IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-14 DOI: 10.1016/j.talanta.2024.127377

Jian Zhang, Xiaojie Tang, Honglan Qi, Zhao Li, Xiaowei He

{"title":"A new near-infrared fluorescence probe for highly selective and sensitive detection and imaging of Butyrylcholinesterase in Alzheimer's disease mice.","authors":"Jian Zhang, Xiaojie Tang, Honglan Qi, Zhao Li, Xiaowei He","doi":"10.1016/j.talanta.2024.127377","DOIUrl":"10.1016/j.talanta.2024.127377","url":null,"abstract":"Butylcholinesterase (BChE) is a key enzyme in living system, closely related to liver and neurological diseases. It is very challenge to develop near-infrared (NIR) fluorescence probe methods for highly selective and sensitive detection of BChE in vivo. Based on the differences in active sites and spatial pockets between acetylcholinesterase (AChE) and BChE, a new NIR BChE-responsive fluorescence probe Probe-BChE (λex/λem = 600 nm/676 nm) was designed and synthesized by introducing dimethyl carbamate group as recognizing moiety to a NIR fluorophore hemicyanine skeleton. It was found that Probe-BChE specifically binds with BChE, rather than AChE, since BChE has a big cavity and strong intermolecular forces with Probe-BChE, which was supported by the molecular docking scores. The fluorescence method for the determination of BChE was developed with a detection limit of 0.14 U/mL BChE and high selectivity as well as short reaction time (∼3 s). The fluorescence imaging method using Probe-BChE efficiently image the levels of endogenous BChE in brains and main organs (heart, liver, spleen, lung and kidney) of Alzheimer's disease (AD) mice. The results reveal that the levels of endogenous BChE in old AD mice is higher than that in young AD mice, and endogenous BChE is enriched in the liver of AD mice. This work demonstrates that Probe-BChE is a promising fluorescence probe for imaging of endogenous BChE in AD mice. The design of NIR fluorescence probes for endogenous BChE in this work will promote to design NIR fluorescence probes for endogenous cholinesterase.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127377"},"PeriodicalIF":5.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fiber array-based large spot confocal Raman system for rapid in situ detection of pathogenic bacterial colonies. 基于光纤阵列的大点共聚焦拉曼系统用于病原菌菌落的快速原位检测。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-16 DOI: 10.1016/j.talanta.2024.127407

Hao Peng, Yu Wang, Lindong Shang, Xusheng Tang, Xiaodong Bao, Peng Liang, Yuntong Wang, Bei Li

引用次数: 0

QSAR-guided strategy for accurate annotation of FAHFA regioisomers. 基于qsar的FAHFA区域异构体准确注释策略。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-18 DOI: 10.1016/j.talanta.2024.127421

Peng-Cheng Mei, Na An, Hua-Ming Xiao, Yao-Yu Chen, Quan-Fei Zhu, Yu-Qi Feng

{"title":"QSAR-guided strategy for accurate annotation of FAHFA regioisomers.","authors":"Peng-Cheng Mei, Na An, Hua-Ming Xiao, Yao-Yu Chen, Quan-Fei Zhu, Yu-Qi Feng","doi":"10.1016/j.talanta.2024.127421","DOIUrl":"10.1016/j.talanta.2024.127421","url":null,"abstract":"Branched fatty acid esters of hydroxy fatty acids (FAHFAs) represent a novel class of bioactive lipids with significant physiological roles. However, their identification, particularly of low-abundance FAHFA regioisomers, remains challenging due to their high structural similarity, low natural abundance, and the limited availability of reliable FAHFA standards. In this study, we present a QSAR-based FAHFA annotation strategy that integrates a QSAR model with an ester bond position (EP) rule to determine the EPs of FAHFA regioisomers. The QSAR model quantitatively relates the retention index (RI) of FAHFAs to the EP descriptor and the GATS2m descriptor, while the EP rule establishes a quantitative relationship between the RI of FAHFA regioisomers and their EP within a given FAHFA family. By applying this QSAR-based strategy, we successfully identified a comprehensive set of 507 FAHFA regioisomers from 1207 FAHFA candidates detected across 16 food samples, achieving nearly a threefold increase in annotation coverage compared to our previous method. Overall, this strategy significantly enhances the identification capability in determining EP for FAHFA regioisomers, providing a promising analytical tool for the further exploration into these lipids.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127421"},"PeriodicalIF":5.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In situ formation of boronic acid-based covalent organic frameworks for specific and ultra-sensitive electrochemical assay of glycosylated amyloid-beta proteins. 基于硼酸的共价有机框架的原位形成，用于糖基化淀粉样蛋白的特异性和超敏感电化学分析。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-19 DOI: 10.1016/j.talanta.2024.127435

