Sensors and Actuators B: Chemical最新文献_第8页

Classification of normal, AML, and ALL bone marrow smears based on deep learning and hyperspectral microscopic imaging

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-14 DOI: 10.1016/j.snb.2025.137800

Hai Yin , Li Li , Qihang Yang , Fangyuan Huang , Jinfang Ma , Zhi Zhou , Danhui Gan , Furong Huang

{"title":"Classification of normal, AML, and ALL bone marrow smears based on deep learning and hyperspectral microscopic imaging","authors":"Hai Yin , Li Li , Qihang Yang , Fangyuan Huang , Jinfang Ma , Zhi Zhou , Danhui Gan , Furong Huang","doi":"10.1016/j.snb.2025.137800","DOIUrl":"10.1016/j.snb.2025.137800","url":null,"abstract":"<div><div>Bone marrow smear examination is critical in leukemia diagnosis, yet traditional manual methods face reliability and efficiency challenges. This study proposes a multimodal open-set recognition method that integrates deep learning with hyperspectral microscopy imaging. By analyzing the proportions of different cell categories, the method automatically classifies bone marrow smears into normal, acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL). Bone marrow smear samples from 120 patients were collected and imaged using a hyperspectral microscopic imaging system. Individual cells were successfully segmented using U²-Net and image registration algorithms, resulting in spectral and image data for a total of 6606 cells. Based on these data, two one-dimensional convolutional neural networks (1D CNNs) architectures were designed for spectral data, two two-dimensional convolutional neural networks (2D CNNs) architectures were created for image data, and a dual-branch heterogeneous architecture consisting of parallel spectral and image branches was developed to simultaneously process both spectral and image data. Experimental results demonstrated that the optimal dual-branch heterogeneous architecture model based on fused spectral-image data achieved an accuracy of 91.57 % in open-set external validation, and attained 100 % accuracy in distinguishing normal, AML, and ALL in a subset of 19 bone marrow smear samples. Thus, by combining deep learning and hyperspectral microscopy imaging technology and introducing an open-set recognition method, this study achieved high-accuracy differentiation of bone marrow smears, significantly enhancing leukemia diagnostic efficiency and accuracy, and providing new insights and methods for leukemia diagnosis and classification.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"438 ","pages":"Article 137800"},"PeriodicalIF":8.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naphthalene-dicyanoisophorone hybrid fluorescent probe for detection of hypochlorite based on cyclization mechanism 基于环化机制的用于检测次氯酸盐的萘-二氰异佛尔酮杂化荧光探针

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-14 DOI: 10.1016/j.snb.2025.137808

Mengjie Liu, Yanjin Wang, Miaoyu Wang, Pengfei Cheng, Kuoxi Xu

引用次数: 0

A versatile 980 nm excitable small molecule for short-wave infrared fluorescence imaging guided type-I photodynamic/photothermal therapy 用于短波红外荧光成像引导的 I 型光动力/光热疗法的多功能 980 纳米可激发小分子

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-14 DOI: 10.1016/j.snb.2025.137807

Qi Wang , Youguang Tang , Guoshuai Yang , Ze Tao , Sheng Li , Ruoqing Wang , Meixing Li , Renyong Geng , Jiefeng Hai , Feng Lu

{"title":"A versatile 980 nm excitable small molecule for short-wave infrared fluorescence imaging guided type-I photodynamic/photothermal therapy","authors":"Qi Wang , Youguang Tang , Guoshuai Yang , Ze Tao , Sheng Li , Ruoqing Wang , Meixing Li , Renyong Geng , Jiefeng Hai , Feng Lu","doi":"10.1016/j.snb.2025.137807","DOIUrl":"10.1016/j.snb.2025.137807","url":null,"abstract":"<div><div>Current nanoagents for efficient deep-seated tumor phototheranostics are still facing many barriers, such as limited light penetration depth, insufficient reactive oxygen species production in anaerobic microenvironment, and dissatisfied imaging accuracy. Herein, an A-D-A type small molecule BTP-3V was synthesized. The strong push-pull effect enabled BTP-3V nanoparticles (NPs) to absorb light in the region of 600–1100 nm (extinction coefficient at 980 nm: 3.92 × 10<sup>4</sup> M<sup>−1</sup> cm<sup>−1</sup>) and emit in the region of 1000–1400 nm (Stokes shift: 283 nm). Upon 980 nm laser excitation, BTP-3V NPs showed efficient hydroxyl radical and superoxide radical production for type-I photodynamic therapy, greatly overcoming the anaerobic disadvantage of malignant tumors. Moreover, the NPs also showed excellent photothermal performance with high photothermal conversion efficiency (39.4 %). In vitro and in vivo investigations corroborated that the biocompatible BTP-3V NPs exhibited remarkable anti-tumor outcome upon 980 nm laser irradiation, benefiting from the combination of type-I photodynamic and photothermal therapy. Significantly, with the short-wave infrared fluorescence emission, BTP-3V NPs could achieve high-resolution imaging of vascular structure, accurate localization of tumor and facile detection of the enrichment and distribution of NPs within the tumor. This study provides valuable insights into nanomaterials for deep-tissue phototheranostics.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"438 ","pages":"Article 137807"},"PeriodicalIF":8.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Se and N doped hierarchical porous carbon nanozyme-mediated colorimetric sensing array for antioxidants discrimination

