Sensors and Actuators Reports最新文献_第6页

Low-cost optical fiber multimode interference biosensor based on a glucose sensitive Glucose-Oxidase enzyme thin-film

IF 6.5

Sensors and Actuators Reports Pub Date : 2024-12-04 DOI: 10.1016/j.snr.2024.100267

W.E. Rodríguez-Rodríguez , A.J. Rodríguez-Rodríguez , A. Juárez-Saldivar , C.R. Zamarreño , I.R. Matias

{"title":"Low-cost optical fiber multimode interference biosensor based on a glucose sensitive Glucose-Oxidase enzyme thin-film","authors":"W.E. Rodríguez-Rodríguez , A.J. Rodríguez-Rodríguez , A. Juárez-Saldivar , C.R. Zamarreño , I.R. Matias","doi":"10.1016/j.snr.2024.100267","DOIUrl":"10.1016/j.snr.2024.100267","url":null,"abstract":"<div><div>In this research we report a contribution for the development of low-cost fiber optical biosensors fabricated by the Single Mode-Multi Mode-Single Mode configuration applied for the glucose monitoring considering clinical concentrations ranges in aqueous analytes. Designed devices are evaluated using health standard detection ranges, such as healthy, pre-diabetic, and diabetic stages operating at the visible spectral region. The sensing regions has been prepared by the etching technique in order to improve the interaction between the evanescent wave with the surrounding medium followed by functionalization of enzyme oxidase glucose via the electrostatic self-assembly using by Poly(allylamine hydrochloride) as an immobilizer matrix. The increase of bilayers number over the sensor surface permits us to demonstrate the enhancement of sensitivity and limit of detection. Experimental results permitted the glucose characterization in the range from 0.3 to 2.4 mg mL-1 obtaining a response time of 9 s and a sensitivity of 1.8 nm/(mg mL-1) allowing to detect hypoglycemia and diabetes stages according to the World Health Organization standards.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100267"},"PeriodicalIF":6.5,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143158251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing point-of-care diagnosis using electrochemical biosensor: Mosquito-borne disease

IF 6.5

Sensors and Actuators Reports Pub Date : 2024-12-02 DOI: 10.1016/j.snr.2024.100261

Muhammad Fadlan Raihan , Ni Luh Wulan Septiani , Gilang Gumilar , Robeth Viktoria Manurung , Siti Nurul Aisyiyah Jenie , Ahmad Nuruddin , Brian Yuliarto

{"title":"Developing point-of-care diagnosis using electrochemical biosensor: Mosquito-borne disease","authors":"Muhammad Fadlan Raihan , Ni Luh Wulan Septiani , Gilang Gumilar , Robeth Viktoria Manurung , Siti Nurul Aisyiyah Jenie , Ahmad Nuruddin , Brian Yuliarto","doi":"10.1016/j.snr.2024.100261","DOIUrl":"10.1016/j.snr.2024.100261","url":null,"abstract":"<div><div>Mosquito-borne diseases continue to pose a significant threat to global health, encompassing a wide range of illnesses caused by pathogens transmitted by mosquito vectors, including viruses, bacteria, and parasites. Diseases such as malaria, dengue, chikungunya, and Zika underscore the urgent need for effective detection methods, along with appropriate preventive measures to mitigate their severity. In response, electrochemical-based biosensor technologies have emerged as a promising solution for rapid, sensitive, and specific diagnosis. This review comprehensively examines recent advances in the utilization of biorecognition elements in electrochemical biosensor systems for detecting mosquito-borne diseases. The discussion covers an overview of the biorecognition elements employed, diagnostic performance assessments, design considerations, and their potential as point-of-care (POC) biosensors. By synthesizing these developments, this review emphasizes the critical role of electrochemical biosensors in advancing global health initiatives against mosquito-borne diseases. Finally, the discussion also addresses the future prospects of POC features in diagnosing these diseases.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100261"},"PeriodicalIF":6.5,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated sensors for electric stimulation of stem cells: A review on microelectrode arrays (MEAs) based systems

IF 6.5

Sensors and Actuators Reports Pub Date : 2024-11-30 DOI: 10.1016/j.snr.2024.100264

