Sensors and Actuators Reports最新文献_第3页

High-frequency electrochemical impedance measurements of self-assembled monolayer formation using CMOS-based nanocapacitor arrays

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-02-01 DOI: 10.1016/j.snr.2025.100293

Selvaraj Chinnathambi , Mohammad Saghafi , Suryasnata Tripathy , Frans P. Widdershoven , Serge G. Lemay

引用次数: 0

SARS-COV-2 viral RNA detection through oligonucleotide-capped nanoporous anodic alumina supports.

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-02-01 DOI: 10.1016/j.snr.2025.100298

Alba López-Palacios , María Nieves Aranda , Isabel Caballos , Andy Hernández-Montoto , Eva Calabuig , María Dolores Gómez-Ruiz , María Ángeles Tormo-Mas , Javier Pemán , Félix Sancenón , Ramón Martínez-Máñez , Elena Aznar , Estela Climent

{"title":"SARS-COV-2 viral RNA detection through oligonucleotide-capped nanoporous anodic alumina supports.","authors":"Alba López-Palacios , María Nieves Aranda , Isabel Caballos , Andy Hernández-Montoto , Eva Calabuig , María Dolores Gómez-Ruiz , María Ángeles Tormo-Mas , Javier Pemán , Félix Sancenón , Ramón Martínez-Máñez , Elena Aznar , Estela Climent","doi":"10.1016/j.snr.2025.100298","DOIUrl":"10.1016/j.snr.2025.100298","url":null,"abstract":"<div><div>We describe herein a sensor containing nanoporous anodic alumina (NAA) as sensing platform to identify SARS-COV-2 RNA using a gating mechanism. The system is based on NAA that contains a fluorescent dye (Rhodamine B; RhB) and is capped with an oligonucleotide sequence that hybridize specifically a region of SARS-CoV-2 genome. In the presence of RNA from SARS-COV-2 virus, the oligonucleotide of the surface is displaced, uncapping the pores, and producing a delivery of RhB. The detection of the virus is achieved measuring the fluorescence of the fluorophore. The nanosensor demonstrates to be highly sensitive and selective in aqueous buffers and in biological media, having a limit of detection (LOD) of 50 ± 30 copies mL<sup>-1</sup> of SARS-CoV-2 RNA extracted from patients. Moreover, preliminary results using 18 real nasopharyngeal swab samples indicate the potential of the system to differentiate between infected and non-infected patients. Compared to the conventional RT-PCR method, in our system there is no need for sample pretreatment or RNA isolation, providing diagnostic outcomes within 60 mins while maintaining a high level of reliability.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100298"},"PeriodicalIF":6.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143348603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The design of paper-based electroanalytical microfluidic device coupled with post-synthesized molecularly imprinted polymers (rGO/Au@Ag2S/PANI/polyacrylamide) for the detection of streptomycin

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-01-31 DOI: 10.1016/j.snr.2025.100297

Mina Adampourezare , Karim Asadpour-Zeynali , Miguel de la Guardia , Jafar Ezzati Nazhad Dolatabadi

{"title":"The design of paper-based electroanalytical microfluidic device coupled with post-synthesized molecularly imprinted polymers (rGO/Au@Ag2S/PANI/polyacrylamide) for the detection of streptomycin","authors":"Mina Adampourezare , Karim Asadpour-Zeynali , Miguel de la Guardia , Jafar Ezzati Nazhad Dolatabadi","doi":"10.1016/j.snr.2025.100297","DOIUrl":"10.1016/j.snr.2025.100297","url":null,"abstract":"<div><div>A highly sensitive three-electrode paper-based microfluidic device has been developed for determinate of streptomycin. Ag/GQD/chitosan nano ink was used to construct reference and counter electrodes and Au@Ag<sub>2</sub>S/GQD/chitosan nano ink was used to construct working electrode. rGO/Au@Ag<sub>2</sub>S/anline nano-sheets were encapsulated with acrylamide as a functional monomer to create novel nano-sized molecular imprinted polymer (MIP) and was used for the modification of electrode working.</div><div>Paper substrate was modified for forming a hydrophobic region around the hydrophilic region on the filter paper and were suitable for the evaluation of target molecules in aqueous environment. All steps of making the MIP and non-imprinted polymer (NIP) sensors are illustrated by FE-SEM, Energy-dispersive X-ray spectroscopy (EDS), and FT-IR. CV and DPV techniques were applied for the measurement of the streptomycin. The fabricated device showed high sensitivity toward streptomycin, which was due to synergistic effects between catalytic properties, electrical conductivity of rGO/Au@Ag<sub>2</sub>S/anline /Polyacrylamide, and considerably increased numbers of imprinted sites. Using these techniques, streptomycin was determined in the linear range of 1pM to 1 μM with a limit of detection of 0.9 × 10<sup>−12</sup> M (Ip (μA) = -2.075x + 31.575, R<sup>2</sup>= 0.9983). The device provided good cyclic stability (RSD < 0.05), high reproducibility and selectivity (RSD < 0.05 obtained from five calibration plots) with a good repeatability (for both milk and serum samples, RSD < 0.05). Finally, it should be noted that this device showed a good analytical performance for the detection of streptomycin in milk and serum samples.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100297"},"PeriodicalIF":6.5,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143348597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnology-driven electrochemical neurotransmitter sensing as a fundamental approach towards improving diagnostics and therapeutics: A review

