Sensors and Actuators B: Chemical最新文献_第8页

Multipole electrodes for driving biohybrid robots via selective muscle contraction 通过选择性肌肉收缩驱动生物混合机器人的多极电极

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-07 DOI: 10.1016/j.snb.2025.138924

Yuya Morimoto , Hirone Yamada , Byeongwook Jo , Minghao Nie , Shoji Takeuchi

{"title":"Multipole electrodes for driving biohybrid robots via selective muscle contraction","authors":"Yuya Morimoto , Hirone Yamada , Byeongwook Jo , Minghao Nie , Shoji Takeuchi","doi":"10.1016/j.snb.2025.138924","DOIUrl":"10.1016/j.snb.2025.138924","url":null,"abstract":"<div><div>Biohybrid robots that integrate living muscle tissues with synthetic structures have emerged as platforms for studying animal-like movements and developing soft robotic systems. Skeletal muscle tissues are particularly attractive as actuators due to their high controllability through electrical stimulation. However, in conventional field electrical stimulation, electrical signals tend to disperse through the conductive culture medium, often causing unintentional activation of non-target muscle tissues. To address this limitation, we developed a multipole electrode capable of concentrating the electric field within a localized region around the target muscle. In the multipole electrode, increasing the number of electrode poles improved electric field convergence and reduced unwanted signal spread into surrounding areas. As a demonstration of the practical applicability of the multipole electrode, we constructed an ocular-like biohybrid robot composed of four cultured skeletal muscle tissues and four multipole electrodes. Through sequential and selective stimulation, the robot successfully performed complex and directional motions, including elliptical trajectories. These results confirm that the multipole electrode enables non-contact, spatially precise stimulation of cultured muscle tissues and offers a promising approach for enhancing the functional complexity and degrees of freedom in biohybrid robotic systems.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"448 ","pages":"Article 138924"},"PeriodicalIF":3.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid and label-free detection of BNP and NT-proBNP in human serum using Ti-doped MoTex film-based extended-gate FET biosensors for heart failure diagnosis 基于ti掺杂MoTex薄膜的扩展栅极场效应晶体管生物传感器用于心衰诊断的快速无标记检测人血清中BNP和NT-proBNP

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-06 DOI: 10.1016/j.snb.2025.138922

Tung-Ming Pan , Chao-Hung Chen , Wei-Che Weng

{"title":"Rapid and label-free detection of BNP and NT-proBNP in human serum using Ti-doped MoTex film-based extended-gate FET biosensors for heart failure diagnosis","authors":"Tung-Ming Pan , Chao-Hung Chen , Wei-Che Weng","doi":"10.1016/j.snb.2025.138922","DOIUrl":"10.1016/j.snb.2025.138922","url":null,"abstract":"<div><div>This study presents the first successful RF sputtering of Ti-doped MoTe<sub>x</sub> films onto flexible polyimide (PI) substrates, serving as active sensing layers in extended-gate field-effect transistors (EGFETs). These nanostructured sensors are designed for clinical applications, including accurate pH monitoring and selective detection of B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) in the serum of heart failure patients. The structural, compositional, and morphological characteristics of the films were investigated using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM). EGFET devices fabricated under varying Ti plasma powers (0, 10, 20, and 30 W) demonstrated a strong correlation between structural modifications and sensing performance. The film produced at 20 W exhibited the best results, with a pH sensitivity of 59.02 mV/pH, ultra-low hysteresis (∼ 0.3 mV), and minimal drift (0.25 mV/h). After 180 days, the sensor maintained a near-Nernstian response of ∼ 58.9 mV/pH, confirming excellent long-term stability. It also withstood 500 bending cycles without performance degradation, highlighting its mechanical robustness. For biosensing applications, the Ti-doped MoTe<sub>x</sub> film was modified with APTES and functionalized with BNP or NT-proBNP antibodies through 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) and N-hydroxysuccinimide (NHS) crosslinking. The resulting biosensor exhibited high sensitivity for BNP and NT-proBNP over a wide dynamic range (10<sup>−2</sup>–10<sup>5</sup> pg/mL). Measurements from patient serum samples closely aligned with enzyme-linked immunosorbent assay (ELISA) results, demonstrating its clinical reliability.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"448 ","pages":"Article 138922"},"PeriodicalIF":3.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LaFeO3/Co3O4 nanofibers with p-p heterojunction for enhanced formaldehyde sensing performance at low temperature 具有p-p异质结的LaFeO3/Co3O4纳米纤维增强了低温甲醛传感性能

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-06 DOI: 10.1016/j.snb.2025.138923

