Sensors and Actuators Reports最新文献

A contamination-free electrolyte-gated organic transistors platform for high-accuracy tumor biomarker detection 一种用于高精度肿瘤生物标志物检测的无污染电解门控有机晶体管平台

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-05-25 DOI: 10.1016/j.snr.2025.100341

Jovana Babic , Alberto Ballesio , Francesca Frascella , Lucia Napione , Mattia Pagani , Matteo Parmeggiani , Simone Luigi Marasso

{"title":"A contamination-free electrolyte-gated organic transistors platform for high-accuracy tumor biomarker detection","authors":"Jovana Babic , Alberto Ballesio , Francesca Frascella , Lucia Napione , Mattia Pagani , Matteo Parmeggiani , Simone Luigi Marasso","doi":"10.1016/j.snr.2025.100341","DOIUrl":"10.1016/j.snr.2025.100341","url":null,"abstract":"<div><div>A novel biosensor platform for high-accuracy tumor biomarker detection exploiting contamination free microfluidics for increasing the signal-to-noise ratio has been successfully developed and tested. Electrolyte-gated organic Transistors (EGOT) has been employed to detect an important tumor marker, Angiopoietin-2 (Ang2). Although organic semiconductors have become popular in the last years in biosensing applications due to their many advantages, there is still a main concern about stability and selectivity. This work presents major improvement in terms of the stability and selective detection of Ang2 in the range of interest for biomedical applications. The semiconducting polymer poly[3-(5-carboxypentyl)thiophene (P3CPT) is deposited by picoliter volume control and micrometer diameter of the droplet to allow for high uniformity and repeatability from sample to sample. The optimized gold electrodes improve the detection of the minimal concentration of the target and microfluidic interfacing by a specific pattern with the desired dimensions is obtained by UV-lithography and wet etching. A microfluidics with multiple flow control allows for maintain a constant fresh solution without analytes on reference gate electrode, while another inlet and functionalized gate is used for sensing, thus reaching high stability and reproducibility. All these (four) optimizations lead to new measuring protocol and new 3D printed top cover that ensure better stabilization and repeatability of the results. The device has successfully detected Ang2 concentrations as low as 10 pM in saline, therefore demonstrating the ability of the device to detect clinically relevant concentrations.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100341"},"PeriodicalIF":6.5,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable devices for monitoring sweat glucose: an integrated strategy for efficient electrochemical sensors 监测汗液葡萄糖的可穿戴设备：高效电化学传感器的集成策略

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-05-21 DOI: 10.1016/j.snr.2025.100339

Ruiyu Luo , Yi Yang , Shayuanzi Huang, Zhi Huang

{"title":"Wearable devices for monitoring sweat glucose: an integrated strategy for efficient electrochemical sensors","authors":"Ruiyu Luo , Yi Yang , Shayuanzi Huang, Zhi Huang","doi":"10.1016/j.snr.2025.100339","DOIUrl":"10.1016/j.snr.2025.100339","url":null,"abstract":"<div><div>In recent years, sweat, as a biological fluid, has become a reliable proxy for blood analyte concentration, and thanks to wearable devices, in vitro biochemical monitoring has been revolutionized to achieve minimally invasive or even non-invasive measurement. Major technological breakthroughs such as continuous glucose monitoring systems have become commonplace, and devices incorporating sweat stimulation technology enable continuous glucose tracking. In the future, continuous sensing technology, especially the new electrochemical sensing mechanism, will become the focus of research. This article reviews the progress of electrochemical sensors for sweat glucose monitoring, covering the sensing mechanism, sweat production and monitoring sensors. Firstly, the principle, classification, application and role of electrochemical sensor in biological fluid monitoring are introduced. Then the structure of sweat glands, sweat production mechanism, collection methods and detection difficulties were reviewed, and the advantages and disadvantages of common detection methods were analyzed. The application of ampere-ampere, photochemistry, OECT and electroluminescent biosensors in sweat glucose detection is discussed, and the advantages and challenges of various sensors are pointed out, such as ampere-ampere/volt-ampere type has fast response but anti-interference needs to be strengthened, photochemistry does not need external voltage but faces light interference, OECT has low power consumption and high integration but selectivity needs to be improved. Electroluminescence has high sensitivity but complex device. Looking forward to the future, the performance of the sensor will be improved with the development of materials, nanotechnology, and biotechnology, providing a better solution for sweat glucose detection and assisting clinical applications.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100339"},"PeriodicalIF":6.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extended gate organic field effect transistor for calcium ion sensing towards biomedical applications 用于生物医学领域钙离子传感的扩展栅极有机场效应晶体管

