Sensors and Actuators Reports最新文献_第6页

SERS detection of antibiotics using dual plasmonic and charge transfer enhancement mechanism of Ag@MoS2 core-shell nanocomposites 利用Ag@MoS2核-壳纳米复合材料的双等离子体和电荷转移增强机制进行抗生素SERS检测

IF 7.6

Sensors and Actuators Reports Pub Date : 2025-12-01 Epub Date: 2025-11-07 DOI: 10.1016/j.snr.2025.100400

Raheel Ahmed Janjua , Chenyu Guo , Nayyar Abbas shah , Ruili Zhang , Sailing He

{"title":"SERS detection of antibiotics using dual plasmonic and charge transfer enhancement mechanism of Ag@MoS2 core-shell nanocomposites","authors":"Raheel Ahmed Janjua , Chenyu Guo , Nayyar Abbas shah , Ruili Zhang , Sailing He","doi":"10.1016/j.snr.2025.100400","DOIUrl":"10.1016/j.snr.2025.100400","url":null,"abstract":"<div><div>The increasing global threat of antibiotic resistance highlights the need for rapid, sensitive, and non-invasive detection methods in biological and environmental samples. In this study, we synthesized Ag@MoS₂ core-shell nanoparticles and evaluated their performance as a substrate for surface-enhanced Raman spectroscopy in detecting antibiotics at trace levels. The Ag@MoS₂ nanocomposites demonstrated significant Raman signal enhancement due to the synergistic effects of the plasmonic properties of silver and chemical enhancement via charge transfer from the MoS₂ shell. Using Rhodamine 6 G as a model molecule, we achieved an impressive detection limit of 10⁻¹⁰ M under both 532 nm and 785 nm excitation, with the latter offering enhanced sensitivity for biological applications. The Ag@MoS₂ core-shell nanocomposites demonstrated a threefold increase in SERS enhancement compared to silver nanoparticles, highlighting their superior performance in amplifying the Raman signal. Additionally, the ability of Ag@MoS₂ to detect antibiotics, specifically Levofloxacin and Tetracycline, at concentrations as low as 10⁻¹⁰ M under 785 nm excitation was demonstrated (surpassing existing SERS-based sensors reported experimentally). The results highlight the excellent sensitivity and potential of Ag@MoS₂ as a powerful platform for SERS-based antibiotic detection. This offers significant promise for environmental monitoring, clinical diagnostics, and combating the growing issue of antibiotic resistance.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"10 ","pages":"Article 100400"},"PeriodicalIF":7.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145516721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecularly imprinted polymer technology for electrochemical detection of diabetes-related biomarkers 分子印迹聚合物技术用于糖尿病相关生物标志物的电化学检测

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-12-01 Epub Date: 2025-06-21 DOI: 10.1016/j.snr.2025.100353

Launa Silky Karenindra Rokhmat , Irkham , Serly Zuliska , Adisyahputra , Yohanes Susanto Ridwan , Retna Putri Fauzia , Putra Rafli Ramdani , Yeni Wahyuni Hartati

