Sensors and Actuators B: Chemical最新文献

Ultrasensitive cortisol detection using Ag@Au SERS sensor with molecularly imprinted polymers 利用分子印迹聚合物Ag@Au SERS传感器进行超灵敏皮质醇检测

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-06-19 DOI: 10.1016/j.snb.2025.138034

Yuyu Peng , Xinyin Zhang , Chunyan Wang , Xin Peng , Jia Huo , Kelei Pang , Xiwang Li , Xiaofeng Zhou

{"title":"Ultrasensitive cortisol detection using Ag@Au SERS sensor with molecularly imprinted polymers","authors":"Yuyu Peng , Xinyin Zhang , Chunyan Wang , Xin Peng , Jia Huo , Kelei Pang , Xiwang Li , Xiaofeng Zhou","doi":"10.1016/j.snb.2025.138034","DOIUrl":"10.1016/j.snb.2025.138034","url":null,"abstract":"<div><div>Rapid and sensitive detection of cortisol, which is essential for diagnosing adrenal and stress-related disorders, has been achieved through the development of a surface-enhanced Raman scattering (SERS) sensor. This sensor integrates molecularly imprinted polymers (MIPs) with silver core-gold shell nanoparticles (Ag@AuNPs) to provide a selective and sensitive means of cortisol detection. By leveraging the surface plasmon resonance (SPR) effect, the sensor is able to amplify SERS signals, while the MIPs offer specific recognition sites for cortisol. Fabricated using a straightforward two-step process that involves chronoamperometry and self-polymerization, the Ag@AuNPs functionalized with MIP (Ag@Au/MIP) sensor is both easy to prepare and highly reproducible. The Ag@AuNPs increases the effective surface area, optimizing the electromagnetic field and significantly boosting the sensor's sensitivity. The sensor demonstrates a strong affinity for cortisol, exhibiting a linear detection range from 100 pM to 0.1 mM and a detection limit as low as 10 pM. Furthermore, it shows excellent specificity against potential interferences and maintains its stability and anti-interference ability in artificial saliva. By providing a rapid, cost-effective, and user-friendly platform for cortisol detection, this Ag@Au/MIP-based SERS sensor holds great promise for clinical diagnosis, health monitoring, and point-of-care testing applications.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"442 ","pages":"Article 138034"},"PeriodicalIF":8.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “An economical, high-throughput protein-protein interaction modulator drug screening technique based on surface-enhanced Raman scattering” [Sens. Actuators B: Chem. 410 (2024) 135683] “基于表面增强拉曼散射的一种经济、高通量蛋白质相互作用调节剂药物筛选技术”[j] .化学学报，2010,41(2024):135683。

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-06-19 DOI: 10.1016/j.snb.2025.138146

Ziming Wang , Shizhi Xu , Shuai Fang , Lili Cong , Lu Dai , Wei Huang , Zhiyi Liu , Lianyou Zheng , Jinbao Xiang , Jiayu Wang , Shuping Xu , Chongyang Liang , Fei Sun

引用次数: 0

Corrigendum to “Robust response to NO2 gas on SnO2 heater/CNT gas sensor applications” [Sens. Actuat. B Chem., 408 (2025) 135357/ SNB_138128] “SnO2加热器/碳纳米管气体传感器应用对NO2气体的稳健响应”的勘误表。B化学。， 408 (2025) 135357/ snb_138128]

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-06-18 DOI: 10.1016/j.snb.2025.138148

Myoungsu Chae , Ikgeun Kwon , Doowon Lee , Ibtisam Ahmad , Mohsin Ali , Taegi Kim , Yuseong Jang , Chanmin Hwang , Sanggyu Bang , Taehee Lee , Dae-un Sung , Kyung-woo Lee , Hee-Dong Kim

引用次数: 0

Self-assembled nanosphere-cooperated mRNA discriminator for electrochemical analysis of breast cancer metastasis 自组装纳米球协同mRNA鉴别器用于乳腺癌转移的电化学分析

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-06-18 DOI: 10.1016/j.snb.2025.138150

Jianan Xia , Zihan Zou , Lingjun Sha , Lijuan Li , Xi Jin , Jing Zhao , Yi Pan , Ayong Cao , Ya Cao

