{"title":"Ion-selective electrode-based sensors from the macro- to the nanoscale","authors":"Yerim Kim , Minjee Seo , Seol Baek","doi":"10.1016/j.snr.2024.100258","DOIUrl":"10.1016/j.snr.2024.100258","url":null,"abstract":"<div><div>Potentiometric ion-selective electrode (ISE) sensors are powerful electrochemical tools used in various applications in different fields, including the biological, clinical, and environmental fields, owing to their high selectivity, sensitivity, simplicity, and versatility. This review highlights recent advancements in ionophore-based polymeric ISE sensors over the past five years, with a particular focus on progress at the micro- and nanoscales. After discussing the conventional ISE configuration and its general operational principles, we explore the notable advancements in terms of the key ion-selective membrane components, such as ionophores, and other techniques combined with ISEs. These advancements have significantly improved the sensing performances and expanded the practical applications. We also examine the progress in the field of miniaturized solid-contact microelectrodes and the incorporation of novel functional materials for efficient ion-to-electron transduction. Miniaturized solid-state ISEs provide low limits of detection with reduced sample volume requirements, extended stability, and rapid response times. When combined with scanning electrochemical microscopy, ion-selective microelectrodes enable highly spatially resolved ion analyses. The integration of solid-contact ISEs into compact, portable, wearable devices has advanced the field of wearable on-body ISE sensors. Finally, we briefly introduce the development of ion-selective optode sensors as promising optical sensors based on ionophores that are particularly advantageous for cellular imaging.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100258"},"PeriodicalIF":6.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"FRET-based reporter assesses lysosomal DNA-degradation ability in live cells","authors":"Jared Morse, Ka Ho Leung","doi":"10.1016/j.snr.2024.100259","DOIUrl":"10.1016/j.snr.2024.100259","url":null,"abstract":"<div><div>Lysosomes are multifunctional organelles that serve as the cell's central hub for metabolic signaling. Lysosomal malfunction disrupts intracellular homeostasis, leading to adverse health effects. Therefore, assessing lysosomal function is vital for advancing disease understanding and guiding therapeutic development. The existing evaluation methods rely primarily on monitoring lysosomal pH and protein degradation. Here we introduce a DNA-based reporter to evaluate lysosomal activity by assessing the DNA-degradation ability of lysosomes using fluorescence imaging. We successfully monitored the lysosomal DNA-degradation ability in dysregulated lysosomes and lysosomes in drug-induced disease model of NP-A/B and NP-C. We found that both pharmacologically induced models resulted in significant reduction in lysosomal DNA-degradation ability. This tool for monitoring lysosomal activity offers valuable insights for both therapeutic development and understanding disease progression.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100259"},"PeriodicalIF":6.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Miniaturized power-integrated and self-powered sensor systems for advanced biomedical applications","authors":"Jeongse Yun , Shanmuganathan Keerthana , Seung-Ryong Kwon","doi":"10.1016/j.snr.2024.100260","DOIUrl":"10.1016/j.snr.2024.100260","url":null,"abstract":"<div><div>With the growing interest in continuous health monitoring and point-of-care diagnostics, researchers from various fields have made significant efforts to meet commercialization criteria. In this context, the role of electrochemistry and relevant technologies are noteworthy due to their versatility in both sensing and energy conversion applications. This review examines recent advancements in self-sufficient electrochemical sensors, with a particular focus on electrochemical energy conversion technologies such as fuel cells, photoelectrochemical cells, hydraulic systems, and iontronic power sources. It also highlights substantial progress in enhancing the practicality of electrochemical sensors for point-of-care diagnostics and wearable electronics. By introducing advanced wearable sensors and disposable devices, this review provides an overview of the integration of cutting-edge technologies in electrode design and fabrication, cell configuration, data readout, and signal transmission, along with meticulous design considerations to enhance usability.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100260"},"PeriodicalIF":6.5,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hayoung Kim , Sunghoon Yoo , Sumin Kim , Hyeon Seung Lee , Tae Jae Lee , Seunghyun Lee
