Sensors and Actuators Reports最新文献

A highly sensitive microfluidic biosensor for rapid and accurate detection of Salmonella in raw chicken products 用于快速准确检测生鸡肉产品中沙门氏菌的高灵敏度微流控生物传感器

IF 6.5

Sensors and Actuators Reports Pub Date : 2024-11-08 DOI: 10.1016/j.snr.2024.100257

Mohammed Almalaysha , Arshdeep Singh , Sura A. Muhsin , Anna V. Carlson , Kate E. Trout , Amit Morey , Shuping Zhang , Lakshmikantha H. Channaiah , Mahmoud Almasri

{"title":"A highly sensitive microfluidic biosensor for rapid and accurate detection of Salmonella in raw chicken products","authors":"Mohammed Almalaysha , Arshdeep Singh , Sura A. Muhsin , Anna V. Carlson , Kate E. Trout , Amit Morey , Shuping Zhang , Lakshmikantha H. Channaiah , Mahmoud Almasri","doi":"10.1016/j.snr.2024.100257","DOIUrl":"10.1016/j.snr.2024.100257","url":null,"abstract":"<div><div>This paper presents an investigation of a fluidic-based impedance biosensor for rapid and accurate detection of <em>Salmonella</em> Typhimurium in raw chicken carcass rinsate. The biosensor is engineered with multiple distinct regions that concentrates <em>Salmonella</em> antigens to a detectable level, subsequently trapping the concentrated <em>Salmonella</em> samples on top of the detection interdigitated electrode array coated with a specific <em>Salmonella</em> antibody, maximizing the number of captured antigens. Detection is achieved through the antibody-antigen binding process, where binding events changes impedance values, providing a reliable method for identifying and quantifying <em>Salmonella</em>. The biosensor demonstrated a low limit of detection (LOD) of 1–2 cells/ml within 40–50 min. The findings demonstrated that the biosensor distinguishes low concentrations of live <em>Salmonella</em> cells, even in the presence of high concentrations of dead <em>Salmonella</em> cells, and non-specific binding pathogens viz.<em>, Listeria</em> monocytogenes and <em>E. coli O157:H7</em>.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100257"},"PeriodicalIF":6.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142652309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing nitrous oxide chemiresistive sensing performance by reducing ionic Oxygen species adsorption in Gold functionalized Tungsten Trioxide nanofibers 通过减少金功能化三氧化钨纳米纤维中的离子氧吸附，提高氧化亚氮化学电阻传感性能

IF 6.5

Sensors and Actuators Reports Pub Date : 2024-11-04 DOI: 10.1016/j.snr.2024.100255

Dung Thi Hanh To, Bingxin Yang, Nosang Vincent Myung

{"title":"Enhancing nitrous oxide chemiresistive sensing performance by reducing ionic Oxygen species adsorption in Gold functionalized Tungsten Trioxide nanofibers","authors":"Dung Thi Hanh To, Bingxin Yang, Nosang Vincent Myung","doi":"10.1016/j.snr.2024.100255","DOIUrl":"10.1016/j.snr.2024.100255","url":null,"abstract":"<div><div>Low-cost nitrous oxide (N<sub>2</sub>O) gas sensor is in great need to provide real-time information to various stakeholders. Herein, various gold functionalized tungsten trioxide nanofibers (Au-WO<sub>3</sub> NFs) with different composition and crystallinity were synthesized by controlling electrospinning solutions and post heat treatment. These sensing materials were systematically exposed to various N<sub>2</sub>O concentrations at different operating temperatures (<em>i.e.,</em> 250 to 450 °C). Among different samples, 1 at % gold functionalized WO<sub>3</sub> nanofibers (1 at % Au-WO<sub>3</sub> NF) annealed at 600 °C for 24 h shows the highest sensitivity (<em>S</em> = R<sub>a</sub>/R<sub>o</sub>) of 38.5 toward 100 ppm at 250 °C with experimentally determined limit of detection (LOD) at 2.5 ppm. Although recovery and recovery time improved, the sensitivity reduced with an increase in operating temperatures. The detailed sensing mechanism studies indicated that the high N<sub>2</sub>O sensing was achieved when there were limited adsorbed ionized oxygen species (<em>e.g.,</em> O<sup>-</sup>). Moreover, N<sub>2</sub>O adsorption and desorption activation energy were estimated to be 0.13 and 0.87 eV where desorption was more strongly temperature dependent than adsorption.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100255"},"PeriodicalIF":6.5,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142652150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical review of hydrogen cyanide (HCN) sensors and their applications 氰化氢 (HCN) 传感器及其应用评述