{"title":"Self-assembled nanosphere-cooperated mRNA discriminator for electrochemical analysis of breast cancer metastasis","authors":"Jianan Xia , Zihan Zou , Lingjun Sha , Lijuan Li , Xi Jin , Jing Zhao , Yi Pan , Ayong Cao , Ya Cao","doi":"10.1016/j.snb.2025.138150","DOIUrl":"10.1016/j.snb.2025.138150","url":null,"abstract":"<div><div>Metastatic breast cancer exhibits specific characteristics closely associated with mRNA expression profiles. Consequently, sensitive detection of specific mRNAs may facilitate the early warning and identification of breast cancer metastasis at the molecular level, significantly improving patient prognosis. Herein, we present a new electrochemical mRNA discriminator as a tool for analyzing breast cancer metastasis. Specifically, we prepare self-assembled nanospheres that are coated with hyaluronic acid and loaded with duplex-specific nucleases (DSNs) and electrochemically tagged DNA probes targeting two breast cancer metastasis-related mRNAs. By recognizing CD44—an antigen highly expressed on the surface of breast cancer cells—the nanospheres effectively deliver the DNA probes and DSNs into target cells. Thereafter, intracellular target mRNAs hybridize with their corresponding DNA probes, initiating DSN-driven target recycling and releasing a large number of relevant electrochemical molecules. Finally, through host-guest interaction-based enrichment, this discriminator allows for detecting two target mRNAs down to 0.170 pM and 0.127 pM, respectively. Meanwhile, this self-assembled nanosphere-cooperated discriminator enables effective discrimination between highly metastatic and low-metastatic breast cancer cells and exhibits good utility in mouse tumor tissue samples. Therefore, this work may offer an effective tool for detecting breast cancer metastasis-related mRNAs, which is expected to provide insights into analyzing breast cancer metastasis.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"442 ","pages":"Article 138150"},"PeriodicalIF":8.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rational design of iridium complex with double-locked mitochondria-targeting for dynamic viscosity monitoring and precision two-photon tumor imaging 具有双锁定线粒体靶向的铱配合物的合理设计，用于动态粘度监测和精确双光子肿瘤成像

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-06-17 DOI: 10.1016/j.snb.2025.138145

Fan Li , Changlin Li , Weijun Huang , Wanying Li , Yuqing Zhang , Zhenbao Li , Yan Liu , Jiabing Tong , Dong Wang , Zhihui Feng

{"title":"Rational design of iridium complex with double-locked mitochondria-targeting for dynamic viscosity monitoring and precision two-photon tumor imaging","authors":"Fan Li , Changlin Li , Weijun Huang , Wanying Li , Yuqing Zhang , Zhenbao Li , Yan Liu , Jiabing Tong , Dong Wang , Zhihui Feng","doi":"10.1016/j.snb.2025.138145","DOIUrl":"10.1016/j.snb.2025.138145","url":null,"abstract":"<div><div>Perceiving the microenvironment around early-stage tumor tissue using mitochondrial viscosity as a nexus is crucial for tumorigenesis tracking and tumor detection. However, the high dependence of most current viscosity-activated mitochondrial probes on mitochondrial membrane potential (MMP) as well as short luminescence lifetimes and poor tissue penetration depths have severely hindered their widespread application. Herein, we report a novel viscosity-activated two-photon phosphorescent probe (<strong>Ir-visc</strong>) employing a double-locking mitochondrial targeting strategy that incorporates electrostatic force and probe-protein molecular docking, enabling real-time monitoring of dynamic changes in mitochondrial viscosity during cancer cell damage. The probe exhibits remarkable 93-fold enhancement of phosphorescence in the presence of highly viscous media and enabling consistent and accurate detection of mitochondrial viscosity, even in damaged mitochondria through its dual-locking strategy. Furthermore, <strong>Ir-visc</strong> has viscosity-activated two-photon absorption (TPA) characteristics, which makes it easily distinguishable from cellular autofluorescence while enhancing imaging depth and sensitivity. Notably, the probe <strong>Ir-visc</strong> selectively labels cancer cells and demonstrates excellent capability for real-time monitoring of viscosity changes in mitochondria. These findings suggest that the Ir (Ⅲ) complex probe offers a versatile strategy for studying mitochondrial viscosity and improving cancer diagnosis.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"442 ","pages":"Article 138145"},"PeriodicalIF":8.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144305189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ti3C2Tx MXene-based multifunctional wearable integrated sensor for simultaneous detection of humidity and pressure stimuli 基于Ti3C2Tx mxeni的多功能可穿戴集成传感器，用于同时检测湿度和压力刺激

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-06-17 DOI: 10.1016/j.snb.2025.138147

Kai Wang , Jia-Nan Ma , Qian Zhao , Jia-Hui Zhang , Kang-Dong Zhang , Yu Zhang , Ling Wang , Sheng-Bo Sang

