Sensors and Actuators B: Chemical最新文献_第10页

Universal strategy to minimize capillary effect in textiles for high-sensitivity inkjet-printed wearable gas sensor 用于高灵敏度喷墨打印可穿戴式气体传感器的通用策略，以尽量减少纺织品中的毛细效应

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-10 DOI: 10.1016/j.snb.2025.137749

Bang Lin , Bolang Cheng , Yong Zhang

{"title":"Universal strategy to minimize capillary effect in textiles for high-sensitivity inkjet-printed wearable gas sensor","authors":"Bang Lin , Bolang Cheng , Yong Zhang","doi":"10.1016/j.snb.2025.137749","DOIUrl":"10.1016/j.snb.2025.137749","url":null,"abstract":"<div><div>Textile-based wearable gas sensor technologies have attracted significant attention due to their large surface area, internal gas adsorption capability, and integrability. However, the rough and porous nature of textiles often leads to non-uniform material deposition, limiting sensor performance. Here, we propose a universal modification method using hydrophobic SiO<sub>2</sub> nanoparticles to reduce the capillary effect in textiles, enabling precise inkjet printing of electrodes and sensing materials. By minimizing the capillary effect, a wearable CO sensor with a highly uniform CuO nanosheets sensing layer and precise Ag interdigitated electrodes is fabricated. At room temperature, the sensor exhibits a response of 76.2 % to 10 ppm CO, with a detection limit as low as 200 ppb (14.42 % response). In conditions of high humidity (98 % RH) and significant bending (120° for 5000 cycles), the sensor still exhibits high sensitivity to 10 ppm CO. This work presents a universal method for minimizing the capillary effect in textiles, offering new possibilities for developing flexible electronics and wearable gas sensors.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"438 ","pages":"Article 137749"},"PeriodicalIF":8.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extreme sensitivity biosensing platform based on Fano resonance and graphene oxide 基于Fano共振和氧化石墨烯的高灵敏度生物传感平台

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-10 DOI: 10.1016/j.snb.2025.137788

Biao Zhao , Yingxian Xue , Yixiao Li , Min Li , Zuxing Zhang , Xuming Zhang , Aoqun Jian

{"title":"Extreme sensitivity biosensing platform based on Fano resonance and graphene oxide","authors":"Biao Zhao , Yingxian Xue , Yixiao Li , Min Li , Zuxing Zhang , Xuming Zhang , Aoqun Jian","doi":"10.1016/j.snb.2025.137788","DOIUrl":"10.1016/j.snb.2025.137788","url":null,"abstract":"<div><div>Improving the sensitivity of surface plasmon resonance (SPR) sensors is a crucial field of research, as it enables the detection of lower concentrations of analytes and smaller biomolecular interactions. This study developed a novel Fano resonance (FR) sensor with exceptional sensitivity and figure of merit (<em>FOM</em>) by combining graphene oxide (GO) with a plasmonic silver film-polydimethylsiloxane (PDMS) hybrid nanostructure. The results demonstrated that the FR-GO sensor achieved an average refractive index (RI) sensitivity of 33.6 μm/RIU, representing a 20.53 % improvement over the FR sensor (27.9 μm/RIU). Additionally, the <em>FOM</em> increased by 36.25 %, reaching a maximum of 2383.82 RUI<sup>−1</sup>, which was two orders of magnitude higher than traditional SPR sensors. To evaluate its practical application, the sensor was used to detect carcinoembryonic antigen (CEA), a tumor biomarker. The proposed sensor exhibited a measurement sensitivity of 5.2 nm/(ng/ml) and a limit of detection (<em>LOD</em>) of 63.5 pg/ml. Furthermore, the method demonstrated good selectivity, reproducibility, and stability. The enhanced sensitivity and <em>FOM</em> of this sensor design have the potential to advance early disease detection and biomolecular interaction studies.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"438 ","pages":"Article 137788"},"PeriodicalIF":8.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimally Invasive Power-Free Continuous Glucose Monitoring Sensor Using Full Color Tunable Photonic Gel of Poly(acrylamide-co-3-fluoro-4-acrylamidophenylboronic acid) Operating at Physiological pH 在生理pH下工作的全彩色可调光子凝胶聚（丙烯酰胺-co-3-氟-4-丙烯酰胺苯硼酸）的微创无功率连续血糖监测传感器

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-10 DOI: 10.1016/j.snb.2025.137775