{"title":"Colorimetric detection and automatic quantitative analysis of mercury(II) ions via selective redox reaction sites on silver-coated gold nanorods","authors":"Hayoung Kim , Sunghoon Yoo , Sumin Kim , Hyeon Seung Lee , Tae Jae Lee , Seunghyun Lee","doi":"10.1016/j.snr.2024.100256","DOIUrl":"10.1016/j.snr.2024.100256","url":null,"abstract":"<div><div>Mercury (Hg), particularly Hg(II), poses significant environmental and health risks. Despite its known hazards, Hg<sup>2+</sup> is widely used in various industries, thereby underscoring the need for simpler, faster, and more cost-effective methods for managing and monitoring Hg<sup>2+</sup> emissions. In this study, we developed a colorimetric detection method for Hg<sup>2+</sup> that leveraged the optical changes induced by the redox processes and amalgamation reactions between Au nanorod(NR)@Ag core-shell plasmonic nanoparticles and mercury ions. These nanoparticles were synthesized to exhibit distinct optical shifts by adjusting the Ag shell thickness. This enabled the visual detection of Hg<sup>2+</sup> concentrations as low as 100 µM. In addition, changes in the optical spectrum of concentrations as low as 10 nM could be detected with UV–vis spectrometry. Furthermore, to account for individual differences in color perception, an automated analysis protocol was developed using ImageJ software for translating the color changes in smartphone-captured images of the solution into quantitative colorimetric data. This novel approach not only enabled the detection of mercury concentrations as low as 10 nM but also offered a simpler and more economical alternative to traditional methods. Furthermore, it demonstrated potential for implementation as on-site application to monitor mercury concentrations via rapid colorimetric reactions.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100256"},"PeriodicalIF":6.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammed Almalaysha , Arshdeep Singh , Sura A. Muhsin , Anna V. Carlson , Kate E. Trout , Amit Morey , Shuping Zhang , Lakshmikantha H. Channaiah , Mahmoud Almasri
{"title":"A highly sensitive microfluidic biosensor for rapid and accurate detection of Salmonella in raw chicken products","authors":"Mohammed Almalaysha , Arshdeep Singh , Sura A. Muhsin , Anna V. Carlson , Kate E. Trout , Amit Morey , Shuping Zhang , Lakshmikantha H. Channaiah , Mahmoud Almasri","doi":"10.1016/j.snr.2024.100257","DOIUrl":"10.1016/j.snr.2024.100257","url":null,"abstract":"<div><div>This paper presents an investigation of a fluidic-based impedance biosensor for rapid and accurate detection of <em>Salmonella</em> Typhimurium in raw chicken carcass rinsate. The biosensor is engineered with multiple distinct regions that concentrates <em>Salmonella</em> antigens to a detectable level, subsequently trapping the concentrated <em>Salmonella</em> samples on top of the detection interdigitated electrode array coated with a specific <em>Salmonella</em> antibody, maximizing the number of captured antigens. Detection is achieved through the antibody-antigen binding process, where binding events changes impedance values, providing a reliable method for identifying and quantifying <em>Salmonella</em>. The biosensor demonstrated a low limit of detection (LOD) of 1–2 cells/ml within 40–50 min. The findings demonstrated that the biosensor distinguishes low concentrations of live <em>Salmonella</em> cells, even in the presence of high concentrations of dead <em>Salmonella</em> cells, and non-specific binding pathogens viz.<em>, Listeria</em> monocytogenes and <em>E. coli O157:H7</em>.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100257"},"PeriodicalIF":6.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142652309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dung Thi Hanh To, Bingxin Yang, Nosang Vincent Myung
