Journal of the World Federation of Orthodontists最新文献

{"title":"Condylar volume changes in class II division 2 cases treated with unlocking the mandible using clear aligners.","authors":"Hanie Morsi, Karla Carpio Horta, William Wiltshire, Giseon Heo, Tarek El-Bialy","doi":"10.1016/j.ejwf.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.ejwf.2025.04.004","url":null,"abstract":"<p><strong>Introduction: </strong>Class II Division 2 malocclusion involves retroclined maxillary incisors and deep overbite, often accompanied by mandibular retrusion. \"Unlocking\" the mandible by proclining the maxillary incisors, correcting the deep bite, and expanding the maxillary arch has been used to treat this malocclusion. However, the impact of this treatment, using Invisalign® clear aligners, on condylar volume remains unclear. This study evaluates three-dimensional changes in condylar volume after using Invisalign® to unlock the mandible in Class II Division 2 growing patients.</p><p><strong>Methods: </strong>Cone-beam computed tomography (CBCT) data were collected from 22 adolescent patients (11 in the treatment group; 11 in the control group) at T1 (pre-treatment) and T2 (1.5-2 years post-T1). Dolphin imaging software was used for cephalometric tracing, while 3D Slicer and ITK-SNAP software calculated condylar volume. Repeated measure ANOVA compared condylar volume changes, and Pearson's Correlation Coefficient assessed the relationship between condylar volume change and ANB angle in the treatment group.</p><p><strong>Results: </strong>Both groups showed significant condylar volume increases between T1 and T2 (treatment: P < 0.001, 127.45 ± 30.97, control: P = 0.015, 98.8 ± 36.31), with no significant difference between groups at T1 (P = 0.289, 89.19 ± 81.2) or T2 (P = 0.167, 117.9 ± 81.7). The change in ANB angle did not correlate with the condylar volume increase in the treatment group (Pearson's R = -0.15, P = 0.681).</p><p><strong>Conclusion: </strong>Unlocking the mandible successfully corrected Class II Division 2 malocclusion, but condylar volume increases in both groups were likely due to normal growth rather than treatment. Condylar volume change was not correlated with malocclusion correction.</p>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of the effectiveness of standard anterior bracket placement versus smile arc protection method: A randomized clinical trial","authors":"Fahimeh Farzanegan,&nbsp;Alireza Ghasemzadeh,&nbsp;Mahsa Ghorbani,&nbsp;Hooman Shafaee","doi":"10.1016/j.ejwf.2025.01.001","DOIUrl":"10.1016/j.ejwf.2025.01.001","url":null,"abstract":"<div><h3>Objectives</h3><div>This randomized two-arm parallel trial aimed to compare the effectiveness of standard anterior bracket positioning with the smile arc protection (SAP) method in terms of occlusal and smile morphometric indices, and perceived post-treatment smile aesthetics.</div></div><div><h3>Methods</h3><div>Patients needing nonextraction orthodontic treatment were randomly assigned to either the SAP or standard bracket placement group. Inclusion criteria were ages 11 to 25 years, nonextraction treatment, and good oral hygiene, all treated using the Roth 0.018 system. Primary outcomes assessed occlusal and smile morphometric changes using cephalograms, study models, and photographs. Perceived smile aesthetics was evaluated with the Visual Analogue Scale (VAS). Statistical analyses included independent t-tests, paired t-tests, Mann–Whitney U test, Wilcoxon signed rank test, and analysis of covariance.</div></div><div><h3>Results</h3><div>Forty-two patients (mean age, 19.5 ± 5.5) were randomized evenly between the SAP and standard groups. Baseline characteristics were similar, and one patient from the SAP group was excluded. No significant differences were found between the groups for occlusal and smile morphometric variables before and after treatment (<em>P</em> &gt; 0.05). Post-treatment, the smile arc significantly improved in the SAP group compared to both the standard method (<em>P</em> = 0.005) and its pretreatment state (<em>P</em> = 0.005). VAS scores from orthodontists and laypersons showed no significant differences (<em>P</em> &gt; 0.05), but general dentists rated the SAP group's smiles as more attractive (<em>P</em> = 0.002).</div></div><div><h3>Conclusions</h3><div>The SAP method was more effective in achieving a consonant smile arc than conventional bracket positioning. While other occlusal and morphometric changes showed no significant differences, general dentists found the SAP group's smiles more attractive. Further research is needed to confirm these results.</div></div><div><h3>Registration</h3><div>The research was registered in the Iranian Registry of Clinical Trials (IRCT) database with the identification code IRCT20220108053669N3.