Buting Sun , Ruijian Chen , Miao Liu , Qingqing Xie , Peng Song

{"title":"LaFeO3/Co3O4 nanofibers with p-p heterojunction for enhanced formaldehyde sensing performance at low temperature","authors":"Buting Sun , Ruijian Chen , Miao Liu , Qingqing Xie , Peng Song","doi":"10.1016/j.snb.2025.138923","DOIUrl":"10.1016/j.snb.2025.138923","url":null,"abstract":"<div><div>Perovskite semiconductors have been developed rapidly in the field of gas sensors because of their unique structure. In this paper, LaFeO<sub>3</sub>/Co<sub>3</sub>O<sub>4</sub> composite nanofibers were prepared by uniaxial electrospinning combined with annealing. The results demonstrate that the LaFeO<sub>3</sub>/Co<sub>3</sub>O<sub>4</sub> composite exhibits a uniform nanofiber structure with a diameter of about 180 nm and a rough and porous surface. The gas-sensing test data that contrasted with pure LaFeO<sub>3</sub>, the response value of LaFeO<sub>3</sub>/Co<sub>3</sub>O<sub>4</sub> nanofibers to formaldehyde gas was markedly improved (from 12.65 to 27.82), and the operating temperature was also reduced (100 ℃). In addition, it has excellent response-recovery time and stability. Through mechanism analysis and density functional theory (DFT) studies, the improved performance of the LaFeO<sub>3</sub>/Co<sub>3</sub>O<sub>4</sub> sensor is attributed to the porous fiber structure, high specific surface area, abundant oxygen vacancy and p-p heterojunction. In addition, the high catalytic activity of Co<sub>3</sub>O<sub>4</sub> promotes surface chemical reactions, accelerates electron transfer, and greatly improves gas-sensing performance. This paper offers an excellent strategy for the design of high-performance LaFeO<sub>3</sub>-based formaldehyde sensors.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"447 ","pages":"Article 138923"},"PeriodicalIF":3.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colorimetric and photothermal dual-mode vertical flow assay for sensitive detection of Escherichia coli O157:H7 based on 4-mercaptophenylboronic acid-functionalized Cu2-xSe-Au nanozyme 基于4-巯基苯硼酸官能化Cu2-xSe-Au纳米酶的比色法和光热双模垂直流灵敏检测大肠杆菌O157:H7

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-06 DOI: 10.1016/j.snb.2025.138915

Tianran Lin, Xinlian Chen, Xiujuan Chen, Jincui Su, Hong Zhao, Shulin Zhao, Li Hou

{"title":"Colorimetric and photothermal dual-mode vertical flow assay for sensitive detection of Escherichia coli O157:H7 based on 4-mercaptophenylboronic acid-functionalized Cu2-xSe-Au nanozyme","authors":"Tianran Lin, Xinlian Chen, Xiujuan Chen, Jincui Su, Hong Zhao, Shulin Zhao, Li Hou","doi":"10.1016/j.snb.2025.138915","DOIUrl":"10.1016/j.snb.2025.138915","url":null,"abstract":"<div><div>Rapid detection of bacteria and sensitive detection of bacteria are like two sides of a coin, making it difficult to achieve both at the same time. This study designed a colorimetric-photothermal dual-mode vertical flow assay based on 4-mercaptophenylboronic acid (MPBA)-functionalized Cu<sub>2-x</sub>Se-Au nanozyme (Cu<sub>2-x</sub>Se-Au@MPBA). The Cu<sub>2-x</sub>Se-Au@MPBA probes were synthesized through in situ reduction. These probes can bind with target bacteria and the antibodies immobilized on the filter membrane, thereby forming a \"nanomaterial-bacteria-antibody\" sandwich structure. The dual-mode signals come from the peroxidase-like activity and photothermal properties of the Cu<sub>2-x</sub>Se-Au@MPBA nanozyme. Both colorimetric and photothermal modes can be completed in 60 min. This assay demonstrates low detection limits of 26.34 CFU mL⁻¹ in colorimetric mode and 1.91 CFU mL⁻¹ in photothermal mode. Real sample analysis by this assay showed excellent anti-interference capability and reliable recovery rates, which demonstrate a significant potential for applications in food safety monitoring and bioanalysis.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"447 ","pages":"Article 138915"},"PeriodicalIF":3.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Signal-amplified electrochemiluminescent aptasensor for ultrasensitive detection of Escherichia coli O157:H7 using ferrocene-quenched HOF-101 and hybridization chain reaction 二茂铁淬灭HOF-101和杂交链式反应用于超灵敏检测大肠杆菌O157:H7的信号放大电化学发光适体传感器