{"title":"Molecularly imprinted polymer technology for electrochemical detection of diabetes-related biomarkers","authors":"Launa Silky Karenindra Rokhmat , Irkham , Serly Zuliska , Adisyahputra , Yohanes Susanto Ridwan , Retna Putri Fauzia , Putra Rafli Ramdani , Yeni Wahyuni Hartati","doi":"10.1016/j.snr.2025.100353","DOIUrl":"10.1016/j.snr.2025.100353","url":null,"abstract":"<div><div>Delayed treatment of diabetes mellitus (DM) can result in severe complications, including cardiovascular disease, neuropathy, and kidney failure, emphasizing the critical importance of early and accurate detection. Key biomarkers for DM diagnosis and monitoring include glucose, insulin, glycated hemoglobin (HbA1c), and glycated albumin (GHSA), which are typically measured using techniques like chromatography, electrophoresis, and immunoassays. While these methods offer high accuracy and reliability, their application is often limited by the need for sophisticated instrumentation, high operational costs, and lengthy analysis times, making them less suitable for point-of-care diagnostics. As an alternative, Molecularly Imprinted Polymers (MIPs) have emerged as a promising solution due to their exceptional specificity in biomarker recognition, mimicking the selective binding properties of natural antibodies. MIPs-based electrochemical sensors offer significant advantages, including high stability, selectivity, reproducibility, and cost-effectiveness, making them highly suitable for rapid and portable biomarker detection. This review provides a comprehensive overview of recent advances in MIPs-based electrochemical sensors for DM biomarker detection, emphasizing various synthesis strategies, including bulk polymerization, surface polymerization, electropolymerization, and cooling polymerization. Furthermore, key factors influencing sensor performance, such as functional monomers, crosslinkers, and initiators, are discussed. The continued development of MIPs-based electrochemical sensors holds great potential for enhancing the accessibility and efficiency of DM biomarker detection, with ongoing research paving the way for their integration into point-of-care diagnostic platforms.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"10 ","pages":"Article 100353"},"PeriodicalIF":6.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in optical biosensors as alternative diagnostics for clinical determination of ESKAPE bacteria 光学生物传感器作为临床检测ESKAPE细菌替代诊断方法的研究进展

IF 7.6

Sensors and Actuators Reports Pub Date : 2025-12-01 Epub Date: 2025-07-23 DOI: 10.1016/j.snr.2025.100365

Maargavi Singh , Sreelakshmi C․S․ , Chiranjay Mukhopadhyay , Sajan D. George , Pooja Nag , Kapil Sadani

{"title":"Advances in optical biosensors as alternative diagnostics for clinical determination of ESKAPE bacteria","authors":"Maargavi Singh , Sreelakshmi C․S․ , Chiranjay Mukhopadhyay , Sajan D. George , Pooja Nag , Kapil Sadani","doi":"10.1016/j.snr.2025.100365","DOIUrl":"10.1016/j.snr.2025.100365","url":null,"abstract":"<div><div>The global rise of antimicrobial resistance (AMR), manifesting as multidrug-resistant, extremely drug-resistant, and pandrug-resistant pathogens, is causing morbidities which are alarmingly translating to mortalities. The issue is pertinent to low and middle-income countries, which rely heavily on their primary and secondary healthcare setups with severely constrained infrastructure and diagnostics. Traditional and molecular diagnostic methods are effective, but have long turnaround times, are expensive, and require specialized facilities. Due to these constraints, these facilities are usually not present at the primary healthcare centers. This review explores the urgent need for alternative diagnostic strategies beyond conventional pathogen identification and antibiotic susceptibility testing, emphasizing the detection of bacterial metabolites and virulence factors as innovative biomarkers for AMR. This article provides critical insight into tailoring optical biosensor technologies as alternate diagnostics for ESKAPE pathogens in resource-limited settings. It highlights the integration of these biosensing platforms with emerging metabolomics and biomarker profiling technologies, offering a promising route toward point-of-care diagnostics. In addition, incorporating artificial intelligence and machine learning algorithms in signal processing and feature extraction enhances biosensor performance and accelerates diagnostic accuracy. The review critiques the current state of the art in AMR diagnostics and provides strategic inroads for developing robust and deployable diagnostics to help better bacterial infection control.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"10 ","pages":"Article 100365"},"PeriodicalIF":7.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144739515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacteria derived bioactive compounds: A valuable tool for the electrochemical detection of arsenic (III) ions in contaminated water 细菌衍生的生物活性化合物：一种有价值的电化学检测污染水中砷（III）离子的工具

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-12-01 Epub Date: 2025-06-16 DOI: 10.1016/j.snr.2025.100349

C. Celesti , D. Iannazzo , C. Gugliandolo , V. Zammuto , L. Calabrese , P. Trifilò , L. Legnani , M.A. Chiacchio , G. Neri

