Sensors and Actuators Reports最新文献

Advances in invasive and non-invasive glucose monitoring: A review of microwave-based sensors 有创和无创血糖监测的进展：微波传感器综述

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-04-24 DOI: 10.1016/j.snr.2025.100332

Ameer B. Alsultani , Katalin Kovács , J. Geoffrey Chase , Balazs Benyo

{"title":"Advances in invasive and non-invasive glucose monitoring: A review of microwave-based sensors","authors":"Ameer B. Alsultani , Katalin Kovács , J. Geoffrey Chase , Balazs Benyo","doi":"10.1016/j.snr.2025.100332","DOIUrl":"10.1016/j.snr.2025.100332","url":null,"abstract":"<div><div>Effective and continuous glucose monitoring is critical in managing diabetes, which remains a global health challenge affecting millions. Traditional invasive glucose monitoring methods, although accurate, cause discomfort and are unsuitable for frequent measurements necessary for optimal diabetes management. To overcome these limitations, microwave-based sensors have emerged as promising alternatives, providing both invasive and non-invasive monitoring capabilities. This review critically evaluates recent advancements in microwave-based glucose sensors, emphasizing their design methodologies, sensitivity, accuracy, and clinical applicability. By leveraging unique dielectric properties of blood and tissues affected by glucose concentrations, microwave sensors enable precise and potentially pain-free glucose measurements. Despite significant progress, existing sensor technologies face challenges including limited sensitivity ranges, interference from biological tissues, and practical considerations for clinical adoption. This paper aims to guide researchers and healthcare providers by highlighting recent technological innovations, addressing current limitations, and suggesting directions for future research to advance glucose monitoring technologies towards widespread clinical use.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100332"},"PeriodicalIF":6.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of haptic technologies for hardware-in-the-loop development 硬件在环开发中的触觉技术综述

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-04-20 DOI: 10.1016/j.snr.2025.100331

Oluwaseun Kayode Ajayi, Shengzhi Du, Syeda Nadiah Fatima Nahri

引用次数: 0

Cascading chemiresistive paper-based enzymatic biosensor for urea detection 用于尿素检测的级联化学纸酶生物传感器

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-04-20 DOI: 10.1016/j.snr.2025.100330

Ronil J. Rath , Jacopo Giaretta , Thanh Phuong Hoang , Riccardo Zulli , Syamak Farajikhah , Sepehr Talebian , Sina Naficy , Fariba Dehghani

{"title":"Cascading chemiresistive paper-based enzymatic biosensor for urea detection","authors":"Ronil J. Rath , Jacopo Giaretta , Thanh Phuong Hoang , Riccardo Zulli , Syamak Farajikhah , Sepehr Talebian , Sina Naficy , Fariba Dehghani","doi":"10.1016/j.snr.2025.100330","DOIUrl":"10.1016/j.snr.2025.100330","url":null,"abstract":"<div><div>The conventional approach for diagnosing high risk metabolic disorders, such as chronic kidney disease (CKD), involves drawing a blood sample, which necessitates access to a centralized facility, making it undesirable for frequent urea monitoring. Alternative biological fluids, such as saliva, have demonstrated potential as non-invasive mediums for CKD monitoring due to the strong correlation between blood urea and salivary urea levels, indicating their suitability for point-of-care test kits. In this study, we present an innovative chemiresistive paper-based enzymatic sensor that utilizes a combination of urease and polystyrene sulfonate (PSS) to measure urea. This sensor detects urea over a broad concentration range (10–110 mg/dl), encompassing the salivary urea levels found in both healthy (20±10 mg/dl) and diseased (100±10 mg/dl) individuals. Furthermore, the sensor’s response to urea remains unaffected by the presence of interfering molecules in saliva such as metabolites, proteins, sugars and acids. The stability and response time of the sensor were also assessed under various temperatures, as encountered during storage. Overall, the sensor developed in this study offers a promising solution for creating a rapid, scalable, cost-effective, and user-friendly point-of-care monitoring test kit for urea screening in resource-limited setting with restricted access to healthcare facilities.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100330"},"PeriodicalIF":6.5,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategies for passivating microneedle-based sensors: development, characterization and comparison 微针传感器钝化策略：发展、表征和比较

