Clinical Optometry最新文献

{"title":"Corneal Thickness, Curvature and Topographic Indices: Implications for Keratoconus Screening in a South African University Clinic Population.","authors":"Pheagane Motsime William Nkoana, Neo Makgatho, Rethabile Ramatsobane Lekgau, Mufhatutshedzwa M Randima, Munei Masiagwala, Moloantoa Morena, Lebogang Shaun Ntsobe, Phuti Germina Matlhadisha","doi":"10.2147/OPTO.S622334","DOIUrl":"10.2147/OPTO.S622334","url":null,"abstract":"<p><strong>Background: </strong>Keratoconus (KC) is a progressive corneal ectatic disorder characterised by thinning and irregular steepening, which may lead to visual impairment if not detected early. Most diagnostic thresholds are derived from non-African populations, limiting their relevance in local settings.</p><p><strong>Aim: </strong>To profile corneal thickness, curvature, eccentricity and topographic indices, and assess their implications for keratoconus screening in a South African university clinic population.</p><p><strong>Methods: </strong>A quantitative cross-sectional study was conducted using clinical data from patients attending a university optometry clinic. Mean central corneal thickness (CCT), radius of curvature (<i>r</i>), eccentricity (<i>e</i>) and KC related indices of 300 clinic patients were measured using Oculus Pentacam. Descriptive and inferential statistics were used to analyse the data.</p><p><strong>Results: </strong>Corneal parameters were generally within normal ranges. The mean CCT was 504.79 ± 33.12 µm. The mean <i>r</i> was 7.83 ± 0.28 mm, indicating relatively flatter corneas compared to some international populations. Mean <i>e-</i>value was 0.47 ± 0.13, suggesting prolate corneal profiles. Keratoconus related indices were largely within normal limits, although they appeared more conservative than corneal thickness in identifying suspected ectasia. Weak to moderate correlations were observed between variables.</p><p><strong>Conclusion: </strong>Corneal characteristics were within normal limits but showed subtle population specific variation. A multi-parameter approach integrating thickness, curvature and indices is recommended to improve KC screening and to strengthen region-specific diagnostic thresholds.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"622334"},"PeriodicalIF":2.4,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Validation of a Comprehensive Vision Screener for Assessing Visual Fitness for Drivers in Mumbai, India.","authors":"Mumtaz Qazi, Prema K Chande, Neha Dattatray Jadhav, Nuzhat Khan","doi":"10.2147/OPTO.S622011","DOIUrl":"10.2147/OPTO.S622011","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the agreement of an all-in-one portable vision screener (VS) with a standard battery of optometrist-administered tests. The purpose is to understand the feasibility of rapid screening for visual functions before providing occupational visual fitness.</p><p><strong>Patients and methods: </strong>A Prospective cross-sectional study was performed among licensed public transport drivers at community eye camps in Mumbai. Distance and near vision, contrast sensitivity (CS), stereopsis, colour vision (CV), and peripheral visual field were assessed using standard tests, including the LogMAR, Titmus Fly, Ishihara, and confrontation test, respectively. The same assessments were repeated using an all-in-one portable screener (VS). The total testing time was recorded for each test. Receiver Operating Characteristic (ROC) curves and Bland-Altman plots were used for statistical analyses.</p><p><strong>Results: </strong>A total of 384 drivers participated, with a mean age of 47.1 ± 9.14 years. The mean presenting distance visual acuity was 0.22 ± 0.16 and 0.20 ± 0.18 LogMAR (p>0.05), the mean values for CS were 2.98 ± 2% and 5.7 ± 10.17% (p<0.05), the values for stereopsis were 863.08 ± 1402.92 and 656.54 ± 933.29 sec of arc (p<0.05) with standard charts and VS, respectively. The integrated colour vision test demonstrated low sensitivity (22.2%) but high specificity (89.2%) for detecting colour vision deficiency. Screening time decreased from 20 ± 5 minutes to 7 ± 3 minutes. ROC analysis showed excellent diagnostic accuracy for distance visual acuity (AUC = 0.861) and modest discriminative ability for stereopsis (AUC = 0.653). Bland-Altman analysis indicated good agreement between the standard test and screener for vision, CS, and stereopsis, with no significant systematic bias.