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-05-21 DOI: 10.1016/j.snr.2025.100340

F․ A. Viola , D. Hatami , F. Mariani , I. Gualandi , F. Terranova , E. Scavetta , A. Bonfiglio , A. Spanu

{"title":"Extended gate organic field effect transistor for calcium ion sensing towards biomedical applications","authors":"F․ A. Viola , D. Hatami , F. Mariani , I. Gualandi , F. Terranova , E. Scavetta , A. Bonfiglio , A. Spanu","doi":"10.1016/j.snr.2025.100340","DOIUrl":"10.1016/j.snr.2025.100340","url":null,"abstract":"<div><div>The measurement of calcium ions (Ca<sup>2+</sup>) concentration is crucial for several biomedical applications because it plays a key role in various physiological processes, including cellular signalling, muscle contraction, bone metabolism, and the release of neurotransmitters. In this paper, we propose an innovative flexible sensor based on an Extended Gate Organic Field Effect Transistor (ExG-OFET) coupled with a liquid-processable ion-selective membrane. This novel approach enables highly sensitive (exceeding 60 mV dec<sup>‑1</sup>) and selective ion detection, with a limit of detection in the low μM range, outperforming conventional ion-sensitive electrodes (ISEs) due to the intrinsic electronic amplification of the transistor architecture.</div><div>Moreover, the simple fabrication process and the use of flexible, cost-effective materials, make this device a versatile, low-cost solution for a wide range of biomedical applications, from in vitro electrophysiology to epidermal electronics. This study highlights the potential of the ExG-OFET platform as a promising alternative to traditional ion detection systems.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100340"},"PeriodicalIF":6.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A graphene integrated Kapton based flexible and highly sensitive plasmonic sensor for uric acid sensing 一种基于石墨烯集成卡普顿的柔性高灵敏度等离子体尿酸传感器

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-05-13 DOI: 10.1016/j.snr.2025.100337

Sagar Kumar Verma , Yadvendra Singh , Harish Subbaraman, Nirmala Kandadai

{"title":"A graphene integrated Kapton based flexible and highly sensitive plasmonic sensor for uric acid sensing","authors":"Sagar Kumar Verma , Yadvendra Singh , Harish Subbaraman, Nirmala Kandadai","doi":"10.1016/j.snr.2025.100337","DOIUrl":"10.1016/j.snr.2025.100337","url":null,"abstract":"<div><div>One of the most common natural waste products from diets high in purines is uric acid that is commonly filtered by human kidneys. Excessive consumption and delayed excretion of uric acid can disrupt blood uric acid levels. Abnormal variations in the normal uric acid level, which is less than 6.8 mg/dL, can lead to several health issues, including kidney stones and gout, etc. Available biosensors for uric acid detection have various issues such as low sensitivity, poor selectivity, shorter shelf life, and poor repeatability. Kretschmann configuration-based plasmonic sensors are prominent candidates for resolving the issues but the available plasmonic chips are expensive because of the involvement of special glass substrates, such as SF11 and BK7. This work mainly focuses on the replacement of SF11 glass sensing chips with a low-cost and flexible Kapton chip that shares the same refractive index as SF11, without compromising the sensor’s sensitivity. Moreover, to enhance the sensitivity of the Kapton based plasmonic chips, they were integrated with 1 – 3 layers of graphene. These graphene-integrated flexible (GiF) plasmonic chips were functionalized with uricase enzyme to develop molecule selective uric acid sensors for point-of-care detection. The developed GiF chips achieved a maximum sensitivity of 0.0810nm/μM and 0.0171nm/μM in the range 0 to 200μM, and 200 to 1000μM, respectively, with a limit of detection of 11.450μM for uric acid. Controlled experiments were also performed to demonstrate the repeatability, stability, and selectivity of the sensors. GiF SPR chip presents its strong potential in developing portable and wearable biosensors.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100337"},"PeriodicalIF":6.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active bi- and multistability in cooperative microactuator systems 协同微执行器系统的主动双稳性和多稳性

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-05-11 DOI: 10.1016/j.snr.2025.100338

