Sensors and Actuators B: Chemical最新文献_第8页

Tunable selectivity: High-performance detection of NO2 and triethylamine enabled by In2O3-Co3O4 heterojunction nanoflowers 选择性可调：利用In2O3-Co3O4异质结纳米花实现NO2和三乙胺的高效检测

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-01 Epub Date: 2026-01-28 DOI: 10.1016/j.snb.2026.139562

Zhidong Jin , Jinbo Zhao , Lin Liu , Fei Liu , Shiqiang Li , Jiurong Liu , Lili Wu

{"title":"Tunable selectivity: High-performance detection of NO2 and triethylamine enabled by In2O3-Co3O4 heterojunction nanoflowers","authors":"Zhidong Jin , Jinbo Zhao , Lin Liu , Fei Liu , Shiqiang Li , Jiurong Liu , Lili Wu","doi":"10.1016/j.snb.2026.139562","DOIUrl":"10.1016/j.snb.2026.139562","url":null,"abstract":"<div><div>This study presents the synthesis of In<sub>2</sub>O<sub>3</sub>-Co<sub>3</sub>O<sub>4</sub> flower-like microspheres via a two-step method, where the In<sub>2</sub>O<sub>3</sub> matrix, composed of ultra-thin nanosheets, serves as a scaffold for the surface dispersion of Co<sub>3</sub>O<sub>4</sub>. By modulating the Co<sub>3</sub>O<sub>4</sub> concentration, two sensors (ICO-1 and ICO-10) were fabricated, demonstrating excellent and distinct selectivity at a low optimal temperature of 100 ℃. Among them, ICO-1 exhibited a high response of 1600–10 ppm NO<sub>2</sub>, while ICO-10 showed a response of 124.32–100 ppm triethylamine (TEA) with tunable selectivity. The sensors as well achieved low theoretical detection limits of 100 ppb for NO<sub>2</sub> and 2.5 ppm for TEA, respectively. Systematic characterizations revealed that the switching of selectivity originates from the synergistic effects of heterojunction formation, electron depletion layer modulation, and the tailored concentrations of surface chemisorbed oxygen and oxygen vacancies. This work elucidates a feasible pathway for designing highly sensitive and selectivity tunable gas sensors by engineering heterojunction composition in metal-oxide semiconductors.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139562"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146098194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cascade DNA system-based ratiometric electrochemical/electrochemiluminescent biosensor for Alzheimer’s disease biomarker 基于级联DNA系统的比例电化学/电化学发光阿尔茨海默病生物标志物生物传感器

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-01 Epub Date: 2026-01-29 DOI: 10.1016/j.snb.2026.139573

Weiwei Liu , Yao Song , Hui Xu , Chen Wang , Qianyu Wang , Huanyu Cheng , Po Wang , Guofang Chen