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-13 DOI: 10.1016/j.snb.2025.137785

Lijuan Yan , Xiangkun Jia , Ruimin Li , Peipei Zong , Chengjie Chen , Dongbo Yan , Xiaotong Li , Congxiao Wang , Yanling Zhai , Lei Jiao

引用次数: 0

Global DNA methylation level sensing using methyl-CpG binding domain-fused luciferase and fluorescent protein

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-12 DOI: 10.1016/j.snb.2025.137797

Yuto Shoji , Yuno Ikeda , Rie Rin , Koichiro Doi , Masayoshi Tanaka , Wataru Yoshida

{"title":"Global DNA methylation level sensing using methyl-CpG binding domain-fused luciferase and fluorescent protein","authors":"Yuto Shoji , Yuno Ikeda , Rie Rin , Koichiro Doi , Masayoshi Tanaka , Wataru Yoshida","doi":"10.1016/j.snb.2025.137797","DOIUrl":"10.1016/j.snb.2025.137797","url":null,"abstract":"<div><div>Methylation at the 5-position of cytosine in CpG dinucleotides is involved in the regulation of gene expression. In cancer cells, aberrant CpG methylation patterns are observed, characterized by promoter hypermethylation on tumor suppressor genes and global hypomethylation inducing genomic instability. We previously reported that global DNA methylation levels were quantified by bioluminescence resonance energy transfer (BRET) between methyl-CpG binding domain (MBD)-fused firefly luciferase and DNA intercalating dye. The assay simply and accurately detects global DNA methylation levels, but requires a 30-min incubation period for the DNA intercalating dye to bind to genomic DNA. In this study, a rapid system for measuring global DNA methylation levels was developed using MBD-fused NanoLuc luciferase (Nluc) and MBD-fused fluorescent protein, monomeric Venus (mVenus). When the MBD-fused Nluc and MBD-fused mVenus simultaneously bind to adjacent methyl-CpGs, the amount of which is associated with the global DNA methylation level, BRET occurs between two. We demonstrated that the BRET signal between MBD-fused Nluc and MBD-fused mVenus was detected on double-stranded DNA containing two methyl-CpG sites, and the efficiency depended on the distance between two methyl-CpG sites. In addition, global DNA methylation levels were quantified within 3min by the BRET assay (<em>R</em><sup>2</sup> = 0.99). These results indicate that the global DNA methylation levels can be easily, accurately, and rapidly quantified by the BRET assay using MBD-fused Nluc and MBD-fused mVenus.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"438 ","pages":"Article 137797"},"PeriodicalIF":8.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Kresling origami-enabled soft robot toward autonomous obstacle avoidance and wall-climbing

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-12 DOI: 10.1016/j.snb.2025.137792

Sicheng Chen , Zhilin Yu , Alin Duan , Amèvi Tongne , Yahui Li , Wenling Zhang

{"title":"A Kresling origami-enabled soft robot toward autonomous obstacle avoidance and wall-climbing","authors":"Sicheng Chen , Zhilin Yu , Alin Duan , Amèvi Tongne , Yahui Li , Wenling Zhang","doi":"10.1016/j.snb.2025.137792","DOIUrl":"10.1016/j.snb.2025.137792","url":null,"abstract":"<div><div>In recent years, soft robotics has rapidly emerged as a prominent research topic, unlocking new possibilities for addressing real-world challenges. However, enabling soft robots to achieve autonomous motion in confined spaces remains a significant hurdle. To address this, we propose a highly integrated soft robot capable of wall-climbing transitional motion and tactile perception in narrow spaces, equipped with closed-loop sensing and control capabilities. The robot's mechanical structure leverages the ingenious design of the Kresling origami architecture combined with flexible materials, enabling smooth transitional movements from flat-surface crawling to various angles ranging from 0° to 90° within a confined 2 cm space. Furthermore, by in-situ integrating a highly sensitive and flexible planar capacitive contact sensor at the robot's tip, it can rapidly detect and respond to obstacles. This customized sensor exhibits an impressive response time and maintains durability over 1000 cycles. The real-time sensing data is fed back to the controller, facilitating closed-loop obstacle avoidance and autonomous motion. This innovative design, combining advanced mechanical architecture with a closed-loop sensing strategy, provides a promising pathway for developing soft robots capable of autonomous operation in constrained and dynamic environments.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"438 ","pages":"Article 137792"},"PeriodicalIF":8.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piezoelectric micro diaphragm based high performance humidity sensor

