Sensors and Actuators B: Chemical最新文献_第2页

Development of a Ti₃C₂ MXene-AgNPs-based SERS platform for ionophore-based ion-selective detection 开发基于 Ti₃C₂ MXene-AgNPs 的 SERS 平台，用于基于离子团的离子选择性检测

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-07 DOI: 10.1016/j.snb.2025.137524

Laiqi Zhang , Elena Zhu , Alejandra Coronel-Zegarra , Dawn Raja Somu , Shankar Dhar , Vivian Merk , Xiaolang Zhang , Renjie Wang

{"title":"Development of a Ti₃C₂ MXene-AgNPs-based SERS platform for ionophore-based ion-selective detection","authors":"Laiqi Zhang , Elena Zhu , Alejandra Coronel-Zegarra , Dawn Raja Somu , Shankar Dhar , Vivian Merk , Xiaolang Zhang , Renjie Wang","doi":"10.1016/j.snb.2025.137524","DOIUrl":"10.1016/j.snb.2025.137524","url":null,"abstract":"<div><div>Surface-enhanced Raman spectroscopy (SERS) has advanced as a crucial analytical technology, benefiting numerous fields with its high sensitivity and versatility. However, its application in detecting ions has been underexplored. In this study, we developed a novel SERS sensing platform for ion detection by creating a Ti<sub>3</sub>C<sub>2</sub> Mxene-AgNPs substrate and integrating it with the ionophore-based ion-selective sensing framework. The Ti<sub>3</sub>C<sub>2</sub> Mxene-AgNPs substrate was successfully prepared via electrodeposition on conductive glass, achieving an enhancement factor of 1.86 × 10<sup>6</sup> and demonstrating good signal repeatability (RSD = 8.17 %). The AgNPs ensure amplified and stable SERS activity, while large surface area of the MXene nanosheets offers a significant advantage for AgNPs and sensing chemical loading. The Ti<sub>3</sub>C<sub>2</sub> Mxene-AgNPs SERS substrate enables ionophore-based ion-selective sensing with exceptional selectivity and high sensitivity for target ion detection, eliminating the need for plasticizers. A selective turn-on SERS response of this platform to various concentrations of K<sup>+</sup>, Na<sup>+</sup>, and Ca<sup>2+</sup> was exemplified in this study, further revealing its excellent generalizability. Moreover, the applicability of this method was preliminarily demonstrated by its successful application in determining Na<sup>+</sup> in human blood serum and environmental water samples (river and estuary). The successful integration of the versatile and rapidly progressing SERS technique, enabled by the Ti<sub>3</sub>C<sub>2</sub> Mxene-AgNPs substrate, for electrolyte cation detection offers a promising avenue for enhancing current ion detection capabilities in biological and environmental samples.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137524"},"PeriodicalIF":8.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Ethanol Concentration Detection Method Based on Capacitive Micromachined Ultrasonic Transducer

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-07 DOI: 10.1016/j.snb.2025.137508

Chenya Zhao, Zhihao Wang, Zhaodong Li, Xiangchen Zeng, Shurui Liu, Jingwen Wang, Licheng Jia, Changde He, Jiangong Cui, Yuhua Yang, Guojun Zhang, Wendong Zhang, Renxin Wang

{"title":"An Ethanol Concentration Detection Method Based on Capacitive Micromachined Ultrasonic Transducer","authors":"Chenya Zhao, Zhihao Wang, Zhaodong Li, Xiangchen Zeng, Shurui Liu, Jingwen Wang, Licheng Jia, Changde He, Jiangong Cui, Yuhua Yang, Guojun Zhang, Wendong Zhang, Renxin Wang","doi":"10.1016/j.snb.2025.137508","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137508","url":null,"abstract":"This paper presents a method for ethanol concentration detection based on capacitive micromachined ultrasonic transducer (CMUT). The system utilizes a pair of CMUT transducers to transmit and receive ultrasonic signals, while a TR6601 temperature sensor continuously monitors the temperature of the solution under test. The acquired electrical signals undergo successive processing steps, including ultrasonic time-of-flight (TOF) measurement, ultrasonic velocity calculation, and temperature compensation. This paper analyzes the ultrasonic velocity of ethanol solutions with varying concentrations and establishes a concentration measurement model based on sound velocity and solution temperature, with the test results presented in the application. The study conducted alcohol concentration tests on four different types of aromatic Chinese spirits, and the final results demonstrates excellent accuracy in determining the volume concentration of ethanol in Baijiu, with a measurement range of 30% to 70% and an error precision of 0.2%. It exhibits stable testing performance and high sensitivity. The concentration measurement of Baijiu samples achieves sufficient accuracy. Furthermore, due to the compact size of the designed CMUT sensor, the ethanol concentration measurement system proposed can take on the role of a highly portable measurement probe for ethanol concentration detection in the Baijiu production and sales processes.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"22 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-responsive near-infrared fluorescent probe for monitoring viscosity and mitochondria-generated peroxynitrite-induced lipid droplet migration in live cells and non-alcoholic fatty liver

