Sensors and Actuators Reports最新文献

{"title":"Unveiling the effect of paper matrix on the electrochemical response of diffusive redox probes","authors":"Dmitry Galyamin ,&nbsp;Eduardo Laborda ,&nbsp;Juan Pablo Esquivel ,&nbsp;Joaquín González ,&nbsp;Neus Sabaté","doi":"10.1016/j.snr.2024.100224","DOIUrl":"10.1016/j.snr.2024.100224","url":null,"abstract":"<div><p>This study evaluates the influence of paper substrate selection on the electrochemical response of an electrochemical paper-based analytical device (ePAD). Various paper substrates commonly employed in this type of devices such as cellulose, nitrocellulose and glass-fibre based medical grade materials are evaluated using chronoamperometric measurements. Both theoretical modelling and experimental analyses are conducted to understand the diffusion behaviour of widely employed two redox probes, [Fe(CN)₆]³⁻ and FcMeOH. Findings show that glass fibre substrates show similar performance to liquid drop conditions while nitrocellulose cause a decrease in current after a short measurement period, mainly due to a thin-layer effect. Cellulose-based substrates decrease the diffusivity of redox species, especially for charged species, indicating potential limitations in their use for chronoamperometric measurements. The study offers valuable insights into the electrochemical behaviour of paper substrates in ePADs, laying the groundwork for future research in this area.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100224"},"PeriodicalIF":6.5,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666053924000407/pdfft?md5=bb215137d80b372495974d62dfaef5da&pid=1-s2.0-S2666053924000407-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141697147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and optimization of a Cr(VI)-Selective Electrode based on a polymeric ß-cyclodextrin membrane modified with sulfur donor groups","authors":"Manuel Ochoa-Pérez ,&nbsp;Jorge Juárez-Gómez ,&nbsp;Sarahy Meneses-Aparicio ,&nbsp;Dafne Sarahia Guzmán-Hernández ,&nbsp;Víctor Lara ,&nbsp;Alberto Rojas-Hernández ,&nbsp;María Teresa Ramírez-Silva","doi":"10.1016/j.snr.2024.100226","DOIUrl":"10.1016/j.snr.2024.100226","url":null,"abstract":"<div><p>This work presents the design and optimization of a new Cr(VI)-selective electrode. The new sensor is based on modifying a glassy carbon electrode with carbon quantum dots, ß-cyclodextrin, and carbon disulfide. The carbon quantum dots aided the electrical properties of the glassy carbon by improving charge transfer; the electropolymerization of ß-cyclodextrin resulted in a polymeric membrane that functions as a recognition element when modified by adding sulfur donor groups to its structure. Modifying the membrane with sulfur atoms gave the sensor excellent selectivity toward Cr(VI) ions. The electrode synthesis was optimized using a 2³ factorial design; the factors studied were pH, the number of cycles in the electropolymerization, and the presence or absence of carbon nanoparticles. Eight different electrodes were constructed, and their potentiometric response to different concentrations of Cr(VI) was evaluated for all of them. The analysis of variance of the experimental design found no significant effect of any factor on the response. However, it suggests a strong interaction between the three factors studied. The sensor that presented the best analytical parameters was synthesized at pH 5 and 50 consecutive cycles in the presence of carbon quantum dots. This new electrode, with its response times of 40 s at different concentrations of the metal ion, exhibiting a slope of (66.0 ± 2.1) mV decade⁻¹ and a detection limit of (5.2 ± 0.1)x10⁻⁷ mol L⁻¹, can be used at pH between 0 and 3 without the effect of hydronium ions. The proposed electrode has good reproducibility and excellent selectivity against various metal ions and has significant advantages over other analysis methods. Its cost, ease of construction, easy handling, ease of operation, ease of storage and transportation, as well as good performance, short response time, and high selectivity make this electrode a valuable tool for easy, fast, and reliable monitoring of Cr(VI) in water samples, contributing to the safety and health of our environment.