Sensors and Actuators B: Chemical最新文献

{"title":"Colourimetric sensor for monitoring ammonia-generating infectious bacteria","authors":"Michaella Watson, Christopher O’Rourke, Andrew Mills","doi":"10.1016/j.snb.2025.138900","DOIUrl":"https://doi.org/10.1016/j.snb.2025.138900","url":null,"abstract":"A simple, inexpensive bromophenol blue (BPB), colourimetric ammonia (NH₃) sensor is used to monitor the growth of different wound associated bacteria in three different, simple wound models which utilise a typical, readily available, commercial occlusive wound dressing. The 25% colour change point of the sensor is ca. 0.0032%NH₃ and its 90% response and recovery times are, 8 and 230<!-- --> <!-- -->s, respectively. Using <em>P. stuartii</em> as the test species, in a model wound with an occlusive dressing, the increase in the sensor’s colour up to the 25% point correlates with that of the exponential growth of the bacterial species (units: CFU/mL) and a simple mathematical model is used to show that a linear relationship should exist between log(CFU/mL) of the initial inoculum and the time it takes for the sensor to reach its 25% colour change point, the threshold time, TT. This prediction is confirmed using the NH₃ producing bacteria, <em>E. coli, E. cloacae, P. stuartii</em>, and <em>K. aerogenes</em> using three different wound models, namely ones in which the ‘wound’ was a non-urea containing agar plug, a urea-containing agar plug and a damaged porcine skin model, respectively. These results suggest that the NH₃ sensor has promise as a <em>non-invasive</em> wound monitoring indicator and the additional work required to progress the sensor in this role is discussed briefly.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"101 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering oxygen vacancy defects on a CeO2-SnO2 micro-nano heterostructure for rapid triethylamine detection and fish freshness monitoring","authors":"Shuang Li, Zhuo Liu, Lin Yang, Mengli Yan, Yan Xu","doi":"10.1016/j.snb.2025.138901","DOIUrl":"https://doi.org/10.1016/j.snb.2025.138901","url":null,"abstract":"Oxygen vacancy defects on the surface of metal oxides can not only increase carrier density and facilitate electron transfer, but also increase more active sites, thereby significantly boosting the overall performance of sensors. In this study, a 3D bundle-like porous CeO₂-SnO₂ heterostructure with abundant oxygen vacancy defects composed of radially cross-bundled mesoporous nanorods is successfully prepared. The synergistic effects of composition regulation, Ce⁴⁺/Ce³⁺ valence engineering, and increased oxygen vacancy defects in the micro-nano structure enhance electron transfer at the interface, creating more active sites for triethylamine (TEA) capture. Consequently, the micro-nano structure shows an outstanding response value of 151.12 towards 100 ppm TEA at 157 °C, about six times higher than SnO₂, with excellent selectivity, fast response/recovery times (9<!-- --> <!-- -->s/123<!-- --> <!-- -->s), superior anti-interference ability, and long-term stability. Also, the sensor can achieve a response value of 11.24 for TEA detection in gases from five-day-stored crucian carp at room temperature, showing potential for freshness monitoring. This work presents an effective strategy to develop TEA sensors for practical applications by using oxygen valence engineering and tailoring multi-scale pore structures in MOF-derived heterostructures.