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-04-19 DOI: 10.1016/j.snr.2025.100328

Andrea Bocchino , Sofia Rodrigues Teixeira , Fiona Barry , Chinmay Thatte , Adam Ryan , Fahima Rahman , Yuan Hu , Simone Iadanza , Paul Galvin , Steffen Kurzhals , Eva Melnik , Giorgio C. Mutinati , Conor O’Mahony

{"title":"Strategies for passivating microneedle-based sensors: development, characterization and comparison","authors":"Andrea Bocchino , Sofia Rodrigues Teixeira , Fiona Barry , Chinmay Thatte , Adam Ryan , Fahima Rahman , Yuan Hu , Simone Iadanza , Paul Galvin , Steffen Kurzhals , Eva Melnik , Giorgio C. Mutinati , Conor O’Mahony","doi":"10.1016/j.snr.2025.100328","DOIUrl":"10.1016/j.snr.2025.100328","url":null,"abstract":"<div><div>Microneedles (MNs) are sharp, pillar-like structures shorter than 1 mm. They can painlessly pierce the <em>stratum corneum</em> (SC), the outermost layer of the skin, and interface with the underlying dermal interstitial fluid, rich in biomarkers. Due to these properties, MNs have been widely investigated for several diagnostic applications. In particular, MN-based biosensors could enable the development of the new generation of minimally invasive continuous monitoring systems. To become a biosensor, the body or the tip of the needles must be functionalized. In addition, the area surrounding the MNs is usually passivated to prevent substrate interferences. Although passivation layers are widely used, there is a lack of characterization of such layers. This work aims at filling this gap, by developing, characterizing, and comparing six different passivation techniques. These include the application of polymethyl methacrylate (PMMA), Epotek 353ND, silicon oxide (SiO<sub>2</sub>), parylene, varnish and an adhesive film to microneedle arrays. The performance of each method was then assessed using electrochemical measurements, optical and SEM imaging, and contact angle analysis.</div><div>Significant variability was observed across the various methods and materials. When assessed in terms of the electrochemically active area available after passivation, the tape and parylene were the most promising layers, while varnish and epoxy were the worst performing materials. The PMMA performed better than the other liquid passivations, but still requires refinement due to the high degree of unwanted coverage of the needles. Finally, the SiO<sub>2</sub> layer seemed to be a viable option, but also remains in need of additional optimization.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100328"},"PeriodicalIF":6.5,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unleashing the potential of UiO-66-NH2 nanozyme: A novel approach to exosomal biomarkers detection in body fluids 释放UiO-66-NH2纳米酶的潜力：体液外泌体生物标志物检测的新方法

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-04-16 DOI: 10.1016/j.snr.2025.100329

Sara Soleimani-Porgou , Tahereh Rohani Bastami , Maryam M. Matin , Azadeh Haghighitalab , Hesamaddyn Babaei , Saeedeh Pourhamedi , Ahmad Reza Bahrami