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100226"},"PeriodicalIF":6.5,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666053924000420/pdfft?md5=5326a7086758dee18ee01ace674f2eca&pid=1-s2.0-S2666053924000420-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141637277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced uric acid detection using functionalized multi-walled carbon nanotube/AgNi nanocomposites: A comparative study on screen-printed carbon electrode (SPCE) and fabric-based biosensors","authors":"Yuan Alfinsyah Sihombing ,&nbsp;Uperianti ,&nbsp;Rizky Indah Sari ,&nbsp;Beni Rio Hermanto ,&nbsp;Murni Handayani ,&nbsp;Samuel Priyantoro Kusumocahyo ,&nbsp;Mokhamad Fakhrul Ulum ,&nbsp;Rikson Siburian ,&nbsp;Cepi Kurniawan ,&nbsp;Nuni Widiarti ,&nbsp;Yeni Wahyuni Hartati ,&nbsp;Isa Anshori","doi":"10.1016/j.snr.2024.100223","DOIUrl":"10.1016/j.snr.2024.100223","url":null,"abstract":"<div><p>In the development of biosensors, it is essential to have sensors that provide rapid responses, exhibit high sensitivity and selectivity, and are non-invasive, such as screen-printed carbon electrode-based biosensors. In this study, SPCE-based and fabric-based biosensors were fabricated by modifying the working electrode (WE) surface using functionalized Multi-walled Carbon Nanotube/AgNi nanocomposites (f-MWCNT/AgNi) to enhance the biosensor's performance in detecting uric acid (UA). The successful synthesis of the f-MWCNT/AgNi nanomaterial was confirmed through UV–Vis, Raman, SEM–EDX, and XRD analyses. The f-MWCNT/AgNi nanomaterials were deposited on the WE surface using drop-casting. Subsequently, electrochemical characteristic tests and UA detection performance were conducted using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods. The DPV curves revealed sensitivities of 27.699 μA/mM and 4.638 μA/mM for SPCE-based and fabric-based electrodes, respectively. The limit of detection (LOD) values for UA detection were 0.024 and 0.017 mM, with linearity (R²) 0.997 and 0.999 observed within the linear ranges of 0.05–1.00 and 1.0–5.0 mM, respectively. Both biosensors exhibited strong selectivity for UA against other components, including ascorbic acid, glucose, lactic acid, and ethanol. Based on these parameter values, f-MWCNT/AgNi-modified SPCE and fabric-based electrodes can be promoted as biosensors for uric acid detection.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100223"},"PeriodicalIF":6.5,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666053924000390/pdfft?md5=4444c744795c204087bdf0feb4ba5baa&pid=1-s2.0-S2666053924000390-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141695414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging detection of carbon-based gases with multiple bonds by activating MoO bonding in Na, Sb-codoped NiMoO4","authors":"Si Hoon Jeong ,&nbsp;Gi Hyeon Han ,&nbsp;Gi Hyun Park ,&nbsp;Changhyun Jin ,&nbsp;Jeong Yun Hwang ,&nbsp;Myung Sik Choi ,&nbsp;Se Hwang Kang ,&nbsp;Joon Hyun Baik ,&nbsp;Kyu Hyoung Lee ,&nbsp;Seung Yong Lee","doi":"10.1016/j.snr.2024.100219","DOIUrl":"https://doi.org/10.1016/j.snr.2024.100219","url":null,"abstract":"<div><p>Exhausting carbon-based gases from building construction or comfortable household supplies have caused the main pollution gas species for the indoor air environment. Given the variety of indoor activities, many reports have been challenged to find room-temperature operational and harmless materials. Here, we report that the activating Mo<img>O vibration mode in Na,Sb doped-NiMoO₄ micro-sized powder reveals the high response of CO and VOC, occupying multiple bonds at room temperature. We performed Na and Sb doping in the α-NiMoO₄ crystal structure, such as introducing the Sb in Ni and interstitial doping of Na in around 4 Å of free space in the NiMoO₄ crystal structure that manipulates the partial β-NiMoO₄ phase. The Na,Sb-codoped NiMoO₄ generates the higher Mo<img>O vibration mode from FT-IR measurement and enables carbon-based gas detection with 38 responses to CO and nearly 20 responses to VOC under 20 ppm of each analyte gases environment. Furthermore, the n-type gas sensing behavior of Na,Sb doped-NiMoO₄ chemiresistor exhibits an immediate sensing response instead of a none-of response than intrinsic or single element doped NiMoO₄. These results suggest that Na,Sb codoped-NiMoO₄ is the applicable material for emergent warning against carbon-based gas exposure in the indoor environment. In addition, activating the electrochemical reaction site of MoO₄^–2 in NiMoO₄ is tailorable by a simple doping process.