Journal of the World Federation of Orthodontists最新文献

{"title":"How satisfied are our patients?","authors":"Vinod Krishnan (Editor-in-Chief)","doi":"10.1016/j.ejwf.2025.02.003","DOIUrl":"10.1016/j.ejwf.2025.02.003","url":null,"abstract":"","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 2","pages":"Pages 65-66"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of restraint stress and orthodontic treatment on physical and psychological states in rats","authors":"Ye Cheng ,&nbsp;Hua Nie ,&nbsp;Jun Qian,&nbsp;Jiangyue Lu,&nbsp;Yanfen Li,&nbsp;Huang Li,&nbsp;Fuhua Yan","doi":"10.1016/j.ejwf.2024.10.002","DOIUrl":"10.1016/j.ejwf.2024.10.002","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the effects of restraint stress and orthodontic tooth movement on the body weight and behavior of rats.</div></div><div><h3>Materials and methods</h3><div>Twenty 8-week-old male Wistar rats were randomly divided into four groups: sham stress nonorthodontic (CC), sham stress orthodontic (CO), stress nonorthodontic (SC) and stress orthodontic (SO). Rats in the stress group were subjected to restraint stress for 21 days, and those in the orthodontic group received molar retraction on days 8 to 21 (D8–D21). The weights of the rats were measured, and behavioral tests were performed on D0, D10, and D20. Serum corticosterone levels in the rats were measured on D0, D4, D8, D12, D16, and D21.</div></div><div><h3>Results</h3><div>The weights of rats in the CO, SC, and SO groups were significantly lower than those in the CC group. In the open-field test, the number of times the rats entered the central zone in the CC group was significantly higher than that in the other three groups. In the elevated plus maze test, at D10, the number of times the rats entered the open arms in the SO, SC, and CO groups was significantly lower than that in the CC group. From D12, the serum corticosterone levels in the CO, SC, and SO groups were significantly higher than those in the CC group.</div></div><div><h3>Conclusions</h3><div>Both restraint stress and orthodontic tooth movement interventions may have adverse effects on weight, behavior, and neuroendocrine responses. However, overlapping the two intervention methods did not increase the magnitude of the effect.</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 2","pages":"Pages 91-96"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated dentition segmentation: 3D UNet-based approach with MIScnn framework","authors":"Min Seok Kim ,&nbsp;Elie Amm ,&nbsp;Goli Parsi ,&nbsp;Tarek ElShebiny ,&nbsp;Melih Motro","doi":"10.1016/j.ejwf.2024.09.008","DOIUrl":"10.1016/j.ejwf.2024.09.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Advancements in technology have led to the adoption of digital workflows in dentistry, which require the segmentation of regions of interest from cone-beam computed tomography (CBCT) scans. These segmentations assist in diagnosis, treatment planning, and research. However, manual segmentation is an expensive and labor-intensive process. Therefore, automated methods, such as convolutional neural networks (CNNs), provide a more efficient way to generate segmentations from CBCT scans.</div></div><div><h3>Methods</h3><div>A three-dimensional UNet-based CNN model, utilizing the Medical Image Segmentation CNN framework, was used for training and generating predictions from CBCT scans. A dataset of 351 CBCT scans, with ground-truth labels created through manual segmentation using AI-assisted segmentation software, was prepared. Data preprocessing, augmentation, and model training were performed, and the performance of the proposed CNN model was analyzed.</div></div><div><h3>Results</h3><div>The CNN model achieved high accuracy in segmenting maxillary and mandibular teeth from CBCT scans, with average Dice Similarity Coefficient values of 91.83% and 91.35% for maxillary and mandibular teeth, respectively. Performance metrics, including Intersection over Union, precision, and recall, further confirmed the model's effectiveness.</div></div><div><h3>Conclusions</h3><div>The study demonstrates the efficacy of the three-dimensional UNet-based CNN model within the Medical Image Segmentation CNN framework for automated segmentation of maxillary and mandibular dentition from CBCT scans. Automated segmentation using CNNs has the potential to deliver accurate and efficient results, offering a significant advantage over traditional segmentation methods.</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 2","pages":"Pages 84-90"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of coated orthodontic miniscrews with chlorhexidine hexametaphosphate antimicrobial nanoparticles: A randomized clinical trial","authors":"Ahmed Ali Al-Hilaly ,&nbsp;Akram Faisal Alhuwaizi","doi":"10.1016/j.ejwf.2024.09.006","DOIUrl":"10.1016/j.ejwf.2024.09.006","url":null,"abstract":"<div><h3>Background</h3><div>Using miniscrews to control anchorage made the application of force for various orthodontic treatment approaches easier and increased their effectiveness. Some problems may occur during the use of miniscrews, such as peri‑implant mucositis, mobility, postoperative pain, and failure. This study compared the success rate of miniscrews coated with chlorhexidine hexametaphosphate antimicrobial nanoparticles with that of uncoated miniscrews.