Babar Ali , Hossein Cheraghi Bidsorkhi , Alessandro G. D'Aloia , Marco Laracca , Maria S. Sarto
{"title":"Wearable graphene-based fabric electrodes for enhanced and long-term biosignal detection","authors":"Babar Ali , Hossein Cheraghi Bidsorkhi , Alessandro G. D'Aloia , Marco Laracca , Maria S. Sarto","doi":"10.1016/j.snr.2023.100161","DOIUrl":"https://doi.org/10.1016/j.snr.2023.100161","url":null,"abstract":"<div><p>Wearable health sensing devices are crucial and the development of multi-sensing textiles for non-invasive and continuous long-term biosignal monitoring is of primary interest. Nowadays, different wearable sensors are available but they usually lack comfort for continuous use during normal daily life activities. In this study, new graphene-based flexible dry electrodes are investigated to overcome the limitations of the currently available electrodes. Briefly, they are realized through casting PVDF (polyvinylidene fluoride)/GNP (graphene nanoplatelets) nanocomposite over commercial textiles. These electrodes are soft and flexible and adhere more easily to the skin. In terms of performance, the PVDF/GNP electrodes show lower impedance per unit area compared to commercial ones, hence they can be employed for biosignal detection. In particular, the developed electrodes are used for electrocardiogram (ECG) signal monitoring. The recorded ECG signal-to-noise ratio (SNR) reached up to 40 dB and all necessary ECG signal features and intervals are clearly distinguishable. Furthermore, the essential ECG signal intervals on each cadiac cycle show very small variations in time. Finally, the superhydrophobic property allows the electrodes to be used repeatedly after washing. As a final note, the developed dry PVDF/GNP electrodes provide reusability, biocompatibility, good skin-electrode contact, and no signs of skin irritation.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"5 ","pages":"Article 100161"},"PeriodicalIF":5.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"2892072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Balla Fall , Diébel Dado Sall , Miryana Hémadi , Abdou Karim Diagne Diaw , Modou Fall , Hyacinthe Randriamahazaka , Sabu Thomas
{"title":"Highly efficient non-enzymatic electrochemical glucose sensor based on carbon nanotubes functionalized by molybdenum disulfide and decorated with nickel nanoparticles (GCE/CNT/MoS2/NiNPs)","authors":"Balla Fall , Diébel Dado Sall , Miryana Hémadi , Abdou Karim Diagne Diaw , Modou Fall , Hyacinthe Randriamahazaka , Sabu Thomas","doi":"10.1016/j.snr.2022.100136","DOIUrl":"https://doi.org/10.1016/j.snr.2022.100136","url":null,"abstract":"<div><p>Glucose detection using sensing materials has lately received interest due to the increased demand for sensitive and selective glucose sensors in pharmaceutical, clinical, and industrial settings. Carbon nanotubes (CNTs) are used intensively as a specific class of effective electrode substances in electrochemical sensing due to their large surface area and interesting physical and electrochemical characteristics. Nickel is an attractive transition metal for glucose electrooxidation with high catalytic activity. In this study, CNT/MoS<sub>2</sub>/NiNPs nanocomposites with different CNT/MoS<sub>2</sub> ratios have been prepared by a hydrothermal reaction. The CNT/MoS<sub>2</sub> nanocomposites were characterized by X-ray diffraction (XRD), Raman spectroscopy and Fourier transform infrared spectroscopy (FTIR), and their morphology and composition were characterized by field emission scanning electron microscopy (FESEM). Electrocatalytic activity of the as-prepared nanomaterials towards glucose oxidation was investigated by cyclic voltammetry and amperometry in alkaline media. An excellent sensitivity value of 1212 μA·mM<sup>−1</sup>·cm<sup>−2</sup> with a wide linear range (0.05–0.65 mM), a low detection threshold of 0.197 μM and a short response time (3 s) were achieved by the hybrid CNT/MoS<sub>2</sub>/NiNPs sensor. Its superior catalytic activity and low cost make this hybrid very promising for applications in the direct sensing of glucose.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"5 ","pages":"Article 100136"},"PeriodicalIF":5.