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100219"},"PeriodicalIF":6.5,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666053924000353/pdfft?md5=041d516ae14063cfc21f25858494ab07&pid=1-s2.0-S2666053924000353-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141606418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focused ion beam fabrication of high-resolution electrochemical-electroluminescence coupling bipolar nanoelectrode array sensors","authors":"Guopeng Li ,&nbsp;Rui Hao","doi":"10.1016/j.snr.2024.100220","DOIUrl":"https://doi.org/10.1016/j.snr.2024.100220","url":null,"abstract":"<div><p>High temporal and spatial resolution electrochemical sensor arrays can greatly benefit various parallel sensing applications. Herein, we provide a simple method for the controlled and scaled fabrication of bipolar nanoelectrode arrays (BPnEAs) for high-resolution electrochemical sensing applications. BPnEAs are prepared on silicon nitride film windows through the dual-beam FIB nanofabrication technique. Coupling a conventional electrochemical redox reaction with a tris (2,20-bipyridyl) ruthenium /2-(dibutylamino)ethanol electrochemiluminescence (ECL) system, which is based on a high-viscosity solvent to reduce molecular diffusion, allows for the reporting of conventional electrochemical redox processes with high spatial and temporal resolution. The use of the BPnEA-ECL sensor is demonstrated on 10 × 10 Pt or C BPnEAs for monitoring the reduction of 0.5 M H₂SO₄. BPnEA-ECL sensors containing different electrode materials (Pt and C) are reported for the first time and are used to monitor the reduction of 0.5 M H₂SO₄, thus revealing the difference in electrocatalytic capacities between Pt and C. Subsequently, we reveal the outstanding capabilities of the BPnEA-ECL system for catalyst screening.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100220"},"PeriodicalIF":6.5,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666053924000365/pdfft?md5=9822c1b2795876cb727ed46899430a88&pid=1-s2.0-S2666053924000365-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-fast detection of pathogens and protein biomarkers using a low-cost silicon plasmonic biosensing platform","authors":"Athanasios Manolis ,&nbsp;Christia Eleftheriou ,&nbsp;Mahmoud A. Elrabiaey ,&nbsp;George Tsekenis ,&nbsp;Sabato D'Auria ,&nbsp;Antonio Varriale ,&nbsp;Alessandro Capo ,&nbsp;Maria Staiano ,&nbsp;Bartos Chmielak ,&nbsp;Anna Lena Schall-Giesecke ,&nbsp;Stephan Suckow ,&nbsp;Dimitris Tsiokos","doi":"10.1016/j.snr.2024.100221","DOIUrl":"https://doi.org/10.1016/j.snr.2024.100221","url":null,"abstract":"<div><p>In this paper, we report, for the first time to our knowledge, a new versatile and future proof diagnostic platform for diverse applications and heterogeneous biological targets. This platform relies on a plasmonic-augmented silicon photonic biochip to detect bacteria and protein biomarkers within minutes. To demonstrate the potential of this platform in diverse applications, we demonstrate the detection of two heterogeneous targets, the bacterium <em>Escherichia coli</em> (<em>E. coli</em>) and the molecule C-reactive protein (CRP) using a universal detection method. <em>E. coli</em> is one of the most commonly encountered bacterial pathogens involved in food monitoring, food born infections and water contamination applications, while CRP is a well-established disease severity indicator frequently used in common clinical practice. The biochip used is fully compatible with CMOS semiconductor manufacturing, while it hosts biosensors arrays for any combination of detection assays. Each biosensor exploits a 70 μm long aluminum plasmonic transducer within a silicon nitride waveguide-based Mach–Zehnder Interferometer. Each aluminum surface was silanized and biomodified with specific antibodies. Biosensing experiments revealed that CRP can be detected in diverse sample mediums, and <em>E. coli</em> detection was achieved in buffer at concentrations as low as 10 cells/ml within 13–25 min. The results are in good agreement with preceding numerical simulations. The modular nature of the reported biosensing platform makes it scalable and customizable, allowing nearly any combination of diagnostic tests targeting pathogens and proteins to be integrated on the same biochip for food quality monitoring, environmental monitoring, drug discovery and modern cell therapy manufacturing, or biomedical applications.