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"8 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boosting CO2 sensitivity via multiphase ZnO heterojunctions and surface-engineered silicon pyramids","authors":"Feng-Renn Juang, Wei-Cheng Sung","doi":"10.1016/j.snb.2025.138895","DOIUrl":"https://doi.org/10.1016/j.snb.2025.138895","url":null,"abstract":"The development of low-temperature and high-sensitivity CO₂ gas sensors is crucial for applications in environmental monitoring and indoor air quality control. In this study, we report a ZnO-based heterostructure sensor fabricated on silicon pyramid arrays to enhance CO₂ detection performance. Vertically aligned ZnO nanorods were synthesized on etched Si substrates via hydrothermal methods, followed by the formation of ZnSnO₃ and Zn₂SnO₄ heterostructures through corrosion and hydrothermal reactions. XRD and EDS analyses confirmed the formation of composite oxide phases, and energy band diagrams revealed favorable n–n type heterojunctions at the ZTO/ZnO interface. Five types of devices were systematically compared, with the ZnSnO₃-ZnO and Zn₂SnO₄-ZnO sensors demonstrating high sensitivities of 365% and 398%, respectively, toward 2500 ppm CO₂ at an optimal operating temperature of 150 °C. These sensors also exhibited excellent stability over 30 days, minimal cross-sensitivity to common interfering gases (ethanol, acetone, hydrogen), and reduced humidity interference under controlled relative humidity (20–80%). Compared with previously reported metal oxide sensors, the proposed structures offer superior sensitivity, fast response/recovery, and reliable low-temperature operation. This work presents a scalable and material-efficient strategy for the fabrication of selective and stable CO₂ sensors suitable for real-world applications.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"325 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Microfluidic Device Integrating Magnetic Stirring with Tangential Flow for High-Efficiency Isolation of Small Extracellular Vesicles","authors":"Hao Zhong, Zeyin Mao, Xuwen Li, Anni Deng, Yihao Zhu, Shihong Wang, Leyang Huang, Jianxin Zhao, Wenqi Lv, Yixuan Shi, Qin Huang, Yabo Zhai, Chenzhou Hui, Xianbo Luo, Li Ma, Rongxin Fu, Xiongjun Ye, Guoliang Huang","doi":"10.1016/j.snb.2025.138898","DOIUrl":"https://doi.org/10.1016/j.snb.2025.138898","url":null,"abstract":"Small extracellular vesicles (sEVs), which are ubiquitously present in bodily fluids, hold significant promise as biomarkers for disease diagnosis and targeted therapy. However, their isolation remains challenging due to their small size (typically &lt; 200<!-- --> <!-- -->nm) and the complexity of biological fluids. This study presents a novel microfluidic strategy integrating Magnetic Stirring with Tangential Flow Filtration (MS-TFF). The automated, portable device (palm-sized, 12.5<!-- --> <!-- -->cm × 11.1<!-- --> <!-- -->cm × 6.25<!-- --> <!-- -->cm) features user-friendly operation: inserting the chip into a slot and closing the lid initiates automated sEV extraction. The system processes 10<!-- --> <!-- -->mL of morning urine or cell culture supernatant within ~40<!-- --> <!-- -->minutes. Compared to ultracentrifugation (UC), MS-TFF reduces processing time from ~4<!-- --> <!-- -->hours to ~40<!-- --> <!-- -->minutes while achieving a 6-fold higher sEV yield. Clinical validation using urine from 16 subjects (6 healthy/10 prostate cancer patients) enabled quantitative ^⁎KLK3/PCA3^⁎ RNA biomarker detection, achieving AUC = 0.93 for cancer diagnosis, confirming its diagnostic potential.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"37 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double enhanced flower-like SERS sensor based on aptamer modification for high specific recognition and sensitive rapidly detection of kanamycin","authors":"Shan Zhang, Fang Mi, Pengfei Geng, Guotong Chen, Xuehui Rao, Ming Guan","doi":"10.1016/j.snb.2025.138899","DOIUrl":"https://doi.org/10.1016/j.snb.2025.138899","url":null,"abstract":"Chronic intake of animal-derived foods with excessive kanamycin (Kana) residues risks human drug accumulation, posing significant health threats. To mitigate this, a layer of 4-mercaptophenyl-boronic acid (MPBA) was incorporated between the branched Au nanoflowers (NFs) core and the Ag shell to generate an inter-metallic nanogap, resulting in an aptamer (Apt)-functionalized surface-enhanced Raman scattering (SERS) probe (Au NFs-MPBA@Ag-Apt). When combined with MPBA as the Raman probes, exhibits an intense SERS signal at 1060<!