Antonio Algarín , Daniel Martín , Paula Daza , Gloria Huertas , Alberto Yúfera

{"title":"Integrated sensors for electric stimulation of stem cells: A review on microelectrode arrays (MEAs) based systems","authors":"Antonio Algarín , Daniel Martín , Paula Daza , Gloria Huertas , Alberto Yúfera","doi":"10.1016/j.snr.2024.100264","DOIUrl":"10.1016/j.snr.2024.100264","url":null,"abstract":"<div><div>This paper provides an update on the sensors and actuators involved in Stem Cells (SC) differentiation processes based on electric stimulation (STIM), including both current and future progress. These techniques are applied in a range of biological and medical protocols, including cell linage derivation, tissue engineering, cellular therapy, cancer research, and cell motility. The typical methodology of SC electric STIM endeavors to emulate biological processes by applying an electrical signal to the cell culture and evaluating the cell response. Cell metabolism is electrically sensitive, responding in some manner to a given stimulus. The precise mechanism by which this occurs is not fully understood, but it is evident that changes in ion density at the cell membrane proximity must excite the cell metabolism (receptors), thereby activating its “differentiation” in response. In order to gain a deeper insight into the cellular mechanisms involved in this process, the physical variables should be better recognized, measured, and quantified during the protocol execution. This work is contributing to the development of a compilation of proposed systems, and specifications required, to identify and better understand the local conditions within the cell environment that are responsible for the activation of the differentiation processes. It is crucial that STIM systems are optimally designed and that the cell response is correctly understood. Two features will be reviewed: the setup employed and the circuits for STIM and monitoring. The nexus between these two elements are the electrodes, and this work will therefore be devoted to the realization of integrated Micro-Electrode Arrays (MEAs), and the design problems associated with it. The focus will be on MEAs, with the same size scale as the cells, and the design issues related to integrated electrodes, under electric stimulation, voltage or current modes.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100264"},"PeriodicalIF":6.5,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ratiometric fluorescence quantitation of amoxicillin based on CDs@Eu-MOFs incorporated 3D hydrogel using smartphone-assisted portable dual mode visual sensing

IF 6.5

Sensors and Actuators Reports Pub Date : 2024-11-29 DOI: 10.1016/j.snr.2024.100262

Kurdistan Fakhraldin Azeez , Abdollah Salimi , Hamed Mohtasham

{"title":"Ratiometric fluorescence quantitation of amoxicillin based on CDs@Eu-MOFs incorporated 3D hydrogel using smartphone-assisted portable dual mode visual sensing","authors":"Kurdistan Fakhraldin Azeez , Abdollah Salimi , Hamed Mohtasham","doi":"10.1016/j.snr.2024.100262","DOIUrl":"10.1016/j.snr.2024.100262","url":null,"abstract":"<div><div>Amoxicillin (AMX) is commonly used antibiotic with a broad activity against Gram-negative and Gram-positive bacteria. Therefore, it is crucial access to an instant and real-time method for accurate and correct AMX determination. Here, we have developed a three-dimensional hydrogel modified with Europium -Metal organic frameworks (Eu-MOFs) and carbon dots (CDs) as fluorophores, which allows for ratiometric fluorescence detection of AMX. The Eu-MOFs and CDs as an AMX probe trapped in Carboxymethyl cellulose (CMC) based hydrogel. In the presence of AMX, the fluorescence intensity of CDs@Eu-MOFs, enhanced at 448 nm and decreased at 568 nm under 360 nm excitation, due to energy transfer process. Under optimal conditions, AMX determined in the linear range of 10 μM to 106.7 μM, with a detection limit of 1.17 μM in liquid state. While, in the hydrogel state, the linear range for AMX detection is from 0.3 μM to 3.07 μM, with a detection limit of 0.08 μM. So, through applying hydrogel state, assay sensitivity is increased 32-times compared with conventional using liquid state. Furthermore, the change of the fluorescence color under UV irradiation also applied for colorimetric sensing of AMX at concentration up to 106 μM with detection limit 0.63 μM using smartphone RGB color sensing software. In addition, presented assay indicates strong selectivity for AMX over other biomolecules, salts and also other antibiotics. Also, it successfully detects different quantities of AMX in water and milk samples with excellent sensitivity, precision, and reliability in both liquid and hydrogel states.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100262"},"PeriodicalIF":6.5,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterial-based biosensors for early detection of Mpox virus: A comprehensive analysis

IF 6.5

Sensors and Actuators Reports Pub Date : 2024-11-28 DOI: 10.1016/j.snr.2024.100263

