Sensors and Actuators B: Chemical最新文献

{"title":"Highly sensitive and rapid optical fiber bio-sensor for endotoxin detection using anti-resonance effect","authors":"Zhibin Li, Yu Zhang, Yongbo Mi, Ziye Wu, Rongfeng Pan, Chenkang Li, Yixin Peng, Jieyuan Tang, Mengyuan Xie, Wenguo Zhu, Huadan Zheng, Yongchun Zhong, Yan Xu, Zheng Xiang, Xiong Deng, Xihua Zou, Zhe Chen, Jianhui Yu","doi":"10.1016/j.snb.2024.136965","DOIUrl":"https://doi.org/10.1016/j.snb.2024.136965","url":null,"abstract":"Endotoxin detection is critical to human health. Reported endotoxin assays usually rely on multistep enrichment or specific modification techniques to improve sensitivity, resulting in long response times (∼1 h) and greater sample consumption (>1 mL). By now, it is still challenging to implement a highly sensitive and ultra-fast response (∼seconds) biosensor for optical endotoxin assays with only micro/nanoliter volume. Here, a new approach is proposed to break the challenges by using an anti-resonance (AR) fiber-optic biosensors with the length-independent and volume-independent sensitivity. The AR fiber-optic biosensor is composed of a side-polished single-mode/hollow-core/single-mode fiber (SP-SHSF) structure, capable of achieving high sensitivity (∼7394 nm/RIU@RI=1.33–1.385 and 33,657.14 nm/RIU@RI=1.436–1.446) with a lowest sample volume limit of down to sub-nanoliter (∼600 pL). A standard Limulus Amebocyte Lysate (LAL) assay was combined to achieve refractive index (RI) increases during LAL gel formation, and endotoxin concentrations were quantified by fixing the response time required for a 5 nm resonance dip drift. The limit of detection (LOD) of endotoxin for the biosensor was measured to be 10⁻⁴ EU/mL with a fast response time of 344 s and only 5 μL consumption of LAL reagent per test. Compared with the traditional LAL test, the fiber-optic biosensor has more than two orders of magnitude lower LOD, about 9 times faster respond and 20 times less sample consumption. The proposed fiber-optic biosensor has the advantages of small size, high sensitivity, reusability, and online detection, which is of great significance for detecting endotoxin contamination in products for biopharmaceuticals and medical devices.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"43 3 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Anti-interference PEC-ECL Biosensing for Cancer-related Gene based on Self-supporting Semi-encapsulated Heterojunction Modulated Interface Polarity-Switching","authors":"Xia Li, Hui Yuan, Xiuhua Yuan, Yanli Li, Fengqi Zhang, Jiajing Xie, Lei Li, Qi Zhang, Chen-Zhong Li, Qingwang Xue","doi":"10.1016/j.snb.2024.136962","DOIUrl":"https://doi.org/10.1016/j.snb.2024.136962","url":null,"abstract":"A novel dual-polarity switching photoelectrochemical-electrochemiluminescence (PEC-ECL) dual-signal biosensor has been developed to detect cancer-related gene (TP53) in biofluids, addressing the limitations of conventional PEC systems that typically operate in a unidirectional mode, making them susceptible to interference and lacking error correction mechanisms. The new platform utilizes self-supporting N-doped TiO₂ nanofibers synthesized via electrospinning to function as an anodic PEC signal generator. Integrating gold nanoparticles (AuNPs) into the N-TiO₂ nanofibers forms a Schottky junction, enhancing hot electron transfer through the localized surface plasmon resonance (LSPR) effect of AuNPs, allowing cathodic photocurrent generation under visible light. The detection mechanism is further enhanced by a TP53-triggered rolling circle amplification (RCA) reaction, which produces DNA-CdS quantum dot (QDs) nanostrings that hybridize with N-TiO₂@Au, creating semi-encapsulated heterojunctions (N-TiO₂@Au@CdS) that significantly amplify the anodic photocurrent and reinstate the anodic \"on\" PEC state. Simultaneously, the proposed heterojunction generates a strong ECL signal in the presence of S₂O₈^2-. The dual-polarity switching capability allows for effective differentiation of the target from coexisting redox disruptors, enhancing detection reliability. The synergistic effects of the extended DNA scaffold from RCA programmed CdS QDs and the strong LSPR effect of AuNPs create high-density carriers with high energy, resulting in enhanced and reproducible PEC and ECL signals. The biosensor achieves detection limits of 0.064 fM for PEC and 1.66 fM for ECL, with excellent stability and applicability in real samples, providing a robust platform for diagnosing and prognosing TP53-related diseases.