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-11 DOI: 10.1016/j.snb.2025.137760

Jihang Liu , Doris Keh Ting Ng , Yul Koh , Subhranu Samanta , Linfang Xu , Md Hazwani Khairy Md Husni , Merugu Srinivas , Alberto Leotti , Young Jik Hur , Qingxin Zhang , Yao Zhu

{"title":"Piezoelectric micro diaphragm based high performance humidity sensor","authors":"Jihang Liu , Doris Keh Ting Ng , Yul Koh , Subhranu Samanta , Linfang Xu , Md Hazwani Khairy Md Husni , Merugu Srinivas , Alberto Leotti , Young Jik Hur , Qingxin Zhang , Yao Zhu","doi":"10.1016/j.snb.2025.137760","DOIUrl":"10.1016/j.snb.2025.137760","url":null,"abstract":"<div><div>This paper presents a novel humidity sensor based on a piezoelectric micro diaphragm (PMD) resonator integrated with a zinc oxide (ZnO) sensing layer, demonstrating exceptional performance through stress-based sensing mechanisms. Unlike conventional mass-loading based sensors, our design uniquely leverages the PMD's flexible vibration modes combined with a ZnO sensing layer to achieve unprecedented sensitivity. The sensor exhibits dual-mode operation at low frequencies of 0.17 MHz and 0.68 MHz, where the second mode demonstrates remarkable humidity sensitivity reaching 638–4110 Hz/%RH and achieves outstanding figure of merit (FOM) values of 943–6080 ppm/%RH from low relative humidity range (0.6 % RH∼80 % RH) to high relative humidity range (80 % RH∼90 % RH), surpassing current state-of-the-art technologies by more than an order of magnitude. Systematic characterization reveals fast response characteristics with T<sub>63</sub> absorption/desorption times of 5/11 s and excellent selectivity against common gases. The enhanced performance of the second mode is attributed to its complex modal pattern enabling more effective stress distribution, as verified through finite element analysis and experimental validation. This work establishes PMD architecture as a promising platform for high-performance humidity sensing applications, offering an optimal balance between sensitivity, response time, and system integration capabilities. Additionally, the versatile stress-based sensing mechanism can be adapted for detecting various gas molecules of societal importance by simply modifying the sensing layer, enabling broader environmental monitoring applications.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"438 ","pages":"Article 137760"},"PeriodicalIF":8.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Balancing the p- and n-type conductivities of the ZnO/graft-poly(3-hexylthiophene) copolymer nanocomposite to achieve sub-ppb NO2 detection in chemiresistive sensors at room temperature

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-11 DOI: 10.1016/j.snb.2025.137726

Piotr Kałużyński , Marcin Procek , Agnieszka Stolarczyk , Karolina Głosz , Tomasz Jarosz

{"title":"Balancing the p- and n-type conductivities of the ZnO/graft-poly(3-hexylthiophene) copolymer nanocomposite to achieve sub-ppb NO2 detection in chemiresistive sensors at room temperature","authors":"Piotr Kałużyński , Marcin Procek , Agnieszka Stolarczyk , Karolina Głosz , Tomasz Jarosz","doi":"10.1016/j.snb.2025.137726","DOIUrl":"10.1016/j.snb.2025.137726","url":null,"abstract":"<div><div>Hybrid organic/inorganic composites are a frequent material used in chemoresistive sensors. These composites typically contain components that exhibit p- and n-type electrical conductivity, so as to enable the formation of p–n junctions and increase the sensitivity of the sensors. The specific mechanism behind the operation of such junctions appears to be well-understood and is rarely examined on a case-by-case basis. The interactions between p- and n-type conductors, however, need not be beneficial to the performance of the sensor. In this work, we provide evidence of the competition between p- and n-type conductivities of a hybrid nanocomposite activated by UV light, subjected to ageing and provide a mechanistic description of the underlying processes, as well as indicate potential for such phenomena to be harnessed in development of future sensor generations. By using nanocomposite consist of nanostructured ZnO and poly(3-hexylthiophene) based graft-comb-copolymers we obtained sensor material that can achieve sub-ppb detection limit of NO<sub>2</sub> (as low as 50 ppt) capabilities at room temperature. It is experimentally demonstrated that proper choice of polymer material used in the nanocomposite provide stabilisation of baseline drift and lowers limit of the detection while ensuring good adhesion of the receptor layer to the substrate.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"438 ","pages":"Article 137726"},"PeriodicalIF":8.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrowetting on swollen dielectric-hydrophobic composite PDMS film for digital microfluidics