-- --> <!-- -->cm⁻¹. Concurrently, magnetic nanoparticles modified with flower-like molybdenum disulfide (Fe₃O₄@MoS₂@Ag-Apt) were synthesized. These particles possess a strongly paramagnetic Fe₃O₄ core enveloped by a high-surface-area, flower-like MoS₂ layer, efficiently anchoring Ag nanoparticles (NPs) and Kana-Apt for enhanced target capture. Coupling semiconductor MoS₂ with Ag NPs creates a coupled enhancement: electromagnetic amplification between Ag NPs and at the Ag NPs-MoS₂ interface boosts “hot spots” density. As a semiconductor, MoS₂ facilitates separation of photogenerated electron-hole pairs when interfaced with Ag NPs, driving substantial interfacial electron transfer toward Kana molecules. This substrate achieves a remarkable enhancement factor (EF) of 8.1 × 10⁹. This integrated SERS sensor, using two types of probes at the same time, enables highly specific recognition, rapid, sensitive quantification of Kana. The detection range was 1 × 10¹ ~ 1 × 10^{6<!-- -->}pg/mL, and the limit of detection (LOD) was 0.23<!-- --> <!-- -->pg/mL. Compared to conventional methods, this biosensor exhibits superior detection breadth and sensitivity. Applied to milk analysis, recoveries were 93.0 ~ 103%. Its portability aligns with point-of-care testing (POCT) needs, offering a viable platform for food safety monitoring.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"39 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ni(OH)2/MXene-decorated plasmonic interface with dual signal enhancement for sensitive PSA immunoassay in serum","authors":"Yanpei Xu, Silong Li, Shuxian Gao, Fudong Jia, Liang Guo, Jiangrong Hou, Shaowei Ma, Heya Zheng, Chuxiao Sun, Qi Wang","doi":"10.1016/j.snb.2025.138797","DOIUrl":"https://doi.org/10.1016/j.snb.2025.138797","url":null,"abstract":"Prostate-specific antigen (PSA) detection is vital for early prostate cancer diagnosis, yet conventional methods suffer from sensitivity and label-dependent limitations. This study presents a surface plasmon resonance (SPR) biosensor enhanced by Ni(OH)&lt;span&gt;&lt;span&gt;&lt;math&gt;&lt;msub is=\"true\"&gt;&lt;mrow is=\"true\"&gt;&lt;/mrow&gt;&lt;mrow is=\"true\"&gt;&lt;mn is=\"true\"&gt;2&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt;&lt;script type=\"math/mml\"&gt;&lt;math&gt;&lt;msub is=\"true\"&gt;&lt;mrow is=\"true\"&gt;&lt;/mrow&gt;&lt;mrow is=\"true\"&gt;&lt;mn is=\"true\"&gt;2&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/script&gt;&lt;/span&gt;/Ti&lt;span&gt;&lt;span&gt;&lt;math&gt;&lt;msub is=\"true\"&gt;&lt;mrow is=\"true\"&gt;&lt;/mrow&gt;&lt;mrow is=\"true\"&gt;&lt;mn is=\"true\"&gt;3&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt;&lt;script type=\"math/mml\"&gt;&lt;math&gt;&lt;msub is=\"true\"&gt;&lt;mrow is=\"true\"&gt;&lt;/mrow&gt;&lt;mrow is=\"true\"&gt;&lt;mn is=\"true\"&gt;3&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/script&gt;&lt;/span&gt;C&lt;span&gt;&lt;span&gt;&lt;math&gt;&lt;msub is=\"true\"&gt;&lt;mrow is=\"true\"&gt;&lt;/mrow&gt;&lt;mrow is=\"true\"&gt;&lt;mn is=\"true\"&gt;2&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt;&lt;script type=\"math/mml\"&gt;&lt;math&gt;&lt;msub is=\"true\"&gt;&lt;mrow is=\"true\"&gt;&lt;/mrow&gt;&lt;mrow is=\"true\"&gt;&lt;mn is=\"true\"&gt;2&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/script&gt;&lt;/span&gt;T&lt;span&gt;&lt;span&gt;&lt;math&gt;&lt;msub is=\"true\"&gt;&lt;mrow is=\"true\"&gt;&lt;/mrow&gt;&lt;mrow is=\"true\"&gt;&lt;mi is=\"true\"&gt;x&lt;/mi&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt;&lt;script type=\"math/mml\"&gt;&lt;math&gt;&lt;msub is=\"true\"&gt;&lt;mrow is=\"true\"&gt;&lt;/mrow&gt;&lt;mrow is=\"true\"&gt;&lt;mi is=\"true\"&gt;x&lt;/mi&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/script&gt;&lt;/span&gt; MXene nanocomposites (NTC) for sensitive detection of total PSA (tPSA) in serum. The NTC architecture synergizes carboxyl-functionalized MXene, amplifying localized electric fields and