Juhi Jannat Mim , Md. Aminul Islam , Safiullah Khan , Fardin Khan , Md. Ahadul Islam Patwary , Md. Mostafizur Rahman Arup , Nayem Hossain

{"title":"Nanomaterial-based biosensors for early detection of Mpox virus: A comprehensive analysis","authors":"Juhi Jannat Mim , Md. Aminul Islam , Safiullah Khan , Fardin Khan , Md. Ahadul Islam Patwary , Md. Mostafizur Rahman Arup , Nayem Hossain","doi":"10.1016/j.snr.2024.100263","DOIUrl":"10.1016/j.snr.2024.100263","url":null,"abstract":"<div><div>Mpox, a zoonotic disease caused by the Mpox virus (MPXV), has re-emerged as a significant public health threat, particularly following the outbreak in 2022. Early and rapid detection of MPXV is crucial for controlling viral spread and preventing severe complications, particularly in vulnerable populations. While effective, traditional diagnostic methods like Polymerase Chain Reaction and genome sequencing are often costly and require complex equipment. Nanomaterial-based biosensors offer a promising alternative due to their unique physicochemical properties, high surface area, biocompatibility, and rapid response times. This review explores various nanomaterials—such as carbon nanotubes (CNTs), graphene, quantum dots (QDs), and gold nanoparticles (AuNPs)—and their application in the development of biosensors for MPXV detection, focusing on research from 2008 to 2024. These materials enable sensitive, specific, and portable biosensors that detect MPXV in real time via electrochemical, optical, piezoelectric, and calorimetric mechanisms. Each detection method leverages the virus's interaction with nanomaterial-functionalized surfaces to generate measurable signals. The review also discusses the advantages of nanomaterial-based biosensors, including enhanced sensitivity, cost-effectiveness, and portability, alongside the current challenges and future directions in the field. Nanomaterial-based biosensors could play a vital role in public health efforts to manage Mpox outbreaks by enabling early detection in clinical and point-of-care settings.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100263"},"PeriodicalIF":6.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable sweat-sensing patches for non-invasive and continuous health tracking

IF 6.5

Sensors and Actuators Reports Pub Date : 2024-11-27 DOI: 10.1016/j.snr.2024.100265

Suraj Shinde , Kang Hyeon Kim , Sang Yoon Park , Jeong Hyeon Kim , Jaechan Kim , Daniel J. Joe , Han Eol Lee

{"title":"Wearable sweat-sensing patches for non-invasive and continuous health tracking","authors":"Suraj Shinde , Kang Hyeon Kim , Sang Yoon Park , Jeong Hyeon Kim , Jaechan Kim , Daniel J. Joe , Han Eol Lee","doi":"10.1016/j.snr.2024.100265","DOIUrl":"10.1016/j.snr.2024.100265","url":null,"abstract":"<div><div>The demand for biosensing systems that accurately detect physiological signals and disease biomarkers while maintaining biocompatible surfaces drives ongoing research into advanced materials and novel designs. Wearable patch-based sensors have emerged as a promising solution for effective sweat management, offering easy induction, reliable collection, and precise analysis. This review systematically explores recent advancements in wearable sweat-sensing patches (WSPs) for personalized healthcare monitoring, highlighting their value in non-invasive and continuous health tracking. While recent reviews on wearable sweat sensing have provided general overviews of sweat sensing technologies, this review focuses on the integration of WSPs with emerging fields like flexible human-machine interfaces and smart healthcare solutions, addressing specific technical challenges and innovative approaches that distinguish current advancements. It provides a thorough analysis of key components, including structural materials, sensing mechanisms, innovative sweat collection techniques, and optimal attachment strategies. Additionally, the review addresses challenges and emerging trends, offering a pathway for integrating WSPs into flexible human-machine interfaces, personalized healthcare solutions, and closed-loop systems.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100265"},"PeriodicalIF":6.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143158255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ion-selective electrode-based sensors from the macro- to the nanoscale 离子选择电极传感器从宏观到纳米尺度

IF 6.5

Sensors and Actuators Reports Pub Date : 2024-11-22 DOI: 10.1016/j.snr.2024.100258