{"title":"Cascade DNA system-based ratiometric electrochemical/electrochemiluminescent biosensor for Alzheimer’s disease biomarker","authors":"Weiwei Liu , Yao Song , Hui Xu , Chen Wang , Qianyu Wang , Huanyu Cheng , Po Wang , Guofang Chen","doi":"10.1016/j.snb.2026.139573","DOIUrl":"10.1016/j.snb.2026.139573","url":null,"abstract":"<div><div>Detecting amyloid-<em>β</em> oligomer (A<em>β</em>O) in a sensitive and reliable manner is crucial for the early diagnosis of Alzheimer’s disease (AD). Here, a ratiometric electrochemical/electrochemiluminescent (EC/ECL) biosensor sensitized with a cascade DNA system was designed for A<em>β</em>O assay, an AD biomarker. Benefited from the strong binding of aptamer to target A<em>β</em>O, this system not only exhibited excellent identification to A<em>β</em>O in interfering substrates, but also achieved the signal transduction from A<em>β</em>O to nucleic acid (M). The releasing M strands triggered the upstream entropy-driven DNA circuit (EDC), which could directly initiate the downstream hybridization chain reaction (HCR). The continuous programmability of cascade DNA system achieved a one-to-multiple amplification effect, enhancing the assembly amount of ferrocene (Fc). The electron transfer and energy transfer between Ru(bpy)<sub>3</sub><sup>2+</sup>-conjugated silica nanoparticles (RuSi NPs) and Fc improved the sensitivity for A<em>β</em>O detection. The reverse change of signals between EC (Fc) and ECL (Ru) introduced intrinsic self-calibration and ensured the reliability of the biosensor. Taking the above advantages, the proposed method exhibited a high sensitivity for A<em>β</em>O quantification in the range of 50 fM to 10 nM and a detection limit of 14 fM. The proposed sensing strategy was also validated using real serum samples, offering a sensitive and efficient approach for AD diagnosis.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139573"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of extracellular vesicle size and surface charge density via precise measurements of Brownian motion, electrophoretic velocity, and applied electric field in a single platform 测定细胞外囊泡大小和表面电荷密度通过精确测量布朗运动，电泳速度，和应用电场在一个单一的平台

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-01 Epub Date: 2026-01-29 DOI: 10.1016/j.snb.2026.139570

Minsu Park , Geeyoon Kang , Jinseock Kong , Hyeri Moon , Junyeong Lee , Ju-Hyun Bae , Moon-Chang Baek , Seungha Kim , Hyowoong Noh , Hongsik Park

{"title":"Determination of extracellular vesicle size and surface charge density via precise measurements of Brownian motion, electrophoretic velocity, and applied electric field in a single platform","authors":"Minsu Park , Geeyoon Kang , Jinseock Kong , Hyeri Moon , Junyeong Lee , Ju-Hyun Bae , Moon-Chang Baek , Seungha Kim , Hyowoong Noh , Hongsik Park","doi":"10.1016/j.snb.2026.139570","DOIUrl":"10.1016/j.snb.2026.139570","url":null,"abstract":"<div><div>The size and surface charge density of extracellular vesicles (EVs) are physical properties correlated with the biological properties of their parent cells. Particle size is typically determined from Brownian motion, while surface charge density is calculated based on both size and zeta potential. However, accurately measuring both size and surface charge density of individual particles in liquids remains challenging because the underlying measurement principles differ and zeta potential analysis is complicated by the difficulty in quantifying the electric field applied to each particle. In this study, we developed a method for determining the precise size and surface charge density of individual EVs by integrating van der Pauw (vdP) and light scattering techniques. Size was determined by monitoring Brownian motion, while surface charge density was derived from the zeta potential, which was calculated using electrophoretic velocity and the applied electric field. The electric field was accurately measured using the vdP method based on the generalized Ohm’s law. The method’s accuracy was validated by measuring the size and zeta potential of standard nanoparticles. This method was further applied to evaluate the size and surface charge density of individual EVs derived from normal and cancerous breast and colon cells. The results revealed that these EV properties correlated with the malignancy level of the parent cells, achieving a classification accuracy of 94.69%. The proposed approach for determining multiple physical properties of individual nanoparticles in liquids may serve as a useful tool for exploring correlations between the physical and biological properties of EVs.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139570"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On-a-chip analysis of lipid-packing defects modulating lung cancer cell metastasis at a tumor-vascular interface 脂质堆积缺陷在肿瘤-血管界面调节肺癌细胞转移的芯片分析

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-01 Epub Date: 2026-02-04 DOI: 10.1016/j.snb.2026.139584

Reyila Maimaiti , Weifei Zhang , Jia Liu , Xuanlin Feng , Wei Li , Ling Wang , Nan Li