</p><p><strong>Conclusion: </strong>The portable vision screener demonstrated high accuracy and strong agreement with standard clinical tests for visual functional tests. It enables rapid, comprehensive assessment of visual functions, making it a practical tool for large-scale vision screening in OHCs or mobile eye screening camps.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"622011"},"PeriodicalIF":2.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractive Error Patterns and the Impact of Cycloplegia in Ametropic Children and Adolescents in Al-Baha, Saudi Arabia.","authors":"Jawaher Mohammad Alshehri, Ibtesam Ibrahem Alsulami, Fatima Ali Asiri, Manal Alshihri, Ali AlRashah, Mustafa Abdu, Kareem Allinjawi, Bandar M Alenezi, Khaled Alzahrani","doi":"10.2147/OPTO.S627158","DOIUrl":"10.2147/OPTO.S627158","url":null,"abstract":"<p><strong>Background and aim: </strong>Ametropia is a leading cause of preventable visual impairment in children and adolescents, yet region-specific data from Al-Baha, Saudi Arabia remain limited. This study aims to characterise the patterns of refractive error and quantify the impact of cycloplegic refraction in a pediatric ametropic population in Al-Baha City.</p><p><strong>Methods: </strong>This hospital-based, prospective, cross-sectional study enrolled 654 ametropic children and adolescents (1,308 eyes), aged 3-18 years, at King Fahad Hospital between November 2022 and November 2023. Participants underwent visual acuity testing, keratometry, and pre- and post-cycloplegic refraction. Data were analysed using SPSS v24 and Microsoft Excel with paired and independent-samples t-tests and Pearson correlations (p < 0.05).</p><p><strong>Results: </strong>The cohort was 51.7% female and 48.3% male (mean age 9.17 ± 3.89 years). Post-cycloplegia, hyperopic astigmatism predominated (62.8%; 822/1,308 eyes), followed by myopic astigmatism (36.1%; 472/1,308). Cycloplegia produced a significant hyperopic shift in mean spherical equivalent, from -0.33 D dry to +0.54 D cycloplegic (paired mean difference +0.87 D, p < 0.001; r = 0.89), with 26.0% of pre-cycloplegic myopic eyes reclassified as hyperopic. Males were more hyperopic than females (+1.04 vs +0.07 D, p < 0.001), and females had steeper keratometry (43.63 vs 42.86 D, p < 0.001). Mean cycloplegic spherical equivalent (SPE) declined with age from +2.18 D at 3-5 years to -0.55 D at 15-18 years, while the proportion with myopia rose from 14.8% to 55.6%.</p><p><strong>Conclusion: </strong>Hyperopic astigmatism dominated the ametropic spectrum in this hospital-based sample of ametropic children and adolescents in Al-Baha, and cycloplegic refraction was essential to avoid misclassification. The observed age-related shift in refractive status supports standardised cycloplegic protocols and region-specific vision screening, although the clinic-based design limits generalisation to the wider paediatric population.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"627158"},"PeriodicalIF":2.4,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Prevalence and Clinical Consequences of Traditional Eye Medicine: A Descriptive Review.","authors":"Kgolane Fredson Hlakudi, Pheagane Motsime William Nkoana","doi":"10.2147/OPTO.S602564","DOIUrl":"10.2147/OPTO.S602564","url":null,"abstract":"<p><strong>Background: </strong>Traditional eye medicine (TEM) is widely used in low- to middle-income countries as an accessible, affordable, and culturally accepted approach to eye care. Despite its prevalence, persons using TEM commonly present for formal late for eye care after the onset of significant ocular complications.</p><p><strong>Purpose: </strong>To synthesize evidence on global TEM utilization, perceptions, determinants, types, administration methods, and associated ocular complications.