</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 3","pages":"Pages 131-139"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating machine learning for treatment decisions in anterior open bite orthodontic cases: A retrospective study","authors":"Matthew Rhee ,&nbsp;Mohammed H. Elnagar ,&nbsp;Veerasathpurush Allareddy ,&nbsp;Omid Halimi Milani ,&nbsp;Ahmet Enis Cetin ,&nbsp;Flavio Jose Sanchez","doi":"10.1016/j.ejwf.2024.12.001","DOIUrl":"10.1016/j.ejwf.2024.12.001","url":null,"abstract":"<div><h3>Introduction</h3><div>This article explores the integration of machine learning (ML) algorithms to aid in treatment planning and extraction decisions for anterior open bite cases, leveraging demographic, clinical, and radiographic data to predict treatment outcomes and informed decision-making.</div></div><div><h3>Materials and Methods</h3><div>A retrospective study was conducted using patient data from the University of Illinois Chicago Department of Orthodontics. Data included demographic, clinical, and radiographic information from 115 anterior open bite patients who successfully completed their treatment. ML algorithms, including random forest, support vector machine, k-nearest neighbor, and convolutional neural networks (CNN), were trained on a subset of the data to predict treatment outcomes.</div></div><div><h3>Results</h3><div>Significant differences were observed in the percentages of males and females between the extraction and nonextraction groups and cephalometric variables between the two groups, which include maxillary depth, maxillary height, SN-palatal plane, facial angle, facial axis-Ricketts, FMA, total facial height, lower facial height, SNA, SNB, and SN-MP e ML algorithms examined consisted of CNN2, CNN1, and Random Forest, which demonstrated the highest accuracy rates (∼83%), while k-Nearest Neighbor had the lowest (∼73%). Key features influencing accuracy included crowding, SN-palatal plane, SNA, FMA, molar relation, and facial height measurements.</div></div><div><h3>Conclusions</h3><div>The study's evaluation of AI algorithms showed that CNN2, CNN1, and random forest had an accuracy of approximately 83% in classifying extraction versus nonextraction cases. Notably, features such as U-crowding, L-crowding, SN-palatal plane, SNA, FMA, molar relation, total facial height, lower facial height, and facial axis-Ricketts were most influential in achieving accuracy rates comparable to traditional methods.</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 3","pages":"Pages 140-147"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Opinion Leaders: The new age influencers!","authors":"Vinod Krishnan","doi":"10.1016/j.ejwf.2025.05.003","DOIUrl":"10.1016/j.ejwf.2025.05.003","url":null,"abstract":"","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 3","pages":"Pages 123-124"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of clear aligner versus removable inclined plane in treatment of anterior crossbite in mixed dentition: A randomized clinical trial","authors":"Asmaa S. Salem ,&nbsp;Nehal F. Albelasy ,&nbsp;Ahmed A. El-Bialy","doi":"10.1016/j.ejwf.2024.11.001","DOIUrl":"10.1016/j.ejwf.2024.11.001","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to compare the efficacy of clear aligners and removable inclined planes (RIP) in management of anterior crossbite in late mixed dentition patients using a 3D digital model.</div></div><div><h3>Materials and Methods</h3><div>Twenty-four patients with functional anterior crossbite, aged 8 to 12 years old, were randomly assigned to two parallel groups: the clear aligner (CA) group with a mean age of 10.74 ± 1.1 years, treated with clear aligner, and the RIP group with a mean age of 10.54 ± 1.06 years. Digital models were obtained for each patient before (T0) and after 4 months of starting the treatment (T1) using an intraoral scanner. The T0 to T1 digital model was superimposed to assess the primary outcome, labial movement of the maxillary incisors. For each model, the following secondary outcomes were evaluated: overbite, intermolar width (IMW), incisor leveling, arch perimeter (AP), and mesiodistal angulation. Data analysis included descriptive statistics, paired <em>t</em> tests, independent <em>t</em> tests, one-way ANOVA, and Tukey's HSD test.</div></div><div><h3>Results</h3><div>There was no significant difference between CA and RIP groups regarding overjet, overbite, incisor leveling, and mesiodistal angulation of the maxillary incisors (<em>P</em> &lt; 0.05). However, a significant difference was found between two groups in IMW, AP, and incisor superimposition (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The CA group showed a more significant increase in labial movement of maxillary incisors, IMW, and AP compared to the RIP group. However, both treatment protocols were effective in treating anterior crossbite.</div><div>This study was recorded in the ClinicalTrials.gov database (identifier: NCT06015386).</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 3","pages":"Pages 125-130"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haplotype-based association between paternal DNMT1 variants and nonsyndromic cleft lip or without cleft palate in Chile","authors":"Verónica Inostroza ,&nbsp;Roberto Pantoja ,&nbsp;Noemí Leiva ,&nbsp;Rosa Pardo ,&nbsp;José Suazo","doi":"10.1016/j.ejwf.2025.01.004","DOIUrl":"10.1016/j.ejwf.2025.01.004","url":null,"abstract":"<div><h3>Background</h3><div>DNA methyltransferase 1 (DNMT1) is responsible for epigenetic remodeling of the genome during spermatogenesis and maintenance of DNA methylation. The current study aimed to assess the possible association between paternal polymorphic variants of the gene encoding DNMT1 enzyme and the risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) expression in offspring.