IF 6.5

Sensors and Actuators Reports Pub Date : 2024-10-23 DOI: 10.1016/j.snr.2024.100254

Dung Thi Hanh To, Nosang V. Myung

引用次数: 0

Design of a microfluidic device for immunoaffinity-based isolation of circulating tumor cells with minimal clogging 基于免疫亲和分离循环肿瘤细胞的微流控装置的设计

IF 5.9

Sensors and Actuators Reports Pub Date : 2023-07-13 DOI: 10.1016/j.snr.2023.100169

Begum Sen-Dogan , Ender Yildirim , Sebnem Sahin , Ebru Ozgur , Ozge Zorlu , Haluk Kulah

{"title":"Design of a microfluidic device for immunoaffinity-based isolation of circulating tumor cells with minimal clogging","authors":"Begum Sen-Dogan , Ender Yildirim , Sebnem Sahin , Ebru Ozgur , Ozge Zorlu , Haluk Kulah","doi":"10.1016/j.snr.2023.100169","DOIUrl":"https://doi.org/10.1016/j.snr.2023.100169","url":null,"abstract":"<div><p>Combining bioaffinity-based techniques with microfluidics is an effective strategy for the selective isolation of rare circulating tumor cells (CTCs) among peripheral blood cells. In this scope, designing a microfluidic channel with high cell-surface interaction is crucial, which can be realized by increasing surface area <em>via</em> micropillars. In such microfluidic channels, the interpillar distance represents a critical design parameter, and the value is decided considering the trade-off between the possibility of clogging and CTC capture efficiency. In this study, a curvilinear microfluidic channel with a wide (150 µm) interpillar distance was developed to prevent clogging while maintaining high CTC capture efficiency. Computational fluid dynamics was used to compare the residence time of particles in the designed channels. For the proof-of-concept study, microfabricated channels were biofunctionalized for immunoaffinity-based isolation of CTCs, using anti-EpCAM antibodies. Enhanced CTC capture was enabled through the micropillars inside the channels helping the increased encounters between the cells and the antibody-functionalized surface. The curvilinear channel effectively isolated cells from MCF-7 breast cancer cell line among white blood cells, with more than 85% capture efficiency. The rate of non-specific binding of white blood cells remained below 20%. This study demonstrated the ability to increase the interactions between particles and surfaces without requiring a dense layout of the micropillars inside the microchannel, therefore minimizing the clogging possibility of the channel without sacrificing performance.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"6 ","pages":"Article 100169"},"PeriodicalIF":5.9,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3209848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterning amyloid-β aggregation under the effect of acetylcholinesterase using a biological nanopore - an in vitro study 乙酰胆碱酯酶作用下淀粉样蛋白-β聚集模式的生物纳米孔体外研究

IF 5.9

Sensors and Actuators Reports Pub Date : 2023-07-08 DOI: 10.1016/j.snr.2023.100170

Nandhini Subramanian , Brittany Watson , Chen-Zhong Li , Melissa Moss , Chang Liu

{"title":"Patterning amyloid-β aggregation under the effect of acetylcholinesterase using a biological nanopore - an in vitro study","authors":"Nandhini Subramanian , Brittany Watson , Chen-Zhong Li , Melissa Moss , Chang Liu","doi":"10.1016/j.snr.2023.100170","DOIUrl":"https://doi.org/10.1016/j.snr.2023.100170","url":null,"abstract":"<div><p>Aggregation of amyloid-β peptide (Aβ) is hypothesized to be the primary cause of Alzheimer's disease (AD) progression. Aβ aggregation has been widely studied using conventional sensing tools like emission fluorescence, electron microscopy, mass spectroscopy, and circular dichroism. However, none of these techniques can provide cost-efficient, highly sensitive quantification of Aβ aggregation kinetics at the molecular level. Among the influences on Aβ aggregation of interest to disease progression is the acceleration of Aβ aggregation by acetylcholinesterase (AChE), which is present in the brain and inflicts the fast progression of disease due to its direct interaction with Aβ. In this work, we demonstrate the ability of a biological nanopore to map and quantify AChE accelerated aggregation of Aβ monomers to mixed oligomers and small soluble aggregates with single-molecule precision. This method will allow future work on testing direct and indirect effects of therapeutic drugs on AChE accelerated Aβ aggregation as well as disease prognosis.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"6 ","pages":"Article 100170"},"PeriodicalIF":5.9,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1629255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Protein biomarker detection in prostate cancer: A comprehensive review of electrochemical biosensors 前列腺癌蛋白质生物标志物检测:电化学生物传感器的综合综述