Habeen Park , Dongyeon Kim , Hwanam Kye , Hyunjung Lee , Wonmok Lee

{"title":"Minimally Invasive Power-Free Continuous Glucose Monitoring Sensor Using Full Color Tunable Photonic Gel of Poly(acrylamide-co-3-fluoro-4-acrylamidophenylboronic acid) Operating at Physiological pH","authors":"Habeen Park , Dongyeon Kim , Hwanam Kye , Hyunjung Lee , Wonmok Lee","doi":"10.1016/j.snb.2025.137775","DOIUrl":"10.1016/j.snb.2025.137775","url":null,"abstract":"<div><div>Real-time monitoring of blood glucose levels is critical for effective diabetes management. In this study, we demonstrate a minimally invasive power-free continuous glucose monitoring systems (CGMS) utilizing optical detection of glucose levels in interstitial fluid (ISF) which can provide intuitive perception of blood glucose level to patient. The system leverages structural color changes in an inverse opal photonic gel (IOPG) film to detect glucose levels with high sensitivity at physiological pH by incorporating 3-fluoro-4-acrylamido phenylboronic acid (3F4APBA) within the photonic gel. The glucose-responsive IOPG fabricated through opal-templated photopolymerization of 3F4APBA and acrylamide, exhibited reversible full color variations by glucose level changes from 0 to 300mg/dL; a blue structural color at hypoglycemic glucose concentrations by Bragg diffraction, which reversibly changed to green color at normal glucose level, and further shifted to red under hyperglycemic condition. In a simulated CGM device, glucose solutions with varying concentrations were introduced through a porous microneedle array (PμNA) in a flow cell to emulate ISF extraction from human skin, and the 3F4APBA-containing IOPG was confirmed to be a promising CGMS for monitoring blood glucose and body fluids.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"438 ","pages":"Article 137775"},"PeriodicalIF":8.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A transistor array biosensor based on reduced graphene oxide prepared electrochemically for detection of multiplex circulating miRNAs of non-small cell lung cancer in human serum 电化学制备了一种基于还原氧化石墨烯的晶体管阵列生物传感器，用于检测人血清中非小细胞肺癌的多重循环mirna

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-10 DOI: 10.1016/j.snb.2025.137787

Yulan Zhao , Rong Zou , Caiyuan Liao , Yu Chen , Zikang Xu , Songmei Liu , Gang Chang , Hanping He

{"title":"A transistor array biosensor based on reduced graphene oxide prepared electrochemically for detection of multiplex circulating miRNAs of non-small cell lung cancer in human serum","authors":"Yulan Zhao , Rong Zou , Caiyuan Liao , Yu Chen , Zikang Xu , Songmei Liu , Gang Chang , Hanping He","doi":"10.1016/j.snb.2025.137787","DOIUrl":"10.1016/j.snb.2025.137787","url":null,"abstract":"<div><div>The early diagnostic of non-small cell lung cancer (NSCLC) at an early stage can improve patient prognosis and patient survival rates. Here, a novel transistor-based array biosensor was developed for the multiplex detection of four miRNAs (miRNA 21, miRNA 486–5p, miRNA 155, and miRNA 205) as circulating miRNA biomarkers in NSCLC. The transistor channel was modified by a reduced graphene oxide (rGO) semiconductor layer that was prepared based on electrochemical reduction of graphene oxide (GO) through optimal condition. The rGO transistor exhibited excellent transistor performance and high stability, which provided enough guarantee for stable detection of biomarkers. Further, PAA/PEDOT film was modified on the surface of rGO layer in channel to improve selectivity, enhance signal response and provide coupling group. The capture DNA was coupled on the surface of PAA/PEDOT film to obtain H/PAA/PEDOT/rGO transistor, then the Y-shape nucleic acid structure was specifically designed to capture target miRNA. Finally, the H/PAA/PEDOT/rGO transistor array biosensor exhibited an excellent linearity for four miRNAs (miRNA 21, miRNA 486–5p, miRNA 155, and miRNA 205), with low detection limit 2.36 fM, had high selectivity, sensitivity and stability. Moreover, the biosensor also had reusability performance, which lowered the cost of biosensor and improved the feasibility of industrialization. These studies indicated that the novel H/PAA/PEDOT/rGO transistor biosensor array would have great promise for applications in early blood diagnosis and postoperative monitoring of NSCLC.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"438 ","pages":"Article 137787"},"PeriodicalIF":8.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative bifunctional copper nanoflowers for sensitive serotonin detection and enhanced depression diagnosis and drug efficacy evaluation 创新的双功能铜纳米花用于敏感血清素检测和增强抑郁症诊断和药物疗效评估