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-11 DOI: 10.1016/j.snb.2025.137793

Xiaodong He, Qingyuan Huang, Jingsong Xu

{"title":"Electrowetting on swollen dielectric-hydrophobic composite PDMS film for digital microfluidics","authors":"Xiaodong He, Qingyuan Huang, Jingsong Xu","doi":"10.1016/j.snb.2025.137793","DOIUrl":"10.1016/j.snb.2025.137793","url":null,"abstract":"<div><div>Polydimethylsiloxane (PDMS), a commonly used material, serves as both a dielectric layer and a hydrophobic surface in digital microfluidics (DMF) systems. However, its low dielectric constant results in suboptimal electrowetting-on-dielectric (EWOD) performance, limiting its application in DMF systems. In this study, a novel dielectric-hydrophobic integrated film, termed swollen composite PDMS (S-CPDMS), was developed. This film was fabricated by combining the ferroelectric polymer Poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) with PDMS and enhancing surface hydrophobicity and smoothness through the application of silicone oil as a liquid lubricant. Experimental results demonstrated that the S-CPDMS film exhibits excellent hydrophobicity, high optical transparency, anti-biofouling properties, and smooth sliding performance. The effects of film composition, applied voltage frequency, and vertical placement time after silicone oil injection on its EWOD behavior were systematically investigated. The findings revealed that the S-CPDMS film achieves optimal EWOD performance when the P(VDF-TrFE) to PDMS ratio is 3:1. Furthermore, under a 1 kHz square wave alternating current (AC), the droplets on the film exhibited strong EWOD responsiveness and high reversibility. Using the S-CPDMS film, a DMF device was constructed, successfully enabling droplet manipulation in both open and closed environments. Finally, glucose colorimetric reactions were successfully performed in the DMF device utilizing the S-CPDMS film. This dielectric-hydrophobic integrated film offers a simple and cost-effective solution for integrating dielectric and hydrophobic layers in DMF systems, opening new possibilities for developing lab-on-a-chip platforms.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"438 ","pages":"Article 137793"},"PeriodicalIF":8.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemiresistive triethylamine sensor based on Rh2O3-loaded core-shell LaFeO3 porous spheres and DFT study to explain its behavior

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-11 DOI: 10.1016/j.snb.2025.137791

Junkai Shao , Shangyan Wang , Yuhang Qi , Guofeng Pan , Xueli Yang , Lianjun Hu , Meiyan Qiu

{"title":"Chemiresistive triethylamine sensor based on Rh2O3-loaded core-shell LaFeO3 porous spheres and DFT study to explain its behavior","authors":"Junkai Shao , Shangyan Wang , Yuhang Qi , Guofeng Pan , Xueli Yang , Lianjun Hu , Meiyan Qiu","doi":"10.1016/j.snb.2025.137791","DOIUrl":"10.1016/j.snb.2025.137791","url":null,"abstract":"<div><div>In this work, LaFeO<sub>3</sub> nanopowders with a core-shell structure were successfully synthesized using a facile hydrothermal method combined with wet impregnation to load varying amounts of Rh<sub>2</sub>O<sub>3</sub> nanoparticles on the surface of core-shell spheres. Characterization results confirm that the synthesized Rh<sub>2</sub>O<sub>3</sub>-Fe<sub>2</sub>O<sub>3</sub>/LaFeO<sub>3</sub> samples have a core-shell structure with uniformly distributed Rh<sub>2</sub>O<sub>3</sub> nanoparticles on the surface. In gas sensing studies, the sensor based on 2 at% Rh<sub>2</sub>O<sub>3</sub>-Fe<sub>2</sub>O<sub>3</sub>/LaFeO<sub>3</sub> core-shell spheres exhibited significantly enhanced performance (more than four times higher) for detecting triethylamine (TEA) compared to pristine Fe<sub>2</sub>O<sub>3</sub>/LaFeO<sub>3</sub> core-shell microspheres. At an operating temperature of 200°C, the sensor showed a response value of 237 for 100 ppm TEA with a very low detection limit (50 ppb, 1.2) and much faster response/recovery time (47 s/12 s). The performance improvement is due to changes in the potential barrier at the Rh<sub>2</sub>O<sub>3</sub> and Fe<sub>2</sub>O<sub>3</sub>/LaFeO<sub>3</sub> interface, enhancing charge transfer. Additionally, based on first principles calculations, this work examines the adsorption energy and possible adsorption configurations of adsorbates. The Rh element acts as a negative charge center, which facilitates gas adsorption and reactions on the surface via a spillover effect. This study offers a promising candidate for TEA sensing and theoretical insights into high-performance sensor development.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"438 ","pages":"Article 137791"},"PeriodicalIF":8.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0