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-06 DOI: 10.1016/j.snb.2025.137580

Xi Xu, Xuehui Wang, Gang Xu, Xi Chen, Tong Chen, Chen Jin, Zhenyu Duan, Jiulin Song, Tao Lv, Yongjie Zhou, Weimin Li, Jiayin Yang, Zixuan Zhan

{"title":"Dual-responsive near-infrared fluorescent probe for monitoring viscosity and mitochondria-generated peroxynitrite-induced lipid droplet migration in live cells and non-alcoholic fatty liver","authors":"Xi Xu, Xuehui Wang, Gang Xu, Xi Chen, Tong Chen, Chen Jin, Zhenyu Duan, Jiulin Song, Tao Lv, Yongjie Zhou, Weimin Li, Jiayin Yang, Zixuan Zhan","doi":"10.1016/j.snb.2025.137580","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137580","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver disease worldwide. Early diagnosis and timely intervention can prevent the progression of liver fibrosis and liver cancer, thereby reducing the risk of death. Growing evidence indicated that the accumulation of lipid droplets (LDs) in hepatocytes, along with increased intracellular viscosity and elevated levels of reactive oxygen species (ROS), is essential to the progression of NAFLD. In this study, we developed a novel dual-responsive near-infrared (NIR) fluorescent probe, <strong>HX-VP-2</strong>, designed for real-time monitoring of viscosity and ONOO<sup>-</sup>. <strong>HX-VP-2</strong> shows enhanced fluorescence at 777 nm in response to viscosity and at 657 nm upon the detection of ONOO<sup>-</sup>. Additionally, <strong>HX-VP-2</strong> facilitates the tracking of LDs migration induced by mitochondria-generated ONOO<sup>-</sup>, offering insights into the mechanistic progression of NAFLD. In addition, <strong>HX-VP-2</strong> was further applied to investigate fluctuations in viscosity and ONOO<sup>-</sup> across different NAFLD stages and treatment models, demonstrating its potential for improving diagnostic accuracy and therapeutic evaluation. Moreover, we also explored the use of <strong>HX-VP-2</strong> to assess the extent of donor liver steatosis. Overall, our study introduces a powerful tool for the in-depth exploration of NAFLD pathogenesis, enhancing both diagnostic precision and understanding of disease mechanisms.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"67 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Host-guest recognition-regulated TiO2@In2S3 S-scheme heterojunction photoactivity: A PEC-EC dual-mode split-type aptasensor for malathion

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-06 DOI: 10.1016/j.snb.2025.137574

Ben-Fang Xu, Jiang-Zhou Wu, Pei Song, Qin-Ying Ai, Ai-Jun Wang, Li-Ping Mei, Yadong Xue, Jiu-Ju Feng