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"193 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Near-infrared Fluorescent Probe for Sensing Cuprous ions","authors":"Meirong Yi, Jintao Zhao, Ruipeng Shen, Tao Ma, Jingwen Tu, Xinming Li, Baoxin Zhang, Jianguo Fang","doi":"10.1016/j.snb.2024.136982","DOIUrl":"https://doi.org/10.1016/j.snb.2024.136982","url":null,"abstract":"The redox character of copper with interconversion between Cu(I) and Cu(II) is essential for many physiological processes. Either deficiency or excess of copper may lead to disease conditions. In this work, a novel fluorescent probe (<strong>NS-5</strong>) for selective recognition of Cu(I) was reported based on the coordination chemistry between Cu(I) and the thioether tetradentate ligand scaffold. The probe features multiple favorable properties, such as near-infrared (NIR) emission (λ_em = 720<!-- --> <!-- -->nm), working in aqueous media, significant fluorescence increase (&gt;13-fold) and preferable mitochondrial localization. The successful imaging of Cu(I) in live cells and mouse demonstrates the practical applications of the probe.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"6 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A porphyrin-based colorimetric and near infrared fluorescent probe for reversible and rapid detection of diethyl chlorophosphate","authors":"Yiting He, Hao Wang, Chun He, Rongjin Zeng, Fenmin Cheng, Yuanqiang Hao, Shu Chen, Peisheng Zhang","doi":"10.1016/j.snb.2024.136983","DOIUrl":"https://doi.org/10.1016/j.snb.2024.136983","url":null,"abstract":"Given the extremely high toxicity of nerve agents, developing methods for their detection with high sensitivity and specificity is of great significance. In this study, we present single pyridyl-porphyrin (TPPyP) as an effective fluorescent probe for the reversible and rapid detection of the nerve agent simulant diethyl chlorophosphate (DCP). The probe demonstrates excellent spectral properties, with DCP rapidly reacting with the pyridine and pyrrole groups on TPPyP, leading to an enhanced intramolecular charge transfer (ICT) effect. This results in a distinct color change from pink to bright green, accompanied by a gradual disappearance of red fluorescence, all occurring within 35<!-- --> <!-- -->seconds. Furthermore, the probe can be retrieved from the detection solution by introducing triethylamine, allowing for reversible detection of DCP. Additionally, TPPyP-loaded filter paper serves as a convenient tool for visualizing gaseous DCP. In solution, the probe exhibits sensitive detection capabilities, and when applied to DCP vapor detection, the filter paper shows a color transition and a reduction in red fluorescence that can be quantitatively analyzed using a smartphone application. The green-to-red ratio (G/R) correlates linearly with DCP concentrations in the range of 0 to 14 ppm, showcasing the probe's potential for field applications. Selectivity and anti-interference tests reveal that only DCP affects the probe's response, confirming its robustness against common interferents. Overall, this TPPyP-based probe offers a rapid, sensitive, and portable solution for detecting nerve agents, with promising implications for environmental monitoring.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"74 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slight modification of a G-quadruplex-targeted quinoxaline may boost type-1 photodynamic therapy for triple-negative breast cancer","authors":"Xiao Zhang, Ming-Hao Hu","doi":"10.1016/j.snb.2024.136952","DOIUrl":"https://doi.org/10.1016/j.snb.2024.136952","url":null,"abstract":"G-quadruplexes (G4s) are potential drug targets in cancer treatment. However, the G4-targeted ligands seem to be lack of enough selectivity between tumors and normal tissues, appealing for more precise therapeutic strategies. Type-1 photodynamic therapy (PDT) is a promising strategy possessing excellent spatiotemporal precision for solid tumors with hypoxic microenvironment. However, rational design of type-1 photosensitizers that target G4s are never reported. In this study, we designed a novel G4-targeted ligand (<strong>DQ4</strong>) by introducing an electron-donating piperazine unit into our previously reported quinoxaline scaffold. Such a slight modification significantly eliminated its intrinsic emission, which made <strong>DQ4</strong> a promising “turn-on” fluorescent probe for detecting G4s. Moreover, this modification greatly boosted the production of type-1 ROS, enabling <strong>DQ4</strong> to be an excellent photosensitizer potentially for treating hypoxic solid tumors.