IF 5.9

Sensors and Actuators Reports Pub Date : 2023-06-26 DOI: 10.1016/j.snr.2023.100168

Hashmatullah Nasimi , Jonna Skov Madsen , Ahmed H. Zedan , Anders Malmendal , Palle Jörn Sloth Osther , Fatima AlZahra'a Alatraktchi

{"title":"Protein biomarker detection in prostate cancer: A comprehensive review of electrochemical biosensors","authors":"Hashmatullah Nasimi , Jonna Skov Madsen , Ahmed H. Zedan , Anders Malmendal , Palle Jörn Sloth Osther , Fatima AlZahra'a Alatraktchi","doi":"10.1016/j.snr.2023.100168","DOIUrl":"https://doi.org/10.1016/j.snr.2023.100168","url":null,"abstract":"<div><p>Rapid on-site electrochemical screening for prostate cancer (PCa) in the clinic holds the potential for early diagnosis of PCa patients. Currently, the accuracy of commonly used biomarkers is insufficient; however, several protein biomarker candidates show promise for diagnostic or prognostic patient screening. Among these candidates are Prostate specific antigen (PSA), Human glandular kallikrein 2 (hK2), Annexins 3 (Annex 3), Beta-2-microglobulin (β2M), Microseminoprotein-beta (MSMB), Serum amyloid A (SAA), and Engrailed-2 (EN2). This review provides an overview of the advancements in electrochemical biosensor development specifically targeting the detection of these seven biomarkers. The selection of these biomarkers was based on their suitability for protein-level detection using electrochemical sensors, as well as their presence in biological fluids. Moreover, we emphasize that relying solely on a single biomarker may not be sufficient to obtain precise diagnostic information. It is now widely accepted that panels of biomarkers measured in a multiplexed fashion are of greater clinical utility than single biomarkers. Therefore, we suggest that future research prioritize the utilization of multiplex electrochemical methods for measuring panels of protein biomarkers, offering a simple and efficient approach for regular PCa monitoring.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"6 ","pages":"Article 100168"},"PeriodicalIF":5.9,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1629254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanocrystalline ZnO quantum dot-based chemiresistive gas sensors: Improving sensing performance towards NO2 and H2S by optimizing operating temperature 基于纳米晶ZnO量子点的化学电阻气体传感器:通过优化工作温度提高对NO2和H2S的传感性能

IF 5.9

Sensors and Actuators Reports Pub Date : 2023-06-03 DOI: 10.1016/j.snr.2023.100166

Dung Thi Hanh To , Ji Young Park , Bingxin Yang , Nosang V. Myung , Yong-Ho Choa

{"title":"Nanocrystalline ZnO quantum dot-based chemiresistive gas sensors: Improving sensing performance towards NO2 and H2S by optimizing operating temperature","authors":"Dung Thi Hanh To , Ji Young Park , Bingxin Yang , Nosang V. Myung , Yong-Ho Choa","doi":"10.1016/j.snr.2023.100166","DOIUrl":"https://doi.org/10.1016/j.snr.2023.100166","url":null,"abstract":"<div><p>Nanocrystalline ZnO quantum dots (QD) with a diameter of 10 nm was synthesized and tested toward eight different toxic industrial chemicals (<em>i.e.,</em> nitrogen dioxide (NO<sub>2</sub>), hydrogen sulfide (H<sub>2</sub>S), ammonia (NH<sub>3</sub>), carbon monoxide (CO), methane (CH<sub>4</sub>), ethanol (C<sub>2</sub>H<sub>5</sub>OH), acetone (CH<sub>3</sub>)<sub>2</sub>CO, and toluene (C<sub>6</sub>H<sub>5</sub>CH<sub>3</sub>)) with a broad concentration range at five different operating temperatures. Systemic studies allow to determine the kinetics of gas sensing as well as the competing reactions of analytes with sensing material and adsorbed oxygen. ZnO QD showed an excellent sensing performance toward NO<sub>2</sub> and H<sub>2</sub>S in comparison to other target analytes. The selectivity can be further improved by controlling the operating temperature (<em>i.e.,</em> higher selectivity toward NO<sub>2</sub> and H<sub>2</sub>S were achieved at 300 °C and 450 °C, respectively). Moreover, the optimal temperature was found to be analyte dependent.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"6 ","pages":"Article 100166"},"PeriodicalIF":5.9,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"2892069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Nanosensor platforms for detection of milk adulterants 牛奶掺假物检测的纳米传感器平台