</div></div><div><h3>Methods</h3><div>Nine <em>DNMT1</em> polymorphic single nucleotide polymorphism (SNP) variants were analyzed in 101 fathers of NSCL/P Chilean cases and 187 fathers of controls. Single marker association for additive, dominant, and recessive models was performed using logistic regression analysis. The haplotype-based association was assessed using 3-SNPs sliding windows with a likelihood-ratio test. Multiple comparison corrections were applied using false discovery rates.</div></div><div><h3>Results</h3><div>None of the <em>DNMT1</em> SNPs remained significant for any genetic models for single marker association. However, after false discovery rates correction, rs2228611-rs2228612-rs16999714 (q = 0.0042) and rs2228612-rs16999714-rs17291414 (q = 0.0014) haplotypes showed association with the phenotype, based on the dominant model.</div></div><div><h3>Conclusions</h3><div>Paternal haplotypes, sharing the rs2228612 and rs16999714 <em>DNMT1</em> SNPs, are associated with NSCL/P expression in the Chilean population. The absence of <em>in vitro/in vivo</em> experimental evidence about the role of these variants on gene expression or protein function opens the opportunity for further investigations.</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 3","pages":"Pages 170-175"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of nasal septum deviation via reformatted computed tomography (CT) imaging following expansion using RPE and MARPE","authors":"Diana Schron ,&nbsp;Marrina Ran-Sukkawala ,&nbsp;Elliott Pereira ,&nbsp;Yan Zhang ,&nbsp;Nicholas Hwang ,&nbsp;In-Won Chang ,&nbsp;Karla Lindquist ,&nbsp;Ryan Williams ,&nbsp;Julia Peng ,&nbsp;Michael Nedjat-Haiem ,&nbsp;Kevin Kang ,&nbsp;Christine Hong ,&nbsp;Audrey Yoon","doi":"10.1016/j.ejwf.2024.11.003","DOIUrl":"10.1016/j.ejwf.2024.11.003","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate whether rapid palatal expansion (RPE) or miniscrew-assisted rapid palatal expansion (MARPE) affects nasal septum deviation (NSD).</div></div><div><h3>Materials and Methods</h3><div>The study population includes 22 RPE patients ages 9.62 ± 1.38 years and 20 MARPE patients ages 19.38 ± 7.82 years with initial diagnostic cone-beam computed tomography (CBCT) scans (T0). Another CBCT scan (T1) was taken after patients underwent RPE or MARPE expansion treatment alone. NSD was evaluated three-dimensionally using a custom landmark analysis on T0 and T1 CBCT scans. Principal component analysis (PCA) and canonical variate analysis (CVA) were used to identify nasal septum shape differences before and after expansion treatment.</div></div><div><h3>Results</h3><div>PCA and CVA showed that while there was change in nasal septum shape from T0 to T1 for MARPE and RPE treatments, the general pattern in morphological change was not found when comparing the variety of phenotypes between individuals. The Procrustes ANOVA regression found <em>P</em>-values for MARPE centroid size and shape were 0.7861 and 1, and RPE centroid size and shape were 0.3508 and 1, respectively, suggesting that there were no significant differences in nasal septum size and shape following expansion. CVA found <em>P</em>-values were 0.99 for MARPE and 0.99 for RPE after 10,000 permutation tests for Procrustes distances, indicating that there were no significant differences between T0 and T1 group means for both treatment groups.</div></div><div><h3>Conclusions</h3><div>MARPE and RPE expansion treatments had no effect on nasal septum deviation from T0 to T1.</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 3","pages":"Pages 148-153"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming three-dimensional challenges through objective decomposition and virtual-digital design: A multidisciplinary case on hypodontia treatment","authors":"Yubohan Zhang ,&nbsp;Haolin Zhang ,&nbsp;Meng Meng ,&nbsp;Jie Gao","doi":"10.1016/j.ejwf.2025.01.003","DOIUrl":"10.1016/j.ejwf.2025.01.003","url":null,"abstract":"<div><div>A 15-year-old female sought multidisciplinary treatment for hypodontia, three-dimensional problems, deep overbite, multiple occlusal interferences, and collapse of the occlusion. Through virtual-digital design with objective decomposition, this patient underwent five steps of orthodontic treatment under the guidelines of the principles: removal of occlusal restriction is a prerequisite; transverse problems are solved first; then sagittal problems; and vertical correction runs through the treatment. After orthodontic and prosthetic treatment, aesthetic appearance and functional occlusion were achieved. In complex multidisciplinary cases with three-dimensional problems, which makes it difficult to formulate the final goal, virtual-digital design under objective composition and standardized comprehensive principle are effective and necessary.