{"title":"Correlation Between Retinal Vascular Oxygen Saturation, Red Blood Cell Parameters and Hemorheology Parameters in Healthy Adults.","authors":"Lu Chang, Dan Li, Keyu Zhu, Mei Liu, Junguo Duan","doi":"10.2147/OPTO.S513381","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Investigate the correlation between retinal vascular oxygen saturation and red blood cell parameters, hemorheology parameters in healthy adults.</p><p><strong>Methods: </strong>The study recruited 120 healthy volunteers, and their elbow venous blood was drawn for examination of RBC parameters and hemorheology. The retinal oximeter measured the retinal vascular oxygen saturation, including retinal arteriolar oxygen saturation (SaO<sub>2</sub>), venous oxygen saturation (SvO<sub>2</sub>) and arteriovenous oxygen saturation Difference (AVD). The <i>Pearson Correlation</i> and <i>Spearman's Correlation</i> methods were used to analyze the correlation between the SaO<sub>2</sub>, SvO<sub>2</sub>, AVD and the red blood cell parameters,hemorheology parameters.</p><p><strong>Results: </strong>The analysis yielded a statistically significant correlation between SaO<sub>2</sub> and BMI (<i>r</i>=0.184, <i>P</i>=0.044). SvO<sub>2</sub> was associated with Gender (<i>r</i>=-0.227, <i>P</i>=0.013), HGB (<i>r</i>=-0.190, <i>P</i>=0.038), HCT (<i>r</i>=-0.236, <i>P</i>=0.009), RDW-CV (<i>r</i>=0.228, <i>P</i>=0.012), WBRIH (<i>r</i>=0.019, <i>P</i>=0.037), WBVL 1/s (<i>r</i>=-0.194, <i>P</i>=0.034), WBVM 50/s (<i>r</i>=-0.206, <i>P</i>=0.024), WBVH 150/s (<i>r</i>=-0.211, <i>P</i>=0.021) and WBVH 200/s (<i>r</i>=-0.222, <i>P</i>=0.015). AVD was associated with Gender (<i>r</i>=-0.318, <i>P</i>=0.000), BMI (<i>r</i>=0.269, <i>P</i>=0.003), RBC (<i>r</i>=0.282, <i>P</i>=0.002), HGB (<i>r</i>=0.263, <i>P</i>=0.004), RBCSI (<i>r</i>=0.187, <i>P</i>=0.041), WBRIH (<i>r</i>=0.289, <i>P</i>=0.001), WBRVH (<i>r</i>=0.247, <i>P</i>=0.006), WBVL 1/s (<i>r</i>=0.220, <i>P</i>=0.016), WBVL 10/s (<i>r</i>=0.289, <i>P</i>=0.001), WBVM 50/s (<i>r</i>=0.323, <i>P</i>=0.000), WBVH 150/s (<i>r</i>=0.320, <i>P</i>=0.000) and WBVH 200/s (<i>r</i>=0.320, <i>P</i>=0.000). Gender (<i>β</i>=-0.297, <i>P</i>=0.005), BMI (<i>β</i>=0.208, <i>P</i>=0.023), PV (<i>β</i>=-0.304, <i>P</i>=0.000) were independent predictors of AVD.</p><p><strong>Conclusion: </strong>Retinal vascular oxygen saturation is correlated with many RBC parameters and hemorheology parameters, indicating that RBC and rheological characteristics of peripheral blood may affect the transport and metabolism of retinal oxygen and are closely related to retinal microcirculation.</p><p><strong>Translational relevance: </strong>The relationship between retinal blood oxygen saturation and red blood cell and hemorheology parameters confirmed the close correlation between ocular microcirculation and systemic blood circulation, which provided a prospective diagnosis and treatment strategy for microcirculatory-related eye diseases.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"17 ","pages":"231-240"},"PeriodicalIF":1.8000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323780/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Optometry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/OPTO.S513381","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: Investigate the correlation between retinal vascular oxygen saturation and red blood cell parameters, hemorheology parameters in healthy adults.
Methods: The study recruited 120 healthy volunteers, and their elbow venous blood was drawn for examination of RBC parameters and hemorheology. The retinal oximeter measured the retinal vascular oxygen saturation, including retinal arteriolar oxygen saturation (SaO2), venous oxygen saturation (SvO2) and arteriovenous oxygen saturation Difference (AVD). The Pearson Correlation and Spearman's Correlation methods were used to analyze the correlation between the SaO2, SvO2, AVD and the red blood cell parameters,hemorheology parameters.
Results: The analysis yielded a statistically significant correlation between SaO2 and BMI (r=0.184, P=0.044). SvO2 was associated with Gender (r=-0.227, P=0.013), HGB (r=-0.190, P=0.038), HCT (r=-0.236, P=0.009), RDW-CV (r=0.228, P=0.012), WBRIH (r=0.019, P=0.037), WBVL 1/s (r=-0.194, P=0.034), WBVM 50/s (r=-0.206, P=0.024), WBVH 150/s (r=-0.211, P=0.021) and WBVH 200/s (r=-0.222, P=0.015). AVD was associated with Gender (r=-0.318, P=0.000), BMI (r=0.269, P=0.003), RBC (r=0.282, P=0.002), HGB (r=0.263, P=0.004), RBCSI (r=0.187, P=0.041), WBRIH (r=0.289, P=0.001), WBRVH (r=0.247, P=0.006), WBVL 1/s (r=0.220, P=0.016), WBVL 10/s (r=0.289, P=0.001), WBVM 50/s (r=0.323, P=0.000), WBVH 150/s (r=0.320, P=0.000) and WBVH 200/s (r=0.320, P=0.000). Gender (β=-0.297, P=0.005), BMI (β=0.208, P=0.023), PV (β=-0.304, P=0.000) were independent predictors of AVD.
Conclusion: Retinal vascular oxygen saturation is correlated with many RBC parameters and hemorheology parameters, indicating that RBC and rheological characteristics of peripheral blood may affect the transport and metabolism of retinal oxygen and are closely related to retinal microcirculation.
Translational relevance: The relationship between retinal blood oxygen saturation and red blood cell and hemorheology parameters confirmed the close correlation between ocular microcirculation and systemic blood circulation, which provided a prospective diagnosis and treatment strategy for microcirculatory-related eye diseases.
期刊介绍：
Clinical Optometry is an international, peer-reviewed, open access journal focusing on clinical optometry. All aspects of patient care are addressed within the journal as well as the practice of optometry including economic and business analyses. Basic and clinical research papers are published that cover all aspects of optics, refraction and its application to the theory and practice of optometry. Specific topics covered in the journal include: Theoretical and applied optics, Delivery of patient care in optometry practice, Refraction and correction of errors, Screening and preventative aspects of eye disease, Extended clinical roles for optometrists including shared care and provision of medications, Teaching and training optometrists, International aspects of optometry, Business practice, Patient adherence, quality of life, satisfaction, Health economic evaluations.
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