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100221"},"PeriodicalIF":6.5,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666053924000377/pdfft?md5=653855a9e597a56d3aacc36cd265887b&pid=1-s2.0-S2666053924000377-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141606417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trace ammonia detection realized by mixed Ti-Zr metal-organic-frameworks and its application in exhaled breath sensing at room temperature","authors":"Zhiming Chen ,&nbsp;Zhiwen Shi ,&nbsp;Peng Zhang ,&nbsp;Li Gao ,&nbsp;Bingxin Liu ,&nbsp;Lijuan Qiao","doi":"10.1016/j.snr.2024.100216","DOIUrl":"https://doi.org/10.1016/j.snr.2024.100216","url":null,"abstract":"<div><p>The presence of ammonia in exhaled human breath serves as a crucial biomarker for renal diseases. This paper presents a highly sensitive ammonia sensor operable at room temperature, utilizing a Ti/Zr dual metal MOF as its core component, synthesized through a straightforward solvothermal reaction approach. The Ti/Zr-MOF demonstrates excellent responsiveness to ammonia gas, with a detection limit of remarkable sensitivity, reaching as low as 2 ppm. Notably, the sensor exhibits practical insensitivity to similar concentrations of other major interfering breath volatiles, including acetone, ethanol, and saturated moisture. Electron Paramagnetic Resonance (EPR) analysis confirms the presence of oxygen vacancies (Ov) in Ti/Zr-MOF materials, with Ti/Zr-MOF exhibiting stronger Ov signals and the potential for enhanced NH3 adsorption and capture. In-situ FTIR spectrum analysis reveals ammonia-induced -OH (H₂O) moiety formation, indicating a reaction between adsorbed <span><math><msubsup><mi>O</mi><mn>2</mn><mo>−</mo></msubsup></math></span> species and ammonia, resulting in decreased electrical resistance of Ti/Zr-MOF.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100216"},"PeriodicalIF":6.5,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666053924000328/pdfft?md5=0289f840f9b6230738f438f83bd68afc&pid=1-s2.0-S2666053924000328-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141543652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prussian blue nanofilm-sensitized plasmonic electrochemical microscopy for spatially resolved detection of the localized delivery of hydrogen peroxide","authors":"Adaly Garcia,&nbsp;Christina Dhoj,&nbsp;Samuel Groysman,&nbsp;Kinsley Wang,&nbsp;Stellina Ao,&nbsp;Aimee Anguiano,&nbsp;Tony Tran,&nbsp;Dianlu Jiang,&nbsp;Yixian Wang","doi":"10.1016/j.snr.2024.100218","DOIUrl":"https://doi.org/10.1016/j.snr.2024.100218","url":null,"abstract":"<div><p>Hydrogen peroxide (H₂O₂) sensing has been widely investigated using various electrochemical methods, yet the challenge of finding an imaging technique capable of real-time, spatially resolved detection remains. Addressing this, we introduce a Prussian blue (PB) nanofilm-sensitized plasmonic electrochemical microscopy (PEM) technique that successfully visualizes the localized delivery of H₂O₂. The PB nanofilm was carefully characterized, and its sensing capability towards H₂O₂ was demonstrated in amperometric mode. Employing a precise micromanipulator system, we controlled a micropipette to create a localized concentration gradient on the sensor surface and monitored the gradient through the PB nanofilm-sensitized PEM. The accuracy of the obtained concentration values was further validated by numerical simulations based on finite-element methods. Our technique ensures dependable localized detection, and we anticipate that advancements in film uniformity will further improve the resolution. The potential applications of this technique are broad and significant, including the opportunity to investigate single-cell exocytosis with neurotransmitters like dopamine, thus offering a promising avenue for future biomedical research.