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"178 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naked-eye Detection of Legionella pneumophila Using Smart Fluorogenic Polymers Prepared as Hydrophilic Films, Coatings, and Electrospun Nanofibers","authors":"Ana Arnaiz, Marta Guembe-García, Mario Martínez, Miriam Trigo-López, Edurne González, Issei Otsuka, Saúl Vallejos","doi":"10.1016/j.snb.2024.136976","DOIUrl":"https://doi.org/10.1016/j.snb.2024.136976","url":null,"abstract":"<em>Legionella pneumophila</em> is a significant public health threat, responsible for severe diseases such as Legionnaires’ disease. Traditional detection methods are often labour-intensive, time-consuming, and require sophisticated equipment. This study introduces smart fluorogenic polymeric materials for the naked-eye detection of <em>L. pneumophila</em> via protease activity. These materials, prepared as hydrophilic films, cellulose-coated linear copolymers, and electrospun nanofibers, operate on an OFF/ON FRET system, emitting fluorescence under UV light upon interaction with <em>L. pneumophila</em> proteases. Characterisation confirmed the successful immobilisation of the peptide substrate and its response to proteases. The sensors showed moderate to high sensitivity and specificity, with detection limits of 2.91×10⁵, 3.64×10⁵, and 4.04×10⁵ CFUs/mL for the film, copolymer, and nanofiber formats, respectively. Cross-reactivity tests identified only <em>Pseudomonas aeruginosa</em> as an interferent. This novel approach offers rapid, simple, and cost-effective <em>L. pneumophila</em> detection with visible results under UV light, suitable for clinical and environmental samples. It highlights the potential for broader pathogen detection applications.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"14 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MOF-derived La-doped ZnO Dodecahedron Nanostructures for Efficient Detection of NO2 Gas","authors":"Shahid Hussain, Song Wang, Jesse Nii Okai Amu-Darko, Amensisa Negasa Begi, Kareem Yusuf, Talib K. Ibrahim, Amjad Iqbal, Rajesh Kumar Manavalan, Xiangzhao Zhang, Guanjun Qiao","doi":"10.1016/j.snb.2024.136954","DOIUrl":"https://doi.org/10.1016/j.snb.2024.136954","url":null,"abstract":"NO₂ is a toxic gas that poses a significant threat to the environment and human health. In this work, we studied the ultra-high NO₂ sensitivity of lanthanum (La)-doped ZnO porous nanocages. La doping into ZnO via a simple one-step co-precipitation MOF encapsulation-calcination route resulted in a significant improvement in NO₂ sensing performance. This study focused on doping ZnO with 2%, 4%, and 8% molar ratios of lanthanide sources. It was revealed that 2% La-doped ZnO was the best possible parameter for NO₂ gas sensitization. The La-doped ZnO sensor outperforms the pure MOF-derived ZnO sensor with a high response of 118 to 50 ppm NO₂, short response time of 28<!-- --> <!-- -->seconds, and a detection limit of 5.68 ppb. The material exhibits good reproducibility and some humidity resistance and has good selectivity for NO₂. The excellent NO₂ sensitivity can be attributed to the nanoporous structure providing abundant adsorption sites and the synergistic effect generated by the formation of a heterojunction between La-doped lanthanum oxide and zinc oxide. These findings can be generalized to the design of porous doped ZnO for high-performance gas sensors and other applications.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"69 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Heterostructured Nanocomposite MgFe2O4/MoO3 for H2S Sensing: Experimental and Theoretical approach by DFT","authors":"S. Uma, D. Vignesh, M.K. Shobana","doi":"10.1016/j.snb.2024.136950","DOIUrl":"https://doi.org/10.1016/j.snb.2024.136950","url":null,"abstract":"A highly selective hydrogen sulfide (H₂S) gas sensor at low temperatures is crucial. A nanocomposite of magnesium ferrite (MgFe₂O₄) and molybdenum oxide (MoO₃) was prepared through facile co-precipitation, hydrothermal, and solid-state mixing methods to enhance gas sensing performance of H₂S. The crystalline structure, surface morphology, and elemental composition were examined through X-ray diffraction (XRD), Field emission scanning electron microscopy (FESEM), and X-ray photoelectron spectroscopy (XPS). A larger surface area of 54.225 m²/g with a mesoporous structure was observed for the fabricated nanocomposite MM2 (20% MoO₃). An enhanced gas sensing response of 31.18% for 7 ppm of H₂S at 135 °C was measured for MM2 nanocomposite and exhibited 1.86 times greater response than MgFe₂O₄ at 135 °C. The synergistic effect of n-n nanocomposite, combination of nanosheets with nanoparticles, and high surface area attribute to a significant improvement in sensing behavior. This article also compared the experimental data with Density Functional Theory (DFT) results.