{"title":"Host-guest recognition-regulated TiO2@In2S3 S-scheme heterojunction photoactivity: A PEC-EC dual-mode split-type aptasensor for malathion","authors":"Ben-Fang Xu, Jiang-Zhou Wu, Pei Song, Qin-Ying Ai, Ai-Jun Wang, Li-Ping Mei, Yadong Xue, Jiu-Ju Feng","doi":"10.1016/j.snb.2025.137574","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137574","url":null,"abstract":"Ensuring the sensitive and rapid detection of residual malathion (MLT) levels in both environment and food is crucial for ecological environment and food safety. Herein, host-guest recognition-regulated the photoactivity of TiO<sub>2</sub>@In<sub>2</sub>S<sub>3</sub> S-scheme heterojunction was applied to construct a photoelectrochemical (PEC) and electrochemical (EC) dual-mode split-type aptasensor for malathion bioassay. The S-scheme charge transfer mechanism, in conjunction with sulfur vacancies in the TiO<sub>2</sub>@In<sub>2</sub>S<sub>3</sub> heterojunction, not only broadens the light absorption range, but also facilitates efficient separation and migration of photogenerated carriers, thus enhancing the original photocurrent response of the sensor. In the presence of MLT, rhodamine B-labelled MLT aptamer (RhB-apta)-MLT conjugates were formed and acted as the guest, which was recognized by β-cyclodextrin as the host on the electrode surface. Leveraging the excellent electroactivity of RhB and its sensitization of TiO<sub>2</sub>@In<sub>2</sub>S<sub>3</sub>, a PEC-EC dual-mode aptasensor for MLT assay was achieved. The proposed aptasensor exhibits a wide linear range (0.001 ~ 50 ng mL<sup>−1</sup>), with a detection limit of 0.12 pg mL<sup>−1</sup> in PEC mode and 0.62 pg mL<sup>−1</sup> in EC mode. The combination of the two detection signals can complement and validate each other, thereby improving the sensitivity, accuracy, and reliability of malathion detection.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"87 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143570176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gas concentration prediction based on temporal attention mechanism in temporal convolutional networks

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-06 DOI: 10.1016/j.snb.2025.137562

Pengfei Jia , Zhicong Chen , Guosheng Mao , Yiyi Zhang , Jiefeng Liu , Min Xu

{"title":"Gas concentration prediction based on temporal attention mechanism in temporal convolutional networks","authors":"Pengfei Jia , Zhicong Chen , Guosheng Mao , Yiyi Zhang , Jiefeng Liu , Min Xu","doi":"10.1016/j.snb.2025.137562","DOIUrl":"10.1016/j.snb.2025.137562","url":null,"abstract":"<div><div>To predict indoor air quality, we can analyze the concentrations of gas present in the air. Accurate prediction of gas concentrations can help individuals identify the presence of harmful gas in the environment, thereby preventing potential accidents. Previous studies have utilized electronic nose (E-nose) in conjunction with traditional neural networks to obtain gas concentration information; However, these neural networks often experience a decline in prediction accuracy when handling longer time series data, failing to meet expected outcomes. To enhance prediction accuracy, this study introduces an innovative Temporal Convolutional Network (AGT-TCN), designed for the prediction of mixed gas concentrations in E-nose. AGT-TCN comprises a temporal convolutional network (TCN), gated recurrent units (GRU), a temporal attention mechanism and residual convolutions. In the experiments, we employed data from carbon monoxide and ethylene mixed gas (CO-ethylene) for concentration predictions and compared the results with baseline models including TCN, GRU, Long and short-term memory network (LSTM), convolutional neural network - long short-term memory network (CNN-LSTM) and Long Short-Term Memory-Transformer (LSTM-Transformer). The results demonstrate that AGT-TCN outperforms baseline in terms of prediction accuracy. This further confirms the applicability of the AGT-TCN in the early prediction of CO-ethylene concentrations.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137562"},"PeriodicalIF":8.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface photografted thermoresponsive hydrogel microvalves on PDMS/Silicon hybrid membrane for light-actuated localized chemical release

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-06 DOI: 10.1016/j.snb.2025.137559

Nafis Mustakim, Mayank Pandey, Sang-Woo Seo

{"title":"Surface photografted thermoresponsive hydrogel microvalves on PDMS/Silicon hybrid membrane for light-actuated localized chemical release","authors":"Nafis Mustakim, Mayank Pandey, Sang-Woo Seo","doi":"10.1016/j.snb.2025.137559","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137559","url":null,"abstract":"On-demand localized chemical release holds great promise for various biomedical applications, including drug delivery systems and neurotransmitter-based prostheses. Temperature-sensitive poly(n-isopropylacrylamide (PNIPAM)-based hydrogel has been widely implemented in on demand drug delivery devices. In particular, surface photografted PNIPAM has the merit of integrating hydrogel film onto a targeted surface through a photo-initiated crosslinking process. This paper explores the integration of surface photografted PNIPAM microvalves into a PDMS (Polydimethylsiloxane)/Silicon hybrid membrane to create a device platform for light-actuated localized chemical release. We have developed unique fabrication processes to create a PDMS/Silicon hybrid membrane and to photograft PNIPAM using benzophenone absorbed in PDMS film. The flow of chemicals in macroscopic pores can be actuated through the surface photografted microvalve. Our platform demonstrates NIR light-actuated localized chemical release by incorporating Polypyrrole (PPy) as a photothermal element. By adjusting several actuation parameters, including laser power and pulse duration, we have investigated the operation of the microvalve. The opening and closing times were measured within 2 s. Each actuation released approximately 2% to 10% of the peak model chemical from the reservoir, depending on NIR laser power levels ranging from 20 to 60 mW/mm<sup>2</sup>. Furthermore, repeated activation of the microvalves exhibited a minimum variation (~8%) in the release profile. The ability to control chemical release at a micron-scale area using light will be of great interest for various neurotransmitter-based prosthetic applications.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"30 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143570175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly sensitive colorimetric detection of ammonia and respiratory ammonia based on ammonia induced perylene diimide anion radical π-dimer dissociation