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-01-30 DOI: 10.1016/j.snr.2025.100292

Mehr Un Nisa , Asim Yaqub , Muhammad Hashim Khan , Fatima Yaseen , Shahaab Jilani , Huma Ajab , Noor S. Shah , Abdulaziz Al-Anazi

{"title":"Nanotechnology-driven electrochemical neurotransmitter sensing as a fundamental approach towards improving diagnostics and therapeutics: A review","authors":"Mehr Un Nisa , Asim Yaqub , Muhammad Hashim Khan , Fatima Yaseen , Shahaab Jilani , Huma Ajab , Noor S. Shah , Abdulaziz Al-Anazi","doi":"10.1016/j.snr.2025.100292","DOIUrl":"10.1016/j.snr.2025.100292","url":null,"abstract":"<div><div>Neurotransmitters (NTs) are endogenous chemical messengers that have a wide range of key roles throughout the nervous system. It is an important signal medium of neural transfers and equally influence physiological conditions. While, abnormal levels are linked with psychotic, physical, and neurodegenerative disorders such as ADHD, autism and tourette syndrome. Therefore, their accurate and sensitive detection is of great importance. Traditional methods of NTs detection are limited to complex sample processing, high cost, and real-time diagnostics. However, an electrochemical sensing has been extensively utilized in the past few years for NTs detection, which shows better sensitivity, selectivity, and capacity for operation in complicated biological environments, constitutes a promising approach. In this review, the most successful and favorable electrochemical sensors based on innovations in electrode materials and nanostructured surfaces having substantial improvement in the analytical performances and overcoming challenges followed by future prospects in NTs detection have been reported. This review additionally looks at the progress accomplished in biosensors for neurotransmitter evaluations in microfluidic lab-on-a-chip systems, smart wearable devices and other advanced technologies for the goal of real-time, portable diagnosis in neuroscience and clinics. These advances are paving the way for more effective applications of electrochemical sensing in neuroscience and clinical diagnostics.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100292"},"PeriodicalIF":6.5,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143334062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laccase-mimicking Cu@CDs-enabled bioinspired immunosensor using CuO nanoparticles for voltametric detection of serum thyroxine level in patients with hyperthyroidism or hypothyroidism

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-01-28 DOI: 10.1016/j.snr.2025.100291

Mohammad Ali Farzin, Seyed Morteza Naghib

{"title":"Laccase-mimicking Cu@CDs-enabled bioinspired immunosensor using CuO nanoparticles for voltametric detection of serum thyroxine level in patients with hyperthyroidism or hypothyroidism","authors":"Mohammad Ali Farzin, Seyed Morteza Naghib","doi":"10.1016/j.snr.2025.100291","DOIUrl":"10.1016/j.snr.2025.100291","url":null,"abstract":"<div><div>In this study, for the first time, a voltammetric bioinspired immunosensor was fabricated to determine free thyroxine (T4) based on the blocking nanozyme-dependent signaling pathway through masking the active sites of the laccase-mimicking Cu-doped CDs (Cu@CDs). The focus shifted to monitoring a vital biomarker for thyroid diseases using a metal-containing nanozyme, showcasing high potential to catalyze the oxidation of phenolic compounds. Thanks to the active sites of Cu@CD nanozyme, the electrocatalytic oxidation of hydroquinone (HQ), as a signal probe, was performed at a high rate. The CuO nanostructures also increased the conductivity as well as specific surface area of electrode. Despite signal amplification of HQ, the binding of antibody to carbon dot reduced enzymatic activity of nanozyme and subsequently resulted in a considerable decrease in the current intensity of GCE/CuO nanoparticles/Cu@CDs-HQ. The bioconjugation of T4 with anti-T4 antibody resulted in the further coverage of the active sites of nanozyme. Therefore, the current of GCE/CuO nanoparticles/Cu@CDs-HQ/Ab decreased proportionally to the T4 concentration in a DLR (dynamic linear range) of 10.0 pM-8.0 nM which comprises the reference range for free T4 (11.5–22.7 pM). The LOD (limit of detection) of 2.8 pM, was lower compared to the values reported in previous studies. Furthermore, this study exhibited the key finding that the highly specific interaction of T4 with immobilized antibody led to a remarkable diminish in the immunosensor signal compared to the interferers. More importantly, spike-recovery studies demonstrated the high potential of the designed immunosensor to detect serum T4 levels in patients with hyperthyroidism or hypothyroidism.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100291"},"PeriodicalIF":6.5,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143158331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface reaction mechanism and characteristics of 2-dimensional TiO2 and 0-dimensional Ag nanocomposites specialized for H2S gas sensing at room temperature