{"title":"On-a-chip analysis of lipid-packing defects modulating lung cancer cell metastasis at a tumor-vascular interface","authors":"Reyila Maimaiti , Weifei Zhang , Jia Liu , Xuanlin Feng , Wei Li , Ling Wang , Nan Li","doi":"10.1016/j.snb.2026.139584","DOIUrl":"10.1016/j.snb.2026.139584","url":null,"abstract":"<div><div>Lipid packing has been considered to play an important role in modulating cell behaviors. However, despite an increasing accumulation of knowledge, applications of lipid-packing manipulation as part of cancer therapy are lagging. In this study, to investigate the effect of lipid-packing defects on A549 lung adenocarcinoma cell metastasis, we established a three-dimensional (3D) microfluidic model of tumor-vascular interface to recreate the endothelial barrier. Two parameters of biological membranes, lipid composition and membrane curvature, were modulated to form lipid-packing defects. Lipid composition was regulated by cholesterol depletion using methyl-β-cyclodextrin (MβCD), and membrane curvature was induced by an amphipathic helical peptide. Lipid packing was assessed via a molecular-scale probe, whose emission spectrum was dependent on the molecular order of the immediate membrane environment. Our results suggested that these two distinct modulation ways for lipid-packing defects have a different effect on tumor cellular behaviors. The extravasation and migration of tumor cells were hampered in cholesterol depletion-caused lipid-packing defects, while facilitated in local curvature-induced lipid-packing defects. Therefore, we proposed that lipid-packing defects might serve as an interesting regulation in tumor metastasis, providing a new insight for anticancer therapy.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139584"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A GSH-detection and tumor therapeutic nanoplatform: Dual regulation through non-redox inhibition of NADPH-driven GSH regeneration and depletion for potentiating oxidative stress and ferroptosis GSH检测和肿瘤治疗纳米平台：通过非氧化还原抑制nadph驱动的GSH再生和消耗来增强氧化应激和铁死亡的双重调节

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-01 Epub Date: 2026-02-05 DOI: 10.1016/j.snb.2026.139611

Ruxia Zhang, Xiaoye Wen, Yongfei Huang, Zhefeng Fan

{"title":"A GSH-detection and tumor therapeutic nanoplatform: Dual regulation through non-redox inhibition of NADPH-driven GSH regeneration and depletion for potentiating oxidative stress and ferroptosis","authors":"Ruxia Zhang, Xiaoye Wen, Yongfei Huang, Zhefeng Fan","doi":"10.1016/j.snb.2026.139611","DOIUrl":"10.1016/j.snb.2026.139611","url":null,"abstract":"<div><div>Currently, novel tumor diagnosis and treatment strategies mediated by the exceptional enzyme-like activities of nanozymes demonstrate significant potential in the field of cancer theranostic. However, constrained by the potent antioxidant system of the tumor microenvironment (TME) and the inadequate catalytic activity of nanozymes, endowing nanozymes with high abundance of enzyme-mimicking activities to promote reactive oxygen species (ROS) burst, as well as detecting tumor environmental markers and designing multi-pathway strategies to disrupt TME redox homeostasis, remains a considerable challenge. Herein, a multifunctional PB@<span>L</span>-Arg CeO<sub>2</sub> nanozymes with triple enzyme-mimicking activities (peroxidase, oxidase, and phosphatase-like properties) and remarkable photothermal conversion efficiency was reasonably constructed via an in-situ self-assembly strategy, achieving dual applications of colorimetric detection of glutathione (GSH) and multimodal synergistic therapy for tumors. Notably, the phosphatase-like activity mimicked by PB@<span>L</span>-Arg CeO<sub>2</sub> nanozymes can directly hydrolyze nicotinamide adenine dinucleotide phosphate (NADPH) via a non-redox pathway and effectively inhibit intracellular GSH supply. Combined with GSH deprivation ability, it substantially disrupts the TME redox balance system and promotes the lipid peroxides (LPO) accumulation, further enhancing the ferroptosis effect, thereby significantly inhibiting tumor growth both in vivo and in vitro. In summary, this work provides a new paradigm for the design of nanozyme platforms for cancer diagnosis and multimodal therapeutic based on GSH levels.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139611"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An electroneutral fluorescent probe for revealing lipid droplet viscosity heterogeneity in giant cell tumor of bone 揭示骨巨细胞瘤中脂滴黏度不均一性的电中性荧光探针