{"title":"Ti3C2Tx MXene-based multifunctional wearable integrated sensor for simultaneous detection of humidity and pressure stimuli","authors":"Kai Wang , Jia-Nan Ma , Qian Zhao , Jia-Hui Zhang , Kang-Dong Zhang , Yu Zhang , Ling Wang , Sheng-Bo Sang","doi":"10.1016/j.snb.2025.138147","DOIUrl":"10.1016/j.snb.2025.138147","url":null,"abstract":"<div><div>Although wearable electronic sensors have demonstrated promising applications in the fields of health monitoring, human-machine interaction, and soft robotics, they still face challenges in multifunctionality, integration, facile production and low cost using conventional materials. MXene, as an emerging two-dimensional material, integrated with favorable physical/chemical properties is expected to solve these problems. Herein, we propose an integrated pressure-humidity sensor using Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene as the sole sensitive material, which can precisely detect and distinguish pressure and humidity signals without cross-talk. Notably, the integrated pressure-humidity sensor exhibits not only a wide response range (8–125 kPa) with high sensitivity (1878.05 kPa<sup>−1</sup>) for pressure detection, but also wide response range (11.5 %-98.1 % RH), high sensitivity (0.67 % (%RH)<sup>−1</sup>) and rapid response (response 3.46 s, recovery 1.50 s) for humidity detection. Based on the above outstanding dual-mode sensing performances, the sensor is applied in monitoring diverse physiological parameters of human such as respiratory patterns, sweat levels, and joint movements, revealing great potential for health monitoring and human-machine interaction.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"442 ","pages":"Article 138147"},"PeriodicalIF":8.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel acridine-based mitochondria-targeted near-infrared fluorescent probe for the detection of HOCl/ONOO- in vivo 一种新的基于吖啶的线粒体靶向近红外荧光探针，用于检测体内HOCl/ONOO-

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-06-17 DOI: 10.1016/j.snb.2025.138143

Yixuan Zhu, Caiyun Liu, Xiaodi Rong, Yuxiao Zhu, Huayan Wen, Min Zheng, Wenlong Sheng, Shengyun Huang, Baocun Zhu

{"title":"A novel acridine-based mitochondria-targeted near-infrared fluorescent probe for the detection of HOCl/ONOO- in vivo","authors":"Yixuan Zhu, Caiyun Liu, Xiaodi Rong, Yuxiao Zhu, Huayan Wen, Min Zheng, Wenlong Sheng, Shengyun Huang, Baocun Zhu","doi":"10.1016/j.snb.2025.138143","DOIUrl":"https://doi.org/10.1016/j.snb.2025.138143","url":null,"abstract":"Fluorescence imaging plays a key role in disease diagnosis. Fluorescent probes constructed with near-infrared (NIR) dyes exhibit negligible light damage to the organism, and excellent deep-tissue penetration. The higher intracellular concentrations of HOCl/ONOO<sup>-</sup> in cancer cells versus normal cells make these species valuable biomarkers for disease diagnosis. Thus, a novel NIR fluorescent probe <strong>AcA-MO</strong> is proposed for HOCl/ONOO<sup>-</sup> detection. <strong>AcA-MO</strong> is constructed based on a new acridine dye with morpholine groups modifying both ends. <strong>AcA-MO</strong> has the advantages of rapid response (within 5 s), visual color transition (from colorless to lake green), high sensitivity (detection limits of 10.9 nM for HOCl and 17.5 nM for ONOO<sup>-</sup>), and excellent selectivity. Furthermore, <strong>AcA-MO</strong> demonstrated accurate mitochondrial targeting capability. The capabilities of <strong>AcA-MO</strong> extended from HOCl/ONOO<sup>-</sup> monitoring in cells and zebrafish to successful implementation of <em>in vivo</em> imaging. Notably, the reaction of <strong>AcA-MO</strong> with HOCl/ONOO<sup>-</sup> resulted in a novel NIR dye <strong>Ac-MO</strong> with excellent properties such as good water solubility, high molar absorbance coefficient (7.82 × 10<sup>4 </sup>L·mol<sup>-1</sup>·cm<sup>-1</sup>) and fluorescence quantum yield (<em>Φ</em> = 0.08). <strong>Ac-MO</strong> provides an innovative design platform for the construction of NIR fluorescent probes. It is anticipated to facilitate the design of additional ROS fluorescent probes, offering robust tools for clinical diagnosis.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"11 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144305188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aza-BODIPY dye with D-π-A architecture for 1064 nm laser-triggered photothermal theranostics 用于1064 nm激光触发光热治疗的D-π-A结构Aza-BODIPY染料