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-01-28 DOI: 10.1016/j.snr.2025.100290

Un Yup Lee , Min Young Kim , Kyu Hyoung Lee , Sol Han , Seung Yong Lee , Ali Mirzaei , Sun-Woo Choi , Myung Sik Choi , Changhyun Jin , Jeong Yun Hwang

{"title":"Surface reaction mechanism and characteristics of 2-dimensional TiO2 and 0-dimensional Ag nanocomposites specialized for H2S gas sensing at room temperature","authors":"Un Yup Lee , Min Young Kim , Kyu Hyoung Lee , Sol Han , Seung Yong Lee , Ali Mirzaei , Sun-Woo Choi , Myung Sik Choi , Changhyun Jin , Jeong Yun Hwang","doi":"10.1016/j.snr.2025.100290","DOIUrl":"10.1016/j.snr.2025.100290","url":null,"abstract":"<div><div>In this study, we provide the synthesis of pristine TiO<sub>2</sub> nanosheets (NSs) via a simple flux method and their decoration with Ag nanoparticles (NPs) using a hydrothermal method for room-temperature H<sub>2</sub>S gas sensing. Gas sensing experiments were conducted at 25 °C, evaluating the response of the Ag NPs-decorated TiO<sub>2</sub> NSs to various gases. Results demonstrated the gas sensor exhibited a superior response to H<sub>2</sub>S gas compared to other gases, outperforming the pristine TiO<sub>2</sub> NSs gas sensor. Additionally, its response to H<sub>2</sub>S gas surpassed that of the TiO<sub>2</sub> NSs gas sensor, highlighting the promising role of Ag decoration for H<sub>2</sub>S gas detection. Sensing behavior in humid atmosphere was also investigated. The improved H<sub>2</sub>S gas sensing performance can be attributed to the catalytic effect of Ag, the formation of Ag/TiO<sub>2</sub> heterojunctions, and the large surface area of the TiO<sub>2</sub> NSs. This study introduces a straightforward approach to enhance the gas sensing capabilities of metal oxide NSs.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100290"},"PeriodicalIF":6.5,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143334064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphology controlled fabrication of zinc phosphate hierarchical microspheres for room temperature ammonia gas sensor

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-01-27 DOI: 10.1016/j.snr.2025.100288

Khalida Akhtar , Naila Zubair , Neelam Zeb , Syed Sajjad Ali Shah , Zia Ullah Khan , Hina Khalid

{"title":"Morphology controlled fabrication of zinc phosphate hierarchical microspheres for room temperature ammonia gas sensor","authors":"Khalida Akhtar , Naila Zubair , Neelam Zeb , Syed Sajjad Ali Shah , Zia Ullah Khan , Hina Khalid","doi":"10.1016/j.snr.2025.100288","DOIUrl":"10.1016/j.snr.2025.100288","url":null,"abstract":"<div><div>Hierarchical Zinc phosphate nano/microstructures with controlled morphological features were synthesized in aqueous solutions through simple and economical route without using any type of surfactant or template. SEM analysis revealed novel morphologies of the synthesized powders i.e., hierarchical microspheres, urchin like microspheres, nanoflowers and nanoellipsoids and unfolded that produced morphologies strongly depended upon the applied experimental conditions. Selected batches of the synthesized powders i.e., hierarchical microspheres, urchin like microspheres and hierarchical nanoellipsoids were selected for further analysis using XRD, FT-IR, BET analysis and gas sensing application and termed as Zinc Phosphate 1 (ZP1), Zinc Phosphate 2 (ZP2), and Zinc Phosphate 3 (ZP3), respectively. XRD results confirmed the crystalline nature of the as-prepared powders with crystallite sizes 16.5 nm, 30. 15 nm and 37.01 nm, for ZP1, ZP2 and ZP3, respectively. Evaluation of gas sensing properties of the selected samples revealed that sensors based on ZP1 showed highest gas sensing response of 89 % with response recovery time 31/12 s, towards 5 ppm ammonia at room temperature. In addition, the lowest detection limit was investigated to be <1 ppm. Because of the excellent gas sensing performance, the synthesized zinc phosphate structures could be employed as promising candidates for developing highly sensitive and selective room temperature ammonia gas sensor.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100288"},"PeriodicalIF":6.5,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143158329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A tactile sensor for recognition of softness using interlocking structure of carbon nanoparticle- polydimethylsiloxane composite