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1629258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lychee-like SnO2 hollow microspheres sensitized by carbon quantum dots for high-sensitivity ethanol sensor","authors":"Zhenyu Yuan, Yongchen Sui, Meige Ding, Hongmin Zhu","doi":"10.1016/j.snr.2023.100157","DOIUrl":"https://doi.org/10.1016/j.snr.2023.100157","url":null,"abstract":"<div><p>In this work, the application of carbon quantum dots as known as CQDs for ethanol detection is pioneered, and a multi-fold improvement in gas sensor performance is achieved through the unique electron transport mechanism of carbon quantum dots. The lychee-like SnO<sub>2</sub> hollow microspheres and CQDs are prepared by a solvent heat method. The composites are assembled by rapid grinding, ultrasonication, and stirring. The minimum detection limit is 500 ppb. The response/recovery time of the best mass percentage composite is 9 s/16 s to ethanol at 100 ppm with an optimum working temperature of 216℃ in the target gas-sensitive test. Such a fast response speed improvement is ascribed to the excellent electron transfer efficiency of the 5 nm diameter carbon quantum dots (CQDs).</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"5 ","pages":"Article 100157"},"PeriodicalIF":5.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1629265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Urša Klun , David Zorko , Leon Stojanov , Valentin Mirčeski , Vasko Jovanovski
{"title":"Amperometric sensor for gaseous H2O2 based on copper redox mediator incorporated electrolyte","authors":"Urša Klun , David Zorko , Leon Stojanov , Valentin Mirčeski , Vasko Jovanovski","doi":"10.1016/j.snr.2023.100144","DOIUrl":"https://doi.org/10.1016/j.snr.2023.100144","url":null,"abstract":"<div><p>The determination of gases and other volatile compounds using electrochemical gas sensors remains a challenge with respect to sensitivity and selectivity. Many real-life situations require fast, sensitive, and yet easy-to-operate sensors for gaseous hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) that can operate at room temperature. Herein, we present an H<sub>2</sub>O<sub>2</sub> gas sensor comprising a polyacrylic acid and NaOH gel electrolyte that included Cu(II) ions acting as a redox mediator and commercially available screen-printed carbon electrodes. Aqueous polyacrylate gel electrolyte containing Cu(II) provided for sensing material that enabled the accumulation and stabilization of the gaseous analyte and via redox interaction with Cu(II) its fast and sensitive detection. The designed sensor exhibited good sensitivity in the low mg m<sup>−3</sup> range with a wide linear response in the examined concentration range of 10–100 mg m<sup>−3</sup> and a rapid detection after only 2 min accumulation under ambient conditions. Sensor's relatively simple setup and solid electroanalytical performance have strong application potential in emerging fields such as clinical diagnostics, explosive detection, environmental monitoring and occupational health and safety.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"5 ","pages":"Article 100144"},"PeriodicalIF":5.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"2378379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inyoung Lee , Sheng Tong , Mika Hatada , Adrianna Masterson , Kentaro Hiraka , Junko Okuda-Shimazaki , Wakako Tsugawa , Gary Hughes , Koji Sode
{"title":"Development of interdigitated electrode based enzyme sensor for triglyceride monitoring using engineered oxygen insensitive glycerol 3-phosphate oxidase","authors":"Inyoung Lee , Sheng Tong , Mika Hatada , Adrianna Masterson , Kentaro Hiraka , Junko Okuda-Shimazaki , Wakako Tsugawa , Gary Hughes , Koji Sode","doi":"10.1016/j.snr.2023.100164","DOIUrl":"https://doi.org/10.1016/j.snr.2023.100164","url":null,"abstract":"<div><p>Triglycerides (TG) are an important biomarker of various diseases including hyper-lipidemia. Current emergent requirements for TG sensing include the development of electrochemical sensors for easy, cost-effective, disposable and single use triglyceride sensors. We propose a TG sensor using an engineered glycerol 3-phosphate oxidase (GlpO) and electrochemical detection. In this study, we aimed to develop an electrochemical TG sensor based on engineering the oxidative half reaction of GlpO to be oxygen insensitive, with the employment of an interdigitated electrode (IDE). To construct an oxygen insensitive mutant GlpO, we constructed a double mutant, Met104Phe/Asp169Glu, which revealed an engineered GlpO exhibiting repressed oxidase activity, while its dye-mediated dehydrogenase activity enhanced. The electrochemical enzyme sensor was constructed for the measurement of TG based on engineered GlpO using