IF 5.9

Sensors and Actuators Reports Pub Date : 2023-06-01 DOI: 10.1016/j.snr.2023.100159

Himshweta , Minni Singh

{"title":"Nanosensor platforms for detection of milk adulterants","authors":"Himshweta , Minni Singh","doi":"10.1016/j.snr.2023.100159","DOIUrl":"https://doi.org/10.1016/j.snr.2023.100159","url":null,"abstract":"<div><p>Milk is a substrate for adulteration, and it is crucial to identify adulterants, and their quantities in milk products. In order to safeguard consumers from fake products and health risks, authenticity of milk products is in high demand. Analytical tools that are comprehensive, quick, and sensitive are necessary to monitor milk quality and screen for any undesirable substances. The traditional methods for the detection of adulterants in milk products are experiencing more difficulties due to their poor selectivity, sensitivity, and unsuitability for complex matrices. The researchers are paying close attention to nanomaterial based sensing systems, which are seen to be among the most effective alternatives to the traditional approaches. This review focuses on optical and electrochemical nanosensors including mechanisms and performances, in relation to their benefits, drawbacks, and applicability to milk products. It also addresses new developments in the field of nanoemsembles platforms for the rapid detection of adulterants in dairy products. A section of particular interest is the detection of milk authenticity, as it is known that milk from different animal species are intermixed.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"5 ","pages":"Article 100159"},"PeriodicalIF":5.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"2378382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Design and development of a novel colorimetric assay and a portable optical system for the detection of aminoglycoside antibiotics 氨基糖苷类抗生素的新型比色测定和便携式光学系统的设计与开发

IF 5.9

Sensors and Actuators Reports Pub Date : 2023-06-01 DOI: 10.1016/j.snr.2023.100151

Navya Sethu, Sreya Krishnakumar, Veena Mitra, Chandrakant Tagad, Renu Vyas

{"title":"Design and development of a novel colorimetric assay and a portable optical system for the detection of aminoglycoside antibiotics","authors":"Navya Sethu, Sreya Krishnakumar, Veena Mitra, Chandrakant Tagad, Renu Vyas","doi":"10.1016/j.snr.2023.100151","DOIUrl":"https://doi.org/10.1016/j.snr.2023.100151","url":null,"abstract":"<div><p>In recent years, environmental contamination with antibiotics has become a severe threat to humankind requiring urgent attention. Presence of incompletely metabolized antibiotics in water bodies, leads to their entry into food chain via live stock and serve as a severe threat to human health. Hence it is imperative that the antibiotics are detected at the source itself. Aminoglycosides are broad spectrum antibiotics known to be more toxic and resistant to multidrug resistant (MDR) organisms compared to other classes of antibiotics. Accordingly in the present work a selective, sensitive and low-cost detection technique for aminoglycoside based antibiotics has been developed. An iron-dependent lipid peroxidation has been explored for the first time to develop a rapid and sensitive colorimetric assay for detecting aminoglycoside antibiotics. A lab-on-chip model (LoC) was designed and developed to miniaturize the colorimetric assay based model for its applications in the real-time analysis of antibiotics. The LoC was integrated with optical fibers, electronic components and associated signal processing circuitry to construct a portable device for antibiotic quantification. Interestingly a selective response towards gentamicin amongst the tested antibiotic was observed. The formation of a colored product within five minutes of reaction time enables a swift and less cumbersome analysis and compared to existing sophisticated analytical techniques. The detection method was validated for gentamicin spiked environmental samples and showed a recovery of more than 90%. This method can serve as a suitable alternative in limited laboratory setups and provides a generic platform for developing a rapid, user-friendly and economical detection methods for environmental monitoring of antibiotics.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"5 ","pages":"Article 100151"},"PeriodicalIF":5.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"2378380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cationic cellulose Nanofibrils-based electro-actuators: The effects of counteranion and electrolyte 基于阳离子纤维素纳米纤维的电动执行器:反阴离子和电解质的影响

IF 5.9

Sensors and Actuators Reports Pub Date : 2023-06-01 DOI: 10.1016/j.snr.2023.100142

Frédéric Héraly, Bo Pang, Jiayin Yuan

引用次数: 0