{"title":"Development of a point-of-care testing (POCT)-use paper-based device for recombinase polymerase amplification (RPA)-based bioassays-: Demonstration of the detection of Neisseria gonorrhoeae","authors":"Po-Yu Chu , Po-Shuan Huang , Chih-Yu Chen , Kun-Yu Tsai , Shu-Ying Chiu , Le-Wei Fan , Yu-Chen Cheng , Chi-Jui Lin , Chia-Hsun Hsieh , Min-Hsien Wu","doi":"10.1016/j.snr.2025.100307","DOIUrl":"10.1016/j.snr.2025.100307","url":null,"abstract":"<div><div>The point of care test (POCT) of pathogens is critical for various applications. Nevertheless, the current immunological- or polymerase chain reaction (PCR)-based assays might not meet the requirements for POCT (e.g., ASSURED: affordable, sensitive, specific, user-friendly, rapid, equipment-free, and delivered proposed by the World Health Organization). To address this issue, this study proposed a paper-based device within which the functions of nucleic acid isolation, recombinase polymerase amplification (RPA)-based nucleic acid amplification, and lateral flow immunoassays were integrated. For RPA, a disposable hand warmer capable of providing 45 °C temperature was attached underneath the paper-based device for achieving equipment-free bioassays. Unlike the other paper-based devices, the presented device maintains the working area for reagent loading at a fixed area to largely simplify the operation procedures making a bioassay user-friendly. In this study, its working performances were evaluated. Results demonstrated that the detection sensitivity was 10 copies of genomic DNA under 10 min RPA reaction time, which was 10 times lower than that (100 copies) based on the conventional RPA-based assays. Also, its application for the detection of <em>Neisseria gonorrhoeae</em> in urine was successfully demonstrated. Results revealed it was able to detect <em>N. gonorrhoeae</em> with detection sensitivity of 1 CFU/ml. Overall, this study presented a paper-based device capable of performing isothermal nucleic acid amplification tests in a user-friendly, low-cost, equipment-free, rapid (30- 35 min) and high detection sensitivity (10 copies of DNA, or 1 CFU/ml of bacteria) manner. These features make it suitable for the applications in POCT, home care, or resource-limited regions.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100307"},"PeriodicalIF":6.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenting Chen , Zhicheng Luo , Jiaxin Guo , Liang Li , Hao Wu
{"title":"Photoelectrochemical immunosensing of amyloid-β peptide using nanoplasmonic macroporous bismuth vanadate for Alzheimer's disease diagnosis","authors":"Wenting Chen , Zhicheng Luo , Jiaxin Guo , Liang Li , Hao Wu","doi":"10.1016/j.snr.2025.100309","DOIUrl":"10.1016/j.snr.2025.100309","url":null,"abstract":"<div><div>Effective monitoring of biomarkers in human serum is essential for early diagnosis of Alzheimer's disease, but it is nontrivial due to the complex environment and ultralow content. Herein, a three-dimensionally ordered macroporous (3DOM) bismuth vanadate (BiVO<sub>4</sub>)-based photoelectrochemical immunosensor is constructed for the ultrasensitive detection of amyloid-<em>β</em> (A<em>β</em>) peptides. The sensing probe is composed of plasmonic Au nanoparticles (NPs) on the surface of 3DOM BiVO<sub>4</sub> with the A<em>β</em>-specific antibody. Attributing to the nanoplasmonic effect and the periodic ordered porous structure, the Au NPs/3DOM BiVO<sub>4</sub> photoelectrode shows a significant photocurrent response resulting from the strong light scattering effect and the enhanced separation of photoinduced charge carriers under simulated sunlight irradiation (AM 1.5G, 100 mW cm<sup>-2</sup>). The A<em>β</em>-specific antibody immobilized on the surface of Au NPs/3DOM BiVO<sub>4</sub> selectively coordinates with the A<em>β</em> peptide, resulting in an ultrasensitive detection for A<em>β</em> with a linear relationship range of 50 fg-150 ng mL<sup>-1</sup> and a detection limit of 25 fg mL<sup>-1</sup> (S/N=3). This work paves the way for constructing highly ordered macroporous photoelectrodes with functional recognition nodes to detect biomarkers for early diagnosis of neurological disorders.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100309"},"PeriodicalIF":6.