Sensors and Actuators B: Chemical最新文献

Evaluation and reduction of matrix effect by deep eutectic solvents in lateral flow assays: A case study for zearalenone detection in different food matrices 深层共晶溶剂在横向流动测定中基质效应的评价和降低：以不同食品基质中玉米赤霉烯酮检测为例

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-30 DOI: 10.1016/j.snb.2025.137901

Qingyue Li , Mengtian Chen , Jieling Ren , Sichang Li , Tong Bu , Yang Wang , Xianqing Huang , Lianjun Song , Liang Liu , Ruifeng Luo , Yexuan Mao , Xiya Zhang

{"title":"Evaluation and reduction of matrix effect by deep eutectic solvents in lateral flow assays: A case study for zearalenone detection in different food matrices","authors":"Qingyue Li , Mengtian Chen , Jieling Ren , Sichang Li , Tong Bu , Yang Wang , Xianqing Huang , Lianjun Song , Liang Liu , Ruifeng Luo , Yexuan Mao , Xiya Zhang","doi":"10.1016/j.snb.2025.137901","DOIUrl":"10.1016/j.snb.2025.137901","url":null,"abstract":"<div><div>The food samples with high-fat content could induce matrix effects and interfere with the accuracy of lateral flow immunoassays (LFA), while deep eutectic solvents (DESs) as the innovative extraction solution had great potential to decrease this effect by rational design. First, 24 samples were evaluated for the detection performance of LFA using zearalenone (ZEN) as the target, and we found that black sesame, pecan, cashew, and pistachio with high-fat content could seriously affect recoveries and limit of detection (LOD), generating high matrix effects. To address this issue, six DESs with different polarities were designed by arrangement of two hydrogen bond donors and three hydrogen bond acceptors. DES-4, composed of betaine and ethylene glycol with a molar ratio of 1:4, displayed a lower molecular polarity index, which was similar to ZEN and possessed significant differences with fatty acids. Subsequently, DES-4 was applied to LFA for ZEN detection in these four high-fat matrices. After centrifugation, 70.5 %-92.3 % of fat in food matrices was transferred to the upper layer, and the fat content of the detection phase and food matrices phase by DESs extraction was 77.0–290.2 mg, obviously lower than that by acetonitrile/water extraction. Moreover, the recoveries ranged from 82.01 % to 114.26 % after diluting 50–70 times, and the LODs were 1.72–4.06 ng/mL, which were 1.4–4.6 times lower than that of acetonitrile/water extraction. Hence, DESs were considered as promising extraction reagents to reduce the high fat-induced matrix effects, which may be broadened to other target detection.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137901"},"PeriodicalIF":8.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecularly Tailored Pd@Pt Nanozymes for Real-Time Smartphone-Assisted Acetylcholinesterase Detection and Therapeutic Inhibitor Assessment 分子定制Pd@Pt纳米酶实时智能手机辅助乙酰胆碱酯酶检测和治疗抑制剂评估

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-30 DOI: 10.1016/j.snb.2025.137889

Yanru Zhou, Tian Luan, Qi Fang, Yu Zhang, Yan Du

{"title":"Molecularly Tailored Pd@Pt Nanozymes for Real-Time Smartphone-Assisted Acetylcholinesterase Detection and Therapeutic Inhibitor Assessment","authors":"Yanru Zhou, Tian Luan, Qi Fang, Yu Zhang, Yan Du","doi":"10.1016/j.snb.2025.137889","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137889","url":null,"abstract":"The detection of acetylcholinesterase (AChE) activity is of paramount importance for diagnosing neurological disorders and screening potential therapeutic inhibitors. Herein, we present a novel colorimetric biosensor for AChE activity and inhibitor detection, enabled by L-isoleucine-modified Pd@Pt nanoparticles (IlePd@Pt NPs) with enhanced peroxidase-like (POD-like) activity. Utilizing twenty-two amino acids as surface ligands, L-isoleucine was identified as the optimal modifier, achieving remarkable catalytic performance through a unique interaction between its side-chain structure and the nanoparticle surface. Molecular dynamics simulations revealed the mechanistic basis of this enhancement, providing atomic-scale insights into the reduced binding energy with substrates (H<sub>2</sub>O<sub>2</sub> and TMB) and the resulting catalytic optimization. The biosensor exhibits high sensitivity, with limits of detection (LODs) of 0.205 mU/mL and 0.799 mU/mL when using a microplate reader and a smartphone, respectively. Its integration with smartphone-based analysis enables portable, cost-effective, and user-friendly point-of-care testing (POCT). Furthermore, the biosensor demonstrated robust performance in real biological samples, including human and fetal bovine serum, with excellent recovery rates. The platform also facilitated the screening of AChE inhibitors, effectively evaluating tacrine with an IC<sub>50</sub> of 14.0 nM, underscoring its potential for drug discovery and clinical applications. This work provides a significant advancement in the field of nanozyme-based biosensors by combining high catalytic activity, computational insights, and practical applicability. The proposed system offers a simplified yet powerful tool for real-time diagnostics and pharmaceutical research, addressing critical needs in healthcare and biomedical science.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"47 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OEVS-Fusion: Olfactory -Enhanced Visual Semantic Recognition Framework for Ground Stain Detection in Indoor Environments oevs融合：用于室内环境中地面污渍检测的嗅觉增强视觉语义识别框架