</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 3","pages":"Pages 176-184"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CDSNet: An automated method for assessing growth stages from various anatomical regions in lateral cephalograms based on deep learning","authors":"Yuchen Zhang ,&nbsp;Zhen Lu ,&nbsp;Jianglin Zhou ,&nbsp;Yi Sun ,&nbsp;Wuci Yi ,&nbsp;Juan Wang ,&nbsp;Tianjing Du ,&nbsp;Dongning Li ,&nbsp;Xinyan Zhao ,&nbsp;Yifei Xu ,&nbsp;Chen Li ,&nbsp;Kun Qi","doi":"10.1016/j.ejwf.2024.09.007","DOIUrl":"10.1016/j.ejwf.2024.09.007","url":null,"abstract":"<div><h3>Background</h3><div>The assessment of growth stages, typically determined by Cervical Vertebrae Maturation (CVM), plays a crucial role in orthodontics. However, there is a potential deviation from actual growth stages when using CVM. This study aimed to introduce CDSNet, an interpretable deep learning model for assessing growth stages based on cervical vertebrae, dentition, and frontal sinus in lateral cephalograms.</div></div><div><h3>Methods</h3><div>A dataset of 1,732 pairs of lateral cephalograms and hand-wrist radiographs from patients who underwent orthodontic treatment was annotated by four dentists. Benchmarks were conducted using CVM and logistic regression. Experiments were designed to evaluate CDSNet's performance in assessing growth stages using various methods and anatomical regions.</div></div><div><h3>Results</h3><div>CDSNet achieved remarkable Accuracy (90.99%), Precision (89.98%), Recall (92.50%), and F-1 Score (91.22%) in assessing growth spurt, representing significant improvements of 26.56%, 27.96%, 30.26%, and 29.30% compared to the CVM-based method. Additionally, when compared to a deep learning method based on cervical vertebrae, improvements of 12.25%, 11.40%, 14.14%, and 12.56% were observed. The interpretable module's side output revealed the involvement of cervical vertebrae, dentition, and frontal sinus in assessing growth spurt.</div></div><div><h3>Conclusions</h3><div>In the clinical domain, CDSNet is able to assist clinicians in determining patients’ growth stages, particularly those near the boundary between two stages with less distinct features. This study demonstrated the role of interpretable deep learning in investigating the external manifestations of craniofacial growth. Integrating algorithmic or clinical research to analyze multiple features on lateral cephalograms proved a feasible approach to assist orthodontists and improve diagnostic efficacy.</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 3","pages":"Pages 154-160"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of customized 3D-printed MARPE appliance on hard tissues, soft tissues, and airway: A prospective CBCT study","authors":"Priyanka Mehta,&nbsp;Ashish Kumar Singh,&nbsp;Abhita Malhotra,&nbsp;Sana Bint Aziz,&nbsp;Puneet Batra","doi":"10.1016/j.ejwf.2024.12.002","DOIUrl":"10.1016/j.ejwf.2024.12.002","url":null,"abstract":"<div><h3>Background</h3><div>The advances in technology have enabled the customization of appliances including mini-screw-assisted rapid palatal expansion (MARPE) appliances for skeletal expansion in young adult patients. The study assessed the short-term effects of customized MARPE appliances on the hard tissues, soft tissues, and airway volume over a period of 6 months.</div></div><div><h3>Methods</h3><div>A total of 15 patients in the age range of 15 to 25 years were treated for transverse maxillary deficiency using a three-dimensional (3D) printed customized MARPE appliance. The changes in hard tissues, soft tissues, and airway volume were evaluated using cone beam computed tomography before expansion (T0) and at 6 months post-expansion (T1). The Digital Imaging and Communications in Medicine files were analyzed for post-expansion changes using the NemoCeph 3D and 3D Slicer 5.6.1 software.</div></div><div><h3>Results</h3><div>An effective skeletal expansion was observed with significant changes in intercanine, interpremolar, and intermolar width; and decreased mid-palatal suture density in the anterior region (<em>P</em> &lt; .05). The changes in tooth inclination and alveolar bone thickness were mostly non-significant apart from a significant decrease in buccal bone thickness in the coronal third region (<em>P</em> &lt; .05). There was no significant root resorption or change in airway volumes (<em>P</em> &gt; .05). The philtrum height increased significantly by 1.17 mm (<em>P</em> = .019) with no significant change on right and left sides.</div></div><div><h3>Conclusions</h3><div>Rapid palatal expansion with 3D-printed customized MARPE enables effective and symmetrical expansion with a significant increase in philtrum height and no significant adverse effects in terms of alveolar bone thickness, dental inclination, root resorption, and airway volumes.</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 3","pages":"Pages 161-169"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143042405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}