Sensors and Actuators B: Chemical最新文献

{"title":"Regulating the hydrophobic part in amphiphilic triphenylamino-diarylethene fluorophores for ultrasensitive and portable detection of urinary albumin","authors":"Caiqiang Liao, Xianwen Liang, Tianyi Qin, Xinfeng Du, Haoyan Xiong, Quan Chen, Cuizhen Lu, Zhongyang Zhang, Zhongyong Xu, Taoyuze Lv, Zhaohui Wang, Yalong Wang, Bin Liu, Mingqiang Zhu","doi":"10.1016/j.snb.2025.137592","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137592","url":null,"abstract":"Sensitive and accurate detection of urinary albumin (<em><strong>u-ALB</strong></em>), preferably by user-friendly smartphone-based portable devices, is essential for the prevention and regular evaluation of chronic kidney disease (CKD). Here, we present a class of ionic aggregation-induced emission fluorogens (AIEgens) containing triphenylamine pyridinium skeleton and extended alkyl chains (<em><strong>TPA-Ps</strong></em>) as novel probes for <em><strong>u-ALB</strong></em>. Different from the previous studies focusing on regulating the number of ionic moieties, we for the first time investigated the effect of extending the hydrophobic tails on enhancing the sensitivity. Specifically, the <em><strong>TPA-P-C6</strong></em> with one ionic moiety yet a n-hexyl chain exhibited the highest fluorescent increasing fold (&gt; 3450) on responding to <em><strong>u-ALB</strong></em>, which has also been the highest degree among the reported ionic AIEgen-based <em><strong>u-ALB</strong></em> probes. Different stages of albuminuria (A1-A3) represented by varying <em><strong>u-ALB</strong></em> concentrations could be clearly revealed through fluorescence spectral signal readout. Additionally, the <em><strong>TPA-P-C6</strong></em> exhibited a restored fluorescence at longer wavelength area in real urine samples, enabling fluorocolorimetric sensing and point-of-care testing by naked eye. With the assistance of smartphones for signal capturing and analysis, portable devices based on test papers, 96-well plate, and 3D-printing technique have been constructed for the on-site detection of <em><strong>u-ALB</strong></em>. Compared with the commercial dye based <em><strong>u-ALB</strong></em> indicator (G250) and test papers, the multi-color sensing signals of our probe can clearly reveal the different stages of albuminuria and offer useful proofs for early diagnosis of CKD.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"16 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rigid DNA tetrahedral scaffold-mediated dumbbell hybridization chain reaction for the ultrasensitive electrochemical detection of ochratoxin A","authors":"Hong Hu, Rong Wang, Tong Yao, Lingqi Kong, Ruo Yuan, Yaqin Chai","doi":"10.1016/j.snb.2025.137593","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137593","url":null,"abstract":"Herein, an innovative and label-free electrochemical biosensing platform based on a rigid DNA tetrahedral scaffold (DTS)-mediated dumbbell hybridization chain reaction (DHCR) system (DMD system) was constructed for the ultrasensitive detection of ochratoxin A (OTA) related to food safety. Impressively, a small amount of target OTA could be converted into a large amount of secondary target S1 by Exonuclease III-assisted cycling, achieving efficient amplification of the target. In addition, due to the spatial domain-limiting effect, ordered spatial distribution, and superior mechanical rigidity of DTS, the DHCR mediated by DTS could efficiently generate a large amount of compact and dense DNA nanostructures to carry more signaling molecules for a notable electrochemical signal, thereby markedly enhancing the sensitivity of the electrochemical biosensor. Consequently, the developed electrochemical biosensing platform achieved ultrasensitive detection of OTA with a detection limit of 1.06 fg/mL, which was lower than those of reported studies, and was successfully applied to detect OTA in red wine and coffee. As a result, this strategy constructed a high-performance sensing platform based on a novel DMD system, which offered a promising approach for the ultrasensitive detection of toxins in food and the environment.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"31 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An aptazyme-based logic gate biosensor for tumor detection in postoperative analysis","authors":"Guangxu Fang, Kai Wen, Qixuan Zhao, Yingxuan Chen, Yanbo Wang, Haobo Han, Quanshun Li","doi":"10.1016/j.snb.2025.137594","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137594","url":null,"abstract":"Postoperative tissue analysis is essential for the evaluation of surgical outcome in the tumor therapy. The identification of tumor biomarkers represents a supplementary approach to histochemical observation, facilitating the diagnosis of cancers at molecular level. Herein, a biosensor was developed by integrating an ATP-responsive aptazyme and its substrate on the surface of streptavidin magnetic beads to achieve the simultaneous detection of ATP and apurinic/apyrimidinic endonuclease 1 (APE1) within cancer cells. This strategy enabled the biosensor to respond to excessive ATP in cancer cells, thereby generating the primer. Meanwhile, the biosensor contained a double-stranded DNA with apurinic/apyrimidinic site, which allowed it to respond to APE1 and produce a padlock. The released primer and padlock triggered the rolling cycle amplification to yield an amplified fluorescent or colorimetric signal. The biosensor functioned as the “AND”-logic gate, effectively distinguishing cancer and non-cancerous cells. Moreover, the biosensor exhibited high specificity and sensitivity in discriminating the tumor and non-tumor tissues isolated from the patients bearing non-small cell lung cancer. Taken together, the biosensor showed the potential in clinical molecular diagnosis, serving as a promising supplementary approach for the postoperative tissue analysis.