{"title":"Bacteria derived bioactive compounds: A valuable tool for the electrochemical detection of arsenic (III) ions in contaminated water","authors":"C. Celesti , D. Iannazzo , C. Gugliandolo , V. Zammuto , L. Calabrese , P. Trifilò , L. Legnani , M.A. Chiacchio , G. Neri","doi":"10.1016/j.snr.2025.100349","DOIUrl":"10.1016/j.snr.2025.100349","url":null,"abstract":"<div><div>A simple, fast and cost-effective electrochemical approach is here reported for the selective and quantitative detection of arsenic (III) ions in water starting from bacteria derived bioactive compounds<em>.</em> The exopolysaccharide (EPS B3–15) produced by the thermophilic, heavy metal tolerant <em>Bacillus licheniformis</em> B3–15, and the biosurfactant obtained from <em>Bacillus horneckiae</em> SBP3 (BS- SBP3) were used as sensitive elements for the electrochemical detection of As<sup>3+</sup> due to their known recognition abilities towards this toxic ion, their thermophilic properties and stability in harsh conditions. The covalent functionalization of screen-printed gold electrodes (SPGE) with these bioactive compounds demonstrated to be advantageous to selectively detect As<sup>3+</sup> in contaminated waters. Electrochemical measurements, performed for the developed sensors SPGE-EPS-B3–15 and SPGE-BS- SBP3, at the normal range of pH in surface water systems (6.5–8.5) demonstrated a higher sensitivity towards As<sup>3+</sup> with respect to the bare electrode, also in the presence of other competing ions, such as Al<sup>3+</sup>, Bi<sup>3+</sup>, Ni<sup>2+</sup> and Pb<sup>2+</sup>,with very low limits of detection (0.19 nM for SPGE-EPS-B3–15 and 0.03 nM for SPGE-BS- SBP3), which are below the legal limits for these heavy metal ions in drinking water (10 μg/L). The reported sensitivity was 1.8 µA nM<sup>−1</sup>cm<sup>−2</sup> for SPGE-EPS-B3–15 and 17.5 µA nM<sup>−1</sup>cm<sup>−2</sup> for SPGE-BS- SBP3. The preferred detection abilities of the chosen bioactive compounds towards As<sup>3+</sup> ions have been also confirmed by complete conformational analysis, using a combination of Molecular Dynamics (MD) and Density Functional Theory (DFT) studies.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"10 ","pages":"Article 100349"},"PeriodicalIF":6.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, fabrication, and characterization of microfluidic-based interferometric porous silicon aptasensors for multiplexed sepsis biomarkers detection 多路脓毒症生物标志物检测微流控干涉多孔硅适体传感器的设计、制造和表征

IF 7.6

Sensors and Actuators Reports Pub Date : 2025-12-01 Epub Date: 2025-09-17 DOI: 10.1016/j.snr.2025.100382

Shima Mohammadi , Fereshteh Rahimi , Ali Hossein Rezayan , Ali Abouei Mehrizi , Mahsa Sedighi , Mahya Mosayebzadeh