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-01 Epub Date: 2026-02-07 DOI: 10.1016/j.snb.2026.139620

Xinyue Li , Mengmeng Dou , Mengqi Yan , Yuezhi Cui , Feifei Sun , Lin Gao , Xuechen Li , Xianhao Shao

{"title":"An electroneutral fluorescent probe for revealing lipid droplet viscosity heterogeneity in giant cell tumor of bone","authors":"Xinyue Li , Mengmeng Dou , Mengqi Yan , Yuezhi Cui , Feifei Sun , Lin Gao , Xuechen Li , Xianhao Shao","doi":"10.1016/j.snb.2026.139620","DOIUrl":"10.1016/j.snb.2026.139620","url":null,"abstract":"<div><div>Dysregulated lipid droplets (LDs) metabolism is implicated in cancer progression, yet its role in giant cell tumor of bone (GCTB) remains obscure due to the lack of suitable imaging tools for the dense tumor microenvironment. Here, we rationally designed an electroneutral molecular rotor as LDs probe based on twisted intramolecular charge transfer (TICT) mechanism. LD-B1 exhibits 13-fold fluorescence enhancement with increasing viscosity (1–1410 cP), high photostability, and excellent specificity for LDs in live cells. Using this probe, we visualized dynamic LDs fusion and mapped spatial heterogeneity in LDs viscosity within patient-derived GCTB tissues. Notably, tumor cells exhibited significantly higher LDs viscosity than myeloid-derived cells. Single-cell/nucleus RNA sequencing revealed the upregulation of lipid metabolic genes (e.g., NNMT and GPX8) in tumor cells. Furthermore, knockdown of these lipid-associated factors led to a decrease in LDs viscosity, while a lipid tracer assay provided direct evidence of intercellular lipid trafficking from myeloid-derived cells to tumor cells. Together, the findings of this work provide a powerful chemical tool for imaging LDs heterogeneity, and reveal LDs viscosity as a potential metabolic hallmark and therapeutic target in musculoskeletal oncology.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139620"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146135284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical capacitance as a Next-Gen tool for kanamycin detection 电化学电容作为新一代卡那霉素检测工具

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-01 Epub Date: 2026-01-30 DOI: 10.1016/j.snb.2026.139552

Amal Rabti , Sami Hamzaoui , Ouassim Ghodbane , Noureddine Raouafi

{"title":"Electrochemical capacitance as a Next-Gen tool for kanamycin detection","authors":"Amal Rabti , Sami Hamzaoui , Ouassim Ghodbane , Noureddine Raouafi","doi":"10.1016/j.snb.2026.139552","DOIUrl":"10.1016/j.snb.2026.139552","url":null,"abstract":"<div><div>Food security is essential for protecting human health; however, the contamination of food and dairy products with antibiotics remains a significant issue. In this study, we developed an innovative capacitance-based aptasensor for kanamycin (KAN) detection by modifying screen-printed electrodes with polyaniline/reduced graphene oxide (PANI/rGO). Electrochemical capacitance spectroscopy (ECS), derived from electrochemical impedance measurements, was successfully used to detect KAN with remarkable sensitivity. Cyclic voltammetry revealed an 85 % decrease in the specific capacitance upon KAN binding, achieving a detection limit of 1.19 fg·mL<sup>−1</sup>. Further analysis of the ECS data allowed the capacitance response to be deconvoluted into double-layer and redox capacitance components, revealing complex interfacial changes and enabling an even lower detection limit of 0.13 fg·mL<sup>−1</sup>. Fitting the ECS data to a Langmuir–Freundlich isotherm indicated heterogeneous binding dynamics between the aptamer and KAN. Across a dynamic range of 1 fg·mL<sup>−1</sup> to 1 ng·mL<sup>−1</sup>, this dual-technique approach provided both highly sensitive detection and a detailed mechanistic understanding of the aptamer–KAN interactions. The combination of ultrasensitive performance and mechanistic insight marks a significant step forward in antibiotic monitoring technologies, with direct implications for food safety applications.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139552"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel photo-controlled CRISPR-Cas12a system based on split crRNA for one-pot detection of multiple viral aerosols 一种基于分裂crRNA的新型光控CRISPR-Cas12a系统，用于一锅检测多种病毒气溶胶