{"title":"Enhancing nitrous oxide chemiresistive sensing performance by reducing ionic Oxygen species adsorption in Gold functionalized Tungsten Trioxide nanofibers","authors":"Dung Thi Hanh To, Bingxin Yang, Nosang Vincent Myung","doi":"10.1016/j.snr.2024.100255","DOIUrl":"10.1016/j.snr.2024.100255","url":null,"abstract":"<div><div>Low-cost nitrous oxide (N<sub>2</sub>O) gas sensor is in great need to provide real-time information to various stakeholders. Herein, various gold functionalized tungsten trioxide nanofibers (Au-WO<sub>3</sub> NFs) with different composition and crystallinity were synthesized by controlling electrospinning solutions and post heat treatment. These sensing materials were systematically exposed to various N<sub>2</sub>O concentrations at different operating temperatures (<em>i.e.,</em> 250 to 450 °C). Among different samples, 1 at % gold functionalized WO<sub>3</sub> nanofibers (1 at % Au-WO<sub>3</sub> NF) annealed at 600 °C for 24 h shows the highest sensitivity (<em>S</em> = R<sub>a</sub>/R<sub>o</sub>) of 38.5 toward 100 ppm at 250 °C with experimentally determined limit of detection (LOD) at 2.5 ppm. Although recovery and recovery time improved, the sensitivity reduced with an increase in operating temperatures. The detailed sensing mechanism studies indicated that the high N<sub>2</sub>O sensing was achieved when there were limited adsorbed ionized oxygen species (<em>e.g.,</em> O<sup>-</sup>). Moreover, N<sub>2</sub>O adsorption and desorption activation energy were estimated to be 0.13 and 0.87 eV where desorption was more strongly temperature dependent than adsorption.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100255"},"PeriodicalIF":6.5,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142652150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Critical review of hydrogen cyanide (HCN) sensors and their applications","authors":"Dung Thi Hanh To, Nosang V. Myung","doi":"10.1016/j.snr.2024.100254","DOIUrl":"10.1016/j.snr.2024.100254","url":null,"abstract":"<div><div>Hydrogen cyanide (HCN) is a poison gas which can be generated from fuel combustion and conversion from aqueous CN<sup>-</sup> ions. Approximately 1.1 million metric tons per year of cyanides are utilized by many industries. HCN is also an indicator of air quality, a biomarker for <em>Pseudomonas aeruginosa</em> infection, and a chemical warfare agent. Depending on applications, requirements for HCN sensors significantly vary. In this review, the past and current works on differents HCN gas detection techniques, including optical, mass-based, electrochemical, and chemiresistive sensors, are systematically reviewed. Additionally, it compares various parameters of sensing performance, such as detection range including lower and upper detection limit, sensitivity, selectivity, setup and operation complexity to help the potential users down select the proper type of sensors for their applications. Furthermore, materials computation to discover next generation HCN gas sensing materials is discussed.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100254"},"PeriodicalIF":6.5,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142652151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Duan Xiong , Zhen Su , Lixin Zhang , Hao Zhang , Zhiwei Su , Xiaoyun Hu , Mailidan Wumaer , Qingqing Guan
{"title":"1D supramolecular assembly-induced emission and colorimetry toward precise onsite mercury(II) detection","authors":"Duan Xiong , Zhen Su , Lixin Zhang , Hao Zhang , Zhiwei Su , Xiaoyun Hu , Mailidan Wumaer , Qingqing Guan","doi":"10.1016/j.snr.2024.100253","DOIUrl":"10.1016/j.snr.2024.100253","url":null,"abstract":"<div><div>Manipulation of the one-dimensional (1D) supramolecular assembly of platinum(II) terpyridyl complex is promising for achieving precise onsite mercury(II) detection in complex environments, but still challenging. Herein, by systematic molecular design of platinum(II) terpyridyl complex, chloride-mediated 1D supramolecular assembly has been successfully achieved, exhibiting not only improved recognition ability but also dual-visual signal, with turn-on red luminescence and high-contrast color change from pale-yellow to orange-red. The probe also shows excellent selectivity and anti-interference properties, fast response rate (< 1 s) and low detection limit, stretching to 20.6 fg when incorporated in a hydrogel matrix. Structure insight for the dual-visual response shows that this high detection performance derives from the ancillary ligand of -NCS, which endows the increase of ion-association ability between platinum(II) terpyridyl complex and [HgCl<sub>4</sub>]<sup>2−</sup>, leading that 1D packing mode with strengthened Pt-Pt interactions. In all, this work highlights a new strategy of 1D supramolecular assembly construction for high performance detection of heavy metal ions.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100253"},"PeriodicalIF":6.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Linglong Wan , Xiaolan Huang , Jin Fu , Fei Xiao , Nan Jia , Yu Zhang , Min Chen , Xiong Zhu , Shijun Li , Juan Zhou , Yi Wang