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"56 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143590204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly sensitive electrochemiluminescence glucose sensor under alkaline conditions based on glucose oxidase@conductive metal-organic framework nanocapsules","authors":"Mengfan Mao, Limin Li, Chuanhui Huang, Zhenyu Lin, Weijia Wang","doi":"10.1016/j.snb.2025.137595","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137595","url":null,"abstract":"Electrochemiluminescence (ECL) sensors based on luminol had been frequently coupled with enzymatic reactions to detect various targets. However, a major challenge arises from the conflict between the neutral environmental required for enzymatic activity and the higher luminescence efficiency of luminol under alkaline conditions. In this study, glucose oxidase (GOx)@Zn-HHTP (HHTP = 2,3,6,7,10,11-hexahydroxytriphenylene) was successfully synthesized, significantly enhancing the stability of encapsulated GOx. At pH 10.0, the enzyme retained 80% of its catalytic activity compared to its performance under neutral conditions. To demonstrate its applicability, GOx@Zn-HHTP had been applied to construct an ECL glucose sensor. Operating under alkaline conditions, this sensor maintained a high luminescence efficiency of luminol, resulting in an 8.5-fold increase in sensitivity and a 25-fold reduction in the detection limit compared to the sensor operating under neutral environments. This sensor was successfully applied for detection of glucose in sweat, effectively mitigating interference from the complex matrix of sweat samples and enabling accurate detection of glucose at low concentrations.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"54 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A dual stimulus-responsive NIR-II photoacoustic probe for precise diagnosis of colon cancer and photothermal-starvation synergistic therapy” [Sens. Actuators: B. Chem. 428 (2025) 137263]","authors":"Yang Wang,&nbsp;Shulong Wang,&nbsp;Min He,&nbsp;Yanli Luo,&nbsp;Fanggui Ye,&nbsp;Jianniao Tian,&nbsp;Shulin Zhao","doi":"10.1016/j.snb.2025.137584","DOIUrl":"10.1016/j.snb.2025.137584","url":null,"abstract":"","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137584"},"PeriodicalIF":8.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced selectivity in detecting matrix metalloproteinase-2 via sequential affinity capture, cascade reaction, and electrochemical measurement","authors":"Seonhwa Park, Minji Gwon, Hyeryeong Lee, Seonghye Kim, Suhkmann Kim, Jung Min Joo, Tae Hyeon Yoo, Haesik Yang","doi":"10.1016/j.snb.2025.137586","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137586","url":null,"abstract":"Selective detection of proteases in complex biological matrices remains a significant challenge due to interference from multiple proteases and inhibitors. This study introduces a novel method for the selective and sensitive detection of matrix metalloproteinase-2 (MMP-2) employing a sequence of affinity capture, cascade reaction, and electrochemical measurement. The method begins with the affinity capture of MMP-2 on an electrode, followed by a washing step to mitigate interference from other proteases and inhibitors present in human serum. This is followed by a cascade reaction, where proteolytic cleavage of auto-inhibited β-lactamase by MMP-2 and subsequent ring-opening hydrolysis of electro-inactive nitrocefin by the activated β-lactamase rapidly produce electro-active open-nitrocefin. Electrochemical measurements of this open-nitrocefin near the electrode surface generate a high signal. This method achieved a detection limit of 20<!-- --> <!-- -->ng/mL for MMP-2 in human serum and demonstrated high selectivity against a range of proteases. The study presents a new strategy for the selective and sensitive detection of proteases in complex biological samples, potentially enhancing diagnostic approaches for protease-related diseases.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"40 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Nanofibrous ZnO-loaded PVA/PEDOT:PSS for selective and enhanced ammonia detection” [Sens. Actuators B: Chem. 426 (2025), 137022]","authors":"Aizhan Rakhmanova ,&nbsp;Baktiyar Soltabayev ,&nbsp;Ahmad Ajjaq ,&nbsp;Natalya Khan ,&nbsp;Sandugash Kalybekkyzy ,&nbsp;Selim Acar ,&nbsp;Almagul Mentbayeva","doi":"10.1016/j.snb.2025.137583","DOIUrl":"10.1016/j.snb.2025.137583","url":null,"abstract":"","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137583"},"PeriodicalIF":8.