</p><p><strong>Methods: </strong>Google Scholar, ScienceDirect, Scopus, PubMed and grey literature up to September 2025 were used to conduct a comprehensive literature search. Studies reporting on TEM use, perceptions, determinants, remedies, administration, and ocular outcomes were included. Fifty-seven studies met inclusion criteria following systematic screening.</p><p><strong>Results: </strong>TEM prevalence varied widely, from 4.3% in Nigeria to 80% in Ethiopia, with other regions reporting rates of 36-65.7%. TEM was used to manage redness, itching, tearing, pain, poor vision, cataracts, and glaucoma. Remedies included plant extracts, honey, rosewater, milk, salts, animal products, and ritualistic substances, administered topically, orally, dermally, nasally, auricularly, or in combination. Determinants of use include accessibility, affordability, cultural beliefs, family influence, rural residence, and dissatisfaction with modern medicine. Perceptions were generally positive, particularly among older adults and communities with active traditional healers (THs). TEM use was frequently linked to ocular complications such as conjunctivitis, corneal ulcers, microbial keratitis, uveitis, staphyloma, panophthalmitis, and blindness. TEM users often presented later to eye care facilities, resulting in poorer visual outcomes compared to non-users.</p><p><strong>Conclusion: </strong>TEM remains a culturally entrenched and widely used form of eye care but carries substantial risks of ocular morbidity and vision loss. Reducing harmful outcomes requires strengthening access to formal eye care, educating communities, and engaging THs to promote safe practices.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"602564"},"PeriodicalIF":2.4,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presbyopic Glaucoma Patients Exhibit Greater Contact Lens Under-Correction Than Non-Glaucomatous Subjects.","authors":"Masahiko Ayaki, Akiko Hanyuda, Kazuno Negishi","doi":"10.2147/OPTO.S624634","DOIUrl":"10.2147/OPTO.S624634","url":null,"abstract":"<p><strong>Objective: </strong>Previous studies have suggested that presbyopia may progress faster in patients with glaucoma. This study aimed to compare glaucoma patients and controls to assess the severity of presbyopia in terms of the preference for contact lens (CL) correction.</p><p><strong>Methods: </strong>We compared 457 glaucoma patients and 500 controls aged 40-69 years, assessing near add power, CL-corrected visual acuity, under-correction with CL (CL power- full correction power), and glaucoma and dry eye-related parameters. Regression analyses were used to evaluate the relationship between the near-add power and ocular parameters. Kaplan-Meier survival analysis estimated the age at which the near add power reached +3.00 D.</p><p><strong>Results: </strong>The mean near add power was 2.27 ± 0.84 D in the control group and 2.47 ± 0.71 D in the glaucoma group (p < 0.01). The CL-corrected visual acuity (LogMAR) was 0.02 ± 0.10 and 0.04 ± 0.11 (p < 0.01), and the under-correction was 0.28 ± 0.69 D and 0.43 ± 0.94 D (p < 0.01), respectively. The glaucoma group showed poorer dry eye-related parameters, and under-correction was associated with myopia, anisometropia, near-add power, lower Schirmer test values, and superficial punctate keratopathy. Kaplan-Meier analysis revealed that glaucoma patients reached +3.00 D near add power significantly earlier than the controls (<i>P</i><0.01).</p><p><strong>Conclusion: </strong>Patients with glaucoma preferred more under-corrected CLs than controls. Our results further confirmed the presence of severe presbyopia in individuals with glaucoma.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"624634"},"PeriodicalIF":2.4,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13431736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Descriptive Study of Refractive Error Among Adults in Selected Practices in Witbank, South Africa.","authors":"Bevily Nukeri, Velibanti Sukati, Pheagane Motsime William Nkoana","doi":"10.2147/OPTO.S600818","DOIUrl":"10.2147/OPTO.S600818","url":null,"abstract":"<p><strong>Purpose: </strong>Refractive errors are among the leading causes of visual impairment globally and remain a significant contributor to avoidable vision loss in South Africa. However, data describing refractive error patterns within private optometry settings in urban areas such as Witbank remains limited.