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-05 DOI: 10.1016/j.snb.2025.138916

Xinyan Zhang , Meifang Hua , Min Chen , Anhui Lin , Tingxiu Ye , Xiaomei Chen

{"title":"Signal-amplified electrochemiluminescent aptasensor for ultrasensitive detection of Escherichia coli O157:H7 using ferrocene-quenched HOF-101 and hybridization chain reaction","authors":"Xinyan Zhang , Meifang Hua , Min Chen , Anhui Lin , Tingxiu Ye , Xiaomei Chen","doi":"10.1016/j.snb.2025.138916","DOIUrl":"10.1016/j.snb.2025.138916","url":null,"abstract":"<div><div>Quick and accurate identification of <em>Escherichia coli</em> O157:H7 is essential for early foodborne illness detection and mitigation. An aptamer-based electrochemiluminescence (ECL) sensor was engineered in this study for fast and precise <em>E. coli</em> O157:H7 detection. Ferrocene (Fc) was identified as an effective quencher of the ECL signal from hydrogen-bonded organic framework material-101 (HOF-101) via electron transfer. Based on this mechanism, HOF-101 was employed as the ECL emitter and Fc as the quencher in the aptasensor design. Furthermore, signal amplification was significantly enhanced through HCR integration with the sensor, which permitted highly sensitive quantification of <em>E. coli</em> O157:H7. For <em>E. coli</em> O157:H7 quantification, the aptasensor showed linearity across 10–10<sup>6</sup> CFU/mL (R<sup>2</sup>=0.993), achieving a remarkable detection limit (LOD) of 0.32 CFU/mL (S/N = 3). Additionally, the ECL aptasensor demonstrated high specificity and sensitivity toward <em>E. coli</em> O157:H7 and was successfully employed for pathogen quantification in spiked milk samples. This work not only establishes a novel approach for detecting foodborne pathogens but also highlights the potential of ECL-based strategies in food safety and environmental monitoring applications.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"447 ","pages":"Article 138916"},"PeriodicalIF":3.7,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic self-oxygen-carrying electrochemical biosensor for highly sensitive detection of sarcosine in a single drop of whole blood 用于高灵敏度检测单滴全血中肌氨酸的仿生自携氧电化学生物传感器

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-05 DOI: 10.1016/j.snb.2025.138918

Ge Wang , Boyuan Zhu , Ke Zhu , Yi Li , Fan Li , Haixia Qin , Yaling Chen , Tianjun Ni , Peng Liu , Yongheng Zhu , Huaping Peng

{"title":"Biomimetic self-oxygen-carrying electrochemical biosensor for highly sensitive detection of sarcosine in a single drop of whole blood","authors":"Ge Wang , Boyuan Zhu , Ke Zhu , Yi Li , Fan Li , Haixia Qin , Yaling Chen , Tianjun Ni , Peng Liu , Yongheng Zhu , Huaping Peng","doi":"10.1016/j.snb.2025.138918","DOIUrl":"10.1016/j.snb.2025.138918","url":null,"abstract":"<div><div>Riboflavin (Rf)-based sarcosine-oxidase mimicry is promising for point-of-care testing (POCT) for sarcosine (Sar) in ultra-micro whole blood. However, its sensitivity is limited by oxygen deficiency and blood interferents. Herein, we engineered a polydopamine (PDA)-coated red blood cell (RBC)-based Rf biosensor (PDA@Rf@RBC) with self-carrying oxygen via haemoglobin, boosting Rf catalysis of Sar while the RBC membrane excludes interferents and the PDA shell relays the electrical signal transmission. These integrated functionalities enable the biomimetic PDA@Rf@RBC biosensor to exhibit high sensitivity and robust anti-interference ability, allowing differential pulse voltammetry analysis with a low detection limit of 200 fM and a wide detection range of 10 pM to 100 μM for Sar. Under normal air conditions, the PDA@Rf@RBC biosensor demonstrates good reproducibility and stability for more than 30 days. Its precision is validated across serum, plasma, and whole blood, allowing POCT of trace abnormal Sar levels from a single drop (25 μL) of whole blood. This capability supports the auxiliary diagnosis of PCa and aids in assessing the risk of cardiovascular diseases. The proposed biomimetic electrochemical biosensor offers an efficient, rapid, and convenient approach for detecting blood Sar levels and establishes a novel design paradigm for oxygen-dependent sensors.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"447 ","pages":"Article 138918"},"PeriodicalIF":3.7,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145229343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

m7G-PIP: Spatially resolved live-cell mapping of m7G-centric RNA-protein interactomes m7G-PIP：以m7g为中心的rna -蛋白相互作用组的空间分辨活细胞定位

