Sensors and Actuators B: Chemical最新文献_第2页

A Dual-Responsive Ratiometric Fluorescent Probe for Simultaneous Monitoring of Lipophagy and HOCl in Non-alcoholic Fatty Liver Disease 双响应比例荧光探针同时监测非酒精性脂肪性肝病的脂噬和HOCl

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-29 DOI: 10.1016/j.snb.2025.137885

Shuyang Zhai, Zhiqiang Mao, Zhihong Liu, Yingbin Liu

{"title":"A Dual-Responsive Ratiometric Fluorescent Probe for Simultaneous Monitoring of Lipophagy and HOCl in Non-alcoholic Fatty Liver Disease","authors":"Shuyang Zhai, Zhiqiang Mao, Zhihong Liu, Yingbin Liu","doi":"10.1016/j.snb.2025.137885","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137885","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is a prevalent liver disorder closely associated with dysregulated lipid metabolism and increased oxidative stress. To better understand the underlying pathological mechanisms of NAFLD and identify potential therapeutic strategies, we developed a novel dual-response fluorescent probe, Pola-HOCl, which enables the simultaneous monitoring of intracellular lipid droplet polarity and hypochlorous acid (HOCl) levels, providing new perspectives for the potential early diagnosis and treatment of NAFLD. By employing the through bond energy transfer (TBET) mechanism, Pola-HOCl minimizes spectral crosstalk, ensuring precise and reliable measurements. Both <em>in vitro</em> and <em>in vivo</em> experiments demonstrated that Pola-HOCl exhibits superior sensitivity and specificity in detecting lipid droplet dynamics and oxidative stress, offering valuable insights into the role of lipophagy in mitigating oxidative damage in NAFLD. This study underscores the practical application of Pola-HOCl for investigating the complex interplay between lipophagy and oxidative stress, and introduces a novel approach to explore the pathophysiological mechanisms underlying NAFLD.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"81 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

All-printed flexible self-powered humidity sensor 全印刷柔性自供电湿度传感器

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-29 DOI: 10.1016/j.snb.2025.137868

Weiwei Zhao, Quancai Li, Qian Wang, Zhiyi Li, Jing Liang, Wei Wu

{"title":"All-printed flexible self-powered humidity sensor","authors":"Weiwei Zhao, Quancai Li, Qian Wang, Zhiyi Li, Jing Liang, Wei Wu","doi":"10.1016/j.snb.2025.137868","DOIUrl":"10.1016/j.snb.2025.137868","url":null,"abstract":"<div><div>Existing humidity sensors are often large in size and complex in structure due to the limitations of the power supply form. Traditional self-powered humidity sensor devices also often require complex preparation processes or have a narrow humidity response range and a low maximum voltage response, which significantly limits their application range. Herein, a paper-based fully printed flexible self-powered humidity sensor (FSHS), based on electrochemical principles, is proposed for the first time. This innovative sensor, combined with conventional screen-printing technology, enables the integration of low-cost, customizable, 2D, and non-contact humidity sensing devices. The anode ink, cathode ink, and sensing layer are printed on the paper as planar interdigital electrodes to form a FSHS with self-powered and humidity sensing functions. This sensor features a simple preparation process, a wide response range (11 %-95 % RH), ultra-high voltage response (1.03 V), excellent long-term stability, rapid response/recovery times, and excellent linearity between voltage response and humidity. It demonstrates exceptional flexibility, with virtually no change in voltage under extreme bending conditions. Additionally, this FSHS can be made into various shapes/patterns, making it ideal for wearable respiratory detection devices, non-contact buttons, and energy storage in specialized circumstances.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137868"},"PeriodicalIF":8.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An integrated microfluidic platform for multi-target nucleic acid detection based on rotational magnetic field-induced uniform bead distribution 基于旋转磁场诱导均匀磁珠分布的多靶点核酸检测集成微流控平台

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-29 DOI: 10.1016/j.snb.2025.137892

Ming Cheng , Jun Li , Shilun Feng , Enjia Zhang , Boyue Wu , Gaozhe Cai , Xiaojun Bian , Chunping Jia , Jianlong Zhao