{"title":"Design, fabrication, and characterization of microfluidic-based interferometric porous silicon aptasensors for multiplexed sepsis biomarkers detection","authors":"Shima Mohammadi , Fereshteh Rahimi , Ali Hossein Rezayan , Ali Abouei Mehrizi , Mahsa Sedighi , Mahya Mosayebzadeh","doi":"10.1016/j.snr.2025.100382","DOIUrl":"10.1016/j.snr.2025.100382","url":null,"abstract":"<div><div>Multiplex biosensors are critical tools for disease diagnosis, as they enable the simultaneous detection of multiple biomarkers, providing a comprehensive assessment of complex conditions such as sepsis, where the involvement of multiple biomarkers and non-specific symptoms poses challenges to conventional diagnostics. This study presents the design and fabrication of a multiplexed microfluidic aptasensor using porous silicon (PSi) thin films as optical transducers in reflectometric interference Fourier transform spectroscopy (RIFTS). The platform targets three key sepsis biomarkers: tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP). Detection relies on real-time monitoring of refractive index changes in the PSi layer, induced by biomarker binding to immobilized aptamers within the nanostructure. The manipulated channels design ensured uniform flow velocity across the biosensor zones, enhancing uniform conditions for testing in three microchannels. A microcontroller-programmed motorized XYZ translation stage enabled automated, precise, and simultaneous real-time monitoring at multiple reading points. The microfluidic aptasensor platform for detecting three sepsis biomarkers demonstrated signal variations below 7 % between individual and mixture modes, with not significant cross-reactivity, confirming selective and multiplex performance. This work advances the development of label-free, multiplex biosensing platforms, highlighting their potential for clinical diagnostics and broader applications in diverse fields.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"10 ","pages":"Article 100382"},"PeriodicalIF":7.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A seed-inspired 3D electroionic flier with obliquely embossed ionic polymer actuators for tunable autorotation and lift 一种受种子启发的三维电子离子飞行器，具有倾斜压纹离子聚合物致动器，可调自旋和升力

IF 7.6

Sensors and Actuators Reports Pub Date : 2025-12-01 Epub Date: 2025-10-08 DOI: 10.1016/j.snr.2025.100393

Seong-Jun Jo, Chanmin Park, Yunsang Kwak, Jaehwan Kim

{"title":"A seed-inspired 3D electroionic flier with obliquely embossed ionic polymer actuators for tunable autorotation and lift","authors":"Seong-Jun Jo, Chanmin Park, Yunsang Kwak, Jaehwan Kim","doi":"10.1016/j.snr.2025.100393","DOIUrl":"10.1016/j.snr.2025.100393","url":null,"abstract":"<div><div>In nature, many plants disperse their seeds with simple wing structures that ride the wind, slow descent, and carry propagules farther. These natural flight morphologies offer blueprints for low-mass, passively stable autorotation and lift generation. Despite extensive seed-mimicking efforts based on this inspiration, most research using stimuli-responsive actuators has focused on reproducing simple bending-dominated shapes rather than on the kinematic flight control of seeds, resulting in only a limited mimicry of the aerodynamic flight of seeds. Here we demonstrate a geometry-programmed ionic polymer actuator approach that enables controllable autorotation in three-dimensional electroionic fliers. Embossed Nafion membranes are patterned so that the pitch sets the magnitude of bending bias and the oblique orientation induces twist, resulting in coupled bending-twisting motion. Asymmetry varies non-monotonically with pitch, reaching at maximum at 1.6 mm, arising from the interplay between reduced ion-ion repulsion at the patterned surface and mechanical stiffening from rib-like surface relief. At 1.5 V and 0.1 Hz sinusoidal input, peak displacements reach -2.76/2.04 mm (embossed/smooth), whereas square-wave input increases displacement to -3.71/2.66 mm and raises asymmetry from 0.72 to 1.05 mm. Assembled from these actuators, a 3D electroionic flier emulating the aerodynamic mechanisms of two different wind-dispersed seeds exhibits a descent speed of 2.980 m s<sup>−1</sup> in a drop test, the lowest among the tested fliers. These results position geometry-programmable ionic polymer actuation as a scalable pathway to autorotation and lift tuning, which should allow the realization of advanced seed-mimetic deployment systems and soft aerial microrobots.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"10 ","pages":"Article 100393"},"PeriodicalIF":7.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145262461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-situ spectroelectrochemical insights into the EC’ mechanism: NADH oxidation catalyzed by an osmium complex 原位光谱电化学洞察EC的机制：由锇络合物催化的NADH氧化

IF 7.6

Sensors and Actuators Reports Pub Date : 2025-12-01 Epub Date: 2025-10-06 DOI: 10.1016/j.snr.2025.100392