{"title":"Rapid detection of human adenovirus by multiple cross displacement amplification combined with nanoparticle-based biosensor platform","authors":"Linglong Wan , Xiaolan Huang , Jin Fu , Fei Xiao , Nan Jia , Yu Zhang , Min Chen , Xiong Zhu , Shijun Li , Juan Zhou , Yi Wang","doi":"10.1016/j.snr.2024.100252","DOIUrl":"10.1016/j.snr.2024.100252","url":null,"abstract":"<div><div>Human adenoviruses (HAdV), particularly serotypes 3 and 7 (HAdV-3 and HAdV-7), are significant respiratory pathogens that contribute to high morbidity rates and severe pneumonia in infants and children. The lack of distinct clinical presentations and effective treatments highlights the urgent need for rapid and reliable diagnostic methods for HAdV-3 and HAdV-7. This study devises a novel detection assay, termed HAdV-MCDA-LFB, which combines isothermal multiple cross displacement amplification (MCDA) with a nanoparticle-based lateral flow biosensor (LFB). Targeting the conserved hexon gene, HAdV-MCDA-LFB demonstrated high sensitivity, detecting low to 10 fg of hexon-containing plasmid per reaction without cross-reaction under the optimized conditions. Moreover, HAdV-MCDA-LFB exhibited comparable diagnostic accuracy to real-time PCR in clinical sample analysis, indicating its practical applicability. The whole procedure, including rapid template preparation (15 min), MCDA reaction (40 min at 67 °C) and result interpretation (<5 min), can be completed within one hour. Together, this rapid turnaround time, coupled with its simplicity and accuracy, makes HAdV-MCDA-LFB a promising point-of-care diagnostic tool for HAdV-3 and HAdV-7, particularly in resource-limited settings.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100252"},"PeriodicalIF":6.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Lasheras , J.S. Garitaonandia , I. Quintana , J.L. Vilas , Ana Catarina Lopes
{"title":"Development of nanocrystallized magnetoelastic sensors with self-biased effect and improved mass sensitivity","authors":"A. Lasheras , J.S. Garitaonandia , I. Quintana , J.L. Vilas , Ana Catarina Lopes","doi":"10.1016/j.snr.2024.100251","DOIUrl":"10.1016/j.snr.2024.100251","url":null,"abstract":"<div><div>The growing demand for cost-effective and wireless sensing technologies requires the development of simple, efficient and optimized sensors able to accurately detecting external agents. Magnetoelastic resonators represent an alternative to the traditional sensing systems, able to combine all the previously cited factors. Several studies have focused on increasing their sensitivity, in order to make it closer to the market. The present study explores thermal treatments as a novel approach to enhance the sensitivity of magnetoelastic resonators, focusing on the positive impact of crystallization processes induced in magnetoelastic platforms. The experimental results confirm an enhancement of resonant frequency and quality factor of the magnetoelastic platforms as treatment temperature increases. Particularly, the sensor annealed at 550 °C shows an increase of the resonant frequency value of 45 % with respect to the <em>as-quenched</em> platform, being that increase of around 1700 % for the quality factor. In addition, the nanocrystallization induction leads to a self-biased resonance, consequence of the intrinsic magnetization resulting from the crystallization in Fe<sub>2</sub>B and FeCo phases. Further, the study shows the importance of stability in resonant frequency, emphasizing the potential of the 550 °C-annealed platform for mass sensor applications. Gold deposition experiments reveal the enhanced sensitivity of the sensor annealed at 550 °C of 40 % compared to the <em>as-quenched</em> sensor, as well as an increase of 38 % on its accuracy. These findings represent a significant step forward in the development of magnetoelastic-based mass sensors, highlighting the pivotal role of thermal treatments in optimizing sensitivity for practical and efficient external agents detection systems.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100251"},"PeriodicalIF":6.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}