Yubing Lv, Yanli Zhou, Chunlan Li, Chaoran Lv, Hui Dong, Maotian Xu, Jing Zhang, Mei Yan

{"title":"In situ formation of boronic acid-based covalent organic frameworks for specific and ultra-sensitive electrochemical assay of glycosylated amyloid-beta proteins.","authors":"Yubing Lv, Yanli Zhou, Chunlan Li, Chaoran Lv, Hui Dong, Maotian Xu, Jing Zhang, Mei Yan","doi":"10.1016/j.talanta.2024.127435","DOIUrl":"10.1016/j.talanta.2024.127435","url":null,"abstract":"Alzheimer's disease (AD) significantly impacts the well-being of older people around the world. However, the accurate detection of glycosylated amyloid-beta (Aβ) proteins, which serve as important biomarkers for AD, remains challenging due to their extremely low levels. To address these issues, we proposed a method for fabricating a flexible and stable sensor platform based on an innovative boronic acid-based covalent organic framework COF-B(OH)2. After in situ formation on carbon cloth (CC) by facile interfacial perturbation, this CC-based COF substrate could further serve as an electrochemical platform for detecting glycosylated-Aβ16 via molecular interactions. The substrate offers abundant molecular recognition sites, a large specific surface area, and excellent electrical conductivity. Furthermore, poly(thymine)-templated copper nanoparticles (CuNPs) linked to the aptamer of glycosylated-Aβ16 were employed as electrochemical probes, providing an amplified signal. The proposed assay for the detection of glycosylated-Aβ16 proteins demonstrated a wide detection range of 5-1800 pg/mL, with an ultralow detection limit of 0.32 pg/mL and high stability. This research offers novel insights into the developing electrochemical biosensors for analyzing glycosylated protein, leveraging advanced COF-B(OH)2 materials.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127435"},"PeriodicalIF":5.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constructing an electrochemical sensor with screen-printed electrodes incorporating Ti₃C₂T_x-PDA-AgNPs for lactate detection in sweat. 构建含Ti3C2Tx-PDA-AgNPs的丝网印刷电极电化学传感器，用于汗液中乳酸的检测。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-22 DOI: 10.1016/j.talanta.2024.127423

Haozi Lu, Junhua Wang, Ziyi Wu, Meiqing Yang, Wei Zhou, Ye Li, Huimin Li, Yang Zhang, Jifei Yang, Gang Yu, Song Liu

{"title":"Constructing an electrochemical sensor with screen-printed electrodes incorporating Ti3C2Tx-PDA-AgNPs for lactate detection in sweat.","authors":"Haozi Lu, Junhua Wang, Ziyi Wu, Meiqing Yang, Wei Zhou, Ye Li, Huimin Li, Yang Zhang, Jifei Yang, Gang Yu, Song Liu","doi":"10.1016/j.talanta.2024.127423","DOIUrl":"10.1016/j.talanta.2024.127423","url":null,"abstract":"Sweat lactate levels are closely related to an individual's physiological state and serve as critical indicators for assessing exercise intensity, muscle fatigue, and certain pathological conditions. Screen-printed electrodes (SPEs) offer a promising avenue for the development of low-cost, high-performance wearable devices for electrochemical sweat analysis. The material composition of SPEs significantly impacts their detection sensitivity and stability. In this study, we designed a screen-printed carbon electrode (SPCE) modified with Ti3C2Tx Polydopamine (PDA), and silver nanoparticles (AgNPs) (Ti3C2Tx-PDA-AgNPs) for lactate detection in sweat. The accordion-like structure of Ti3C2Tx provides a large specific surface area and exceptional electrical conductivity. PDA, acting as both a reducing agent and binder, supports the in-situ formation of AgNPs on the Ti3C2Tx nanosheets. These AgNPs prevent the restacking of Ti3C2Tx layers, further improving conductivity. The sensor exhibited sensitivities of 0.145 μA mM-1, with limit of detection (LOD) of 0.181 mM (S/N = 3) in phosphate-buffered saline (PBS), meeting the requirements for for sweat lactate detection. The sensor was integrated into a wearable micro-electrochemical platform paired with a custom Android application for real-time sweat analysis. Testing on human sweat demonstrated the platform's potential for practical fitness monitoring and healthcare diagnostics applications.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127423"},"PeriodicalIF":5.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A luminescent lanthanide functionalized hydrogen-bonded organic framework hydrogel: Fluorescence sensing platform for copper and iron ions detection. 发光镧系功能化氢键有机框架水凝胶：铜和铁离子检测的荧光传感平台。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-18 DOI: 10.1016/j.talanta.2024.127420