antibody-binding sites, with Ni(OH)&lt;span&gt;&lt;span&gt;&lt;math&gt;&lt;msub is=\"true\"&gt;&lt;mrow is=\"true\"&gt;&lt;/mrow&gt;&lt;mrow is=\"true\"&gt;&lt;mn is=\"true\"&gt;2&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/span&gt;&lt;script type=\"math/mml\"&gt;&lt;math&gt;&lt;msub is=\"true\"&gt;&lt;mrow is=\"true\"&gt;&lt;/mrow&gt;&lt;mrow is=\"true\"&gt;&lt;mn is=\"true\"&gt;2&lt;/mn&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;/math&gt;&lt;/script&gt;&lt;/span&gt; nanoflowers that prevent MXene stacking and enhance refractive index (RI) sensitivity. Optimized via finite element modeling (50-nm Au film, 72.4 ° incident angle), the Au-NTC architecture achieved a 39.34% improvement in RI sensitivity (3064.86 nm/RIU) compared to pristine Au. Through the dual signal amplification mechanism of synergistic enhancement by nanomaterials and sandwich method with gold nanoparticles, enabled detection of tPSA in 20% serum across a wide dynamic range (0.2–160 ng/mL), fully covering the clinical risk threshold (4–10 ng/mL). The platform demonstrated an ultralow limit of detection (LOD) of 0.0361 ng/mL (0.5157 pM) and high specificity against interferons. Kinetic analysis revealed strong antigen-antibody affinity (equilibrium dissociation constant &lt;span&gt;&lt;span&gt;&lt;math&gt;&lt;mrow is=\"true\"&gt;&lt;msub is=\"true\"&gt;&lt;mrow is=\"true\"&gt;&lt;mi is=\"true\"&gt;K&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow is=\"true\"&gt;&lt;mtext is=\"true\"&gt;D&lt;/mtext&gt;&lt;/mrow&gt;&lt;/msub&gt;&lt;mo is=\"true\" linebreak=\"goodbreak\" linebreakstyle=\"after\"&gt;=&lt;/mo&gt;&lt;mn is=\"true\"&gt;4&lt;/mn&gt;&lt;mo is=\"true\"&gt;.&lt;/mo&gt;&lt;mn is=\"true\"&gt;26&lt;/mn&gt;&lt;mo is=\"true\" linebreak=\"goodbreak\" linebreakstyle=\"after\"&gt;×&lt;/mo&gt;&lt;mn is=\"true\"&gt;1&lt;/mn&gt;&lt;msup is=\"true\"&gt;&lt;mrow is=\"true\"&gt;&lt;mn is=\"true\"&gt;0&lt;/mn&gt;&lt;/mrow&gt;&lt;mr","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"7 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Situ Chemical Conversion Approach for Growth of Magnesium-Aluminium-Layered Double Hydroxide Thin Films: Room Temperature NO2 Sensing","authors":"Shweta Talekar, Prashant Sawant, Shraddha Pawar, Shashikant Patole, Mayura Medhekar, Ganesh Khande, Sayali Kulkarni, Hemraj Yadav, Jayavant Gunjakar","doi":"10.1016/j.snb.2025.138890","DOIUrl":"https://doi.org/10.1016/j.snb.2025.138890","url":null,"abstract":"The direct deposition of layered double hydroxide on a substrate is highly desirable for a gas sensor. In this work, we demonstrate the direct deposition of magnesium-aluminum-layered double hydroxide (MA-LDH) thin film (TF) by chemical conversion of magnesium oxide (MgO) TF. The chemical conversion of MgO TFs produces well-crystalline, porous microsheets composed of an interconnected nanoparticle network of MA-LDH, which provides an enhanced surface area with a highly accessible framework, making MA-LDH TFs promising candidates for efficient gas sensor electrodes. Furthermore, the resulting MA-LDH TFs are tested as resistive sensor electrodes to detect different oxidizing (SO₂, Cl₂, and NO₂) and reducing (LPG, CO, CO₂, H₂, H₂S, and NH₃) gases. The MA-LDH TF exhibited excellent selectivity towards NO₂ gas with a maximum response of 54% at room temperature (300 ± 2<!-- --> <!-- -->K) compared to pristine MgO TFs (14%) at 473<!-- --> <!-- -->K for 100 ppm. Also, it exhibits a quick response time of 10<!-- --> <!-- -->s, a detection limit of 0.02 ppm, and prolonged stability. Of prime interest is that the MA-LDH sensor displayed high tolerance to humidity conditions. The excellent NO₂ sensing performance of the MA-LDH TFs is attributed to the expanded surface area, which is composed of porous microsheets formed by interconnected nanoparticles network. The direct deposition of an interconnected microsheet network provides abundant active adsorption sites, thereby enhancing gas sensing efficiency.