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-09 DOI: 10.1016/j.snb.2025.137745

Shengnan Yang , Li Li , Qiang Chen , Xiaona Du , Hailin Zhang

{"title":"Innovative bifunctional copper nanoflowers for sensitive serotonin detection and enhanced depression diagnosis and drug efficacy evaluation","authors":"Shengnan Yang , Li Li , Qiang Chen , Xiaona Du , Hailin Zhang","doi":"10.1016/j.snb.2025.137745","DOIUrl":"10.1016/j.snb.2025.137745","url":null,"abstract":"<div><div>Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter crucial for mood regulation. Quantitative assessment of the 5-HT levels provides an objective indicator of depression. However, stringent conditions are required for effectively and conveniently detecting trace-level concentrations of 5-HT in complex biological matrices. Despite the high specificity of enzyme-mediated signal amplification, which is widely used in biosensing, detecting low-abundance biomarkers under such conditions remains challenging. Herein, streptavidin (SA) and horseradish peroxidase (HRP) were integrated to synthesize bifunctional copper nanoflowers (Cu<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>–SA–HRP NFs) for the development of a straightforward 5-HT-detection biosensor. The prepared hybrid NFs offer inherent advantages such as enzyme protection, remarkably enhancing enzyme catalytic capability and stability relative to those of free enzymes. Cu<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>–SA–HRP NFs demonstrate notable simplicity and sensitivity, exhibiting a low detection limit (LOD) of 310.65 pg mL<sup>−1</sup>. Sensitive assessments of the 5-HT levels in the rat serum and hippocampus are performed, allowing for the evaluation of the antidepressant effects of various drugs. Stable and sensitive detection results are obtained for the spiked human serum samples. Overall, the proposed colorimetric sensor presents a promising, straightforward platform for evaluating drug efficacy and monitoring depression.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"437 ","pages":"Article 137745"},"PeriodicalIF":8.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel activation-triggered-immobilizing fluorescent probe for real-time tracking of mitochondrial ONOOˉ with high fidelity 一种新型活化触发固定荧光探针，用于高保真实时跟踪线粒体 ONOOˉ

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-09 DOI: 10.1016/j.snb.2025.137774

Yuxiao Zhu, Caiyun Liu, Xiaodi Rong, Min Zheng, Huayan Wen, Kun Wang, Wenlong Sheng, Baocun Zhu

{"title":"A novel activation-triggered-immobilizing fluorescent probe for real-time tracking of mitochondrial ONOOˉ with high fidelity","authors":"Yuxiao Zhu, Caiyun Liu, Xiaodi Rong, Min Zheng, Huayan Wen, Kun Wang, Wenlong Sheng, Baocun Zhu","doi":"10.1016/j.snb.2025.137774","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137774","url":null,"abstract":"Peroxynitrite (ONOOˉ) can participate in signal transduction, immune response and other processes in organisms. It has been shown to be associated with multifarious diseases and metabolic disorders. The mitochondrial respiratory chain is the main site for endogenous ONOOˉ production and response. Thus, monitoring ONOOˉ dynamics in mitochondria is crucial for understanding its physiological and pathological roles. Herein, we designed and synthesized a mitochondria-immobilizing fluorescent probe <strong>CB-IMP</strong> employing an activation-triggered-immobilizing strategy. <strong>CB-IMP</strong> consists of a coumarin modified with an arylboronic ester as a recognition receptor, and a quaternized thiomorpholine salt with positive charge for mitochondria targeting and immobilization. <strong>CB-IMP</strong> with superior water solubility exhibits rapid response (t ˂ 5 s), outstanding selectivity and highly sensitive recognition towards ONOOˉ (LOD = 9 nM). Notably, the activation-triggered-immobilizing strategy provides <strong>CB-IMP</strong> with <em>in situ</em> tracking ability for mitochondrial ONOOˉ (P = 0.9513). Therefore, combined the low cytotoxicity and high membrane permeability, <strong>CB-IMP</strong> is allowed for highly sensitive detection and high-fidelity imaging of endogenous/exogenous mitochondrial ONOOˉ in live cells and zebrafish. It has the potential to provide new insights for the detection of mitochondrial dysfunction and early imaging and diagnosis of various related diseases.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"2 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An innovative hydrogel-based colorimetric freshness indicator array for smart packaging of bananas, apples, and pears 用于香蕉、苹果和梨智能包装的创新型水凝胶比色新鲜度指示器阵列

