Sensors and Actuators B: Chemical最新文献

{"title":"A novel fluorescent sensing strategy for point-of-care monitoring of Hg2 +-induced oxidative stress in HeLa cells, zebrafish and mice models","authors":"Meiqing Zhu ,&nbsp;Manjie Chen ,&nbsp;Xinfu Zhu ,&nbsp;Xingyu Zhu ,&nbsp;Rimao Hua ,&nbsp;Xiaofan Yang ,&nbsp;Saraschandra Naraginti ,&nbsp;Yi Wang","doi":"10.1016/j.snb.2025.137956","DOIUrl":"10.1016/j.snb.2025.137956","url":null,"abstract":"<div><div>Hg²⁺-induced oxidative stress is an important pathway mediating biotoxicity, and the dynamics of reactive oxygen/nitrogen species (ROS/RNS) is a key indicator for quantitatively assessing the level of oxidative stress. Herein, a novel “targeted dual recognition” NIR fluorescent chemosensor (DDPT) was constructed for the specific recognition of Hg²⁺ and ONOO^-. The DDPT activated by Hg²⁺ for the detection of ONOO^- exhibited rapid response (&lt;50 s), high sensitivity (16.8 nM) and excellent selectivity. The P = S bond in DDPT is oxidized to P = O by Hg²⁺, followed by ONOO^- the specific attack on the P-O bond to break it, releasing the DDPT-OH to generate a significant fluorescence enhancement (with a Stokes shift up to 188 nm). The response mechanism of DDPT was systematically verified by ¹HNMR, HRMS and DFT theoretical calculations. Furthermore, DDPT was successfully evaluated for imaging Hg²⁺-induced ONOO^- dynamics in cellular, zebrafish and mouse models due to its advantages of low cytotoxicity, high tissue permeability and biocompatibility. The results reveal that Hg²⁺ induces oxidative stress and increases ONOO^- concentration to destroy the antioxidant defense system of organisms, thus triggering the toxic pathway of oxidative stress. The development of DDPT provides a basis for analyzing pollutant-oxidative stress interactions, assessing health risks, and developing targeted intervention strategies.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137956"},"PeriodicalIF":8.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Integration of glucose and lactate biosensors into human cartilage-on-a-chip models for long-term monitoring of metabolic shifts in osteoarthritis” [Sens. Actuators B: Chem. 427 (2025), 137123]","authors":"Mario Rothbauer ,&nbsp;Jonathan Strauss ,&nbsp;Eva I. Reihs ,&nbsp;Johannes Heidenberger ,&nbsp;Juergen Alphonsus ,&nbsp;Sally Gowers ,&nbsp;Yu-Chih Chen ,&nbsp;James McLeod ,&nbsp;Stefan Toegel ,&nbsp;Peter Ertl ,&nbsp;Reinhard Windhager ,&nbsp;Martyn Boutelle ,&nbsp;Danny O’Hare","doi":"10.1016/j.snb.2025.137940","DOIUrl":"10.1016/j.snb.2025.137940","url":null,"abstract":"","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137940"},"PeriodicalIF":8.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UV-activated TiO2 nanoparticles for sensitively detecting ppb-level dimethyl sulfide at room temperature","authors":"Dandan Rong ,&nbsp;Gang Meng ,&nbsp;Longqing Mi ,&nbsp;Meng Li ,&nbsp;Ruofan Zhang ,&nbsp;Xiaohua Ji ,&nbsp;Tiantian Dai ,&nbsp;Hongtao Li ,&nbsp;Xiaodong Fang ,&nbsp;Libing You (professor) ,&nbsp;Zanhong Deng (associate professor)","doi":"10.1016/j.snb.2025.137966","DOIUrl":"10.1016/j.snb.2025.137966","url":null,"abstract":"<div><div>Dimethyl sulfide (DMS) is one kind of volatile sulfur compounds (VSCs) possessing disagreeable odor, with a low olfactory threshold around 20 ppb. Highly sensitive detection of DMS at room temperature (RT) is critically needed for emerging application with low power consumption, but it remains a significant challenge owing to its low reactivity. Herein, UV photoactivated titanium dioxide (TiO₂) nanoparticles (NPs) have been employed for detecting DMS at RT. An eco-friendly ultrasonic crushing solution spray technique was developed to prepare TiO₂ based sensors. An ultrahigh response of 30–500 ppb DMS and a low experimental limit of detection (<em>R</em>_a/<em>R</em>_g = 2.7@50 ppb) could be achieved at RT under UV light activation. This work opens a new avenue to achieve highly sensitive, energy-efficient sensors for trace VSCs detection at RT in ambient odor monitoring.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137966"},"PeriodicalIF":8.