Shuang Meng, Xuanting He, Boyu Li, Yuanyuan Yang, Shun Mao, Zhuo Li

{"title":"A luminescent lanthanide functionalized hydrogen-bonded organic framework hydrogel: Fluorescence sensing platform for copper and iron ions detection.","authors":"Shuang Meng, Xuanting He, Boyu Li, Yuanyuan Yang, Shun Mao, Zhuo Li","doi":"10.1016/j.talanta.2024.127420","DOIUrl":"10.1016/j.talanta.2024.127420","url":null,"abstract":"The excessive presence of the metal ions Cu2+ and Fe3+ in the environment poses a serious threat to ecosystems and human health, so timely and accurate detection of them has become essential and urgent. In this paper, a novel hydrogel-based fluorescent sensor, named ME-IPA@SA-TbZn, was fabricated facilely through an in-situ cross-linking modification method and was used for the detection of Cu2+ and Fe3+ in water bodies. The ME-IPA@SA-TbZn is essentially a hybrid hydrogel bead that exhibits vibrant fluorescence, employing Tb and Zn functionalized hydrogen-bonded organic frameworks (HOFs) as the fluorescence functional core and sodium alginate (SA) as the hydrogel matrix. The synthesized hydrogel sensor ME-IPA@SA-TbZn exhibits remarkable capabilities in detecting and distinguishing between Cu2+ and Fe3+ with high selectivity and sensitivity. Specifically, it achieves limits of detection (LODs) of 1.275 μM for Cu2+ and 0.549 μM for Fe3+, respectively, both are below the maximum allowable concentrations set by the U.S. Environmental Protection Agency (EPA) for drinking water. Importantly, the hydrogel sensing platform delivers intuitive and visible results under simple operating conditions, and has been successfully applied to Cu2+ and Fe3+ detection in river samples. In addition, it was demonstrated that disruption of the \"antenna\" effect, absorption competition quenching (ACQ) effect, and ion exchange (IE) effect are the main mechanisms leading to fluorescence quenching. Based on these results, ME-IPA@SA-TbZn hold promise as a fluorescent sensor for detecting Cu2+ and Fe3+ ions.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127420"},"PeriodicalIF":5.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of uranyl ions by single-hairpin based self-hybridization chain reaction. 基于单发夹的自杂交链式反应检测铀酰离子。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-13 DOI: 10.1016/j.talanta.2024.127374

Fengyi Lin, Yuxin Cheng, Min Li, Zhi Li, Jianyuan Dai

引用次数: 0

Synthesis of Mg doped ZnO cauli-flower nanostructures using chemical spray and its investigation for ammonia gas sensing at room temperature. 化学喷雾法制备Mg掺杂氧化锌菜花纳米结构及其室温氨气传感研究。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-18 DOI: 10.1016/j.talanta.2024.127403

S A Jadhav, S D Lokhande, G Umadevi, V D Mote

{"title":"Synthesis of Mg doped ZnO cauli-flower nanostructures using chemical spray and its investigation for ammonia gas sensing at room temperature.","authors":"S A Jadhav, S D Lokhande, G Umadevi, V D Mote","doi":"10.1016/j.talanta.2024.127403","DOIUrl":"10.1016/j.talanta.2024.127403","url":null,"abstract":"In this study, we report the synthesis, optical characterization and ultra-sensitive ammonia gas sensing properties of Mg-doped ZnO cauliflower like nanostructures obtained via chemical spray pyrolysis technique. The morphological and structural properties of the prepared films were investigated by Field Emission Scanning electron microscope (FESEM) and X-ray diffraction (XRD). Gas sensing and optical characterizations were carried out using Keithley electrometer and Uv-Vis. Spectrophotometer. Cauliflower-like nanostructures were obtained with diameter 33.16 nm of 5 % Mg-doped ZnO films. Significant changes in the pivot-like morphology of 1 % Mg-doped ZnO sample to cauliflower like morphology indicates that higher Mg doping concentration affects the morphology. Surface to volume ratio increased as the particle size reduced from 38 nm to 33 nm with increasing Mg doping. This emphasizes that the morphology and the surface area play an important role in the surface phenomenon of materials. The XRD results reveal that obtained films have hexagonal (wurtzite) crystal structure of ZnO. The gas sensing properties of Mg-doped ZnO nanostructures were tested based on resistance variation upon the exposure of ammonia vapor at room temperature. The ability 5 % Mg-doped ZnO nanostructures to sense 5 ppm ammonia gas was enhanced with least response (24 s) and recovery time (27 s). It may be due to Mg-doping tuned the required surface morphology of ZnO. Moreover, the ammonia gas sensing mechanism of Mg-doped ZnO nanostructures is demonstrated. Optical energy bandgap is decreased due to the increased defects formation with higher Mg doping. Based on the gas sensing and optical properties, Mg-doped ZnO materials are the promising candidate for ammonia gas sensor and opto-electronic device applications.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127403"},"PeriodicalIF":5.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proof-of-concept chemometric approach for environmental forensic sourcing of crude oil samples using SPME-GC-MS. 使用SPME-GC-MS对原油样品进行环境法医采购的概念验证化学计量方法。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-13 DOI: 10.1016/j.talanta.2024.127381