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-09 DOI: 10.1016/j.snb.2025.137743

Kimia Esmaeili, Hanieh Golshahi, Kheibar Dashtian , Rouholah Zare-Dorabei

{"title":"An innovative hydrogel-based colorimetric freshness indicator array for smart packaging of bananas, apples, and pears","authors":"Kimia Esmaeili, Hanieh Golshahi, Kheibar Dashtian , Rouholah Zare-Dorabei","doi":"10.1016/j.snb.2025.137743","DOIUrl":"10.1016/j.snb.2025.137743","url":null,"abstract":"<div><div>Real-time monitoring of volatile organic compounds (VOCs) released from perishable fruits is essential for predicting their freshness. Herein, we designed a non-destructive and portable hydrogel-based colorimetric freshness indicator array for on-site monitoring of acetone, acetaldehyde, and propionaldehyde markers in yellow fruits such as bananas, apples, and pears. These VOCs serve as critical indicators of fruit spoilage. The colorimetric sensor array is constructed from a calcium alginate pad (CAP) modified with a hydrogel blend of xanthan (XG) and tragacanth gum (TG), incorporating zinc oxide nanoparticles (ZnO-NPs) as a stabilizing filler. Additionally, the array utilizes glycerol as a crosslinker, along with bromocresol purple (BCP), methyl orange (MO), BCP/thymol blue (ThB), and bromocresol green (BCG) as color-sensitive materials. This array is integrated with smartphone technology and color analysis software, allowing for real-time detection of color changes. The results demonstrate a strong correlation between the concentrations of acetaldehyde, propionaldehyde and acetone, and the color intensity, with measurable ranges of 0.117–3.92 ppm, 0.153–5.202 ppm and 0.088–5.032 ppm and the respective limits of detection were determined to be 0.11, 0.14 and 0.07 ppm, respectively. Furthermore, the sensors exhibited no adverse effects on water vapor permeability or the VOC materials. They showed a desirable recovery, enabling effective monitoring of quality changes in fruits during storage at both room temperature and in refrigeration. This research provides valuable insights for the design and development of solid-state strip sensors and simple packaging indicators, facilitating the assessment of fruit freshness through smartphone-based online signaling and data analysis.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"438 ","pages":"Article 137743"},"PeriodicalIF":8.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient in-droplet concentration of particles for digital microfluidics on coplanar electrodes by integrating electrowetting-on-dielectric (EWOD) and surface acoustic wave (SAW) technologies 通过集成电介质电润湿（EWOD）和表面声波（SAW）技术，在共面电极上实现数字微流体的高效液滴内颗粒浓缩

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-08 DOI: 10.1016/j.snb.2025.137765

Chun-Hong Chen , Kai-Hsiang Yang

{"title":"Efficient in-droplet concentration of particles for digital microfluidics on coplanar electrodes by integrating electrowetting-on-dielectric (EWOD) and surface acoustic wave (SAW) technologies","authors":"Chun-Hong Chen , Kai-Hsiang Yang","doi":"10.1016/j.snb.2025.137765","DOIUrl":"10.1016/j.snb.2025.137765","url":null,"abstract":"<div><div>Recently, few medical applications have employed coplanar electrodes for digital microfluidics (DMF), as DMF manipulation on coplanar electrodes requires high operation voltage. In this study, we present the first device of in-droplet particle concentration and droplet splitting on coplanar electrodes by integrating surface acoustic wave (SAW) and electrowetting-on-dielectric (EWOD) technologies. In our device, particles are concentrated on one side of the droplet by SAW, with subsequent droplet cutting by EWOD. In addition, quantitative analysis was used to evaluate the method, and showed that 97.8 % of particles can be concentrated. Compared to traditional parallel-plate EWOD and SAW devices, our novel device can provide high concentration efficiency and simple fabrication (without a top plate and microchannel) in digital microfluidics. The novel in-droplet concentration and droplet cutting method could integrate many particle assays and digital microfluidics on coplanar electrodes to extend their applications.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"438 ","pages":"Article 137765"},"PeriodicalIF":8.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-element transition metal electrochemiluminescence system based on efficient quenching strategy for sensitive detection of glial fibrillary acidic protein 基于高效淬火策略的多元素过渡金属电化学发光系统，用于灵敏检测神经胶质纤维酸性蛋白