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-01-24 DOI: 10.1016/j.snr.2025.100289

Sangmin Lee, Jaewon Jang, Wanjun Park

引用次数: 0

A highly sensitive tapered fiber biosensor modified by PDMS combustion product and graphene oxide for MUC1 detection

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-01-23 DOI: 10.1016/j.snr.2025.100287

Bo Wang, Shanren Liu, Mengmeng Gao, Yuanjun Li, Heer Yang, Cai Sun, Qi Guo, Yongsen Yu

{"title":"A highly sensitive tapered fiber biosensor modified by PDMS combustion product and graphene oxide for MUC1 detection","authors":"Bo Wang, Shanren Liu, Mengmeng Gao, Yuanjun Li, Heer Yang, Cai Sun, Qi Guo, Yongsen Yu","doi":"10.1016/j.snr.2025.100287","DOIUrl":"10.1016/j.snr.2025.100287","url":null,"abstract":"<div><div>It is a critical challenge to develop reliable, stable, and sensitive biosensors for specific detection of mucin 1 (MUC1). In this paper, a label-free biosensor based on polydimethylsiloxane (PDMS) combustion product and graphene oxide (GO) functionalized tapered fiber (PGTF) was proposed and demonstrated for high sensitivity MUC1 detection. The PDMS combustion product is mainly composed of SiO<sub>2</sub>, which can be firmly bonded to the surface of the fiber, effectively increasing the specific surface area of the fiber. At the same time, the combination of the PDMS combustion product and the fiber cladding material will generate defects in the cladding, resulting in easier leakage of light inside the fiber core. Therefore, a strong evanescent field and interference effect can be obtained without drawing the tapered fiber waist very thin, which contributes to improving the sensitivity of fiber biosensor. In addition, GO has good biological affinity, a large specific surface area, and abundant functional groups, which can provide more binding sites for the attachment of biomolecule. The detection limit of the PGTF is 0.11 pM when the diameter of the fiber taper is 50 μm and modified with five layers of PDMS combustion product. Experimentally demonstrated sensor specificity and reproducibility, indicating that the sensor has a practical value for real applications. The PGTF has great potential as a simple, sensitive, and label-free assay in the field of cancer marker detection.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100287"},"PeriodicalIF":6.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging EM wave sensors for non-invasive glucose monitoring: Review, techniques and developments

IF 6.5

Sensors and Actuators Reports Pub Date : 2025-01-18 DOI: 10.1016/j.snr.2025.100282

Sudershan Dutt , Rajat Thakur , Abhishek Kandwal , Pawan Kumar , Rohit Jasrotia , Natrayan Lakshmaiya , Louis WY Liu , Sachin Kumar , Bancha Luadang , Choon Kit Chan

{"title":"Emerging EM wave sensors for non-invasive glucose monitoring: Review, techniques and developments","authors":"Sudershan Dutt , Rajat Thakur , Abhishek Kandwal , Pawan Kumar , Rohit Jasrotia , Natrayan Lakshmaiya , Louis WY Liu , Sachin Kumar , Bancha Luadang , Choon Kit Chan","doi":"10.1016/j.snr.2025.100282","DOIUrl":"10.1016/j.snr.2025.100282","url":null,"abstract":"<div><div>As a chronic disease, diabetes has impacted millions of individuals across the globe and is spreading at a very fast rate among adults mainly. Continuous observations of essential indicators like pulse rate, arterial pressure, and blood sugar levels, and oxygen saturation are crucial to maintain a healthy life and preventing severe complications associated with these. Using non-invasive method of blood glucose monitoring has paved its way to be one of the most prominent safest technique without harming the skin of the patients. This examination delves into the application of planar resonant sensors utilizing microwaves for quantifying glucose concentrations. The sensors based on RF EM waves mainly operating in the region from few MHz to GHz frequencies have garnered notable attention in the scientific community in recent years due to their significant contributions. They can detect alterations in dielectric properties caused by fluctuations in glucose concentrations. These sensors exhibit electrical reactions that rely on the dielectric properties of their surroundings. This review offers a current assessment of this sensing methodology, categorized by sensing parameters, and suggests typical non-invasive microwave sensor varieties for assessment. It further examines the key aspects of different sensor types, outlines potential future avenues, and addresses challenges in the field of glucose monitoring.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"9 ","pages":"Article 100282"},"PeriodicalIF":6.5,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143158767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0