{"title":"Unleashing the potential of UiO-66-NH2 nanozyme: A novel approach to exosomal biomarkers detection in body fluids","authors":"Sara Soleimani-Porgou , Tahereh Rohani Bastami , Maryam M. Matin , Azadeh Haghighitalab , Hesamaddyn Babaei , Saeedeh Pourhamedi , Ahmad Reza Bahrami","doi":"10.1016/j.snr.2025.100329","DOIUrl":"10.1016/j.snr.2025.100329","url":null,"abstract":"<div><div>Exosomes, a subgroup of extracellular vesicles (EVs), are gaining their position as promising tools for diagnostic and treatment purposes. Their widespread application is however hindered by the lack of cost-effective and straightforward methods for detection and characterization. Addressing this challenge, our study introduces a colorimetric nanosensor utilizing a UiO-66-NH<sub>2</sub> nanozyme (UiO-66-NH<sub>2</sub> NZ) for the detection of exosomes. The nanozyme was synthesized successfully and characterized using various techniques including XRD, FTIR, EDS, TEM, DLS, and zeta potential. For this purpose, exosomes from human TERT-immortalized MSCs (hTERT-MSCs) were extracted and then characterized using FE-SEM imaging, AFM imaging, DLS analysis, zeta potential measurement, and flow cytometry for specific markers. The efficacy of UiO-66-NH<sub>2</sub> NZs was tested for conditioned cell culture medium and human blood plasma. In this way, the limits of detection (LOD) and the trend of response for different concentrations of exosomes were defined. Based on a colorimetric analysis, at lower exosome concentrations, the nanozyme induced a visible color shift from colorless to green-blue within two minutes. The selectivity of our method was validated by comparing exosome concentrations with those of exosome lysates and cell suspensions. Further assessment was conducted by confirming the suitability of the test for the samples from blood plasma, with potential applications at the clinical level. Compared with CD63 aptamer-modified nanozymes, the utility of bare UiO-66-NH<sub>2</sub> NZs in exosome detection was prominent. The rapid detection of exosomes from HT-29 colorectal adenocarcinoma cells and HFF fibroblastic cells confirmed the suitability of this assay as a promising approach for developing specific exosome-based clinical applications.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100329"},"PeriodicalIF":6.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid and low-cost droplet pcr using a novel microfluidic setup with a numerical study on micromixer effects 基于新型微流控装置的快速低成本液滴pcr及微混合器效应的数值研究

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-04-16 DOI: 10.1016/j.snr.2025.100327

Mohammad Hossein Pourghasemian , Ali Kheirkhah Barzoki , Mahdi Dizani , Amir Hossein Kazemipour Ashkezari , Amir Shamloo

{"title":"Rapid and low-cost droplet pcr using a novel microfluidic setup with a numerical study on micromixer effects","authors":"Mohammad Hossein Pourghasemian , Ali Kheirkhah Barzoki , Mahdi Dizani , Amir Hossein Kazemipour Ashkezari , Amir Shamloo","doi":"10.1016/j.snr.2025.100327","DOIUrl":"10.1016/j.snr.2025.100327","url":null,"abstract":"<div><div>Droplet microfluidics, recognized for its precise dispensing and sample handling capabilities at microliter and lower volumes, has emerged as a popular method for miniaturizing polymerase chain reaction (PCR) platforms. This technology enables the accurate detection of low-abundance biological variations through droplet PCR (dPCR). In this study, we introduce a low-cost PCR thermal cycler setup, an optical system for DNA detection, and a 3D-printed droplet-based microfluidic device engineered to produce hundreds of nanoliter water-in-oil droplets. The microfluidic chip incorporates 21 cycles, each equipped with a micromixer. For the first time, we investigate the impact of integrating micromixers into the PCR chip cycles and demonstrate that this integration enhances the efficiency and specificity of the PCR process. Following the completion of the PCR cycles, the droplets are gathered in a chamber located at the end of the chip for amplification detection. A simple fluorescent optical setup is developed for fluorescence detection and accurate measurement of DNA concentration in the sample. This setup comprises a cost-effective high-resolution camera, a dichroic mirror, and an LED light source. Subsequently, the fluorescent images captured are processed using Python (OpenCV library) and analyzed for fluorescent emission intensity and droplet size distribution. The outcomes of the dPCR conducted with the microfluidic chip are subsequently assessed through a gel electrophoresis test and compared to the identical results from a commercial quantitative PCR (qPCR) device. Our study demonstrates the ability to perform rapid dPCR analysis via endpoint imaging utilizing a cost-effective and easy-to-fabricate setup.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100327"},"PeriodicalIF":6.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly sensitive gold nanostar based optical fiber sensor with tunable plasmonic resonance 具有可调谐等离子体共振的高灵敏度金纳米光纤传感器

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-04-11 DOI: 10.1016/j.snr.2025.100326

Amin Moslemi , Lucia Sansone , Flavio Esposito , Carlos Marques , Stefania Campopiano , Michele Giordano , Agostino Iadicicco