Yerim Kim , Minjee Seo , Seol Baek

{"title":"Ion-selective electrode-based sensors from the macro- to the nanoscale","authors":"Yerim Kim , Minjee Seo , Seol Baek","doi":"10.1016/j.snr.2024.100258","DOIUrl":"10.1016/j.snr.2024.100258","url":null,"abstract":"<div><div>Potentiometric ion-selective electrode (ISE) sensors are powerful electrochemical tools used in various applications in different fields, including the biological, clinical, and environmental fields, owing to their high selectivity, sensitivity, simplicity, and versatility. This review highlights recent advancements in ionophore-based polymeric ISE sensors over the past five years, with a particular focus on progress at the micro- and nanoscales. After discussing the conventional ISE configuration and its general operational principles, we explore the notable advancements in terms of the key ion-selective membrane components, such as ionophores, and other techniques combined with ISEs. These advancements have significantly improved the sensing performances and expanded the practical applications. We also examine the progress in the field of miniaturized solid-contact microelectrodes and the incorporation of novel functional materials for efficient ion-to-electron transduction. Miniaturized solid-state ISEs provide low limits of detection with reduced sample volume requirements, extended stability, and rapid response times. When combined with scanning electrochemical microscopy, ion-selective microelectrodes enable highly spatially resolved ion analyses. The integration of solid-contact ISEs into compact, portable, wearable devices has advanced the field of wearable on-body ISE sensors. Finally, we briefly introduce the development of ion-selective optode sensors as promising optical sensors based on ionophores that are particularly advantageous for cellular imaging.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100258"},"PeriodicalIF":6.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FRET-based reporter assesses lysosomal DNA-degradation ability in live cells 基于fret的报告评估活细胞中溶酶体dna降解能力

IF 6.5

Sensors and Actuators Reports Pub Date : 2024-11-20 DOI: 10.1016/j.snr.2024.100259

Jared Morse, Ka Ho Leung

引用次数: 0

Miniaturized power-integrated and self-powered sensor systems for advanced biomedical applications 用于先进生物医学应用的小型化电源集成和自供电传感器系统

IF 6.5

Sensors and Actuators Reports Pub Date : 2024-11-19 DOI: 10.1016/j.snr.2024.100260

Jeongse Yun , Shanmuganathan Keerthana , Seung-Ryong Kwon

引用次数: 0

Colorimetric detection and automatic quantitative analysis of mercury(II) ions via selective redox reaction sites on silver-coated gold nanorods 通过银涂层金纳米棒上的选择性氧化还原反应位点对汞（II）离子进行比色检测和自动定量分析

IF 6.5

Sensors and Actuators Reports Pub Date : 2024-11-14 DOI: 10.1016/j.snr.2024.100256

Hayoung Kim , Sunghoon Yoo , Sumin Kim , Hyeon Seung Lee , Tae Jae Lee , Seunghyun Lee

{"title":"Colorimetric detection and automatic quantitative analysis of mercury(II) ions via selective redox reaction sites on silver-coated gold nanorods","authors":"Hayoung Kim , Sunghoon Yoo , Sumin Kim , Hyeon Seung Lee , Tae Jae Lee , Seunghyun Lee","doi":"10.1016/j.snr.2024.100256","DOIUrl":"10.1016/j.snr.2024.100256","url":null,"abstract":"<div><div>Mercury (Hg), particularly Hg(II), poses significant environmental and health risks. Despite its known hazards, Hg<sup>2+</sup> is widely used in various industries, thereby underscoring the need for simpler, faster, and more cost-effective methods for managing and monitoring Hg<sup>2+</sup> emissions. In this study, we developed a colorimetric detection method for Hg<sup>2+</sup> that leveraged the optical changes induced by the redox processes and amalgamation reactions between Au nanorod(NR)@Ag core-shell plasmonic nanoparticles and mercury ions. These nanoparticles were synthesized to exhibit distinct optical shifts by adjusting the Ag shell thickness. This enabled the visual detection of Hg<sup>2+</sup> concentrations as low as 100 µM. In addition, changes in the optical spectrum of concentrations as low as 10 nM could be detected with UV–vis spectrometry. Furthermore, to account for individual differences in color perception, an automated analysis protocol was developed using ImageJ software for translating the color changes in smartphone-captured images of the solution into quantitative colorimetric data. This novel approach not only enabled the detection of mercury concentrations as low as 10 nM but also offered a simpler and more economical alternative to traditional methods. Furthermore, it demonstrated potential for implementation as on-site application to monitor mercury concentrations via rapid colorimetric reactions.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100256"},"PeriodicalIF":6.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0