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-30 DOI: 10.1016/j.snb.2025.137902

Long Zhang, Jiantao Shi, Xiang Wei, Lihang Feng

引用次数: 0

Brilliant hollow SiO2-based structural colors for water infiltration, warning and information encoding 明亮的空心sio2结构色，用于水渗透、预警和信息编码

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-30 DOI: 10.1016/j.snb.2025.137904

Guoyi Pan, Jiaying Zhang, Zhiyi Huang, Jiaxin Li, Xingshan Yin, Wenjing Lin, Xiaofeng Lin, Yingjuan Sun, Guobin Yi

{"title":"Brilliant hollow SiO2-based structural colors for water infiltration, warning and information encoding","authors":"Guoyi Pan, Jiaying Zhang, Zhiyi Huang, Jiaxin Li, Xingshan Yin, Wenjing Lin, Xiaofeng Lin, Yingjuan Sun, Guobin Yi","doi":"10.1016/j.snb.2025.137904","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137904","url":null,"abstract":"A series of functional stimulus-response indicators based on the multi-color regulation mechanisms of Bragg's law were developed. However, they were basically fast-response and high-sensitivity systems. Herein, this paper introduced a novel approach using slow water infiltration to regulate structural color photonic band gaps (PBG), which was more conducive to temporal monitoring, with applications in water penetration, warning systems, and information encoding. The hollow SiO<sub>2</sub> and polyethylene glycol diacrylate (PEGDA) films were employed as structural units, showing that the color-changing ability of the hollow SiO<sub>2</sub>-based structural color films was negatively correlated with the SiO<sub>2</sub> thickness. Additionally, the RGB values were analyzed through images, demonstrating the slow color-changing characteristics of these films. The results indicated that both methods exhibited similar trends, confirming that these two characterization techniques effectively reflected the color change under water infiltration conditions. Furthermore, these bright and water-permeable materials, when used in conjunction with inverse PC structures for synergistic water-induced color-change response tags, were effective for reversible information recognition. Moreover, this type of material possessed excellent water-penetration rate adjustment capabilities, which could further enhance its encryption potential. Therefore, the hollow SiO<sub>2</sub>-based structural color material was further applied in fields such as large indoor cold storage warehouses and eco-smart aquariums. These tags were able to effectively prevent temperature rise risks in frozen goods due to power outages and served as built-in anti-counterfeiting labels, offering strong anti-counterfeiting capabilities.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"25 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Dual-Responsive Ratiometric Fluorescent Probe for Simultaneous Monitoring of Lipophagy and HOCl in Non-alcoholic Fatty Liver Disease 双响应比例荧光探针同时监测非酒精性脂肪性肝病的脂噬和HOCl

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-29 DOI: 10.1016/j.snb.2025.137885

Shuyang Zhai, Zhiqiang Mao, Zhihong Liu, Yingbin Liu

{"title":"A Dual-Responsive Ratiometric Fluorescent Probe for Simultaneous Monitoring of Lipophagy and HOCl in Non-alcoholic Fatty Liver Disease","authors":"Shuyang Zhai, Zhiqiang Mao, Zhihong Liu, Yingbin Liu","doi":"10.1016/j.snb.2025.137885","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137885","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is a prevalent liver disorder closely associated with dysregulated lipid metabolism and increased oxidative stress. To better understand the underlying pathological mechanisms of NAFLD and identify potential therapeutic strategies, we developed a novel dual-response fluorescent probe, Pola-HOCl, which enables the simultaneous monitoring of intracellular lipid droplet polarity and hypochlorous acid (HOCl) levels, providing new perspectives for the potential early diagnosis and treatment of NAFLD. By employing the through bond energy transfer (TBET) mechanism, Pola-HOCl minimizes spectral crosstalk, ensuring precise and reliable measurements. Both <em>in vitro</em> and <em>in vivo</em> experiments demonstrated that Pola-HOCl exhibits superior sensitivity and specificity in detecting lipid droplet dynamics and oxidative stress, offering valuable insights into the role of lipophagy in mitigating oxidative damage in NAFLD. This study underscores the practical application of Pola-HOCl for investigating the complex interplay between lipophagy and oxidative stress, and introduces a novel approach to explore the pathophysiological mechanisms underlying NAFLD.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"81 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