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-01 Epub Date: 2026-02-05 DOI: 10.1016/j.snb.2026.139607

Ze Fan, Xiaoyun Yin, Bin Du, Zhiwei Liu, Jiwei Xu, Xihui Mu, Bing Liu, Jianjie Xu, Zhaoyang Tong

{"title":"A novel photo-controlled CRISPR-Cas12a system based on split crRNA for one-pot detection of multiple viral aerosols","authors":"Ze Fan, Xiaoyun Yin, Bin Du, Zhiwei Liu, Jiwei Xu, Xihui Mu, Bing Liu, Jianjie Xu, Zhaoyang Tong","doi":"10.1016/j.snb.2026.139607","DOIUrl":"10.1016/j.snb.2026.139607","url":null,"abstract":"<div><div>CRISPR-Cas12 technology has revolutionized the field of nucleic acid detection. Although aerosols are a critical transmission route for epidemic viruses, most current CRISPR-based detection technologies focus on liquid samples. Direct detection of viruses in aerosols remains uncommon. In this study, we designed a novel photo-controlled CRISPR-Cas12a detection system based on split crRNA and integrated it with reverse transcription-recombinase polymerase amplification (RT-RPA) technology to develop a “one-pot” detection protocol for viruses in aerosols. By integrating the processes of viral aerosol capture and nucleic acid enrichment, the system can enable the process from aerosol sample input to detection signal output within 1 h. The modular photo-activated CRISPR-Cas12a system constructed in this study, based on split crRNA, addresses the issues in traditional photo-controlled strategies, such as the need to customize blocking sequences for different targets and the cumbersome system optimization process. It provides a universal molecular tool for the detection of various viruses, significantly reducing design costs and enables the simultaneous detection and early warning of H7N9 influenza virus and SARS-CoV-2 in aerosols. This study marks the first application of photo-controlled CRISPR technology in the field of viral aerosol detection. It establishes an integrated platform for viral aerosol detection, enabling both fluorescent detection and LFA-based visual detection of low-abundance viruses in aerosols. The platform provides an accurate, sensitive, rapid, and easy-to-operate universal technical solution for diverse detection needs, and holds practical value for the prevention and control of viral transmission.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139607"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CNN-assisted multimodal biosensing of Staphylococcus aureus using a bimetallic MOF@MXene hybrid nanomaterial 使用双金属MOF@MXene杂化纳米材料的cnn辅助金黄色葡萄球菌的多模态生物传感

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-01 Epub Date: 2026-02-10 DOI: 10.1016/j.snb.2026.139631

Yang Liu , Zhongrui Ma , Zhi Zeng , Huiwen Gu , Xiao Luo , Xiaoli Yin , Ying Chen

