symptoms and tear-film stability and surface wettability. In contrast, the present study specifically evaluated objective clinical signs of allergic conjunctivitis, which were not the primary outcomes of those previous studies.</p><p><strong>Methods: </strong>The study included 62 CL wearers, comprising 124 eyes, who experienced CL discomfort. Participants were randomized to a cross-over design, wearing narafilcon A and verofilcon A each for 2 weeks. Ten clinical signs associated with allergic conjunctivitis related to the palpebral conjunctiva, bulbar conjunctiva, corneal limbus, and cornea were scored on a 4-point scale (0-3) according to the Japanese guidelines for allergic conjunctival diseases (3rd edition). The total score was calculated by summing the scores of the 10 items (0-30, with lower scores indicating better outcomes).</p><p><strong>Results: </strong>No participants discontinued narafilcon A or verofilcon A due to intolerance during the study period. Compared to baseline, there was no significant worsening of the mean total allergic conjunctivitis score for either narafilcon A or verofilcon A. Furthermore, the mean total score was significantly lower for verofilcon A (1.8 ± 1.4) compared to narafilcon A (4.1 ± 3.0, p < 0.01).</p><p><strong>Conclusion: </strong>These findings suggest that verofilcon A may be associated with more favorable clinical signs of allergic conjunctivitis than narafilcon A in CL wearers with CL discomfort.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"652435"},"PeriodicalIF":2.4,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13665681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design Characteristics, Content Quality, and Credibility Indicators of Online Infographics for Contact Lens Wearers.","authors":"Genis Cardona, Pengbo Xia, Silvia Alonso-Matarín","doi":"10.2147/OPTO.S645899","DOIUrl":"10.2147/OPTO.S645899","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the design, scientific accuracy and clinical usefulness of freely available online infographics as educational tools addressed to contact lens wearers.</p><p><strong>Methods: </strong>A Google search was conducted to collect static non-interactive infographics related to contact lens wear and maintenance. A 25-item ad hoc non-validated rubric was employed by two assessors to evaluate eligible Google Images results, selected using a convenience-based stopping rule, in terms of overall description (5 items), scientific and clinical content (9 items) and design (11 items).</p><p><strong>Results: </strong>A sample of 200 infographics was included in the study. The main sources of the infographics were commercial (30.5%), unknown (26.0%) and healthcare center (22.5%). Most infographics lacked credibility indicators such as authorship, publication date or references. Median scientific accuracy and expert-rated clinical usefulness were 9.5 and 9 (on a 0-10 scale), with differences in both items depending on the source (p<0.001). Search engine order of appearance was weakly correlated with scientific accuracy (rho=-0.273, p<0.001) and clinical usefulness (rho=-0.369, p<0.001). Overall, graphic design choices such as use of color, typography and layout were adequate. Information saturation was not correlated with scientific accuracy (rho=0.157, p=0.026).</p><p><strong>Conclusion: </strong>This study evaluated existing online infographics. Overall, graphic design choices, scientific accuracy and clinical usefulness were adequate, although areas for improvement were detected in the availability of credibility indicators, such as the lack of authorship and publication details, insufficient supporting references, and use of technical jargon. Further research should explore the actual effectiveness of infographics among contact lens wearers.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"645899"},"PeriodicalIF":2.4,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13665669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro Sorption of Lysozyme in Reusable Silicone Hydrogel Contact Lenses: The Impact of Material and Care Solution.","authors":"Charles Bahr, Megumi Kitamura, Ryuji Hisamura, Ryohei Takeichi, Cristina Schnider, Katsuhide Yamasaki","doi":"10.2147/OPTO.S637196","DOIUrl":"https://doi.org/10.2147/OPTO.S637196","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize lysozyme sorption and denaturation in two SiHy lens materials (comfilcon A and Lotrafilcon B), and compare the effects of three lens care systems - one based on the disinfectant povidone-iodine that contains the protease subtilisin, one based on hydrogen peroxide, and one multipurpose solution - on their ability to remove lysozyme from these lens materials, via established methods.</p><p><strong>Methods: </strong>Test lenses were exposed to an artificial tear solution to simulate in vitro deposition. Lysozyme sorption and denaturation were quantified using high-performance liquid chromatography and a <i>Micrococcus</i> assay. Confocal laser scanning microscopy with fluorescently labeled lysozyme was used to localize sorption within the lenses and quantify removal following treatment with the three care systems.