All-printed flexible self-powered humidity sensor 全印刷柔性自供电湿度传感器

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-29 DOI: 10.1016/j.snb.2025.137868

Weiwei Zhao, Quancai Li, Qian Wang, Zhiyi Li, Jing Liang, Wei Wu

{"title":"All-printed flexible self-powered humidity sensor","authors":"Weiwei Zhao, Quancai Li, Qian Wang, Zhiyi Li, Jing Liang, Wei Wu","doi":"10.1016/j.snb.2025.137868","DOIUrl":"10.1016/j.snb.2025.137868","url":null,"abstract":"<div><div>Existing humidity sensors are often large in size and complex in structure due to the limitations of the power supply form. Traditional self-powered humidity sensor devices also often require complex preparation processes or have a narrow humidity response range and a low maximum voltage response, which significantly limits their application range. Herein, a paper-based fully printed flexible self-powered humidity sensor (FSHS), based on electrochemical principles, is proposed for the first time. This innovative sensor, combined with conventional screen-printing technology, enables the integration of low-cost, customizable, 2D, and non-contact humidity sensing devices. The anode ink, cathode ink, and sensing layer are printed on the paper as planar interdigital electrodes to form a FSHS with self-powered and humidity sensing functions. This sensor features a simple preparation process, a wide response range (11 %-95 % RH), ultra-high voltage response (1.03 V), excellent long-term stability, rapid response/recovery times, and excellent linearity between voltage response and humidity. It demonstrates exceptional flexibility, with virtually no change in voltage under extreme bending conditions. Additionally, this FSHS can be made into various shapes/patterns, making it ideal for wearable respiratory detection devices, non-contact buttons, and energy storage in specialized circumstances.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137868"},"PeriodicalIF":8.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An integrated microfluidic platform for multi-target nucleic acid detection based on rotational magnetic field-induced uniform bead distribution 基于旋转磁场诱导均匀磁珠分布的多靶点核酸检测集成微流控平台

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-29 DOI: 10.1016/j.snb.2025.137892

Ming Cheng , Jun Li , Shilun Feng , Enjia Zhang , Boyue Wu , Gaozhe Cai , Xiaojun Bian , Chunping Jia , Jianlong Zhao

{"title":"An integrated microfluidic platform for multi-target nucleic acid detection based on rotational magnetic field-induced uniform bead distribution","authors":"Ming Cheng , Jun Li , Shilun Feng , Enjia Zhang , Boyue Wu , Gaozhe Cai , Xiaojun Bian , Chunping Jia , Jianlong Zhao","doi":"10.1016/j.snb.2025.137892","DOIUrl":"10.1016/j.snb.2025.137892","url":null,"abstract":"<div><div>Efficient multi-pathogen detection remains crucial during concurrent respiratory disease outbreaks, yet existing multiplex platforms are limited by complex fluorescent encoding and high reagent costs. This study introduces a novel microfluidic chip system incorporating rotational magnetic control for simultaneous multi-pathogen nucleic acid detection. The system utilized a unique rotating magnetic field to drive the magnetic beads to actively and dynamically capture nucleic acid in the solution, enabling a \"one-to-four division\" of the beads and subsequently achieving a \"one-to-four division\" of the nucleic acid sample. Under optimized conditions, a rotating magnetic field generated by four symmetrically arranged permanent magnets was employed to achieve precise manipulation of magnetic beads, enabling fully automated nucleic acid extraction (NAE) within 10 minutes. The extraction efficiency was demonstrated to be comparable to that of conventional manual methods utilizing commercial extraction kits, ensuring both reliability and consistency. This developed system demonstrated the ability to detect SARS-CoV-2 RNA at levels as low as < 10 copies/test and exhibited excellent specificity and a broad dynamic detection range (10 ¹–10⁵ copies/μL) in multiplex detection of 12 respiratory pathogens. Validation with clinical samples confirmed its accuracy in identifying both single and co-infections, with results fully consistent with clinical diagnoses. This study represents an initial demonstration of a technical paradigm for multi-target detection via physical sample allocation, implementing a \"single-sample input, multi-result output\" strategy with external amplification support. It provides a promising approach for the rapid and accurate clinical diagnosis of multiple pathogens.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137892"},"PeriodicalIF":8.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards Understanding Temperature Modulated SMOX Gas Sensor Arrays for Outdoor Air Quality Applications 了解用于室外空气质量应用的温度调制SMOX气体传感器阵列