Vidia A Gokool, Michelle Karpinsky, Kenneth G Furton, Lauryn E DeGreeff

{"title":"Proof-of-concept chemometric approach for environmental forensic sourcing of crude oil samples using SPME-GC-MS.","authors":"Vidia A Gokool, Michelle Karpinsky, Kenneth G Furton, Lauryn E DeGreeff","doi":"10.1016/j.talanta.2024.127381","DOIUrl":"10.1016/j.talanta.2024.127381","url":null,"abstract":"Environmental exposure to crude oil through seepage and spillage poses risks to the immediate environment and the broader ecosystem as areas along the oil distribution path are affected by the influx of crude petroleum as well as the environmental, economic, and civil unrest that accompanies it. There is a large financial burden associated with the lost resources, including the cost of rehabilitation, and the affected sources of revenue for communities affected by oil spills. As such, it is crucial to determine the responsible parties. This work outlines an environmental forensics approach to determining the source of an un-weathered crude oil sample. The researchers employed solid phase microextraction coupled with gas chromatography mass spectrometry (SPME-GC-MS) to capture and analyze the gaseous components emitted by crude oil samples sourced from five locations. Samples were analyzed using Spearman's rank correlation and 3D covariance analysis. Both chemometric approaches yielded optimal performance results with no misclassifications, true positive rate (TPR) = 100 % and false positive rate (FPR) = 0 %. The similarity metrics calculated by each test noted clear delineations between the values of same-source and differently sourced samples. The Spearman's rank correlation test and 3D covariance calculations both demonstrated the ability to correctly identify sample source origin in this dataset. The authors outline an approach to the future application of these tests and suggest their joint use in future crude oil sourcing endeavors.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127381"},"PeriodicalIF":5.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-mode colorimetric and chemiluminescence aptasensor for organophosphorus pesticides detection using aptamer-regulated peroxidase-like activity of TA-Cu. 利用配体调控TA-Cu过氧化物酶样活性的双模比色和化学发光配体检测有机磷农药。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-19 DOI: 10.1016/j.talanta.2024.127410

Wenjie Jing, Qihao Shi, Shan Qiang, Yu Wang, Yizhuo Li, Teng Zhao, Yuan Li, Dingkuo Liu, Yihan Liu, Fufeng Liu

{"title":"Dual-mode colorimetric and chemiluminescence aptasensor for organophosphorus pesticides detection using aptamer-regulated peroxidase-like activity of TA-Cu.","authors":"Wenjie Jing, Qihao Shi, Shan Qiang, Yu Wang, Yizhuo Li, Teng Zhao, Yuan Li, Dingkuo Liu, Yihan Liu, Fufeng Liu","doi":"10.1016/j.talanta.2024.127410","DOIUrl":"10.1016/j.talanta.2024.127410","url":null,"abstract":"The residues of organophosphorus pesticides (OPs) in food pose a huge threat to human health. Therefore, the development of detection methods with simple design and high sensitivity is urgently needed. Here, a colorimetric/chemiluminescence (CL) dual-mode aptasensor strategy with high selectivity and sensitivity for detecting Parathion-methyl (PM) was designed based on aptamer-regulated nanozyme activity. The Parathion-methyl specific aptamer was anchored onto the surface of trimesic acid-Cu (TA-Cu) nanozyme, which can regulate the catalytic ability of TA-Cu nanozyme towards substrates and also serve as a specific recognition unit for PM. In the presence of PM, the aptamers bind to PM and detach from the surface of TA-Cu nanozyme, which effects the catalytic ability of TA-Cu nanozyme towards substrates. Based on the above experimental phenomena, a colorimetric/CL dual-mode aptasensor method for PM was developed, with the linear ranges of 0.01-20 and 1-100 ng/mL, the limit of detections of 0.004 and 0.45 ng/mL, respectively. More importantly, compared with most single mode analysis methods, this dual-mode sensing system can conduct self-inspection by comparing the detection results of each mode, thus improving the reliability of the detection results.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127410"},"PeriodicalIF":5.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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