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-08 DOI: 10.1016/j.snb.2025.137767

Fangqin Han , Chunfang Cheng , Jingyu Zhao , Chunxiao Li , Yue Wang , Xiaorong Cao , Yaoguang Wang , Yan Zhang , Guanhui Zhao

{"title":"Multi-element transition metal electrochemiluminescence system based on efficient quenching strategy for sensitive detection of glial fibrillary acidic protein","authors":"Fangqin Han , Chunfang Cheng , Jingyu Zhao , Chunxiao Li , Yue Wang , Xiaorong Cao , Yaoguang Wang , Yan Zhang , Guanhui Zhao","doi":"10.1016/j.snb.2025.137767","DOIUrl":"10.1016/j.snb.2025.137767","url":null,"abstract":"<div><div>In this study, we skillfully selected six transition metals and designed two materials with superior performance. NiMoO<sub>4</sub> was used for immobilization of Ru to engineer RuMoNi nanorods (NRs) through a facile hydrothermal approach, functioning as potent ECL emitters. The robust binding interaction between Ru and NiMoO<sub>4</sub> effectively addressed the instability issue caused by strong solubility of Ru. This incorporation not only narrowed the band gap, but facilitated the formation of active sites. Furthermore, we incorporated Pt into the transition metals Cu and Co to form a ternary alloy, PtCuCo, as the signal-off probe that exhibited exceptional biocompatibility. This combination leveraged the synergistic effect among the three elements to enhance the sensor’s sensitivity by inhibiting the luminescence process, thereby improving a quenching performance while simultaneously reducing the Pt loading. By rationally utilizing interactions such as resonance energy and electron transfer, we constructed a sandwich-type ECL immunosensor with high signal response and low background noise to detect glial fibrillary acidic protein. Remarkably, the developed immunosensor demonstrated an impressive detection limit of 1.66 pg mL<sup>−1</sup> and it has been carried out to the analysis of human serum samples, proving great prospects as an immunoassay platform for early diagnosis and treatment of gliomas.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"438 ","pages":"Article 137767"},"PeriodicalIF":8.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143798230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-mode probe for identifying multiple polyphenols by colorimetry and surface-enhanced Raman scattering 用比色法和表面增强拉曼散射识别多种多酚的双模探针

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-04-07 DOI: 10.1016/j.snb.2025.137763

Diantao Chen , Xiaolei Song , Chenchen Wang , Dingzhong Wang , Peng Li , Shihao Sun , Yong Wang , Wei Wei

{"title":"Dual-mode probe for identifying multiple polyphenols by colorimetry and surface-enhanced Raman scattering","authors":"Diantao Chen , Xiaolei Song , Chenchen Wang , Dingzhong Wang , Peng Li , Shihao Sun , Yong Wang , Wei Wei","doi":"10.1016/j.snb.2025.137763","DOIUrl":"10.1016/j.snb.2025.137763","url":null,"abstract":"<div><div>Astringency is closely associated with polyphenols found in food and beverages. Given their importance to both the food industry and human health, accurate detection of polyphenols has become a focal point of research. In this study, a dual-mode probe was constructed for polyphenol detection by colorimetry alongside surface-enhanced Raman scattering (SERS). The probe is core-molecule-shell gold/4-MBA/silver nanorods (Au@M@Ag NRs). The silver shell on the surface of Au@M@Ag NRs can be etched by hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), resulting in a significant red-shift in UV absorption spectra and a marked decrease in SERS signal output from 4-MBA. Upon introducing polyphenols with strong antioxidant properties, the etching process of the silver shell is inhibited, thereby protecting the shell-core ratio of Au@M@Ag NRs. This process can be readily monitored through both colorimetry and SERS analysis. In our work, harnessing the anti-etching effect exhibited by kaempferol, a type of polyphenol, our dual-mode sensor demonstrates superior detection limits (43.2 nM for colorimetry and 0.786 nM for SERS) compared to previously reported methods. We successfully distinguished five different polyphenols with varying antioxidant capacities: chlorogenic acid, epicatechin, epigallocatechin gallate, kaempferol, and tannic acid through linear discriminant analysis (LDA). This dual-mode sensor can decrease false-positive results while offering promising applications for determining and identifying polyphenols within complex food samples.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"437 ","pages":"Article 137763"},"PeriodicalIF":8.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0