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-06-16 DOI: 10.1016/j.snb.2025.138144

Di An, Weinan Jiang, Ziyang Zhang, Shupan Wang, Weili Wang, Chunyang Miao, Jinjun Shao, Xiaochen Dong

引用次数: 0

Extract ZnO from spent catalysts for the rapid detection of NH₃ at room temperature 从废催化剂中提取氧化锌，在室温下快速检测NH₃。

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-06-16 DOI: 10.1016/j.snb.2025.138129

Miaomiao Liu , Yan Li , Yueguang Li , Junxi Cheng , Yuqing Zhu , Qihua Sun , Zhaofeng Wu

{"title":"Extract ZnO from spent catalysts for the rapid detection of NH₃ at room temperature","authors":"Miaomiao Liu , Yan Li , Yueguang Li , Junxi Cheng , Yuqing Zhu , Qihua Sun , Zhaofeng Wu","doi":"10.1016/j.snb.2025.138129","DOIUrl":"10.1016/j.snb.2025.138129","url":null,"abstract":"<div><div>Zn metal-based catalysts are widely used in many fields due to their unique advantages. After a long period of large-scale use, the waste catalysts not only occupy land resources but also cause environmental pollution. Therefore, there is an urgent need for strategies that can handle spent catalysts. In this work, ZnO was extracted from the spent catalyst by acid leaching method and ZnO based sensor was prepared for NH<sub>3</sub> detection. The gas-sensitive characteristics of the ZnO sensor to NH<sub>3</sub> were studied systematically. The response to 500 ppm ammonia can reach 101 at room temperature, and the response/recovery time is only 8/3 s, thus realizing rapid detection of NH<sub>3</sub>, in addition to excellent selectivity, and excellent long-term stability. The strategy proposed in this work effectively reduces the production cost of ZnO sensing materials, suggests a new approach for the preparation of sensing materials, and realizes a circular economy from waste to recycling, which has far-reaching implications for sustainable development.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"442 ","pages":"Article 138129"},"PeriodicalIF":8.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening synthetic cathinones mixed with instant coffee and fruit juice powder using hydrophobic carbon dot probes 疏水碳点探针筛选速溶咖啡和果汁粉混合合成卡西酮

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-06-16 DOI: 10.1016/j.snb.2025.138127

Yao-Te Yen , Huai-Han Chang , Yu-Ti Wang , Wei-Ting Chen , Tzu-Ching Lin , San-Chong Chyueh , Chien-Fu Chen

{"title":"Screening synthetic cathinones mixed with instant coffee and fruit juice powder using hydrophobic carbon dot probes","authors":"Yao-Te Yen , Huai-Han Chang , Yu-Ti Wang , Wei-Ting Chen , Tzu-Ching Lin , San-Chong Chyueh , Chien-Fu Chen","doi":"10.1016/j.snb.2025.138127","DOIUrl":"10.1016/j.snb.2025.138127","url":null,"abstract":"<div><div>Synthetic cathinones, a category of new psychoactive substance (NPS) with diverse structures and appearances in forms such as powder, tablets, and pills, have caused severe social problems. To make them attractive to teenagers, synthetic cathinones may be mixed with instant coffee and fruit juice powders. Difficulties in detecting these drugs in complex matrices complicate seizure of synthetic cathinones. Herein, a novel probe kit comprising hydrophobic tryptophan-carbon dots (htC-dots) with a liquid–liquid extraction procedure was used to detect 4-chloromethcathinone (4-CMC) and other synthetic cathinones mixed into instant coffee and fruit juice powder. Additionally, a self-made fluorescence detector controlled with an Arduino system was developed for the htC-dot probe kits. For 4-CMC, the dynamic ranges and detection limits were assessed as 0.125–0.75 mM and 0.08 mM, respectively, for the microplate reader and as 0.625–5 mM and 0.42 mM, respectively for the self-made fluorescence detector. The sensory mechanism of the probe kit involved photoluminescence (PL) quenching of htC-dots through electron and hot electron transfer under an excitation wavelength of 302 nm. The matrix effects of five brands of instant coffee and fruit juice powder were evaluated, and a cut-off htC-dot solution was prepared to assess htC-dot probe kit accuracy. Finally, 24 real-world samples were tested using the htC-dot probe kits, and the results were confirmed using gas chromatography–mass spectrometer (GC–MS). The results suggested that the htC-dot probe kits have considerable potential for on-site screening of synthetic cathinones mixed into instant coffee and fruit juice powder.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"442 ","pages":"Article 138127"},"PeriodicalIF":8.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0