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-06 DOI: 10.1016/j.snb.2025.137555

Yahua Zhu , Gengwen Yin , Wei Li , Rui Tan , Wenlong Hou , Xueqiang Liu , Yuzhen Zhao , Haiquan Zhang

{"title":"Highly sensitive colorimetric detection of ammonia and respiratory ammonia based on ammonia induced perylene diimide anion radical π-dimer dissociation","authors":"Yahua Zhu , Gengwen Yin , Wei Li , Rui Tan , Wenlong Hou , Xueqiang Liu , Yuzhen Zhao , Haiquan Zhang","doi":"10.1016/j.snb.2025.137555","DOIUrl":"10.1016/j.snb.2025.137555","url":null,"abstract":"<div><div>Ammonia is not only a crucial respiratory biomarker for chronic kidney diseases, but also an important raw material in chemical industry. Ammonia has important economic value, however, it also has harmful effects. Therefore, the sensitive and rapid detection of low concentration ammonia is always a hot and challenging topic in sensing field. Recently, we discovered a type of perylene diimide anionic radical π-dimers which the absorbance spectrum depends on the hydrogen bond between two radical molecules. Herein, the colorimetric detection of NH<sub>3</sub>·H<sub>2</sub>O, NH<sub>3</sub> gas, and respiratory NH<sub>3</sub> is achieved through the color changes resulting from the hydrogen bond in the π-dimer being broken by NH<sub>3</sub>. The π-dimer solution achieving a lowest detection limits of 0.26 ppb for NH<sub>3</sub>·H<sub>2</sub>O, and provided high precision recognition with approximately 90 % accuracy based on UV–vis spectrum and color change. The colorimetric films based on the π-dimer/silica gel can detect NH<sub>3</sub> gases at ppb level, and achieving high precision recognition with about 94 % accuracy. The cotton fibers dyed by π-dimers were successfully used in detecting 830 ppb NH<sub>3</sub> gas (the NH<sub>3</sub> concentration in exhaled breath of early chronic kidney diseases) based on the visible color changes. We believe that these environmental sensitive radical derivatives can serve as candidate colorimetric probes, which offers a novel and non-invasive approach for the early warning of chronic kidney disease.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137555"},"PeriodicalIF":8.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid and sensitive identification of Pseudomonas aeruginosa through a fluorescent probe utilizing a magnetic 3D DNA walker and APE1 enzyme-powered cascade signal amplification

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-06 DOI: 10.1016/j.snb.2025.137585

Kun Wang , Siyu Jiang , Yufeng Hu , Tianhan Kai

{"title":"Rapid and sensitive identification of Pseudomonas aeruginosa through a fluorescent probe utilizing a magnetic 3D DNA walker and APE1 enzyme-powered cascade signal amplification","authors":"Kun Wang , Siyu Jiang , Yufeng Hu , Tianhan Kai","doi":"10.1016/j.snb.2025.137585","DOIUrl":"10.1016/j.snb.2025.137585","url":null,"abstract":"<div><div>The efficient and accurate identification of Pseudomonas aeruginosa (PA) is vital for reducing the risk of disease spread, and nucleic acid detection (NAT) is an excellent approach for the early diagnosis of this infectious agent. Herein, we created a fluorescent probe utilizing a magnetic 3D DNA walker that incorporates APE1 enzyme-driven signal enhancement (MDWAE) to quickly and precisely identify PA 16S rRNA. The DNA walker, activated by PA 16S rRNA, generates cleavage products that hybridize with molecular beacons containing apurinic sites, enabling APE1-mediated fluorescence amplification. This cascade process achieved PA determination within one hour with a detection limit of 1 CFU/mL while effectively differentiating PA from other bacteria. Recovery tests further confirmed that the cascade fluorescence probe is capable of detecting PA in spiked milk and orange juice samples, pointing to its potential for significant application in food safety assessments, environmental monitoring, and disease diagnosis.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137585"},"PeriodicalIF":8.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143570177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A high signal-to-noise ratio NIR fluorescent probe for viscosity detection in NAFLD diagnosis