</div></div><div><h3>Methods</h3><div>In a double-blind randomized controlled clinical trial using a split-mouth design, 80 miniscrews were inserted symmetrically into 40 individuals between the maxillary second premolar and first molar. Random allocation software was used to distribute the coated and uncoated miniscrews. The patients were monitored monthly, for a duration of 4 months. The main measure of interest was the success rate of miniscrews, which was assessed throughout follow-up periods of up to 4 months. The secondary objective was the assessment of the mobility of the miniscrews, peri‑implant health, and pain perception. A Wilcoxon signed-rank test and Kaplan–Meier survival analysis were applied to analyze the data.</div></div><div><h3>Results</h3><div><em>Main outcome</em>: After the 4-month follow-up, the success rates of the miniscrews for coated and uncoated samples were 81.3% and 84.4%, respectively, which was a statistically insignificant difference. <em>Secondary outcome:</em> Mobility and peri‑implant health were not statistically different between the coated and uncoated miniscrew groups. Pain intensity was rated higher on the first day, then decreased gradually, diminishing completely on the sixth and seventh day. However, the pain perception between the coated and uncoated miniscrews did not differ statistically.</div></div><div><h3>Conclusions</h3><div>Chlorhexidine-hexametaphosphate nanoparticles did not increase the success rate and stability, nor did they enhance peri‑implant health or affect pain perception during the short observation period.</div></div><div><h3>Trial registration</h3><div>This trial was registered at ClinicalTrials.gov; ID: NCT06124235.</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 2","pages":"Pages 67-75"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lip and incisor changes in patients with different ethnicities treated with extraction versus nonextraction: A cone-beam computed tomography study","authors":"Rahma ElNaghy ,&nbsp;Stephanie Grossman ,&nbsp;Majd Hasanin ,&nbsp;Riyad Al-Qawasmi","doi":"10.1016/j.ejwf.2024.09.009","DOIUrl":"10.1016/j.ejwf.2024.09.009","url":null,"abstract":"<div><h3>Background</h3><div>This study used cone-beam computed tomography (CBCT) via voxel-based superimposition to evaluate lip and incisor changes after orthodontic treatment with four premolar extractions (Ext) versus nonextraction (Non-Ext) among African American (AA) and White (W) patients.</div></div><div><h3>Methods</h3><div>A total of 240 CBCTs of 120 adolescent orthodontic patients with Class I skeletal/dental relationships were included. Patients were initially divided according to treatment, and then each group was subdivided according to patients’ ethnicity (Ext/W = 30, Ext/AA = 30, Non-Ext/W = 30, and Non-Ext/AA = 30). CBCTs were imported into Invivo6 for voxel-based superimposition. Lip and incisor measurements were recorded. Independent <em>t</em> tests and two-way ANOVA were used for statistical assessment.</div></div><div><h3>Results</h3><div>The Non-Ext/W group had a greater increase in all outcome variables compared with the Non-Ext/AA group, with a significant change in volume and position of upper (UL) and lower lips (LL), inclination of upper (U1) and lower incisors (L1), and position of U1. The Ext/AA group had a greater decrease in all measured outcomes compared with the Ext/W group, with significant change in inclination of U1 and L1, and position and volume of LL. W patients had more crowding than AA patients in both treatment approaches. Retraction ratios of 6.5:1 and 2.1:1 were recorded between the U1 and UL positions, and L1 and LL positions, respectively. There were no direct interaction effects between ethnicity and treatment, nor were there any significant effects of ethnicity after controlling for the covariates.</div></div><div><h3>Conclusions</h3><div>Ethnicity alone has no impact on incisor and lip position after treatment. However, ethnicity in the form of initial presentation of malocclusion can have a significant influence.