{"title":"An integrated microfluidic platform for multi-target nucleic acid detection based on rotational magnetic field-induced uniform bead distribution","authors":"Ming Cheng , Jun Li , Shilun Feng , Enjia Zhang , Boyue Wu , Gaozhe Cai , Xiaojun Bian , Chunping Jia , Jianlong Zhao","doi":"10.1016/j.snb.2025.137892","DOIUrl":"10.1016/j.snb.2025.137892","url":null,"abstract":"<div><div>Efficient multi-pathogen detection remains crucial during concurrent respiratory disease outbreaks, yet existing multiplex platforms are limited by complex fluorescent encoding and high reagent costs. This study introduces a novel microfluidic chip system incorporating rotational magnetic control for simultaneous multi-pathogen nucleic acid detection. The system utilized a unique rotating magnetic field to drive the magnetic beads to actively and dynamically capture nucleic acid in the solution, enabling a \"one-to-four division\" of the beads and subsequently achieving a \"one-to-four division\" of the nucleic acid sample. Under optimized conditions, a rotating magnetic field generated by four symmetrically arranged permanent magnets was employed to achieve precise manipulation of magnetic beads, enabling fully automated nucleic acid extraction (NAE) within 10 minutes. The extraction efficiency was demonstrated to be comparable to that of conventional manual methods utilizing commercial extraction kits, ensuring both reliability and consistency. This developed system demonstrated the ability to detect SARS-CoV-2 RNA at levels as low as < 10 copies/test and exhibited excellent specificity and a broad dynamic detection range (10 ¹–10⁵ copies/μL) in multiplex detection of 12 respiratory pathogens. Validation with clinical samples confirmed its accuracy in identifying both single and co-infections, with results fully consistent with clinical diagnoses. This study represents an initial demonstration of a technical paradigm for multi-target detection via physical sample allocation, implementing a \"single-sample input, multi-result output\" strategy with external amplification support. It provides a promising approach for the rapid and accurate clinical diagnosis of multiple pathogens.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137892"},"PeriodicalIF":8.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards Understanding Temperature Modulated SMOX Gas Sensor Arrays for Outdoor Air Quality Applications 了解用于室外空气质量应用的温度调制SMOX气体传感器阵列

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-29 DOI: 10.1016/j.snb.2025.137879

Arne Kobald, Udo Weimar, Nicolae Bârsan

引用次数: 0

MOF-in-Cavity Structure with Co-Location Effect of Hotspots and Molecules Suitable for Both Ex-Situ and In-Situ SERS Detections 具有热点和分子共定位效应的mof腔内结构，适用于原位和非原位SERS检测

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-28 DOI: 10.1016/j.snb.2025.137883

Yumeng Wang, Hao Li, Zhigang Tan, Jing Yu, Xiaofei Zhao, Zhen Li, Chao Zhang, Chonghui Li, Fengcai Lei

{"title":"MOF-in-Cavity Structure with Co-Location Effect of Hotspots and Molecules Suitable for Both Ex-Situ and In-Situ SERS Detections","authors":"Yumeng Wang, Hao Li, Zhigang Tan, Jing Yu, Xiaofei Zhao, Zhen Li, Chao Zhang, Chonghui Li, Fengcai Lei","doi":"10.1016/j.snb.2025.137883","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137883","url":null,"abstract":"Metal particle-in-cavity (M-PIC) structure is an excellent SERS model with rich cascade hotspot patterns. However, in most cases, the volume hotspots (VHSs) in conventional M-PIC structures are usually only appropriate for liquid- or gas-phase <em>in-situ</em> detection, greatly limiting their application scenarios. To solve this problem, we proposed a MOF particle-in-cavity (MOF-PIC) model and used it as a basis for designing a SERS substrate based on AAO/Ag/Au/ZIF-8 structure. The ZIF-8 particles in this structure act as the electric field modulation units as well as the spatial carriers of the target analytes, effectively realizing the spatial co-enrichment and co-location of the localized electric field and target analytes within the same micro region. Compared with the conventional M-PIC structure, this MOF-PIC structure shows better SERS enhancement, especially in the <em>ex-situ</em> detection scenario. Taking H<sub>2</sub>S in solution as an example, the limit of detection of AAO/Ag/Au/ZIF-8 for it is down to 10<sup>-10 </sup>M. Based on this, we can easily detect trace H<sub>2</sub>S generated during cancer cell culture or beer manufacturing and storage respectively, in both <em>in-situ</em> and <em>ex-situ</em> detection scenarios, which proves that the MOF-PIC model has a good adaptability in various applications.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"17 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resonance-interference concurrent fiber sensor: Enabling simultaneous detection of temperature and humidity 共振干涉并发光纤传感器：可同时检测温度和湿度

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-28 DOI: 10.1016/j.snb.2025.137888