Seokjin Oh , Eun Joong Kim , Chung Mu Kang , Donghoon Han

{"title":"In-situ spectroelectrochemical insights into the EC’ mechanism: NADH oxidation catalyzed by an osmium complex","authors":"Seokjin Oh , Eun Joong Kim , Chung Mu Kang , Donghoon Han","doi":"10.1016/j.snr.2025.100392","DOIUrl":"10.1016/j.snr.2025.100392","url":null,"abstract":"<div><div>In-situ analytical techniques serve as powerful tools for visualizing reaction processes. Spectroelectrochemical methods, which integrate spectroscopy with electrochemistry, provide critical insights into electrochemical reactions. Molecules that undergo spectral changes due to oxidation- or reduction-induced alterations in their electronic structures can be monitored in real time, enabling direct confirmation of redox processes. In this study, ultraviolet-visible (UV-vis) absorption spectroscopy was combined with electrochemical analysis to investigate potential-dependent absorbance changes associated with the oxidation of NADH in the presence of an osmium complex serving as an electron transfer mediator. A distinct decrease in NADH-related absorbance was observed at potentials lower than its intrinsic onset potential, attributable to the catalytic activity of the mediator. These findings provide direct visual evidence for an EC’ (electrochemical-catalytic) reaction mechanism, wherein the mediator facilitates electron transfer by promoting NADH oxidation at reduced overpotentials.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"10 ","pages":"Article 100392"},"PeriodicalIF":7.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145262542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moisture-thermo dual-responsive hydrogel structure for liquid composition change detection and programmed actuation via vertical crosslinking gradient based defocusing photolithography 基于垂直交联梯度离焦光刻的液体成分变化检测和程序驱动的湿热双响应水凝胶结构

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-12-01 Epub Date: 2025-06-30 DOI: 10.1016/j.snr.2025.100356

Jinsik Yoon , Kibeom Kim , Junghyun Bae , Wook Park

{"title":"Moisture-thermo dual-responsive hydrogel structure for liquid composition change detection and programmed actuation via vertical crosslinking gradient based defocusing photolithography","authors":"Jinsik Yoon , Kibeom Kim , Junghyun Bae , Wook Park","doi":"10.1016/j.snr.2025.100356","DOIUrl":"10.1016/j.snr.2025.100356","url":null,"abstract":"<div><div>Multifarious detection and response mechanisms have been introduced and implemented because responsive materials, particularly hydrogel polymers, adopt certain transformations by external reactions and recover their original appearance. Heterogeneous structures are usually fabricated to obtain responsive hydrogels. In addition, component frame gradation methods have been applied to overcome the limitations of material composition. In this study, we present versatile responsive hydrogel structures that perform as sensor or actuator. The structures are fabricated using a defocusing maskless photolithography system with an objective lens, and consist of a single hydrogel-retained polymeric crosslinking density gradient. The hydrogel structures immersed in anhydrous hygroscopic solutions fail to swell, thereby maintaining their curved shapes. The solutions, improperly stored and left unattended, naturally absorb ambient moisture, and the resulting increase in water content enhances water–polymer interactions proportionally. This enhanced interaction induces swelling of the hydrogel, leading to curvature changes, enabling the structure to function as a sensor for detecting changes in liquid composition. By utilizing the structure, a change in moisture content of approximately 3% is easily verified without mechanical assistance. In contrast, temperature-dependent property changes in ethanol solutions with minimal water content predominantly affect solution–polymer interactions rather than polymer–polymer interactions. Reversible structural responses of the hydrogel are analyzed under repeated thermal cycling, and actuators such as a gripper and walking robot operating via thermal switching are successfully developed.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"10 ","pages":"Article 100356"},"PeriodicalIF":6.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel impedimetric biosensor based on titanium nitride nano-electrode arrays for influenza A H1N1 testing 基于氮化钛纳米电极阵列的新型抗阻生物传感器用于甲型H1N1流感检测

IF 7.6

Sensors and Actuators Reports Pub Date : 2025-12-01 Epub Date: 2025-09-14 DOI: 10.1016/j.snr.2025.100384