</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 2","pages":"Pages 76-83"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protraction of a mandibular second molar into the adjacent atrophic first-molar extraction site with ridge-split technique through clear aligners: A case report","authors":"Jialun Li,&nbsp;Qi Fan,&nbsp;Lu Liu,&nbsp;Shangyou Wen,&nbsp;Xuechun Yuan,&nbsp;Xian He,&nbsp;Wenli Lai,&nbsp;Hu Long","doi":"10.1016/j.ejwf.2024.09.010","DOIUrl":"10.1016/j.ejwf.2024.09.010","url":null,"abstract":"<div><div>This case report describes the successful orthodontic management of a 25-year-old female patient presenting with Class II Division 2 malocclusion, moderate maxillary anterior crowding, and a missing mandibular left first molar. Treatment plan involved extraction of two maxillary first premolars to address crowding and protraction of two mandibular left molars, combined with the strategic use of mini-implants for precise tooth movement control. Ridge-split surgery was adopted to manage alveolar ridge resorption in the edentulous area. This procedure was essential for widening the narrow alveolar ridge, thereby reducing resistance and facilitating the mesial movement of two mandibular left molars. Lingual and labial biomechanics, including linguoincisal elastics and a cantilever system, were utilized to optimize torque control and molar protraction. Clear aligners were employed throughout the treatment phases, navigating challenges such as the closure of extraction spaces and achieving stable buccal interdigitation. The treatment spanned 4 years, using a total of 175 aligners. The initial phase required 66 aligners to close maxillary extraction spaces and the mandibular edentulous space, followed by 52 aligners in the first refinement and 57 aligners in the second refinement phase. Posttreatment evaluations demonstrated successful alignment of dental arches, correction of malocclusion, and enhancement of facial aesthetics. This case highlights the efficacy of integrated orthodontic techniques in achieving comprehensive functional and aesthetic outcomes in complex orthodontic cases.</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 2","pages":"Pages 111-122"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro physical properties and clinical stability of reused orthodontic miniscrews: A systematic review and meta-analysis","authors":"Arezoo Jahanbin ,&nbsp;Farnaz Ziya ,&nbsp;Erfan Bardideh ,&nbsp;Sara Hafez ,&nbsp;Mostafa Abtahi","doi":"10.1016/j.ejwf.2024.09.005","DOIUrl":"10.1016/j.ejwf.2024.09.005","url":null,"abstract":"<div><h3>Background</h3><div>While orthodontic miniscrews have been widely documented for their successful application, limited research exists on the stability and effectiveness of reused miniscrews.</div><div>This systematic review aims to evaluate the stability and effectiveness of reused miniscrews in orthodontic treatments.</div></div><div><h3>Methods</h3><div>An electronic search was conducted for studies published up to February 2024 across MEDLINE, Web of Science, EMBASE, Scopus, and Cochrane CENTRAL. Additionally, gray literature sources and manual searches of prominent orthodontic journals from 2010 to 2023, were also examined.</div><div>Studies that investigated the use of miniscrews after retrieval and sterilization involving both in vitro studies and clinical trials were included.</div></div><div><h3>Results</h3><div>From 946 searched studies, 18 were finally included in our review. Thirteen studies investigated retrieved and sterilized miniscrews, while five examined unused and sterilized miniscrews to isolate the effects of sterilization. After performing a meta-analysis on in vitro studies, no significant difference in insertion, removal, or fracture torque between retrieved and unretrieved miniscrews was found, though sterilized miniscrews had a statistically significant increase in insertion torque without affecting fracture resistance. Meta-analysis of clinical studies revealed that retrieved miniscrews exhibited a significantly higher failure rate with a risk ratio of 0.46 (95% confidence interval = 0.24, 0.69), indicating a higher likelihood of failure on reuse.</div></div><div><h3>Conclusion</h3><div>There were no significant differences in insertion and fracture torque between new and reused miniscrews. However, reused miniscrews were associated with a higher failure rate. This outcome may be influenced by factors such as sterilization methods, insertion technique, and patient-specific anatomical considerations.</div></div>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":"14 2","pages":"Pages 97-110"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance in answering orthodontic patients' frequently asked questions: Conversational artificial intelligence versus orthodontists.","authors":"Xinlianyi Zhou, Yao Chen, Ehab A Abdulghani, Xu Zhang, Wei Zheng, Yu Li","doi":"10.1016/j.ejwf.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.ejwf.2025.02.001","url":null,"abstract":"<p><strong>Objectives: </strong>Can conversational artificial intelligence (AI) help alleviate orthodontic patients' general doubts? This study aimed to investigate the performance of conversational AI in answering frequently asked questions (FAQs) from orthodontic patients, with comparison to orthodontists.</p><p><strong>Materials and methods: </strong>Thirty FAQs were selected covering the pre-, during-, and postorthodontic treatment stages. Each question was respectively answered by AI (Chat Generative Pretrained Transformer [ChatGPT]-4) and two orthodontists (Ortho. A and Ortho. B), randomly drawn out of a panel. Their responses to the 30 FAQs were ranked by four raters, randomly selected from another panel of orthodontists, resulting in 120 rankings. All the participants were Chinese, and all the questions and answers were conducted in Chinese.