Mingyue Wang, Yutong Sun, Hongkun Zheng, Ya-nan Zhang

{"title":"Resonance-interference concurrent fiber sensor: Enabling simultaneous detection of temperature and humidity","authors":"Mingyue Wang, Yutong Sun, Hongkun Zheng, Ya-nan Zhang","doi":"10.1016/j.snb.2025.137888","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137888","url":null,"abstract":"This paper presents an innovative fiber sensor that enables concurrent measurement of relative humidity (RH) and temperature. The sensor predominantly comprises a polyvinyl alcohol (PVA) microbottle resonator (MBR) operating on resonance and a silica coupler functioning via interference. The two components are fabricated by simple self-assembly and arc fusion respectively, and then coupled into an integrated sensor. The coupler serves a dual role as both a temperature sensor that capitalizes on the thermal response of silica and a coupling component that excites the resonance circulated in the MBR. Meanwhile, PVA exhibits variable shrinkage and expansion behaviors subjected to the stimulation of diverse temperatures and RH, which triggers the refractive index and radius evolution of MBR, thereby modulating the resonance dip shift. For RH measurement (32-84% RH), the resonance dip exhibits an average sensitivity of 103.34 pm/%RH. For temperature measurement (24-60℃), the average sensitivity of the resonance dip is -22.41 pm/℃ and that of the interference dip is -29.35 pm/℃. In addition, comprehensive characterizations were carried out on its repeatability, dynamic response, reversibility, and stability. The superior comprehensive behavior positions the sensor favorably for simultaneous RH and temperature measurement in intricate and challenging environments.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"9 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical process modulating colorimetry for dual-mode reliable detection of patulin based on target-induced DNA walker-triggered RCA-CHA cascade amplification 基于靶诱导DNA步行者触发RCA-CHA级联扩增的电化学过程调制比色法双模可靠检测展霉素

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-28 DOI: 10.1016/j.snb.2025.137881

Chenchen Jin , Yu Ya , Yunzhi Ma , Qingnian Wu , Jun Yan , Ke-Jing Huang , Xuecai Tan , Yun Duan

{"title":"Electrochemical process modulating colorimetry for dual-mode reliable detection of patulin based on target-induced DNA walker-triggered RCA-CHA cascade amplification","authors":"Chenchen Jin , Yu Ya , Yunzhi Ma , Qingnian Wu , Jun Yan , Ke-Jing Huang , Xuecai Tan , Yun Duan","doi":"10.1016/j.snb.2025.137881","DOIUrl":"10.1016/j.snb.2025.137881","url":null,"abstract":"<div><div>Patulin (PAT) is a toxic fungal metabolite widely present in nature, posing a significant threat to human and animal health. Herein, a self-powered sensing platform is developed for electrochemical/colorimetric detection of PAT, which leverages a target-induced DNA Walker-triggered rolling circle amplification (RCA) and catalytic hairpin assembly (CHA) cascade reaction, along with the synergistic catalysis of nanoenzymes and biological enzymes. In the detection system, the presence of PAT leads to the specific binding of the aptamer to activate the DNA Walker, which subsequently triggers the RCA-CHA cascade reaction, and then adsorbs abundant methylene blue to enhance the output signal. Under optimized conditions, the linear detection range of this method is 10<sup>−13</sup>-10<sup>−5</sup> mg/mL, with detection limits of 2.8 × 10<sup>−14</sup> mg/mL (electrochemical) and 1.8 × 10<sup>−14</sup> mg/mL (colorimetric). The method is applied to detect PAT in banana samples with recoveries of 80.0–106.0 %, which demonstrates its high accuracy and significant potential for practical application.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137881"},"PeriodicalIF":8.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triethylamine gas sensor based on Au-functionalized CdGa2O4 for the practical detection of fish freshness 基于au功能化CdGa2O4的三乙胺气体传感器用于鱼类新鲜度检测

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-28 DOI: 10.1016/j.snb.2025.137891

Shengyuan Xie , Zizhan Wan , Huixuan Chen , Jiayu Li , Ertai Na , Fang Wang , Ruiqin Gao , Yuxue Wu , Shuyan Wang , Guo-Dong Li

{"title":"Triethylamine gas sensor based on Au-functionalized CdGa2O4 for the practical detection of fish freshness","authors":"Shengyuan Xie , Zizhan Wan , Huixuan Chen , Jiayu Li , Ertai Na , Fang Wang , Ruiqin Gao , Yuxue Wu , Shuyan Wang , Guo-Dong Li","doi":"10.1016/j.snb.2025.137891","DOIUrl":"10.1016/j.snb.2025.137891","url":null,"abstract":"<div><div>Triethylamine (TEA) is a volatile organic compound characterized as flammability, high toxicity and an ammonia-like odor. Due to its prevalent use in chemical production, the development of a highly sensitive and rapidly responding TEA detector holds significant importance for both environment safety and human health. Heterostructures have been shown to effectively enhance the sensitivity of sensors towards target gases, however the specific roles and dynamic evolution of the heterojunctions and semiconductor oxides remain inadequately understood during the gas response process. Herein, Au nanoparticle-modified CdGa<sub>2</sub>O<sub>4</sub> microspheres were prepared by wet impregnation method and their gas sensing properties were examined. The 1.8Au-CdGa<sub>2</sub>O<sub>4</sub>-based sensor demonstrates a superior response value (S=128), a shorter response/recovery time (5/32 s) and a lower detection (1.54 ppb). Furthermore, practical experiments assessing fish freshness have confirmed that the sensor based on 1.8Au-CdGa<sub>2</sub>O<sub>4</sub> has significant potential for real-world applications in fish freshness testing.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137891"},"PeriodicalIF":8.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A boronic acid functionalized fully conjugated covalent organic framework for significantly improved affinity and fluorescence detection for sialic acid 一个硼酸功能化的全共轭共价有机框架，显著提高了对唾液酸的亲和力和荧光检测