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143940512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COX-2 targeting and hypoxia activation of IMC-NTR for cancer diagnosis and therapeutics: In vitro and in vivo studies","authors":"Maxine Mambo Fortibui ,&nbsp;Jongtae Roh ,&nbsp;Sung-Kyun Ko ,&nbsp;Min Hee Lee","doi":"10.1016/j.snb.2025.137970","DOIUrl":"10.1016/j.snb.2025.137970","url":null,"abstract":"<div><div>A significant challenge in cancer diagnosis and treatment lies in tumor heterogeneity and the insufficient specificity of biomarkers such as cyclooxygenase-2 (COX-2) and nitroreductase (NTR), which often limits the efficacy of conventional therapies. To address this, we developed a novel theranostic probe, <strong>IMC-NTR</strong>, designed to selectively target COX-2 and NTR under hypoxic conditions, enabling both real-time fluorescence imaging of cancer progression and inhibition of metastasis. <strong>IMC-NTR</strong> was rationally constructed by conjugating indomethacin (IMC), a selective COX-2 inhibitor, with a nitro-functionalized naphthalimide that undergoes NTR-mediated bioreduction under hypoxia, resulting in a significant fluorescence turn-on at 534 nm. The probe exhibited high selectivity and sensitivity for NTR over other biologically relevant species, with a 22-fold signal-to-noise ratio, and a detection limit of 0.0211 μg/mL. The cancer-targeting ability of <strong>IMC-NTR</strong> was validated in vitro using COX-2 positive A549 lung cancer cells and in vivo in zebrafish models. Furthermore, wound-healing and invasion assays demonstrated that <strong>IMC-NTR</strong> effectively suppressed cancer cell migration and invasion, both of which are critical processes in metastasis. In zebrafish, <strong>IMC-NTR</strong> specifically localized to the intestine, a COX-2-enriched organ, confirming its in vivo targeting specificity and biological relevance. Taken together, these results suggest that <strong>IMC-NTR</strong> enables sensitive detection of NTR activity under hypoxia and holds promise as a dual-function agent for cancer imaging and therapeutic intervention. Further studies are warranted to assess its clinical potential and to address limitations related to potential off-target interactions.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137970"},"PeriodicalIF":8.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143940531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabricating a mitochondrial viscosity-activated fluorescent probe for highly sensitive imaging of kidney injury in vivo","authors":"Xiangui Zheng ,&nbsp;Hongshuai Zhang ,&nbsp;Yuanyuan Wang ,&nbsp;Mei Yuan ,&nbsp;Xuefeng Yang ,&nbsp;Liu Zeng ,&nbsp;Longwei He ,&nbsp;Dan Cheng","doi":"10.1016/j.snb.2025.137972","DOIUrl":"10.1016/j.snb.2025.137972","url":null,"abstract":"<div><div>Diabetic kidney injury has become one of the considerable causes of kidney diseases. Early detection and intervention can effectively delay the development of kidney diseases. Viscosity, as a critical parameter of the cellular microenvironment, plays a pivotal role in maintaining mitochondrial function and cellular homeostasis, and its dysregulation is closely associated with the pathogenesis of diabetic kidney injury. However, it is rarely reported that fluorescent probes are used to determine mitochondria viscosity changes in the process of diabetic kidney injury. Herein, a hemicyanine-based near-infrared (NIR) fluorescent probe <strong>P4</strong> was developed using a “progressive optimization (PO)” strategy, enabling targeted imaging of mitochondrial viscosity changes in kidney cells and <em>in vivo</em>. The <strong>P4</strong> probe possessed high sensitivity and selectivity toward viscosity and exhibited an approximately 146-fold signal enhancement in high-viscosity environments with a linear relationship (R²=0.995). And the fluorescence quantum yield (Φ) of <strong>P4</strong> increased from &lt; 0.001 in PBS (low viscosity) to 0.12 in 90 % glycerol (high viscosity). Moreover, <strong>P4</strong> probe showed excellent mitochondrial localization efficiency, enabling real-time monitoring of mitochondrial viscosity changes during diabetic kidney injury progression and therapeutic intervention. In addition, <strong>P4</strong> probe detected viscosity variations with a 1.5-fold signal intensity increase in diabetic kidney injury models compared to healthy controls <em>in vivo</em>. Using <strong>P4</strong> probe, the viscosity changes related to ferroptosis were also accounted in the high glucose-induced kidney cell injury model for the first time. This work would provide a meaningful tool for gaining deeper insight into the viscosity variations in the kidney diseases, and it is expected to promote early diagnosis and treatment of kidney diseases.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137972"},"PeriodicalIF":8.