</p><p><strong>Patients and methods: </strong>A retrospective cross-sectional study of 1245 clinical records selected through systematic random sampling at three selected private optometry practices in Witbank. Data included demographic characteristics, unaided visual acuity, refractive status, and presbyopia. The mean age of participants was 44.58 ± 13.9 years, with an age range from 18 to 101 years. Data were analysed using SPSS version 28, employing descriptive and inferential statistics with statistical significance set at P<0.05.</p><p><strong>Results: </strong>Overall, 66% presented with refractive error,51% were female and 49% were male. The majority of the participants with refractive error were black Africans (72%), followed by whites (25%). Astigmatism was the most prevalent (43%), followed by myopia (13%) and hyperopia (10%). Compound myopic astigmatism (51%) was the dominant subtype. Hyperopic participants had a mean age of 57.82 years, while myopic individuals had a mean age of 39.29 years. Most patients presenting with reduced unaided visual acuity had astigmatism (58%), followed by myopia (28%). No significant associations were found between refractive errors: myopia (p<0.376; Cramer's V=0.437), hyperopia (p<0.284; Cramer's V =0.4), and astigmatism (p<0.888, Cramer's V=0.159), and gender. Similarly, no significant association was found between refractive errors (myopia (p<0.208; Cramer's V=0.448), hyperopia (p<0.719; Cramer's V=0.347), and astigmatism (p<0.325; Cramer's V=0.205)) and ethnicity. The majority (70.6%) of participants aged 35 and older had presbyopia.</p><p><strong>Conclusion: </strong>The study's findings reveal a significant prevalence of refractive errors in the population examined, with astigmatism constituting nearly half of all identified cases. This data provides a valuable baseline for eye care planning in similar clinical settings.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"600818"},"PeriodicalIF":2.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13404348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148608572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Dimensional Changes After 12 Months of Orthokeratology and Single-Vision Spectacle Use: A Three-Dimensional Magnetic Resonance Imaging Study.","authors":"Yu Chen Low, Bariah Mohd-Ali, Mizhanim Mohamad Shahimin, Norhani Mohidin, Wan Haslina Wan Abdul Halim, Siti Salasiah Mokri, Hamzaini Abdul-Hamid","doi":"10.2147/OPTO.S611080","DOIUrl":"10.2147/OPTO.S611080","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the 12-month impact of orthokeratology (Ortho-K) treatment on eyeball dimensions using magnetic resonance imaging (MRI). Results were compared with single-vision spectacle wearers (SVS).</p><p><strong>Patients and methods: </strong>A total of 70 Chinese schoolchildren (mean age: 8.31 ± 0.47 years) with myopia were assigned to Ortho-K (n = 45) and SVS (n = 25). Baseline spherical equivalent (SE), visual acuity (VA), and flat keratometry (FK) were measured. MRI was performed at baseline and at 12 months to measure three-dimensional ocular dimensions, including longitudinal axial length (LAL), horizontal width (HW), and vertical sagittal height (VSH). Standard slit-lamp examinations ensured ocular health at all follow-up visits.</p><p><strong>Results: </strong>At 12 months, the Ortho-K group showed significant reductions in SE and FK (p < 0.001), whereas the SVS group exhibited a significant increase (p < 0.05). LAL was significantly shorter in the Ortho-K group compared to SVS (p < 0.05). Although individual HW and VSH did not reach independent significance, repeated measures analysis of variance confirmed significant between-group differences in global eyeball shape over 12 months (p < 0.05). Correlation analysis revealed a significant association between SE and LAL in the SVS group (p < 0.05). In the Ortho-K group, SE showed no significant correlation with ocular dimensional changes (p > 0.05). In contrast, FK in the Ortho-K group demonstrated significant correlations with all dimensional parameters (p < 0.05), a pattern not observed in the SVS group.