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100218"},"PeriodicalIF":6.5,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666053924000341/pdfft?md5=e4f2e9be16552a6853b9f0f6d1fda91b&pid=1-s2.0-S2666053924000341-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141595101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone enabled machine learning approach assisted copper (II) quantification and opto-electrochemical explosive recognition by Aldazine-functionalized chemobiosensor","authors":"Mohit Kumar Chattopadhyay ,&nbsp;Amita Mondal ,&nbsp;Abhijit Hazra ,&nbsp;Swarup Kumar Tarai ,&nbsp;Bishwajit Singh Kapoor ,&nbsp;Sudit S. Mukhopadhyay ,&nbsp;Surya Sarkar ,&nbsp;Priyabrata Banerjee","doi":"10.1016/j.snr.2024.100215","DOIUrl":"https://doi.org/10.1016/j.snr.2024.100215","url":null,"abstract":"<div><p>An Aldazine-based optoelectrochemical sensor, <strong>BMH</strong> (1-(quinolin-4-ylmethylene)hydrazono)methyl)naphthalen-2-ol) has been introduced herein for selective detection of aqueous copper (Cu²⁺) and 2, 4, 6-Trinitrophenol (TNP) at an ultra-low level detection limit (0.09 ppm for Cu²⁺ and 0.019 ppm for TNP). Multichannel recognition aptitude of the chemosensor (<strong>BMH</strong>) towards both Cu²⁺ and TNP along with bountiful practical applications ascertained it as an innovative one in the environmental and biomedical domains. <strong>BMH</strong> can detect Cu²⁺ in water, fetal bovine serum, and human urine samples, while explosive TNP can be identified in water, soil, and matches powder. The intracellular Cu²⁺ and TNP recognition efficiencies of <strong>BMH</strong> have been investigated in human lung cancer cell lines (A459). The hassle-free smartphone ensemble machine learning approach for Cu²⁺quantification has been introduced which would certainly be a significant addition in the domain of water quality analysis. Moreover, the ethylenediaminetetraacetic acid (EDTA) mediated reversibility of the probe could serve as a logic gate imitating electrical circuitry.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100215"},"PeriodicalIF":6.5,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666053924000316/pdfft?md5=62cf8594c970cd8e7b0642370a1aabef&pid=1-s2.0-S2666053924000316-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141543653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel molecularly imprinted polymer sensor for sweat cortisol with embedded probe based on the co-deposition of Prussian Blue and Polypyrrole","authors":"Zixuan Song ,&nbsp;Minghui Yin ,&nbsp;Bo Rui ,&nbsp;Tiezhu Liu ,&nbsp;Wei Song ,&nbsp;Li Sun ,&nbsp;Shengmin Li ,&nbsp;Jun Wang ,&nbsp;Mengdi Han ,&nbsp;Guangyang Gou ,&nbsp;Ning Xue ,&nbsp;Chunxiu Liu","doi":"10.1016/j.snr.2024.100217","DOIUrl":"https://doi.org/10.1016/j.snr.2024.100217","url":null,"abstract":"<div><p>The cortisol in human body is a crucial biomarker in terms of wellness management, mental state monitoring and stress-related disorder diagnosis. Therefore, the rapid, reliable and facile measurement of cortisol concentration has attracted extensive research interest. However, traditional cortisol detection such as immunosensing requires demanding laboratory layout, lengthy procedures and high costs, which means, consequently, it is incompatible with the current goal of cortisol sensing. Given the contradiction, an electrochemical sensor based on molecularly imprinted polymer (MIP) for simple, efficient, non-invasive cortisol detection was proposed. The two-step approach employed is simple enough and allows for the mass production of devices. And the embedding of Prussian Blue (PB) within the MIP layer eliminates the need for complex external probes, thereby making the resultant sensors more suitable for integration into wearable devices. We firstly demonstrated the feasibility of the proposed strategy and characterized the successful formation of cavities specific to cortisol molecules. Thereafter, we measured the dependence of the current response on cortisol concentration in Phosphate Buffered Saline (PBS) buffer, which revealed a near-linear relationship between the logarithm of the cortisol concentration and the redox current from 10⁻⁹ mol/L to 10⁻⁵ mol/L, covering the optimal range of cortisol concentration in sweat. Subsequently, sensors with the same specifications were prepared and tested in PBS buffer, exhibiting good consistency. In artificial sweat, we further demonstrated that they have benign selectivity, interference immunity and great potential in practical applications.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100217"},"PeriodicalIF":6.5,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266605392400033X/pdfft?md5=bafba738e360ac53a37ed0a8095eba57&pid=1-s2.0-S266605392400033X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}