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-28 DOI: 10.1016/j.snb.2025.137876

Yingfei Hui, Hao Guo, Mingyue Wang, Liping Peng, Henglong Ren, Borong Ren, Wu Yang

{"title":"A boronic acid functionalized fully conjugated covalent organic framework for significantly improved affinity and fluorescence detection for sialic acid","authors":"Yingfei Hui, Hao Guo, Mingyue Wang, Liping Peng, Henglong Ren, Borong Ren, Wu Yang","doi":"10.1016/j.snb.2025.137876","DOIUrl":"10.1016/j.snb.2025.137876","url":null,"abstract":"<div><div>Detection of sialic acid (SA) is crucial for the early diagnosis of ovarian cancer. In this study, we present the construction of a novel boronic acid functionalized covalent organic framework (TMTA-PBA-COF) for the first time for the accurate detection of SA. By combining the excellent luminescent properties of TMTA-COF with the specific binding capability of the boronic acid moiety to the cis-diol moiety in SA, the constructed fluorescent sensor achieved a sensitive and selective detection of SA in human serum within the linear range of 1–500 μM with a low detection limit of 0.45 μM. Crucially, we also established an intelligent back propagation neural network model to process the fluorescence sensing results, enabling accurate identification of SA concentrations through deep machine learning without cumbersome data processing. In addition, the practical application of TMTA-PBA-COF is extended to the visual identification of latent fingerprints. This work provides an intelligent and efficient analytical method for the early diagnosis of ovarian cancer and expands the multifunctional application of the material.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137876"},"PeriodicalIF":8.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-specificity near-infrared fluorescent probe for chymotrypsin imaging: Innovative diagnostic tool for pancreatic diseases 胰凝乳蛋白酶成像的高特异性近红外荧光探针：胰腺疾病的创新诊断工具

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-28 DOI: 10.1016/j.snb.2025.137886

Jingkang Li , Mo Ma , Chen Zhao , Lanyun Zhang , Wanqi Li , Pinyi Ma , Shan Jiao , Daqian Song

{"title":"High-specificity near-infrared fluorescent probe for chymotrypsin imaging: Innovative diagnostic tool for pancreatic diseases","authors":"Jingkang Li , Mo Ma , Chen Zhao , Lanyun Zhang , Wanqi Li , Pinyi Ma , Shan Jiao , Daqian Song","doi":"10.1016/j.snb.2025.137886","DOIUrl":"10.1016/j.snb.2025.137886","url":null,"abstract":"<div><div>Pancreatic diseases are closely linked with the abnormal activity of various proteases, including chymotrypsin. Currently, probes specifically designed for the detection of chymotrypsin in pancreatic disorders are unavailable. In this study, we developed a highly specific and sensitive fluorescent probe for the detection of chymotrypsin activity to enable precise diagnosis of pancreatic diseases. The probe was incorporated with Nile red as the fluorescent moiety and 4-bromobutanoyl as the recognition and quenching group to facilitate a \"fluorescence switch\" response upon enzymatic cleavage. The probe had high specificity and sensitivity to chymotrypsin, which remained unaffected in the presence of 52 biological interferents. It had a linear detection range of 0.1–0.75 μg/mL and a limit of detection of 0.0203 μg/mL, indicative of superior analytical performance. Cellular assays showed that the probe could effectively distinguish between normal pancreatic cells and tumor cells. Furthermore, the applications of the probe in pancreatitis models revealed its capability to accurately differentiate between normal tissue, chronic pancreatitis, and acute pancreatitis and to provide robust support for real-time imaging and disease progression monitoring. Subsequent <em>in vivo</em> experiments further validated the probe's diagnostic efficacy, highlighting its potential in the diagnosis of pancreatic diseases. These findings provide a solid foundation for developing molecular tools for early diagnosis and therapeutic monitoring of pancreatic disorders, demonstrating its significant potential in clinical diagnostics and precision medicine.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137886"},"PeriodicalIF":8.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0