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-05 DOI: 10.1016/j.snb.2025.138920

Yao Cheng, Zhong-Da He, Meng-Die Zhu, Qing-Qing Ye, Qing Zhang, Zhi-Gang Wang, Shu-Lin Liu

{"title":"m7G-PIP: Spatially resolved live-cell mapping of m7G-centric RNA-protein interactomes","authors":"Yao Cheng, Zhong-Da He, Meng-Die Zhu, Qing-Qing Ye, Qing Zhang, Zhi-Gang Wang, Shu-Lin Liu","doi":"10.1016/j.snb.2025.138920","DOIUrl":"10.1016/j.snb.2025.138920","url":null,"abstract":"<div><div>m⁷G modification regulates mRNA life cycle and drives progression of cancers and viral infections. Current detection methods, however, rely on antibodies and disrupt native cellular architecture, making live-cell in situ mapping of m⁷G an unmet challenge. To address this, we develop m⁷G-Proximity Interactome Profiling (m⁷G-PIP). This antibody-free technology uses proximity labeling to biotinylate biomolecules proximal to bound m⁷G sites, amplifying signals for nanoscale-resolution (< 20 nm) mapping of RNA-protein interactomes in live cells. Applying this technology to herpes simplex virus-1 (HSV-1), we reveal dynamic m⁷G-centered networks during infection and identify internal m⁷G modifications on viral transcripts—the first such evidence on HSV-1. The modular design of m⁷G-PIP is readily adaptable to profile other RNA modifications with binding proteins. Our work establishes a spatiotemporal framework for epitranscriptome regulation and provides a versatile platform for developing antivirals targeting RNA modification pathways.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"447 ","pages":"Article 138920"},"PeriodicalIF":3.7,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly sensitive cholesterol detection using electrophoretic deposition of silica-coated gold nanoparticles to enhance the FRET effect 高灵敏度的胆固醇检测使用电泳沉积的硅涂层金纳米颗粒，以增强FRET的效果

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-04 DOI: 10.1016/j.snb.2025.138917

Yang Liu, Peng-Fei Xu, Liu Liu, Da-Di Xu, Ao Liu, Ya-Wen Zheng, Yu-Yao Li, Tian-Ning Li, Xiao-Cong Huang, Hong-Wu Tang

{"title":"Highly sensitive cholesterol detection using electrophoretic deposition of silica-coated gold nanoparticles to enhance the FRET effect","authors":"Yang Liu, Peng-Fei Xu, Liu Liu, Da-Di Xu, Ao Liu, Ya-Wen Zheng, Yu-Yao Li, Tian-Ning Li, Xiao-Cong Huang, Hong-Wu Tang","doi":"10.1016/j.snb.2025.138917","DOIUrl":"10.1016/j.snb.2025.138917","url":null,"abstract":"<div><div>We report a sensitive detection method that employs silica‑coated gold nanoparticles (Au@SiO₂) to enhance Förster resonance energy transfer (FRET) between fluorescence molecules rhodamine green (RG) and rhodamine B (RB), which has been applied to the detection of cholesterol as a proof-of-concept study. Excitation spectroscopy and time-resolved fluorescence decay analyses revealed that the presence of Au@SiO<sub>2</sub> enhanced the excitation of RB, shortened the donor’s fluorescence lifetime, facilitated the energy transfer process, and increased both the FRET efficiency and rate. In this process, uniformly sized Au@SiO₂ nanoparticles are synthesized using a one-pot method, with their localized surface plasmon resonance (LSPR) peak matching the excitation peak of RB. An enhancement substrate is fabricated by immobilization of these nanoparticles on an ITO slide using an optimized electrophoretic deposition method, followed by surface amination with aminopropyl silane. RG-modified carboxymethyl-β-cyclodextrin (CR) is employed as the cholesterol recognition unit, which is subsequently linked with the amino-functionalized Au@SiO₂ nanoparticles through an amide bonding reaction. RB was employed as the FRET acceptor, and cholesterol is detected by recording the fluorescence of CR, achieving a detection limit of 8.0 pmol/L, and the system also demonstrates reusable performance.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"447 ","pages":"Article 138917"},"PeriodicalIF":3.7,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of mitochondria-immobilized polarity/viscosity-responsive near-infrared (NIR)-emissive fluorescent probes for the ferroptosis-associated drug screening 线粒体固定化极性/黏度响应近红外（NIR）发射荧光探针用于铁中毒相关药物筛选的开发