Yi-Chen Li , Shu-Tsai Cheng , Chun-Lung Lien , Jeng-Huei Shiau , Ching-Fen Shen , Chao-Min Cheng

{"title":"A novel impedimetric biosensor based on titanium nitride nano-electrode arrays for influenza A H1N1 testing","authors":"Yi-Chen Li , Shu-Tsai Cheng , Chun-Lung Lien , Jeng-Huei Shiau , Ching-Fen Shen , Chao-Min Cheng","doi":"10.1016/j.snr.2025.100384","DOIUrl":"10.1016/j.snr.2025.100384","url":null,"abstract":"<div><div>The development of point-of-care testing devices for real-time detection of influenza A H1N1 virus is critical for early diagnosis, and for continuous disease monitoring. In this study, we developed a novel impedimetric biosensor for detecting influenza A H1N1 virus, using a nano-electrode array fabricated through standard complementary metal-oxide-semiconductor technology. Each nano-electrode is a raised structure with a radius of 100 nanometers and a height of 200 nanometers. Titanium nitride was chosen as the electrode material for its biocompatibility and compatibility with semiconductor processes. The electrode surfaces were modified by diazonium electrografting to introduce carboxyl groups, which enabled antibody immobilization via carbodiimide coupling chemistry. We analyzed the relationship between the reduction peak current and the percentage change in charge transfer resistance before and after each modification step, and further examined the correlation between changes during modification and antibody binding. The completed biosensor successfully detected influenza A H1N1 antigens in phosphate-buffered saline, achieving a detection limit of 0.00025 EU/mL. The sensor’s response also showed a strong positive correlation with viral RNA content (Pearson <em>r</em> = 0.9702), indicating its potential for quantitative virus detection. These results demonstrate the feasibility of using semiconductor-based nano-electrode array biosensors for point-of-care infectious disease diagnostics.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"10 ","pages":"Article 100384"},"PeriodicalIF":7.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145094745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Straightforward and sensitive detection of micro-nano plastics with surface-enhanced Raman spectroscopy by the filtration-dissolution- adsorption strategy 采用过滤-溶解-吸附策略的表面增强拉曼光谱对微纳塑料进行简单、灵敏的检测

IF 7.6

Sensors and Actuators Reports Pub Date : 2025-12-01 Epub Date: 2025-08-21 DOI: 10.1016/j.snr.2025.100376

Hao Liu , Hui Liang , Siyuan Zheng , Rui Hu , Wenqiang Pei , Le Wang , Yongchao Lai

{"title":"Straightforward and sensitive detection of micro-nano plastics with surface-enhanced Raman spectroscopy by the filtration-dissolution- adsorption strategy","authors":"Hao Liu , Hui Liang , Siyuan Zheng , Rui Hu , Wenqiang Pei , Le Wang , Yongchao Lai","doi":"10.1016/j.snr.2025.100376","DOIUrl":"10.1016/j.snr.2025.100376","url":null,"abstract":"<div><div>Micro-nano plastics (MNPs) have become pervasive throughout the environment and emerged as significant pollutants, posing a potential threat to the natural environment and human health. Nonetheless, there remains a technological gap in the accurate analysis of trace and small-size MNPs in the environment. This study proposes a refined strategy for sample pretreatment and surface-enhanced Raman spectroscopy (SERS) analysis of MNPs in a water environment. MNPs were initially captured from the matrix using filter membranes, and subsequently released using an appropriate solvent. This approach not only separated the MNPs from the matrix and impurities, but also allowed the irregular and rigid MNPs to fit the surface of the KI-modified SERS substrates. This SERS-based approach facilitates the analysis of polystyrene (PS) MNPs of varying sizes at a concentration of 0.05 ng/mL across multiple water matrices. Furthermore, PS MNPs released from disposable cups were found using this method in everyday life. This simple and highly efficient strategy is ideal for the analyzing MNPs in everyday life and has the potential to facilitate future research on MNPs in the environment and their impact on human health.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"10 ","pages":"Article 100376"},"PeriodicalIF":7.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144892040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0