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143570589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Detection of HPV-16 L1 antigen using MoS2 nanosheets and amine-functionalized copper doped carbon dots","authors":"Rajmohan Swetha , Karutha Pandian Divya , Lakshmi Devi A , T.G. Satheesh Babu","doi":"10.1016/j.snr.2025.100308","DOIUrl":"10.1016/j.snr.2025.100308","url":null,"abstract":"<div><div>HPV-16L1 is one of the important biomarkers for chronic cervical cancer. The present work deals with the development of a label-free electrochemical immunosensor by modification of electrode surface using 2D MoS<sub>2</sub> nanosheets and amine functionalized copper doped carbon dots (f-CuCD). The copper doped carbon dot with high surface area 2D material like MoS<sub>2</sub> provides a stable platform for the immobilization of antibody which aids in the sensor performance. The use of MoS<sub>2</sub>/f-CuCD is the highlight of this work through which effective anti-HPV immobilization on the surface is achieved. Electrochemical impedance spectroscopy (EIS) was used to analyse the response of different concentrations of HPV-16L1 on the modified screen printed carbon electrode (SPCE). On increasing the concentration of HPV-16L1, the R<sub>CT</sub> value gradually increased and the peak current decreased due to the low conductivity of the protein molecule. The developed immunosensor was found to detect wide concentration ranges of 0.01–100 ng/µL with a low detection limit of 8.30 pg/µL for HPV-16L1. Spiked human serum samples were also analysed. It also proves to be a sensitive, selective, stable and feasible tool for the determination of HPV-16L1.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100308"},"PeriodicalIF":6.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lavita Nuraviana Rizalputri , José Ilton de Oliveira Filho , Saptami Suresh Shetty , Eckaard le Roux , Abdullah Bukhamsin , Bandar Alshehri , Veerappan Mani , Khaled Nabil Salama
{"title":"A multiplexed laser-scribed graphene immunosensor for simultaneous detection of adiponectin and leptin: A point-of-care solution for early insulin resistance diagnosis","authors":"Lavita Nuraviana Rizalputri , José Ilton de Oliveira Filho , Saptami Suresh Shetty , Eckaard le Roux , Abdullah Bukhamsin , Bandar Alshehri , Veerappan Mani , Khaled Nabil Salama","doi":"10.1016/j.snr.2025.100306","DOIUrl":"10.1016/j.snr.2025.100306","url":null,"abstract":"<div><div>The increasing prevalence of insulin resistance (IR) highlights the importance of early diagnosis and timely medical intervention. The ratio of adiponectin to leptin proteins (A/L) is believed to be a key indicator of IR, but the lack of adequate ways of tracking it prevents its clinical utilization. To that end, we have developed a laser-scribed graphene (LSG) based immunosensor capable of detecting adiponectin and leptin simultaneously. The sensors are decorated with gold nanostructure (AuNS) that are bio-functionalized with adiponectin and leptin antibodies via EDC/NHS covalent chemistry. We demonstrate that the immunosensor is suitable for clinical utilization, with a detection limit of 0.59 μg/mL for adiponectin and 0.18 ng/mL for leptin. Furthermore, the multiplexed nature of the assay allows for IR assessments at reduced sample volume whilst not compromising accuracy. Lastly, we validate the applicability of the immunosensor for point-of-care (PoC) settings by integrating with a customized miniaturized potentiostat connected to a smartphone application. The resulting device can be used for the facile quantification of A/L at clinically relevant accuracy, facilitating faster IR assessment relative to conventional methods that rely on independent measurements of the two biomarkers.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100306"},"PeriodicalIF":6.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hui Dong , Linlin Zheng , Zuying Wang , Ke Xu , Wentian Chen , Zi Liu , Zhu Chang , Yanli Zhou , Xu Zhu , Yintang Zhang , Maotian Xu