</p><p><strong>Conclusion: </strong>Findings indicate that myopic progression in the SVS group is primarily driven by axial elongation, whereas refractive changes in the Ortho-K group arise from corneal reshaping. Over 12 months, Ortho-K wear modifies ocular dimensions and inhibits AL elongation more significantly than SVS, providing a structural basis for controlling myopic progression.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"611080"},"PeriodicalIF":2.4,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13381602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148608595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contact Lenses and Vision-Related Quality of Life: Evidence and Clinical Insights.","authors":"Eugene Appenteng Osae, Kwaku A Osei, Natalie C Edwards, Edward Wygonik, Caroline A Blackie","doi":"10.2147/OPTO.S598390","DOIUrl":"10.2147/OPTO.S598390","url":null,"abstract":"<p><strong>Background: </strong>Contact lenses are a cornerstone of vision correction for ametropia and can be of particular value for management of irregular astigmatism and corneal ectasia. Beyond objective measures of visual acuity and corneal health, patient-reported outcomes and vision-related quality of life (VR-QoL) have emerged as critical endpoints. This review aimed to synthesize evidence on VR-QoL outcomes with contact lenses.</p><p><strong>Methods: </strong>We conducted a narrative review of studies published between 2000 and 2025 on the influence of various contact lens modalities including soft conventional lenses, rigid gas-permeable (RGP) lenses, scleral and mini-scleral lenses, orthokeratology, and specialty designs on VR-QoL across myopia, keratoconus, dry-eye disease, and other conditions. Descriptive tables were developed for all identified studies, and a synthesis of the impact of contact lenses on VR-QoL findings is presented. Evidence for VR-QoL measurement and instrumentation, special considerations for pediatric/adolescent populations, and barriers/limitations to sustained contact lens wear were also appraised.</p><p><strong>Results: </strong>VR-QoL evaluations using validated instruments demonstrate favorable findings with contact lenses. VR-QoL gains with contact lenses are more favorable compared with spectacle correction, particularly in appearance, activities, peer perception, and psychological domains. In keratoconus, RGP and scleral lenses dramatically improve NEI-VFQ-25 composite scores, even in cases of advanced disease. Barriers to sustained wear of contact lenses mostly relate to lens discomfort and dry eye due to ocular surface complications, although studies in patients with ocular surface disease/dry eye still derive VR-QoL benefits with contact lenses. There is a lack of head-to-head trials for certain modalities (eg, an absence of studies directly comparing multifocal contact lenses to spectacles for fall rates).</p><p><strong>Conclusion: </strong>Contact lenses provide significant and clinically meaningful gains in VR-QoL among adult and pediatric patients with refractive error, keratoconus, ocular surface disease or dry eye, and other indications. The VR-QoL benefits of contact lenses may exceed those achieved with spectacles.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"598390"},"PeriodicalIF":2.4,"publicationDate":"2026-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13374603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148473449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Avastin in Improving Visual Acuity and Reducing Retinal Swelling in Patients with Diabetic Retinopathy at a Hospital in Gauteng (SA).","authors":"Motebang Theodora Mosala, Thokozile Ingrid Metsing","doi":"10.2147/OPTO.S596147","DOIUrl":"10.2147/OPTO.S596147","url":null,"abstract":"<p><strong>Background: </strong>Globally, diabetic retinopathy (DR) has been identified as the cause of blindness among adults with both Type 1 diabetes (T1DM) and Type 2 diabetes (T2DM).</p><p><strong>Purpose: </strong>The study aimed to investigate the efficacy of Avastin in improving visual acuity (VA) and reducing central foveal (CFT) and parafoveal thicknesses (PFT) in participants with DR.