Manfred Kohl , Christoph Ament , Gowtham Arivanandhan , Tamara Bechtold , Peter Conrad , Sipontina Croce , Vincent Gottwald , Martin Hoffmann , Jonas Hubertus , Alexander Kopp , Zixiong Li , Michael Olbrich , Kirill Poletkin , Alberto Priuli , Gianluca Rizzello , Arwed Schuetz , Guenter Schultes , Stefan Seelecke , Lena Seigner , Hamid Shahsavari , Stephan Wulfinghoff

{"title":"Active bi- and multistability in cooperative microactuator systems","authors":"Manfred Kohl , Christoph Ament , Gowtham Arivanandhan , Tamara Bechtold , Peter Conrad , Sipontina Croce , Vincent Gottwald , Martin Hoffmann , Jonas Hubertus , Alexander Kopp , Zixiong Li , Michael Olbrich , Kirill Poletkin , Alberto Priuli , Gianluca Rizzello , Arwed Schuetz , Guenter Schultes , Stefan Seelecke , Lena Seigner , Hamid Shahsavari , Stephan Wulfinghoff","doi":"10.1016/j.snr.2025.100338","DOIUrl":"10.1016/j.snr.2025.100338","url":null,"abstract":"<div><div>The smart coupling of microactuators to cooperative microactuator systems enables new functionalities like active bi- and multistability requiring no external force for switching between stable states. This review explores different concepts of cooperative microactuator systems combining microactuation based on either the same or different transducer principles. The transducer principles comprise electrostatic, magnetic, dielectric elastomer and shape memory effects as well as combinations thereof. Thereby, active bi-/multistable switching is achieved via selective control of the microactuators using diverse control signals based on thermal, electrical or magnetic stimuli. The combination of the microactuators in confined space gives rise to various coupling effects and cross-sensitivities that need to be considered. In the following, the engineering aspects of material properties, microsystems design and fabrication, as well as experimental and numerical characterization of system performances and dependencies on design parameters will be discussed. The presented microactuator systems will be assessed with respect to their energy characteristics and critical forces for switching. Their application potential will be highlighted.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100338"},"PeriodicalIF":6.5,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic immunoassay for the detection of SARS-CoV-2 neutralizing antibodies in ultralow-volume human plasma samples 微流控免疫分析法检测超低容量人血浆样品中SARS-CoV-2中和抗体

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-05-06 DOI: 10.1016/j.snr.2025.100336

Silvia Schobesberger , Helena Thumfart , Florian Selinger , Sarah Spitz , Carla Gonzalez , Lei Pei , Marko Poglitsch , Peter Ertl

{"title":"Microfluidic immunoassay for the detection of SARS-CoV-2 neutralizing antibodies in ultralow-volume human plasma samples","authors":"Silvia Schobesberger , Helena Thumfart , Florian Selinger , Sarah Spitz , Carla Gonzalez , Lei Pei , Marko Poglitsch , Peter Ertl","doi":"10.1016/j.snr.2025.100336","DOIUrl":"10.1016/j.snr.2025.100336","url":null,"abstract":"<div><div>Infectious disease outbreaks are not only a globally recognized threat to human health, they can also put a significant strain on any country’s healthcare system. Consequently, effective immunization strategies, including the maintenance of the immune protection within a population, are crucial to either prevent disease outbreaks or limit their severity. However, due to the inherent variability between individuals, it is often unclear how long immunity lasts. By assessing the presence of neutralizing antibodies, vaccination efficacy and, ultimately, an individual’s immune response can be determined. However, to gain a deeper understanding of the correlation between antibody titer and disease severity, large-scale testing regimes need to be implemented to truly predict vaccine efficiencies. To make neutralizing antibody testing broadly accessible, we developed an easy-to-use microfluidic fluorescent beads immunoassay, capable of detecting neutralizing antibodies within 30 min with a detection limit of 46 IU/mL. As a practical example, neutralizing antibodies against SARS-CoV-2 of human plasma samples were analyzed, requiring a maximum sample volume of 1.35 µL. This was accomplished by developing a fluorescent beads immunoassay that detects primarily the inhibition of binding events between trimeric spike proteins of the virus envelope and angiotensin-converting enzyme 2 cell surface receptor in the presence of neutralizing antibodies. By emulating the virus-host interaction on this novel biochip platform it is possible to assess the efficacy of neutralizing antibodies against SARS-CoV-2 infections, thus providing insight into an individual’s protective status.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100336"},"PeriodicalIF":6.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical genosensors on-a-chip: Applications in early diagnosis of pathogens 芯片上电化学基因传感器：在病原体早期诊断中的应用

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-05-06 DOI: 10.1016/j.snr.2025.100335