{"title":"Dual-mode ratiometric electrochemical and turn-on fluorescent probe for reliably detecting H2O2 in Parkinson's disease serum","authors":"Hui Dong , Linlin Zheng , Zuying Wang , Ke Xu , Wentian Chen , Zi Liu , Zhu Chang , Yanli Zhou , Xu Zhu , Yintang Zhang , Maotian Xu","doi":"10.1016/j.snr.2025.100305","DOIUrl":"10.1016/j.snr.2025.100305","url":null,"abstract":"<div><div>Accurate diagnosis and effective treatment of Parkinson's disease (PD) rely on the accurate detection of the corresponding biomarkers. The build-up of reactive oxygen species (ROS), for instance, hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), resulting in oxidative stress inside cells is closely related to the pathogenesis of PD. In this study, two compounds, Re-B and Re-OB, were synthesized through a simple one-step reaction. Upon reacting with H<sub>2</sub>O<sub>2</sub>, the borate ester group in Re-B is selectively cleaved, restoring the phenol group. This leads to both a dual-signal ratiometric electrochemical response and a ``turn-on'' fluorescence effect. The Re-B probe demonstrates a clear ``turn-on'' electrochemical current response at −311.1 mV, followed by a ``turn-off'' response at −257.6 mV when interacting with H<sub>2</sub>O<sub>2</sub> on a single-walled carbon nanotube-modified screen-printed carbon electrode (SPCE/SWCNTs). Concurrently, the fluorescence spectrum shows a ``turn-on'' response with an emission peak at 586 nm. The fluorescence and ratiometric electrochemical methods developed in this study show exceptionally high sensitivity and selectivity for H<sub>2</sub>O<sub>2</sub>, with detection limits as low as 0.5 μM for the electrochemical method and 0.1 μM for fluorescence. The consistency between the results from both electrochemical and fluorescence quantification of H<sub>2</sub>O<sub>2</sub> levels in serum underscores its reliability. This approach has significant potential as a point-of-care diagnostic device for PD early detection, providing valuable information for timely diagnosis and treatment.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100305"},"PeriodicalIF":6.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iman Najafipour , Pegah Sadeh , Ali Mohammad Amani , Hesam Kamyab , Shreeshivadasan Chelliapan , Saravanan Rajendran , Ana Belén Peñaherrera-Pazmiño , Sajad Jamalpour
{"title":"Dielectrophoresis-based microfluidics for detection and separation of circulating tumor cells","authors":"Iman Najafipour , Pegah Sadeh , Ali Mohammad Amani , Hesam Kamyab , Shreeshivadasan Chelliapan , Saravanan Rajendran , Ana Belén Peñaherrera-Pazmiño , Sajad Jamalpour","doi":"10.1016/j.snr.2025.100304","DOIUrl":"10.1016/j.snr.2025.100304","url":null,"abstract":"<div><div>Circulating tumor cells (CTCs) represent a critical focus in cancer research due to their potential to enable early detection, monitor disease progression, and facilitate personalized therapies. However, existing isolation techniques often face significant limitations, including low specificity, reduced recovery rates, and the inability to preserve cellular viability for downstream applications such as genetic profiling and drug testing. This review addresses a key knowledge gap in the development of efficient, label-free, and scalable technologies for CTC isolation, emphasizing the role of dielectrophoresis (DEP)-based microfluidic systems. DEP leverages the intrinsic dielectric properties of cells to enable selective and non-invasive separation, eliminating the need for surface markers and ensuring high cell integrity. The study highlights the integration of nanomaterials, such as gold nanoparticles and graphene oxide nanosheets, as a novel approach to overcome existing challenges in DEP-based platforms. These nanomaterials improve the specificity and sensitivity of CTC capture by increasing surface area and biocompatibility. Key advancements discussed include the optimization of electrode designs, tuning of electric field parameters, and innovative system configurations that enhance recovery efficiency and separation purity. The review also compares various DEP configurations, such as electrode-based, insulator-based, and contactless systems, evaluating their unique advantages and suitability for different applications. In addition to reviewing current advancements, the paper outlines future directions for the field, emphasizing the need for large-scale clinical validation to establish DEP-based systems as reliable diagnostic tools. This review provides a comprehensive framework for advancing DEP-based microfluidic platforms, offering a transformative approach for early cancer detection, personalized medicine, and the broader application of innovative diagnostic technologies in clinical settings.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100304"},"PeriodicalIF":6.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giuliana Grasso , Riccardo Scarfiello , Francesco Colella , Valentina Onesto , Stefania Forciniti , Giuseppe Gigli , Luigi Carbone , Loretta L. del Mercato