{"title":"CNN-assisted multimodal biosensing of Staphylococcus aureus using a bimetallic MOF@MXene hybrid nanomaterial","authors":"Yang Liu , Zhongrui Ma , Zhi Zeng , Huiwen Gu , Xiao Luo , Xiaoli Yin , Ying Chen","doi":"10.1016/j.snb.2026.139631","DOIUrl":"10.1016/j.snb.2026.139631","url":null,"abstract":"<div><div>The rapid and accurate detection of foodborne pathogenic bacteria is critical for ensuring public health and mitigating the global burden of foodborne diseases. Here, we present a multimodal sensing platform enabled by a novel bimetallic hybrid nanomaterial, Au/MOF-919/Ti<sub>3</sub>C<sub>2</sub>T<sub>X</sub>, which integrates intrinsic electrochemical properties with dual enzyme-mimetic activities. This innovative material serves as the cornerstone of a highly sensitive and selective biosensor for the detection of <em>Staphylococcus aureus</em> (<em>S. aureus</em>), a major foodborne pathogen. The detection mechanism leverages a catalytic hairpin assembly cascade reaction on magnetic nanoparticles, amplified by the multifunctional Au/MOF-919/Ti<sub>3</sub>C<sub>2</sub>T<sub>X</sub>, to generate electrochemical and colorimetric signals proportional to the target concentration. Convolutional neural networks were employed to classify and quantify <em>S. aureus</em> concentrations from captured images, enabling intelligent, real-time pathogen identification with precision. The biosensor demonstrates exceptional performance, with a broad linear detection range (10–10<sup>8</sup> CFU mL<sup>−1</sup>) and low detection limits of 5.5 CFU mL<sup>−1</sup> (electrochemical) and 6.6 CFU mL<sup>−1</sup> (colorimetric). Validated in complex food matrices, this platform represents a transformative advance in food safety monitoring, offering a robust, rapid, and scalable solution for pathogen detection. Its integration of nanotechnology, artificial intelligence, and multimodal sensing heralds a new era in biosensing technology, with far-reaching implications for public health and food security.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139631"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146153230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatially differential gold nanocluster amplification of LSPR for ultrasensitive, label-free optical immunoassays LSPR的空间差异金纳米团簇扩增用于超灵敏、无标记光学免疫分析

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-01 Epub Date: 2026-01-29 DOI: 10.1016/j.snb.2026.139569

Zetai Liu , Bangfeng Wang , Yaru Wan , Yangcheng Liu , Mingyu Zhang , Wenqin Wu , Peng Chen , Wei Du , Yiwei Li , Guoping Wang , Xiaojun Feng , Bi-Feng Liu

{"title":"Spatially differential gold nanocluster amplification of LSPR for ultrasensitive, label-free optical immunoassays","authors":"Zetai Liu , Bangfeng Wang , Yaru Wan , Yangcheng Liu , Mingyu Zhang , Wenqin Wu , Peng Chen , Wei Du , Yiwei Li , Guoping Wang , Xiaojun Feng , Bi-Feng Liu","doi":"10.1016/j.snb.2026.139569","DOIUrl":"10.1016/j.snb.2026.139569","url":null,"abstract":"<div><div>The global impact of COVID-19 highlights the critical need for technologies enabling pre-symptomatic pathogen detection to curb pandemics. Addressing this need requires diagnostic sensors with significantly enhanced sensitivity for reliable low-abundance target detection. Here, we report a planar synergistic Cluster-Pore biosensing microchip (CP-Chip) that couples gold nanoclusters (AuNCs) fluorescence with gold nanopore localized surface plasmon resonance (LSPR). We demonstrate that this plasmonic coupling critically depends on the spatial distribution of AuNCs relative to the nanopores. Exploiting spatially differential AuNCs amplification, we designed the CP-Chip so specific target binding modulates AuNCs distribution. This label-free, wash-free approach amplifies optical signals under target-positive conditions while suppressing background in target-negative states, enhancing differential output. The CP-Chip achieves ultrasensitive SARS-CoV-2 nucleocapsid (N) protein detection with a limit of detection of 150 fg/mL—marking a sensitivity gain exceeding three orders of magnitude over previous LSPR methods and proving suitable for low-abundance analysis. Integration with a mobile health platform enables rapid on-site testing. Validated via simulation and targeted antigen-antibody experiments, the CP-Chip emerges as a promising tool for early-stage infectious disease screening.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139569"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0