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"18 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen vacancy-rich SnO2/CdIn2S4 heterojunction with self-primed multi-cycle amplification for sensitive ctDNA detection","authors":"Xiao Yang, Xue Dan Xiao, Zhe Sun, Hong Rong Mou, Hong Ran Tao, Hong Qun Luo, Nian Bing Li","doi":"10.1016/j.snb.2024.136979","DOIUrl":"https://doi.org/10.1016/j.snb.2024.136979","url":null,"abstract":"Currently, sensitive detection of circulating tumor DNA (ctDNA) serves as a critical indicator for tumor diagnosis and therapeutic assessment. Therefore, we have developed a signal quenching photoelectrochemical (PEC) sensor that integrates novel photoactive materials and DNA conformation transformation assistance to initiate self-primed multi-cycle strand displacement amplification (MC-SDA), achieving sensitive detection of ctDNA. The oxygen vacancy-rich SnO₂ (SnO₂-OV) forms an S-scheme heterojunction with CdIn₂S₄, serving as a photoelectrochemical (PEC) active material and providing excellent initial photocurrent signals. In the presence of the ctDNA, triggering the conformational transformation of the template chain (HP) initiates the MC-SDA reaction, resulting in exponential amplification and generating abundant S2 chains. On the electrode surface, the introduction of S2 triggers hybridization chain reaction, leading to the formation of numerous G4@hemin composite structures with peroxidase-like activity. This structure catalyzes the oxidation of 3-amino-9-ethylcarbazole by H₂O₂, performing the biocatalytic precipitation reaction on the electrode surface. This effectively impedes electron transfer, ultimately causing the quenching of the photocurrent signal. Under optimal conditions, this PEC sensor exhibits highly efficient and sensitive detection performance, with a wide linear range for ctDNA from 0.1 fM-100 pM and a low detection limit of 21.8 aM. Additionally, this biosensor can be applied to analyze ctDNA concentrations in real serum samples. Therefore, this PEC sensor holds potential as a promising alternative tool for tumor diagnosis and assessment.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"197 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bifunctional Cu0.4Co2.6O4 nanocube induced by Cu substitution with superior peroxidase-like activity: Application in hydroquinone multi-mode detection","authors":"Miaomiao Li, Yan Dai, Zhiguang Liu, Shufeng Liang, Yujie Han, Lifang Fan, Zhongping Li, Boyang Dong, Yujing Guo","doi":"10.1016/j.snb.2024.136980","DOIUrl":"https://doi.org/10.1016/j.snb.2024.136980","url":null,"abstract":"Hydroquinone (HQ), a phenolic compound, poses substantial risks to human health due to its low degradability and high toxicity. Consequently, developing sensitive, accurate, and portable approaches for monitoring HQ is of significant importance. Herein, M-substituted (M=Cu, Mn, Ni, and La) Co₃O₄ nanocube (Co₃O₄ NC) was developed for improving the peroxidase-like activity of Co₃O₄ NC. Among these, Cu-substituted Co₃O₄ NC (Cu_0.4Co_2.6O₄ NC) exhibited optimal peroxidase-like performance. Investigation into the catalytic mechanism revealed that the generation of hydroxyl radical and the increase of superoxide anion significantly enhanced the catalytic activity of Cu_0.4Co_2.6O₄ NC. Cu_0.4Co_2.6O₄ NC could catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) with H₂O₂ to form a blue-color product. In the existence of HQ, the chromogenic reaction of TMB was inhibited due to the competition between HQ and TMB for the reactive oxygen species in the catalytic system. Additionally, a smartphone-mediated portable hydrogel sensor was integrated with color change to facilitate on-site detection. Furthermore, Cu_0.4Co_2.6O₄ NC served as an electrocatalyst for electrochemical analysis of HQ. Considering these findings, we proposed a colorimetrical, hydrogel, and electrochemical multi-mode sensor for detecting HQ, showing wide linear ranges and low detection limits. The multi-mode sensor features self-verification for more reliable results and is suitable for various analysis conditions. It successfully determined HQ in real water samples, accompanied by consistent results with HPLC. This work not only provides an efficient pathway for developing nanozymes with superior catalytic properties but also demonstrates application potential in environmental protection.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"6 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}