{"title":"Ratiometric fluorescent biosensors for quantitative lactic acid detection using CdTe@CdS quantum dots and lactate oxidase","authors":"Giuliana Grasso , Riccardo Scarfiello , Francesco Colella , Valentina Onesto , Stefania Forciniti , Giuseppe Gigli , Luigi Carbone , Loretta L. del Mercato","doi":"10.1016/j.snr.2025.100303","DOIUrl":"10.1016/j.snr.2025.100303","url":null,"abstract":"<div><div>Lactic acid plays a crucial role in various physiological processes, particularly in cellular metabolism and muscle activity, as it is a key marker of anaerobic respiration and metabolic stress. In this study, we present a ratiometric fluorescent biosensor for lactic acid detection, utilizing a fluorescence quenching mechanism. The sensor comprises a hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-sensing unit, based on photoluminescent core-shell cadmium telluride@cadmium sulfide quantum dots (CdTe@CdS QDs), along with a reference probe covalently bound to silica microparticle (SiO<sub>2</sub> MPs), which acts as the substrate. Lactate oxidase (LOx) is immobilized on the microparticle surface, where it catalyzes the aerobic oxidation of <span>l</span>-lactate into pyruvate, generating H<sub>2</sub>O<sub>2</sub> in the process. The increasing concentrations of lactate (0–30 mM) result in proportional quenching of the CdTe@CdS QDs’ photoluminescence due to H<sub>2</sub>O<sub>2</sub>, while the reference fluorescence emission remains stable. A lactate calibration curve has been determined using confocal laser scanning microscopy (CLSM), enabling quantitative evaluation of the sensor's ratiometric response and colorimetric shifts via image analysis. To demonstrate the versatility of this approach, we engineered two variations of the microsensor with distinct ratiometric setups, one using green- and the other red-emitting CdTe@CdS QDs, paired with either rhodamine isothiocyanate (RBITC) or 7-(diethylamino)coumarin-3-carboxylic acid (7ACC1) as the reference dyes, both co-immobilized with LOx enzyme on the microparticle surface. These innovative microsensors offer a simple yet effective tool for the quantitative detection of lactic acid, leveraging its H<sub>2</sub>O<sub>2</sub>-sensing capability of CdTe@CdS QDs in combination with to LOx enzyme activity.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100303"},"PeriodicalIF":6.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Ali Mangi , Hassan Elahi , Ahsan Ali , Hamid Jabbar , Anas Bin Aqeel , Aasia Farrukh , Saira Bibi , Wael A. Altabey , Sallam A. Kouritem , Mohammad Noori
{"title":"Applications of piezoelectric-based sensors, actuators, and energy harvesters","authors":"Mohammad Ali Mangi , Hassan Elahi , Ahsan Ali , Hamid Jabbar , Anas Bin Aqeel , Aasia Farrukh , Saira Bibi , Wael A. Altabey , Sallam A. Kouritem , Mohammad Noori","doi":"10.1016/j.snr.2025.100302","DOIUrl":"10.1016/j.snr.2025.100302","url":null,"abstract":"<div><div>From the last few decades, piezoelectric materials have played an important role in the field of sensing and actuating. They have voltage-dependent actuation, which allows them to serve as energy harvesters and structural health monitoring of the system. This phenomenon makes piezoelectric sensors and actuators useful for monitoring and controlling various physical phenomena, such as vibration, shock, position, displacement, stress, strain load, and precision motion. In this review article, a comprehensive summary of the uses of piezoelectric sensors, actuators and energy harvesters is elaborated in detail. Moreover, the discussion on the different types of piezoelectric sensors, actuators and energy harvesters, their working principles, different configurations and their use in various industrial applications is carried out. Overall, this review article demonstrates the versatility and effectiveness of piezoelectric sensors and actuators in various industrial applications and provides valuable insights for researchers, engineers, and industry professionals.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100302"},"PeriodicalIF":6.5,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rohit Jasrotia , Kanika Raj , Basant Singh , Abdullah H. Alluhayb , Alaa M. Younis , Suman , M. Ramya , Abhishek Kandwal , Virat Khanna , Virender Pratap Singh , Chan Choon Kit