{"title":"Highly sensitive gold nanostar based optical fiber sensor with tunable plasmonic resonance","authors":"Amin Moslemi , Lucia Sansone , Flavio Esposito , Carlos Marques , Stefania Campopiano , Michele Giordano , Agostino Iadicicco","doi":"10.1016/j.snr.2025.100326","DOIUrl":"10.1016/j.snr.2025.100326","url":null,"abstract":"<div><div>In this work, we present a detailed numerical and experimental investigation of highly sensitive optical fiber sensors based on localized surface plasmon resonance (LSPR). These sensors are enhanced by the deposition of nanoparticles (NPs) and nanostars (NSs) onto uncladded silica multi-mode optical fiber. The unique optical properties of NSs - featuring a 40 nm gold core surrounded by silver branches of variable size and shape - allows for precise tuning of the LSPR effect. For comparison, we also explored spherical gold NPs with a 40 nm diameter to assess performance differences. Our findings, both numerical and experimental, demonstrate that the LSPR wavelength and sensitivity to surrounding refractive index can be finely tuned by adjusting the morphology of the NS branches. This is achieved by varying the silver nitrate content during their synthesis. Using the Finite Element Method-based design tool we performed simplified study cases, that led to experimental sensitivity of approximately 560 nm/RIU for an LSPR wavelength near 810 nm. As a practical demonstration, the sensor was successfully employed to detect Thiram, a common agricultural pesticide, with a wide dynamic range from 10 pM to 100 µM and an impressive low limit of detection of 0.3 pM. Moreover, we investigated the sensor selectivity, stability and response to environmental temperature changes. This study emphasizes the simplicity, cost-effectiveness, and tunable performance of NS-based optical fiber sensors. By manipulating nanostructure morphology, we can significantly enhance sensor performance, positioning this technology as a highly promising solution for environmental monitoring, biomedical diagnostics, and chemical detection.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100326"},"PeriodicalIF":6.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of low-cost impedimetric biosensors for the quantitative detection of cortisol and the human growth hormone 用于定量检测皮质醇和人类生长激素的低成本阻抗生物传感器的开发

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-04-10 DOI: 10.1016/j.snr.2025.100325

Rachel Ashton , Mohammad Rizwan , Christopher Gwenin

{"title":"Development of low-cost impedimetric biosensors for the quantitative detection of cortisol and the human growth hormone","authors":"Rachel Ashton , Mohammad Rizwan , Christopher Gwenin","doi":"10.1016/j.snr.2025.100325","DOIUrl":"10.1016/j.snr.2025.100325","url":null,"abstract":"<div><div>Cortisol and human growth hormone can be used as reliable biomarkers for the response of the hypothalamus-pituitary-adrenal axis. The hypothalamus-pituitary-adrenal axis is complex and dependent on many factors. However, generally, increased cortisol production is the hypothalamus-pituitary-adrenal axis's physiological response to an external stressor. Growth hormone is also regulated through the hypothalamus-pituitary-adrenal axis and secreted from the anterior pituitary gland. Hence point-of-care sensing devices for the quantification of cortisol and growth hormone would be versatile for the diagnosis of hypothalamus-pituitary-adrenal axis activity. The practical uses for a stress indicator would be diverse, inclusive of the medical and pharmaceutical sectors as well as sports and performance. Therefore, this work discusses the development of two electrochemical biosensors, designed to accurately detect and quantify cortisol and growth hormone concentration levels with potential practical applications. The device relies on impedance values which are produced when cortisol and growth hormone are immobilized onto electrode surfaces through antibody-antigen bonding. Calibration data was achieved for both Gold (Au, 111) slide electrodes and inexpensive screen-printed gold electrode-based sensor biochips with a strong correlation between impedance and concentration of cortisol, with detection range 30–300 ng/mL for Au (111) platform and 60 – 360 ng/mL for screen-printed gold electrode platform, while recombinant human growth hormone detection range was observed 5–30 ng/mL using both Au (111) platform, and screen-printed gold electrode platform.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100325"},"PeriodicalIF":6.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated microphotonic platform for highly sensitive virus detection 集成微光子平台，用于高灵敏度病毒检测