</p><p><strong>Results: </strong>Comfilcon A sorbed 1.01 ± 0.16 µg of lysozyme after one day of simulated wear in vitro, with 87 ± 17% of that penetrating the lens bulk. Lotrafilcon B similarly sorbed 0.94 ± 0.19 µg after one cycle, although nearly 100% was retained at the lens surface. All three contact lens care systems removed a significant proportion of lysozyme from comfilcon A (p <0.05). The PVP-I-based solution removed significantly more lysozyme from Lotrafilcon B than the other two systems (p < 0.01).</p><p><strong>Conclusion: </strong>Lysozyme deposition remains a persistent issue with reusable silicone hydrogel contact lenses. Differential lens properties may affect its sorption, denaturation, and the cleaning efficacy of different lens care systems. These preliminary data suggest that enzymatic removal of protein with a PVP-I-based system may contribute to more consistent outcomes for reusable SiHy lens wearers.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"637196"},"PeriodicalIF":2.4,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real World Axial Elongation in Children Wearing Diversified Segmental Defocus Optimization Spectacle Lenses: A Longitudinal Cohort Study with External Benchmarks.","authors":"Shuo Wu, Sitong Chen, Kai Wang","doi":"10.2147/OPTO.S650391","DOIUrl":"https://doi.org/10.2147/OPTO.S650391","url":null,"abstract":"<p><strong>Purpose: </strong>To describe longitudinal axial elongation in children wearing spectacle lenses incorporating Diversified Segmental Defocus Optimization (D.S.D.O.) technology in routine clinical practice and to place the observed change in context using two historical external benchmarks.</p><p><strong>Methods: </strong>This retrospective cohort included first time D.S.D.O. spectacle lens users with no documented prior myopia control lens wear and bilateral follow up of at least 12 months. Repeated axial length measurements from March 2022 through July 2026 underwent prespecified longitudinal quality control. The primary mixed effects model adjusted for age, sex, baseline axial length, baseline spherical equivalent, and any recorded atropine use. Sensitivity analyses addressed cycloplegic refraction, quality control exclusions, delay between lens initiation and baseline measurement, missing baseline refraction, and longitudinal covariance. External benchmarks used a Chinese pediatric normative model and age updated piecewise axial elongation rates from two Hong Kong single vision spectacle cohorts.</p><p><strong>Results: </strong>The cohort comprised 2396 children and 4792 eyes. Mean age was 9.23 ± 2.18 years and median follow up was 1.92 years. The primary adjusted axial elongation rate was 0.173 mm/year (95% CI, 0.171 to 0.174), with similar point estimates in cycloplegic, alternative quality control, baseline timing, missing refraction, random slope, and robust covariance analyses. Among 1665 children eligible for the Chinese model, observed change was 0.323 mm versus 0.625 mm expected, an absolute difference of 0.302 mm (95% CI, 0.290 to 0.314). Among 1515 children eligible for the Hong Kong benchmark, age updated expected change was 0.425 mm versus 0.319 mm observed, an absolute difference of 0.106 mm (95% CI, 0.096 to 0.117). Findings were similar after excluding children with any atropine record.</p><p><strong>Conclusion: </strong>Axial elongation during D.S.D.O. spectacle lens wear averaged approximately 0.17 mm/year in this large routine care cohort. Observed changes were lower than both historical external expectations, but these benchmark contrasts are descriptive associations and should not be interpreted as causal efficacy estimates. Prospective studies with concurrent controls and standardized behavioral and treatment exposure data are required.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"650391"},"PeriodicalIF":2.4,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13658431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges of Scleral Lens Practice in Yemen: Insights from a Tertiary Referral Eye Center in Sana'a.","authors":"Ahmed Almaweri","doi":"10.2147/OPTO.S648858","DOIUrl":"https://doi.org/10.2147/OPTO.S648858","url":null,"abstract":"<p><p>While scleral lenses provide effective visual rehabilitation and excellent wearing comfort for patients with complex ocular surface diseases and irregular corneas, evidence regarding their delivery in resource-limited settings remains scarce. This narrative commentary highlights the major challenges of establishing and maintaining scleral lens services in Yemen, based primarily on clinical experience at a tertiary eye center in Sana'a. In our setting, healthcare infrastructure, supply chains, and access to specialized eye care are compromised. Here, we discuss the impact of financial constraints, restricted access to advanced fitting technologies, interrupted supply chains, misconceptions, and lack of patient awareness, as well as the