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-04 DOI: 10.1016/j.snb.2025.138912

Yu Zhang , Xiaochan Tang , Jiale Ma , Xiuqi Kong , Tao Yue , Baoli Dong

{"title":"Development of mitochondria-immobilized polarity/viscosity-responsive near-infrared (NIR)-emissive fluorescent probes for the ferroptosis-associated drug screening","authors":"Yu Zhang , Xiaochan Tang , Jiale Ma , Xiuqi Kong , Tao Yue , Baoli Dong","doi":"10.1016/j.snb.2025.138912","DOIUrl":"10.1016/j.snb.2025.138912","url":null,"abstract":"<div><div>Exploration of new ferroptosis-associated drugs can provide creationary cytoprotective approaches and innovative therapeutic methods for the formerly incurable diseases. Herein, we present a strategy for the ferroptosis-associated drug screening by employing mitochondria-immobilized NIR-emissive fluorescent probes (<strong>DCP</strong> and <strong>BCV</strong>). Bioimaging results validated <strong>DCP</strong> and <strong>BCV</strong> possessed brilliant mitochondria-immobilized capacity, and erastin-induced ferroptosis observably increases mitochondrial polarity/viscosity. Quercetin was esterified to provide various derivatives with higher partition coefficients (logP). By using mitochondrial polarity/viscosity as indicators, the acetylated quercetin was screened as a potent drug to inhibit ferroptosis. Aided by optical tests and HPLC analysis, the inhibition mechanism of acetylated quercetin to ferroptosis was speculated to base on the integration of the Fe(II)-chelating effect and antioxidative activity of quercetin. Collectively, this work demonstrated that fluorescence imaging of mitochondrial polarity/viscosity can afford a convenient and tangible strategy to screen new ferroptosis-associated drugs.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"447 ","pages":"Article 138912"},"PeriodicalIF":3.7,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasticized PVC/CNT flexible electrodes for highly responsive, stable, and durable soft actuators and wearable sensors 塑化PVC/碳纳米管柔性电极的高响应，稳定，耐用的软执行器和可穿戴传感器

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-03 DOI: 10.1016/j.snb.2025.138894

Yi Li , Ziqian Zhang , Hangzhong Zhu , Jiaxing Sun , Mingfei Guo , Xi Zeng , Yanbiao Li , Minoru Hashimoto

{"title":"Plasticized PVC/CNT flexible electrodes for highly responsive, stable, and durable soft actuators and wearable sensors","authors":"Yi Li , Ziqian Zhang , Hangzhong Zhu , Jiaxing Sun , Mingfei Guo , Xi Zeng , Yanbiao Li , Minoru Hashimoto","doi":"10.1016/j.snb.2025.138894","DOIUrl":"10.1016/j.snb.2025.138894","url":null,"abstract":"<div><div>Plasticized polyvinyl chloride (PVC) gels have shown increasing potential for developing integrated actuation and sensing devices in soft robotics and wearable electronics. Notably, the flexible electrodes in PVC gel-based devices are crucial to their overall performance. However, traditional carbon grease electrodes substantially limit the functionality and stability of such devices, primarily due to their uneven distribution and inherent durability. To address these limitations, we propose a novel PVC/carbon nanotubes (CNTs) gel electrode (GE) for constructing dual-mode actuation-sensing devices with high performance and stability. We investigated the effects of three representative fillers-carbon black, graphene, and CNTs on the formation of molecular networks of the gel. Owing to its intrinsic one-dimensional geometry, CNTs facilitate the formation of a 3D percolating network, enabling PVC/CNTs GE (PCGE) to achieve an unprecedented charge carrier density of 3.31 × 10 ¹ ⁷ cm⁻³ . The PCGE demonstrates a high electrical conductivity of 79.9 mS/cm (4.2 times higher than carbon grease), an ultralow 30-day impedance growth rate of 8.4 % (a 70-fold reduction), and a minimal 10,000-cycle drift of 1.25 %(a 51-fold improvement), surpassing carbon grease in both conductivity and durability for flexible electronic applications. The PCGE-based bending actuators exhibited remarkable performance (182° at 3 V/μm) and a fast response (2 Hz). Moreover, the PCGE-based sensors achieved high sensitivity (GF>35), precise resolution (0.06 %), and ideal dynamic response (0.5–4 Hz), addressing the durability limitations of carbon grease. Additionally, the actuators achieve biomimetic applications in robotics, demonstrating their potential as artificial muscles. In contrast, the sensors enable motion tracking, showcasing broad applicability in intelligent sensing systems.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"447 ","pages":"Article 138894"},"PeriodicalIF":3.7,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0