</p><p><strong>Patients and methods: </strong>A cross-sectional observational study was conducted at a tertiary hospital in the Gauteng Province (South Africa). A total of 55 participants were included in the study, with VA's that were less than 0.5 LogMAR units and CFT's greater than 300 microns (µm). Measurements of VA's, CFT (µm), and PFT (µm) were conducted at baseline, after three and six months of receiving Avastin treatment. Numerical data were collected and analysed using IBM SPSS Version 28, and non-parametric tests were used to compare the means of the variables.</p><p><strong>Results: </strong>The mean VA improved from 1.00±0.71 LogMAR at baseline to 0.66±0.51 and 0.57±0.48 LogMAR at 3 and 6 months, respectively (p <0.001). The mean CFT improved from 441.22±142.35 µm at baseline to 355.58±129.38 µm and 308.40±137.60 µm at 3 and 6 months, respectively (p <0.001). The superior parafoveal thickness (SPFT) showed the highest decrease from a mean baseline of 379.04 µm to a mean baseline of 317.36 µm at 3 months. At 6 months, the decrease in the NPFT was statistically significant (p <0.025) in improving VA.</p><p><strong>Conclusion: </strong>Early administration of Avastin treatment in diabetic patients is effective in reducing the mean CFT, NPFT, and improving the mean VA.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"596147"},"PeriodicalIF":2.4,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13366071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148449843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World in-Home Use Test Evaluation of a Unique Multi-Purpose Solution for Planned Replacement Soft Contact Lens Users.","authors":"Chi Nguyen, Jeffery Schafer, Marjorie J Rah, Mark Schaeffer","doi":"10.2147/OPTO.S585916","DOIUrl":"10.2147/OPTO.S585916","url":null,"abstract":"<p><strong>Purpose: </strong>Contact lens (CL) wear may induce changes to the tear film, leading to sensations of ocular dryness and CL discomfort, key reasons for CL discontinuation. CL care solutions can help address underlying mechanisms of CL discomfort, improving wear experience. We report outcomes of an in-home use test of Biotrue^® Hydration Plus Multi-Purpose Solution (BHP MPS; Bausch + Lomb, Rochester, NY, USA), which is formulated to maintain ocular surface homeostasis and improve CL comfort.</p><p><strong>Patients and methods: </strong>In this IRB-approved, real-world survey study, adult soft CL users used BHP MPS for 7 days before completing a survey rating their experience (agreement/disagreement for attributes including CL cleanliness, comfort [including during extended screen use], prevention of CL dryness, perception of CL hydration, gentleness on eyes, and likelihood to recommend to others). A power analysis estimated sample size for 80% statistical power. Responses were analyzed with 2-sided exact binomial tests for agreement in >50% of responses (significance level α=0.05).</p><p><strong>Results: </strong>Participants (N=435) were demographically balanced (mean age 42.5 years; 52.9% female). Over 60% of participants reported baseline CL dryness and tired eyes; 8.0% were likely to discontinue CL wear. At the end of the trial period, 98.9% were satisfied with how their CLs felt. Individual responses were significantly >50% for all attributes (p<0.05), including 91.7% agreeing that BHP MPS positively impacted CL comfort (and helped to keep CLs feeling clean [96.8%], keep CLs comfortable so that eyes do not feel tired [93.1%], maintain CL comfort [94.7%], prevent CL dryness [93.6%], maintain comfort with extended screen use [92.0%], and maintain hydration [94.7%] while being gentle on eyes [96.6%]); 94.0% would recommend BHP MPS to other CL wearers. No adverse events were reported.</p><p><strong>Conclusion: </strong>BHP MPS demonstrated strong performance across all key criteria evaluated in this real-world cohort of soft CL wearers for improved CL wear experience.</p>","PeriodicalId":43701,"journal":{"name":"Clinical Optometry","volume":"18 ","pages":"585916"},"PeriodicalIF":2.4,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}