difficulties in ensuring continuity of care and long-term follow-up. To address these challenges, we describe flexible, context-specific strategies, including individualized patient management and comprehensive patient education, to facilitate scleral lens care despite significant resource limitations. Ultimately, we delineate practical recommendations tailored to enhancing practitioner training, improving patient education, expanding access to scleral lens services through regional and international collaboration, and developing clinical frameworks and context-appropriate referral pathways. Although grounded in the experience of Yemen, the perspectives conveyed can inform policymakers, eye care providers, and clinicians operating under similar challenges in other resource-limited settings.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"648858"},"PeriodicalIF":2.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Meibomian Gland Composite Score (MGCS): A Novel Grading System Integrating Existing Scales for Meibomian Gland Dysfunction.","authors":"Kaleb S Abbott, Anna A Tichenor, Stephanie Martich, Andrew D Pucker","doi":"10.2147/OPTO.S644992","DOIUrl":"10.2147/OPTO.S644992","url":null,"abstract":"<p><strong>Purpose: </strong>To introduce and evaluate the clinical performance of the Meibomian Gland Composite Score (MGCS), a novel, standardized, video- and pictorial-based grading system designed to provide a linear, gland-specific assessment of meibomian gland dysfunction (MGD) severity.</p><p><strong>Methods: </strong>The MGCS evaluates meibum quality on a 0 to 4 scale based on texture and expressibility across the central 8 upper eyelid glands (score 0-32) and central 5 lower eyelid glands (score 0-20). To evaluate clinical performance, two independent providers performed a retrospective chart review of 53 patients (mean age 60.9 ± 16.4 years; 75.5% female). Receiver operating characteristic (ROC) curves were generated using tear breakup time (TBUT ≤5 seconds) as the reference standard for evaporative dry eye disease (DED) to determine optimal diagnostic cut points.</p><p><strong>Results: </strong>The MGCS demonstrated strong diagnostic accuracy for evaporative DED, with area under the curve (AUC) values of 0.9539 (right upper eyelid), 0.9182 (right lower eyelid), 0.9105 (left upper eyelid), and 0.7779 (left lower eyelid). An MGCS score ≥10 for an individual eyelid provided optimal diagnostic balance (sensitivity up to 93.75%, specificity up to 85.71%) for identifying abnormal gland function.</p><p><strong>Conclusion: </strong>The MGCS offers a standardized and continuous scale for assessing MGD severity. By incorporating detailed meibum texture descriptions supported by standardized pictorial and video references, the scale facilitates precise disease tracking and robust statistical analysis in both clinical practice and research settings.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"644992"},"PeriodicalIF":2.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Working Distance on Wesson Card Fixation Disparity and Its Clinical Predictors in Symptomatic Patients.","authors":"Thokozile Ingrid Metsing, Gloria Tsholofelo Tamenti","doi":"10.2147/OPTO.S631362","DOIUrl":"https://doi.org/10.2147/OPTO.S631362","url":null,"abstract":"<p><strong>Aim: </strong>Fixation disparity (FD) is a sensitive marker of binocular vision stress and is often assessed in patients with asthenopia. Working distance alters accommodative and vergence demands. However, its effect on FD under routine clinical settings is not well established.</p><p><strong>Purpose: </strong>To investigate the effect of working distance on FD measured using the Wesson fixation disparity card (WFDC) at 25 cm and 40 cm in symptomatic young adults, and to explore associations with selected binocular vision and accommodative measures.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 25 symptomatic participants aged 18-25 years. FD was measured at 25 cm and 40 cm using the WFDC under standard clinical conditions. Binocular vision and accommodative assessments included near phoria, near point of convergence (NPC), accommodative response (MEM), amplitude of accommodation, and stereoacuity. Paired t-tests were used to compare FD between distances. Agreement was assessed using Bland-Altman analysis and intraclass correlation coefficients (ICC), and associations were explored using correlation analysis.</p><p><strong>Results: </strong>Mean FD was -3.76 ± 6.63 arcmin at 25 cm and -4.78 ± 7.20 arcmin at 40 cm, with no significant difference between distances (p = 0.20). A strong positive correlation (r = 0.84) and good agreement (ICC = 0.84) were observed, although the limits of agreement were relatively wide. No significant associations were found between FD and clinical measures.</p><p><strong>Conclusion: </strong>FD is a sensitive indicator of binocular stress, often assessed in asthenopic patients. While working distance affects accommodation and vergence demands, its impact on FD in clinical practice remains unclear.