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-04-09 DOI: 10.1016/j.snr.2025.100320

A. la Grasta , M.I. Gómez-Gómez , A. Griol , E. Gómez , M. De Carlo , V.M.N. Passaro , A. Martínez , F. Dell’Olio

{"title":"Integrated microphotonic platform for highly sensitive virus detection","authors":"A. la Grasta , M.I. Gómez-Gómez , A. Griol , E. Gómez , M. De Carlo , V.M.N. Passaro , A. Martínez , F. Dell’Olio","doi":"10.1016/j.snr.2025.100320","DOIUrl":"10.1016/j.snr.2025.100320","url":null,"abstract":"<div><div>Chip-scale micro-photonic biosensors have matured significantly over the past two decades, with various platforms developed for detecting biomarkers, including proteins in biological fluids. The COVID-19 pandemic has further accelerated research in virus detection, leading to the development of resonant and interferometric biosensors for identifying viruses like SARS-CoV-2. Despite these advancements, there remains a need for technical solutions that ensure point-of-care features such as low cost, rapid response, and low limit-of-detection (LoD). This paper presents an integrated silicon nitride microphotonic platform based on ring resonator technology, specifically designed for highly sensitive virus detection. The sensors, fabricated using strip and slot waveguides, are tested under flow conditions using ethanol and BSA-antiBSA solutions to evaluate bulk and surface sensitivity. The results indicate that the slot waveguide-based ring resonators exhibit the highest sensitivity. The platform uses functionalization protocols to immobilize specific antibodies for detecting SARS-CoV-2. The sensor successfully identifies the target analyte at concentrations as low as 1.5 nM, with a LoD of 36 pM using in situ functionalization, underscoring the importance of antibody orientation through an intermediate protein A layer. These results demonstrate the platform’s potential for rapid and sensitive virus diagnosis and represent a significant step toward the development of portable, point-of-care diagnostic technologies for infectious disease monitoring.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100320"},"PeriodicalIF":6.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultra-sensitive aptameric field-effect transistor for cortisol sensing 用于皮质醇传感的超灵敏适体场效应晶体管

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-04-08 DOI: 10.1016/j.snr.2025.100324

Thi Thanh Ha Nguyen , Cong Minh Nguyen , Minh Anh Huynh , Quang Thang Trinh , Philip Tanner , Sven Ingebrandt , Xuan Thang Vu , Tuan-Khoa Nguyen , Nam-Trung Nguyen

{"title":"Ultra-sensitive aptameric field-effect transistor for cortisol sensing","authors":"Thi Thanh Ha Nguyen , Cong Minh Nguyen , Minh Anh Huynh , Quang Thang Trinh , Philip Tanner , Sven Ingebrandt , Xuan Thang Vu , Tuan-Khoa Nguyen , Nam-Trung Nguyen","doi":"10.1016/j.snr.2025.100324","DOIUrl":"10.1016/j.snr.2025.100324","url":null,"abstract":"<div><div>Existing diagnostic methods for major depressive disorders, emerging mental disorders globally, are restrictive and inaccurate due to the lack of evidence-based assessments. Recent developments incorporating advanced material, micro/nano manufacturing and biology enable new clinical pathways using biosensors that can provide new opportunities for the diagnosis of mental condition from an early developmental stage. In this work, we present an ultra-sensitive lab-on-chip biosensor platform that is capable of detecting cortisol, a key biomarker for depression in physiological fluid. Utilizing advanced microfabrication techniques, our biosensor achieves a compact footprint of 5.0 mm by 2.5 mm, making it suitable for integration into portable and wearable devices. The device exhibits an ultra-low detection limit of 1 fM and a wide dynamic detection range spanning from 1 fM to 1 µM, covering the concentration present in physiological body fluids of human. Our finding shows a great potential for the development of accurate, and point-of-care monitoring system for early detection of depression disorders to advance the mental health diagnosis.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100324"},"PeriodicalIF":6.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0