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel fluorescent probe for the in-situ visualization of superoxide anions during pulmonary fibrosis","authors":"Liangchao Yuan, Yuyao Cao, Yanjun He, Qingcai Jiao, Zhongchang Wang, Hai-Liang Zhu","doi":"10.1016/j.snb.2025.137589","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137589","url":null,"abstract":"Pulmonary fibrosis (PF) is a progressive and refractory lung disease characterized by fibrosis that can result in the accumulation of extracellular matrix, impair alveolar elasticity, and consequently increase mortality. Superoxide anion (O₂^•−), as one of the initial intracellular reactive oxygen species, plays a pivotal role in cell signaling networks and redox homeostasis. Abnormal levels of this species can directly reflect the state of intracellular oxidative stress. Nevertheless, the relationship between O₂^•− and PF has remained unclear. Accordingly, a fluorescent probe, designated <strong>SOACHO</strong>, was devised and constructed for the purpose of detecting O₂^•−. The fluorescence emission peak of <strong>SOACHO</strong> in response to O₂^•− was observed to occur at a wavelength of 627<!-- --> <!-- -->nm. The <strong>SOACHO</strong> demonstrated high specificity and sensitivity to O₂^•−, with a response time of less than 300<!-- --> <!-- -->seconds and a detection limit of 12<!-- --> <!-- -->nM. <strong>SOACHO</strong> was capable of specifically detecting the endogenous O₂^•− levels in cells without interference from nucleophilic reagents and oxidants, and subsequently monitoring the levels of O₂^•− in oxidative stress and pulmonary fibrosis cell models. Furthermore, <strong>SOACHO</strong> was able to monitor the levels of O₂^•− in the lungs of mice in real-time, providing insights into the progression of pulmonary fibrosis. The severity of pulmonary fibrosis was found to be positively correlated with O₂^•−, as evidenced by the correlation with hydroxyproline content, lung coefficients, histopathological observations, and immunohistochemical analyses. The aforementioned results may offer a novel perspective on the early treatment of pulmonary fibrosis.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"91 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper-doped tellurium nanowire-based gas sensor for chemiresistive detection of nitrogen dioxide","authors":"Seonyeop Kim, In Ho Kim, Hossein Fattahimoghaddam, Moon-Kyu Cho, Yong Jin Jeong, Wonseok Lee","doi":"10.1016/j.snb.2025.137587","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137587","url":null,"abstract":"We propose an eco-friendly hydrothermal synthesis method with glucose as reducing agent to facilitate the easy fabrication and modification of one-dimensional tellurium (Te) nanowires (NWs). Doping copper (Cu) with Te NWs significantly enhances the thermoelectric properties (<em>e.g.,</em> Seebeck coefficient and electrical conductivity) of Te NWs. In this work, we fabricated a copper-doped Te NW-based gas sensor for the detection of nitrogen dioxide (NO₂)—a toxic air pollutant. The Cu (II) doping of Te NWs increased the number of holes and electrical conductivity, thereby enhancing the gas-sensing performance with a detection limit of 7.2 ppb. Moreover, the Cu-doped Te NW-based gas sensor exhibited a reliable NO₂-detecting response under different humidity conditions and highly selective sensing properties toward other gases. The study results show that Cu doping of Te NWs significantly improves both the thermoelectric and gas-sensing properties, thereby demonstrating the potential of Te NWs in various semiconductor application technologies.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"87 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypyrrole Encapsulated Ferric Vanadate Nanorods Decorated with Palladium Nanoparticles for the Chemiresistive Detection of Indole Biomarker","authors":"Xiaxia Xing, Zhenxu Li, Xinhua Zhao, Xiaoyu Chen, Xiaoyan Lang, Yi Zhang, Dachi Yang","doi":"10.1016/j.snb.2025.137590","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137590","url":null,"abstract":"Escherichia coli (E. coli) as a pathogenic bacterium may cause food contamination and foodborne diseases, it is desired to develop a facile way such as newly-emerged gas sensing detection of indole biomarker to indirectly monitor E. coli. Here, we report an advanced indole sensing built with polypyrrole encapsulated ferric vanadate nanorods decorated with palladium nanoparticles (Pd@FeVO₄-ppy). Experimentally, the Pd@FeVO₄-ppy nanocomposites (NCPs) have been synthesized by combined microwave hydrothermal and subsequent doping, which are observed of porous FeVO₄ nanorods decorated with Pd and ppy nanoparticles (NPs). Beneficially, the sensor prototypes with Pd@FeVO₄-ppy NCPs show selective and stable sensing response to 1-50 ppm indole. Meanwhile, high temperature and humidity dependence of indole sensing have been investigated. Theoretically, the sensing resistance variations of Pd@FeVO₄-ppy NCPs is interpreted as the redox reaction between chemisorbed oxygen and indole, the decoration of Pd and ppy NPs increased active oxygen species and electron transfer. Practically, the Pd@FeVO₄-ppy NCPs sensor prototype has been simulated for detection of indole and has been communicated with a smartphone, showing the potential in monitoring E. coli.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"53 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}