</p><p><strong>Results: </strong>Among the 120 rankings, ChatGPT was ranked first in 61 instances (50.8%), second in 35 instances (29.2%), and third in 24 instances (20.0%). Furthermore, the mean rank of ChatGPT was 1.69 ± 0.79, significantly better than that of Ortho. A (2.23 ± 0.79, P < 0.001) and Ortho. B (2.08 ± 0.79, P < 0.05). No significant difference was found between the two orthodontist groups. Additionally, the Spearman correlation coefficient between the average ranking of ChatGPT and the inter-rater agreement was 0.69 (P < 0.001), indicating a strong positive correlation between the two variables.</p><p><strong>Conclusions: </strong>Overall, the conversational AI ChatGPT-4 may outperform orthodontists in addressing orthodontic patients' FAQs, even in a non-English language. In addition, ChatGPT tends to perform better when responding to questions with answers widely accepted among orthodontic professionals, and vice versa.</p>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of the effectiveness of standard anterior bracket placement versus smile arc protection method: A randomized clinical trial.","authors":"Fahimeh Farzanegan, Alireza Ghasemzadeh, Mahsa Ghorbani, Hooman Shafaee","doi":"10.1016/j.ejwf.2025.01.001","DOIUrl":"https://doi.org/10.1016/j.ejwf.2025.01.001","url":null,"abstract":"<p><strong>Objectives: </strong>This randomized two-arm parallel trial aimed to compare the effectiveness of standard anterior bracket positioning with the smile arc protection (SAP) method in terms of occlusal and smile morphometric indices, and perceived post-treatment smile aesthetics.</p><p><strong>Methods: </strong>Patients needing nonextraction orthodontic treatment were randomly assigned to either the SAP or standard bracket placement group. Inclusion criteria were ages 11 to 25 years, nonextraction treatment, and good oral hygiene, all treated using the Roth 0.018 system. Primary outcomes assessed occlusal and smile morphometric changes using cephalograms, study models, and photographs. Perceived smile aesthetics was evaluated with the Visual Analogue Scale (VAS). Statistical analyses included independent t-tests, paired t-tests, Mann-Whitney U test, Wilcoxon signed rank test, and analysis of covariance.</p><p><strong>Results: </strong>Forty-two patients (mean age, 19.5 ± 5.5) were randomized evenly between the SAP and standard groups. Baseline characteristics were similar, and one patient from the SAP group was excluded. No significant differences were found between the groups for occlusal and smile morphometric variables before and after treatment (P > 0.05). Post-treatment, the smile arc significantly improved in the SAP group compared to both the standard method (P = 0.005) and its pretreatment state (P = 0.005). VAS scores from orthodontists and laypersons showed no significant differences (P > 0.05), but general dentists rated the SAP group's smiles as more attractive (P = 0.002).</p><p><strong>Conclusions: </strong>The SAP method was more effective in achieving a consonant smile arc than conventional bracket positioning. While other occlusal and morphometric changes showed no significant differences, general dentists found the SAP group's smiles more attractive. Further research is needed to confirm these results.</p><p><strong>Registration: </strong>The research was registered in the Iranian Registry of Clinical Trials (IRCT) database with the identification code IRCT20220108053669N3.</p>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming three-dimensional challenges through objective decomposition and virtual-digital design: A multidisciplinary case on hypodontia treatment.","authors":"Yubohan Zhang, Haolin Zhang, Meng Meng, Jie Gao","doi":"10.1016/j.ejwf.2025.01.003","DOIUrl":"https://doi.org/10.1016/j.ejwf.2025.01.003","url":null,"abstract":"<p><p>A 15-year-old female sought multidisciplinary treatment for hypodontia, three-dimensional problems, deep overbite, multiple occlusal interferences, and collapse of the occlusion. Through virtual-digital design with objective decomposition, this patient underwent five steps of orthodontic treatment under the guidelines of the principles: removal of occlusal restriction is a prerequisite; transverse problems are solved first; then sagittal problems; and vertical correction runs through the treatment. After orthodontic and prosthetic treatment, aesthetic appearance and functional occlusion were achieved. In complex multidisciplinary cases with three-dimensional problems, which makes it difficult to formulate the final goal, virtual-digital design under objective composition and standardized comprehensive principle are effective and necessary.</p>","PeriodicalId":43456,"journal":{"name":"Journal of the World Federation of Orthodontists","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}