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"631362"},"PeriodicalIF":2.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wear-Related Visible Surface Alteration and <i>Pseudomonas aeruginosa</i> Adhesion in Orthokeratology Lenses.","authors":"Huiyan Yu, Ruoxiang Sun, Lin Jin, Chunxiao Yan, Lijun Zhang","doi":"10.2147/OPTO.S640725","DOIUrl":"https://doi.org/10.2147/OPTO.S640725","url":null,"abstract":"<p><strong>Purpose: </strong>To compare grayscale-derived visible surface characteristics and <i>Pseudomonas aeruginosa</i> adhesion between unworn orthokeratology lenses and lenses worn for approximately 12 months, and to explore associations between grayscale-derived parameters and bacterial adhesion.</p><p><strong>Methods: </strong>Sixty orthokeratology lenses were analyzed, including 20 unworn lenses and 40 lenses worn for approximately 12 months. Each worn lens was collected from a different wearer during routine replacement. Standardized slit-lamp images were analyzed with ImageJ to obtain mean gray value and gray-level standard deviation within the central 6.0-mm optical zone. In vitro <i>P. aeruginosa</i> adhesion was quantified as log10-transformed colony-forming units. Group differences were assessed using two-way ANOVA followed by exploratory simple-effect comparisons with Holm adjustment, and correlations between grayscale-derived parameters and bacterial adhesion were explored among worn lenses.</p><p><strong>Results: </strong>Clinical wear was associated with significantly higher mean gray value, gray-level standard deviation, and <i>P. aeruginosa</i> adhesion compared with unworn lenses (all P < 0.001). Exploratory simple-effect comparisons identified higher mean gray value and bacterial adhesion in worn type A than worn type Z lenses after Holm correction, whereas the gray-level standard deviation difference did not remain significant after correction. None of the wear × lens-system interaction terms in the primary ANOVA was statistically significant. Grayscale-derived parameters were only weakly correlated with bacterial adhesion, and these associations were not significant after correction for multiple testing.</p><p><strong>Conclusion: </strong>Orthokeratology lenses worn for approximately 12 months showed greater grayscale-derived visible surface alteration and higher <i>P. aeruginosa</i> adhesion than unworn lenses. These laboratory findings do not establish an increased clinical infection risk or an optimal replacement interval and require prospective clinical validation.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"640725"},"PeriodicalIF":2.4,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149116299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Performance and Wearer Experience with Two Contemporary Daily Disposable Silicone Hydrogel Lenses.","authors":"Karen Walsh, Amir M Moezzi, Sarah Guthrie, Jill Woods, Jose Vega","doi":"10.2147/OPTO.S628296","DOIUrl":"https://doi.org/10.2147/OPTO.S628296","url":null,"abstract":"<p><strong>Objective: </strong>To compare the clinical performance and wearer experience of two contemporary spherical daily disposable silicone hydrogel lenses, somofilcon A and verofilcon A.</p><p><strong>Methods: </strong>In this prospective, double-masked, bilateral, randomized, crossover study, habitual contact lens wearers were recruited at a single site. Participants wore somofilcon A or verofilcon A lenses bilaterally on a daily disposable basis for one week, then crossed over to the alternate lens. The primary endpoint was participant-reported handling (insertion and removal) at the 1-week follow-up. Secondary outcomes included lens fit, surface wettability and deposits, non-invasive tear break-up time (NITBUT), visual acuity, subjective comfort, satisfaction, preference, diary ratings, and slit-lamp ocular health.</p><p><strong>Results: </strong>Of 51 participants screened, 47 completed the study. Handling ratings were high for both lenses, with no differences for insertion. Removal handling was slightly higher for somofilcon A on Day 1 (9.2 ± 1.2 vs 8.6 ± 2.1; p = 0.02), though not clinically meaningful. Verofilcon A showed marginally better centration at dispensing and 1 week, and somofilcon A demonstrated slightly better visual acuity at 1 week and lower deposition at dispensing; however, all differences were small and not clinically meaningful. No significant between-lens differences were observed for movement, fit, NITBUT, wettability, comfort, dryness, vision clarity, satisfaction, or preference (all p > 0.05).</p><p><strong>Conclusion: </strong>Both lenses showed high and comparable clinical and subjective performance over one week. While minor statistical differences were observed, none were clinically meaningful, indicating similar performance across handling, fit, vision, tear stability, and wearer-reported outcomes.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT04305912.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"628296"},"PeriodicalIF":2.4,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}