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-06 DOI: 10.1016/j.snb.2025.137581

Junlei Hao , Suntao Shi , Yaoling Zhang , Xiao Li , Xiaowen Ren , Jia Gao , Shuijuan Liu , Haijuan Zhang , Jiang Wu , Baoxin Zhang

{"title":"A high signal-to-noise ratio NIR fluorescent probe for viscosity detection in NAFLD diagnosis","authors":"Junlei Hao , Suntao Shi , Yaoling Zhang , Xiao Li , Xiaowen Ren , Jia Gao , Shuijuan Liu , Haijuan Zhang , Jiang Wu , Baoxin Zhang","doi":"10.1016/j.snb.2025.137581","DOIUrl":"10.1016/j.snb.2025.137581","url":null,"abstract":"<div><div>Viscosity is a critical parameter within the cellular environment, playing a fundamental role in various biochemical processes and the functional integrity of organelles. Abnormal viscosity fluctuations are often linked to conditions such as Non-alcoholic fatty liver disease (NAFLD), diabetes, and neurodegenerative disorders. Thus, monitoring viscosity variations in biological systems is vital for disease-related research. In this study, we have styled and synthesized <strong>VFP-4</strong>, a near-infrared (NIR) fluorescent probe with a high signal-to-noise ratio (436.4-fold), which demonstrates highly sensitive responsiveness to viscosity changes while remaining unaffected by pH and various interfering substances. Furthermore, <strong>VFP-4</strong> was successfully employed in the imaging of viscosity in live cells treated with dexamethasone (DXM) or lipopolysaccharide (LPS), showing precise targeting of lipid droplets (LDs). Notably, due to its NIR emission and exceptional sensitivity to viscosity, <strong>VFP-4</strong> can detect real-time viscosity changes in zebrafish and mouse models of NAFLD while exhibiting excellent photostability during imaging. This work holds significant potential for advancing our understanding of cellular processes and developing novel diagnostic and therapeutic strategies by enabling real-time, non-invasive monitoring of intracellular viscosity changes.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137581"},"PeriodicalIF":8.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143570179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An integrated flexible dual-mode optical-electrochemical sensing microcatheter platform for inflammation monitoring

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-06 DOI: 10.1016/j.snb.2025.137514

Atul Sharma , Nafize Ishtiaque Hossain , Sameer Sonkusale

{"title":"An integrated flexible dual-mode optical-electrochemical sensing microcatheter platform for inflammation monitoring","authors":"Atul Sharma , Nafize Ishtiaque Hossain , Sameer Sonkusale","doi":"10.1016/j.snb.2025.137514","DOIUrl":"10.1016/j.snb.2025.137514","url":null,"abstract":"<div><div>Timely monitoring of inflammation following transplant surgery is essential to prevent complications such as ischemia or death. Centralized testing often leads to delays. Point-of-care immunoassays offer some promise. However, they lack the form factor and the performance needed for localized monitoring of inflammation. This work demonstrates a novel dual-mode microcatheter platform for <em>in situ</em> quantification of inflammatory biomarkers, such as interleukin- 6 (IL-6). By combining an electrochemical approach, namely differential pulse voltammetry (DPV), and an optical approach, namely localized surface plasmon resonance (LSPR), the platform enables reliable, on-demand, precise monitoring of inflammation. The novelty of the approach is using surgical sutures for electrochemical sensing and its co-integration with an optical fiber for LSPR sensing in a miniaturized and flexible microcatheter platform. This platform can locally probe the surgical or wound site for inflammation monitoring, providing high precision and reliability. The dual-mode approach enhances detection accuracy, precision, and dynamic range. The dual-mode microcatheter sensor exhibited a broad dynamic range from 0.1 to 1000 pg/mL for IL-6 measurement with a limit of detection (LOD) of 0.076 pg/mL for the electrochemical approach and 0.10 pg/mL for the optical LSPR approach. Furthermore, the performance of the dual-mode sensing microcatheter was successfully evaluated in buffer, artificial serum, skin-gel, and human serum samples with co-interferents in the clinical range.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137514"},"PeriodicalIF":8.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0