disposable screen-printed carbon electrode (SPCE) or disposable IDE using Ru complex as the electron mediator. By using the disposable IDE sensor, a highly sensitive electrochemical sensor for Glp was achieved, with the sensitivity of 0.4 µA/mM. The improved sensitivity was 2.4 times higher than that of SPCE (0.17 µA/mM), with LOD of 0.022 mM. Furthermore, the dry sensor strip, where the double mutant GlpO and Ru complex were dropcasted and dried on the IDE, was prepared and the Glp concentration was successfully measured in the delipidized serum solution. Therefore, by the employment of the established pretreatment method for TG to release Glp, a highly sensitive, accurate, easy and rapid electrochemical measurement method for TG will be developed using constructed M104F/D169E mutant GlpO with the combination of IDE.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"5 ","pages":"Article 100164"},"PeriodicalIF":5.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3209850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhanced response and selective gold nanoparticles/carbon nanotubes biosensor for the early detection of HER2 biomarker","authors":"Yahia Makableh , Tamara Athamneh , Manar Ajlouni , Sara Hijazi , Aseel Alnaimi","doi":"10.1016/j.snr.2023.100158","DOIUrl":"https://doi.org/10.1016/j.snr.2023.100158","url":null,"abstract":"<div><p>A screen-printed carbon electrode was used to develop a biosensor with an improved response and selectivity for detecting human epidermal growth factor receptor 2 (HER2). To investigate the performance of the biosensor, electrochemical characterizations such as impedance spectroscopy, differential pulse and cyclic voltammetry were used, in addition to Fourier transform infrared spectroscopy and atomic force microscopy. The biosensor responds in a quick manner, taking only 5 min to bind to the target protein. Furthermore, the results show that the nano-biosensor has a detection limit of 4.4 Pg/ml. The findings suggest that the biosensor can be used as a potential analytical tool for HER2 detection, particularly at low concentrations, which can be a tool used in the early detection of breast cancer.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"5 ","pages":"Article 100158"},"PeriodicalIF":5.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"2378381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Review of point-of-care platforms for diabetes: (2) medications and devices","authors":"Yiqun Liu , Li Yang , Yue Cui","doi":"10.1016/j.snr.2023.100150","DOIUrl":"https://doi.org/10.1016/j.snr.2023.100150","url":null,"abstract":"<div><p>Diabetes mellitus is a chronic heterogeneous metabolic disease characterized primarily by hyperglycemia due to impaired insulin secretion or impaired insulin efficacy. In recent years, a number of novel point-of-care platforms have been developed for sustained and controlled drug delivery. These platforms allow the patients to ingest insulin via transbuccal, nasal, inhalation, transdermal or subcutaneous routes, thereby effectively releasing insulin molecules the need for inconvenient and frequent needle injections. There are several issues needed to be addressed in developing such as platform: How many routes of administration are available for a point-of-care medication platform? What device components and configurations are available? What is the status of their application? This review will highlight our early attempts to address these questions. It is expected this review could provide a comprehensive overview of the medication platforms for diabetes, as well as open new avenues for developing the next-generation drug delivery devices for patients with diabetes.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"5 ","pages":"Article 100150"},"PeriodicalIF":5.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1629262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chemiluminescence and fluorescence biosensors for food application: A review","authors":"Kanchanmala Deshpande , Lizy Kanungo","doi":"10.1016/j.snr.2022.100137","DOIUrl":"https://doi.org/10.1016/j.snr.2022.100137","url":null,"abstract":"<div><p>Nowadays, the analysis of food is of high concern in terms of quality and safety. Analysis of food samples becomes tedious when complex food matrixes cause interference during analysis. Optical biosensors based on chemiluminescence (CL) and fluorescence (FL) detection have been dedicated to different food analysis over the last few decades. These CL and FL-based biosensors offer several merits over routinely used conventional methods in terms of sensitivity and selectivity. They also facilitate the ease of analysing different samples with minimal sample preparation. This article compiles data from CL and FL-based biosensing in various food samples with varied sample matrices. The main focus of this article is to provide brief introduction to the topic, systematize current literature on CL and FL-based biosensors for food analysis and discuss critical challenges as well as future prospects in this field.