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"101 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-cost CMOS-based luminescence lifetime imaging with oxygen, temperature and pH sensors","authors":"Gauthier Rousseau, Marianne Pons, Hessel Adelerhof, Nathan Pellerin, Mart Giesbergen, Bastien Carde, Martin Wolff, Koen Blanckaert, Sergey M. Borisov, Benoit Fond","doi":"10.1016/j.snb.2025.138849","DOIUrl":"https://doi.org/10.1016/j.snb.2025.138849","url":null,"abstract":"Luminescence imaging enables spatiotemporal visualization of physical and chemical quantities, yet widespread adoption has been hindered by expensive, specialized instrumentation. Here, we present a compact platform that employs a consumer CMOS camera for versatile luminescence imaging across biomedical research, geosciences, and aerospace engineering applications. Our approach exploits the on-chip charge accumulation capability to perform multiple exposures in one frame, thereby combining the robustness of lifetime-based measurements with the superior signal quality of time-integrated detection. We demonstrate platform versatility through three applications: (i) oxygen mapping using phosphorescent platinum(II) benzoporphyrin optodes ; (ii) the first demonstration of temperature mapping in fluid using thermally-activated delayed fluorescence (TADF) nanoparticles in a laser plane, achieving ±1 °C (1&lt;span&gt;&lt;span style=\"\"&gt;&lt;/span&gt;&lt;span data-mathml='&lt;math xmlns=\"http://www.w3.org/1998/Math/MathML\"&gt;&lt;mi is=\"true\"&gt;&amp;#x3C3;&lt;/mi&gt;&lt;/math&gt;' role=\"presentation\" style=\"font-size: 90%; display: inline-block; position: relative;\" tabindex=\"0\"&gt;&lt;svg aria-hidden=\"true\" focusable=\"false\" height=\"1.394ex\" role=\"img\" style=\"vertical-align: -0.235ex;\" viewbox=\"0 -498.8 572.5 600.2\" width=\"1.33ex\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"&gt;&lt;g fill=\"currentColor\" stroke=\"currentColor\" stroke-width=\"0\" transform=\"matrix(1 0 0 -1 0 0)\"&gt;&lt;g is=\"true\"&gt;&lt;use xlink:href=\"#MJMATHI-3C3\"&gt;&lt;/use&gt;&lt;/g&gt;&lt;/g&gt;&lt;/svg&gt;&lt;span role=\"presentation\"&gt;&lt;math xmlns=\"http://www.w3.org/1998/Math/MathML\"&gt;&lt;mi is=\"true\"&gt;σ&lt;/mi&gt;&lt;/math&gt;&lt;/span&gt;&lt;/span&gt;&lt;script type=\"math/mml\"&gt;&lt;math&gt;&lt;mi is=\"true\"&gt;σ&lt;/mi&gt;&lt;/math&gt;&lt;/script&gt;&lt;/span&gt;) precision for single-shot single-pixel at a &lt;span&gt;&lt;span style=\"\"&gt;&lt;/span&gt;&lt;span data-mathml='&lt;math xmlns=\"http://www.w3.org/1998/Math/MathML\"&gt;&lt;mrow is=\"true\"&gt;&lt;mn is=\"true\"&gt;500&lt;/mn&gt;&lt;mspace width=\"0.33em\" is=\"true\" /&gt;&lt;mtext is=\"true\"&gt;&amp;#xB5;m&lt;/mtext&gt;&lt;/mrow&gt;&lt;/math&gt;' role=\"presentation\" style=\"font-size: 90%; display: inline-block; position: relative;\" tabindex=\"0\"&gt;&lt;svg aria-hidden=\"true\" focusable=\"false\" height=\"2.432ex\" role=\"img\" style=\"vertical-align: -0.582ex;\" viewbox=\"0 -796.9 3123 1047.3\" width=\"7.253ex\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"&gt;&lt;g fill=\"currentColor\" stroke=\"currentColor\" stroke-width=\"0\" transform=\"matrix(1 0 0 -1 0 0)\"&gt;&lt;g is=\"true\"&gt;&lt;g is=\"true\"&gt;&lt;use xlink:href=\"#MJMAIN-35\"&gt;&lt;/use&gt;&lt;use x=\"500\" xlink:href=\"#MJMAIN-30\" y=\"0\"&gt;&lt;/use&gt;&lt;use x=\"1001\" xlink:href=\"#MJMAIN-30\" y=\"0\"&gt;&lt;/use&gt;&lt;/g&gt;&lt;g is=\"true\"&gt;&lt;/g&gt;&lt;g is=\"true\" transform=\"translate(1831,0)\"&gt;&lt;text font-family=\"STIXGeneral,'Arial Unicode MS',serif\" stroke=\"none\" transform=\"scale(55.199) matrix(1 0 0 -1 0 0)\"&gt;µ&lt;/text&gt;&lt;use x=\"457\" xlink:href=\"#MJMAIN-6D\" y=\"0\"&gt;&lt;/use&gt;&lt;/g&gt;&lt;/g&gt;&lt;/g&gt;&lt;/svg&gt;&lt;span role=\"presentation\"&gt;&lt;math xmlns=\"http://www.w3.org/1998/Math/MathML\"&gt;&lt;mrow is=\"true\"&gt;&lt;mn is=\"true\"&gt;500&lt;/mn&gt;&lt;mspace is=\"true\" width=\"0.33em\"&gt;&lt;/mspace&gt;&lt;mtext ","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"38 