{"title":"Innovative ferrite sensors: Advancing non-enzymatic glucose detection","authors":"Rohit Jasrotia , Kanika Raj , Basant Singh , Abdullah H. Alluhayb , Alaa M. Younis , Suman , M. Ramya , Abhishek Kandwal , Virat Khanna , Virender Pratap Singh , Chan Choon Kit","doi":"10.1016/j.snr.2025.100295","DOIUrl":"10.1016/j.snr.2025.100295","url":null,"abstract":"<div><div>Ferrite-based nanomaterials have surfaced as capable candidates for glucose sensing owing to their distinctive magnetic, electrical, and structural properties. This review article offers a wide-ranging overview of current studies in the expansion and use of ferrite-based glucose sensors. In this review, the synthesis methods and characterization techniques for the various ferrite nanomaterials, including spinel ferrite, highlighting their enhanced sensitivity, stability, and selectivity in glucose detection has been discussed thoroughly. The mechanism of glucose sensing is explained, focusing on the role of ferrite nanoparticles in facilitating electron transfer and catalytic activity. Additionally, the integration of ferrite-based sensors with the various transducing elements such as electrochemical, optical, and magnetic systems is examined. Alongside, obstacles and future scopes in this field has been explained, emphasizing the potential for ferrite-based materials to aid to the enhancement of low-cost, and non-invasive glucose monitoring devices with high efficiency. Through this critical analysis, we aim to provide insights into the ongoing research and inspire future innovations in ferrite-based glucose sensing technologies.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100295"},"PeriodicalIF":6.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Coral Salvo-Comino , Luis E. Alonso-Pastor , Clara Pérez-González , Stefano Pettinelli , Karina C. Núñez Carrero , Miguel Ángel Rodríguez-Pérez , María Luz Rodríguez-Méndez
{"title":"Impact of molecular structure and plasticization of PVC membranes in the response of solid-state ion-selective electrodes","authors":"Coral Salvo-Comino , Luis E. Alonso-Pastor , Clara Pérez-González , Stefano Pettinelli , Karina C. Núñez Carrero , Miguel Ángel Rodríguez-Pérez , María Luz Rodríguez-Méndez","doi":"10.1016/j.snr.2025.100301","DOIUrl":"10.1016/j.snr.2025.100301","url":null,"abstract":"<div><div>Potentiometric sensors are essential in various industries due to their high sensitivity, simplicity, and cost-effectiveness. However, enhancing sensitivity, largely dependent on membrane diffusion, remains challenging. This study investigates the role of polyvinyl chloride (PVC) molecular weight and plasticizer type on optimizing potentiometric sensor performance for tartaric acid detection. Two PVCs with different molecular weights (HIGH and LOW) and distinct plasticizers were evaluated. Results demonstrated that membranes plasticized with dibutyl sebacate, a linear plasticizer, exhibited high sensitivity (0.0239 mV/pX) and repeatability, achieving a lower limit of detection (LOD = 4.31 × 10⁻⁵ M) compared to those with a bulky plasticizer. Specifically, HIGH PVC combined with a linear plasticizer provided saturation-free measurements, ensuring greater accuracy in tartaric acid quantification. This research underscores the impact of plasticizer selection on sensor optimization, enhancing accuracy and reliability in food quality control. By establishing the relationship between PVC structure and plasticizer type, this study contributes to advancing sensor technology for improved food safety and quality assessment.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100301"},"PeriodicalIF":6.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143334065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}