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-29 DOI: 10.1016/j.snb.2025.137879

Arne Kobald, Udo Weimar, Nicolae Bârsan

引用次数: 0

MOF-in-Cavity Structure with Co-Location Effect of Hotspots and Molecules Suitable for Both Ex-Situ and In-Situ SERS Detections 具有热点和分子共定位效应的mof腔内结构，适用于原位和非原位SERS检测

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-28 DOI: 10.1016/j.snb.2025.137883

Yumeng Wang, Hao Li, Zhigang Tan, Jing Yu, Xiaofei Zhao, Zhen Li, Chao Zhang, Chonghui Li, Fengcai Lei

{"title":"MOF-in-Cavity Structure with Co-Location Effect of Hotspots and Molecules Suitable for Both Ex-Situ and In-Situ SERS Detections","authors":"Yumeng Wang, Hao Li, Zhigang Tan, Jing Yu, Xiaofei Zhao, Zhen Li, Chao Zhang, Chonghui Li, Fengcai Lei","doi":"10.1016/j.snb.2025.137883","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137883","url":null,"abstract":"Metal particle-in-cavity (M-PIC) structure is an excellent SERS model with rich cascade hotspot patterns. However, in most cases, the volume hotspots (VHSs) in conventional M-PIC structures are usually only appropriate for liquid- or gas-phase <em>in-situ</em> detection, greatly limiting their application scenarios. To solve this problem, we proposed a MOF particle-in-cavity (MOF-PIC) model and used it as a basis for designing a SERS substrate based on AAO/Ag/Au/ZIF-8 structure. The ZIF-8 particles in this structure act as the electric field modulation units as well as the spatial carriers of the target analytes, effectively realizing the spatial co-enrichment and co-location of the localized electric field and target analytes within the same micro region. Compared with the conventional M-PIC structure, this MOF-PIC structure shows better SERS enhancement, especially in the <em>ex-situ</em> detection scenario. Taking H<sub>2</sub>S in solution as an example, the limit of detection of AAO/Ag/Au/ZIF-8 for it is down to 10<sup>-10 </sup>M. Based on this, we can easily detect trace H<sub>2</sub>S generated during cancer cell culture or beer manufacturing and storage respectively, in both <em>in-situ</em> and <em>ex-situ</em> detection scenarios, which proves that the MOF-PIC model has a good adaptability in various applications.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"17 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resonance-interference concurrent fiber sensor: Enabling simultaneous detection of temperature and humidity 共振干涉并发光纤传感器：可同时检测温度和湿度

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-28 DOI: 10.1016/j.snb.2025.137888

Mingyue Wang, Yutong Sun, Hongkun Zheng, Ya-nan Zhang

{"title":"Resonance-interference concurrent fiber sensor: Enabling simultaneous detection of temperature and humidity","authors":"Mingyue Wang, Yutong Sun, Hongkun Zheng, Ya-nan Zhang","doi":"10.1016/j.snb.2025.137888","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137888","url":null,"abstract":"This paper presents an innovative fiber sensor that enables concurrent measurement of relative humidity (RH) and temperature. The sensor predominantly comprises a polyvinyl alcohol (PVA) microbottle resonator (MBR) operating on resonance and a silica coupler functioning via interference. The two components are fabricated by simple self-assembly and arc fusion respectively, and then coupled into an integrated sensor. The coupler serves a dual role as both a temperature sensor that capitalizes on the thermal response of silica and a coupling component that excites the resonance circulated in the MBR. Meanwhile, PVA exhibits variable shrinkage and expansion behaviors subjected to the stimulation of diverse temperatures and RH, which triggers the refractive index and radius evolution of MBR, thereby modulating the resonance dip shift. For RH measurement (32-84% RH), the resonance dip exhibits an average sensitivity of 103.34 pm/%RH. For temperature measurement (24-60℃), the average sensitivity of the resonance dip is -22.41 pm/℃ and that of the interference dip is -29.35 pm/℃. In addition, comprehensive characterizations were carried out on its repeatability, dynamic response, reversibility, and stability. The superior comprehensive behavior positions the sensor favorably for simultaneous RH and temperature measurement in intricate and challenging environments.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"9 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0