A. Dehghan , M.J. Kiani , A. Gholizadeh , J. Aminizadeh , A. Rahi , I. Zare , E. Pishbin , H. Heli

{"title":"Electrochemical genosensors on-a-chip: Applications in early diagnosis of pathogens","authors":"A. Dehghan , M.J. Kiani , A. Gholizadeh , J. Aminizadeh , A. Rahi , I. Zare , E. Pishbin , H. Heli","doi":"10.1016/j.snr.2025.100335","DOIUrl":"10.1016/j.snr.2025.100335","url":null,"abstract":"<div><div>Electrochemical genosensors have emerged as a powerful tool for the early diagnosis of pathogens, offering advantages such as high sensitivity, rapid response times, low cost, and easy adaptability for point-of-care applications. This review highlights recent advancements in CRISPR-Cas-integrated electrochemical systems, novel nanomaterial architectures, and label-free detection mechanisms. Key innovations include anisotropic gold nanostructures, MXene composites with exceptional conductivity, and poly(ortho-aminophenol) films, which enable attomolar detection limits for pathogens such as bacteria and parasites. We evaluate DNA hybridization-based approaches, emphasizing innovations in signal amplification strategies such as saltatory rolling circle amplification and self-assembled monolayers, which address specificity challenges in complex matrices. Additionally, we highlight the integration of electrochemical genosensors with microfluidic platforms, including automated sample-to-answer workflows and multiplexed detection architectures, which address traditional laboratory bottlenecks. By cataloging advancements in material science, bioreceptor design, and microfluidic automation, this work provides a comprehensive yet focused resource for researchers advancing the frontiers of rapid, portable pathogen diagnostics. Furthermore, we explore the commercial potential of these technologies, providing insights that could guide the development of highly sensitive, field-deployable biosensors for clinical and environmental applications.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100335"},"PeriodicalIF":6.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transepithelial/endothelial electrical measurement using a low-cost and customizable Arduino-based sensor 使用低成本和可定制的基于arduino的传感器进行经上皮/内皮电测量

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-05-01 DOI: 10.1016/j.snr.2025.100334

Davide Lattanzi , Ludovica Montesi , Alice Sartini, Rossana Rauti

引用次数: 0

Early stage E-diagnosis of neurodegenerative diseases using label-free sensing of taurine biomarker by superconductive silver nano-ink: A miniaturized electro-device towards rapid neuro-analysis 利用超导银纳米墨水对牛磺酸生物标志物进行无标记传感的神经退行性疾病的早期电子诊断：一种面向快速神经分析的小型化电子设备

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-04-30 DOI: 10.1016/j.snr.2025.100333

Rokhsareh Ebrahimi , Nasrin Shadjou , Mohammad Hasanzadeh , Farnaz Bahavarnia

引用次数: 0

Advances in invasive and non-invasive glucose monitoring: A review of microwave-based sensors 有创和无创血糖监测的进展：微波传感器综述

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-04-24 DOI: 10.1016/j.snr.2025.100332

Ameer B. Alsultani , Katalin Kovács , J. Geoffrey Chase , Balazs Benyo

{"title":"Advances in invasive and non-invasive glucose monitoring: A review of microwave-based sensors","authors":"Ameer B. Alsultani , Katalin Kovács , J. Geoffrey Chase , Balazs Benyo","doi":"10.1016/j.snr.2025.100332","DOIUrl":"10.1016/j.snr.2025.100332","url":null,"abstract":"<div><div>Effective and continuous glucose monitoring is critical in managing diabetes, which remains a global health challenge affecting millions. Traditional invasive glucose monitoring methods, although accurate, cause discomfort and are unsuitable for frequent measurements necessary for optimal diabetes management. To overcome these limitations, microwave-based sensors have emerged as promising alternatives, providing both invasive and non-invasive monitoring capabilities. This review critically evaluates recent advancements in microwave-based glucose sensors, emphasizing their design methodologies, sensitivity, accuracy, and clinical applicability. By leveraging unique dielectric properties of blood and tissues affected by glucose concentrations, microwave sensors enable precise and potentially pain-free glucose measurements. Despite significant progress, existing sensor technologies face challenges including limited sensitivity ranges, interference from biological tissues, and practical considerations for clinical adoption. This paper aims to guide researchers and healthcare providers by highlighting recent technological innovations, addressing current limitations, and suggesting directions for future research to advance glucose monitoring technologies towards widespread clinical use.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100332"},"PeriodicalIF":6.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0