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chain-based precision amplification biosensor for microRNA detection based on dCas13a system and iridium complex","authors":"Yiming Zhang, Zhi Chen, Songrui Wei, Yujun Zhang, Yingxia Liu, Hui Li, Jing Wang, Qi Gao, Defa Li, Han Zhang, Zhongjian Xie","doi":"10.1016/j.snb.2025.138881","DOIUrl":"https://doi.org/10.1016/j.snb.2025.138881","url":null,"abstract":"Considering the close association between the abnormal expression of multiple microRNAs (miRNAs) and various diseases, multi-channel detection of miRNAs holds significant importance for disease diagnosis. However, traditional miRNA detection methods fall short of simultaneously achieving the required specificity, sensitivity, and multi-channel capability. To address this challenge, we developed a chain-based precision amplification photoelectrochemical biosensor for the simultaneous detection of multiple miRNAs, based on dCas13a system and iridium complex. The precise recognition of miRNA is achieved by the dCas13a-crRNA complex and then converted into a significant photocurrent response from iridium nanocomposite attached to a long double-stranded nucleic acid chain, thereby enabling signal amplification, namely chain-based precision amplification. The dCas13a-crRNA complex is modified onto a multi-channel electrode to simultaneously recognize and bind multiple target miRNAs. The iridium complex is modified on the surface of energy-level-matched quantum dots to suppress carrier recombination, and Au nanoparticles are further modified on the surface of the quantum dots, thereby constructing a nanocomposite for efficient photoelectric conversion. A double-stranded sequence is constructed at the 3' end of the miRNA to increase the attachment sites for the nanocomposite. The biosensor demonstrates exceptional specificity and sensitivity, capable of distinguishing single-base differences with a detection limit as low as the aM level, benefiting from the chain-based precision amplification. Furthermore, clinical sample testing underscores the practical applicability of the biosensor in clinical diagnostics. This multi-channel chain-based precision amplification biosensor offers a highly valuable and innovative approach for the simultaneous detection of multiple miRNAs, with considerable potential for clinical diagnostic applications.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"116 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Lung Cancer Aldehydes Biomarker by Al2O3/Ag/ZIF-8 SERS Quasi Cavity with Co-Confinement Effect","authors":"Lingmeng Fang, Yunhai Zhang, Hao Li, Jing Yu, Maosen Yang","doi":"10.1016/j.snb.2025.138878","DOIUrl":"https://doi.org/10.1016/j.snb.2025.138878","url":null,"abstract":"The utilization of surface-enhanced Raman scattering (SERS) technology for monitoring aldehydes in human exhaled gas represents a burgeoning method for early screening of lung cancer; however, it currently faces several challenges: firstly, the limited capacity of SERS substrates to capture aldehyde molecules, and secondly, the low degree of co-localization between aldehyde molecules and hotspot spatial distribution. To address these issues, this study proposes an Al₂O₃/Ag/ZIF-8 SERS quasi-cavity structure, which enables the dual regulation of intramolecular hotspots, the capture of gaseous analytes, and the micro-localized co-localization of \"hotspots-analytes.\" Leveraging this structure, we achieved sensitive detection of ethyl benzaldehyde molecules over a concentration range of 0.2 ppb-20 ppm, and preliminarily explored its specific recognition of aldehyde biomarkers in human exhaled gas. This research provides a versatile SERS detection strategy for gaseous molecules, offering significant reference value for the accurate detection of various cancer-associated gaseous biomarkers in human exhalations.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"1 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}