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"5 ","pages":"Article 100137"},"PeriodicalIF":5.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3209849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A miniaturization scheme of flexible inkjet-printed Ag/AgCl(s) reference electrodes using the ionic liquid (IL)-typed PVC membrane with the addition of graphene for electrochemical sensing applications","authors":"Kun-Lin Tsou, Yu-Ting Cheng","doi":"10.1016/j.snr.2023.100145","DOIUrl":"https://doi.org/10.1016/j.snr.2023.100145","url":null,"abstract":"<div><p>In this paper, we study size effects on the reference electrode performance of flexible inkjet printed electrochemical (EC) sensors and present a scheme to print a reliable miniaturized Ag/AgCl(s) electrode for biomedical device applications. The newly printed electrode only with a size of 6900 μm<sup>2</sup>, i.e., equivalent to 83 × 83 μm<sup>2</sup> can perform as well as the commercial one. Experimental results show the electrode impedance is effectively reduced via the incorporation of graphene flakes into the ionic liquid-based PVC film coated on the electrode to accelerate the ion-transferring rate of the chloride ions, thereby facilitating rapid chloride ion redistribution for the film to reach a quick potential balance with the reference electrode for open circuit potential (OCP) measurement. The EC sensors using the reference electrode can exhibit a fixed OCP output with a low potential variation, quick response time and potential drift, which are ±2.1 mV variant, 50 s, and 23.5 μV/h, respectively regardless of the concentration of chloride ions in the tested environment.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"5 ","pages":"Article 100145"},"PeriodicalIF":5.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1549524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimizing the sensing performance of amperometric creatinine detection based on creatinine deiminase/Nafion®-nanostructured polyaniline composite film by mixture design method","authors":"Jing-Shan Do, Yu-Hsuan Chang","doi":"10.1016/j.snr.2022.100135","DOIUrl":"https://doi.org/10.1016/j.snr.2022.100135","url":null,"abstract":"<div><p>Nafion®-nanostructured polyaniline (nsPANi) composite film is prepared using cyclic voltammetry (CV) and immobilized with creatinine deiminase (CD) enzyme and is used to sense creatinine in a buffer phosphate solution. The conditions for preparing Nafion®-nsPANi composite film are optimized by using a mixture design for which the sensitivity is the response. The relationship between the sensitivity of the amperometric creatinine biosensor (<em>y</em>) and the normalized aniline concentration (<em>Y</em><sub>1</sub>), HCl concentration (<em>Y</em><sub>2</sub>) and scanning rate (<em>Y</em><sub>3</sub>) is <em>y</em> = 119.44<em>Y</em><sub>1</sub> + 45.23<em>Y</em><sub>2</sub> + 100.93<em>Y</em><sub>3</sub> + 255.69<em>Y</em><sub>1</sub><em>Y</em><sub>2</sub> + 313.16<em>Y</em><sub>1</sub><em>Y</em><sub>3</sub> + 430.56<em>Y</em><sub>1</sub><em>Y</em><sub>2</sub><em>Y</em><sub>3</sub></p><p>The maximum sensitivity of an amperometric creatinine biosensor that is constructed using Nafion®-nsPANi composite film in 0.0943 M aniline, 0.9024 M HCl and using a scanning rate of 27.88 mV <em>s</em> <sup>−</sup> <sup>1</sup> is 2013.2 μA mM<sup>−1</sup> cm<sup>−2</sup>, which is 54.9% better than the sensitivity of a conventional experimental technique. The amperometric creatinine biosensor is 6.60% less sensitive after sensing 0.15 mM creatinine 240 times. The amperometric creatinine biosensor incurs insignificant interference in 0.138 mM urea, 0.085 mM ascorbic acid (AA) and 5.54 mM glucose.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"5 ","pages":"Article 100135"},"PeriodicalIF":5.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1629256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}