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZIF derived coral-like hierarchically structured CoO@CoMn-LDH nanoarray self-supported electrocatalyst for enhanced formaldehyde electrochemical sensing in food samples","authors":"Yao Xu ,&nbsp;Li Xu ,&nbsp;Junchun Guo ,&nbsp;Xiangwei Yuan ,&nbsp;Sheng Li ,&nbsp;Xiaoli Xiong","doi":"10.1016/j.snb.2025.137969","DOIUrl":"10.1016/j.snb.2025.137969","url":null,"abstract":"<div><div>Formaldehyde (FA) is a toxic substance and represents a risk to human health. It is urgent to develop a low-cost and sensitive electrochemical detection technology for FA based on inexpensive transition metal nanomaterials. In this work, using Co(OH)F nanorods and ZIF-67 as precursors, a self-supporting coral-like CoO@CoMn-LDH nanoarray electrocatalyst with hierarchical structure was synthesized in situ on nickel foam (NF) substrate by two-step template strategy. The integration of hierarchically structured LDH onto the conductive nickel foam substrate offers a robust solution to the disadvantages of low electrical conductivity and easy agglomeration of LDH. Consequently, the engineered coral-like nanoarray significantly enhances the specific surface area and density of active sites of the electrocatalyst, while also facilitating an improved electron transport rate and enhanced mass transfer capacity. As a working electrode, the FA sensor shows superior electrochemical detection performance with a wide response linear range (0.035–7 mM) and a low detection limit (7.8 ×10⁻³ mM (S/N = 3)), and it has also been effectively utilized to measure FA concentrations in real food samples. This study offers a novel approach and method for developing an efficient and sensitive electrochemical detection technology for FA.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137969"},"PeriodicalIF":8.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143940511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasensitive electrochemical immunosensor for the detection of ancient sheepskin artifacts","authors":"Lianpeng Lv ,&nbsp;Yefeng Deng ,&nbsp;Feng Liu ,&nbsp;Tao Wang ,&nbsp;Chao Zhang ,&nbsp;Hao Du ,&nbsp;Ruixue Sun ,&nbsp;Haoyu Luo ,&nbsp;Hailiang Yang ,&nbsp;Yang Zhou ,&nbsp;Bing Wang","doi":"10.1016/j.snb.2025.137968","DOIUrl":"10.1016/j.snb.2025.137968","url":null,"abstract":"<div><div>The identification of leather artifacts assumes a crucial role in subsequent classification, restoration and conservation. Conventional methods are prone to environmental and technical impacts, and they exhibit deficiencies in detecting accuracy and sensitivity. To solve this problem, an electrochemical immunosensor was fabricated based on polypyrrole (PPy) and gold nanoparticles (AuNPs) for the detection of leather artifacts. This sensor has an extremely low limit of detection (LOD) of approximately 1.66 pg/mL and a linear range of 5 pg/mL-1 ng/mL, which meets the requirements of ultrasensitive detection. Moreover, the sensor demonstrates excellent selectivity and reproducibility, and its performance surpasses that of ELISA in detecting leather relics. Therefore, the proposed electrochemical immunosensor provides a new strategy for the identification of leather residues, showing profound prospect in analyzing protein materials in the archaeological field.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137968"},"PeriodicalIF":8.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143940543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sample-to-answer Aggregation-Induced Emission Lateral Flow Immunoassay (ALFIA) for rapid and sensitive on-site detection of Toxoplasma gondii antibodies across multiple host species","authors":"Yuan-Hui He ,&nbsp;Shusen Ji ,&nbsp;Ze-Xuan Wu ,&nbsp;Shi-Chen Xie ,&nbsp;Yao Liang ,&nbsp;Yi-Han Lv ,&nbsp;Xing-Quan Zhu ,&nbsp;Bin Wang","doi":"10.1016/j.snb.2025.137960","DOIUrl":"10.1016/j.snb.2025.137960","url":null,"abstract":"<div><div><em>Toxoplasma gondii</em> (<em>T. gondii</em>) is an apicomplexan parasite capable of infecting any nucleated cell in humans and warm-blooded animals. Unfortunately, there is currently no effective treatment or vaccine available for <em>T. gondii</em> infection. Consequently, early detection, particularly methods that support rapid on-site testing across multiple host species, becomes crucial for controlling and preventing <em>T. gondii</em> infection. To address this issue, based on the double antigen sandwich principle, we developed the <u>A</u>ggregation-Induced Emission (AIE) <u>L</u>ateral <u>F</u>low <u>I</u>mmuno<u>A</u>ssay (ALFIA) for detecting <em>T. gondii</em> antibodies. ALFIA employs <em>T. gondii</em> antigen for both capturing and detecting <em>T. gondii</em> antibodies, eliminating the need for secondary antibodies of specific species and enabling cross-species detection of <em>T. gondii</em> antibodies. Compared to commonly used colloidal gold test strips, the proposed ALFIA demonstrated a 16-fold improvement in sensitivity when visually inspected and a 32-fold enhancement when using a commercial test strip reader. Furthermore, clinical verifications showed that ALFIA reached 100 % accuracy in detecting porcine and feline sera, with no discrepancies compared to commercial ELISA kits. ALFIA offers the capability of achieving sample-to-answer detection in 10 min. It is anticipated that ALFIA will serve as an effective clinical solution for rapid on-site detection of <em>T. gondii</em> antibodies across various host species.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137960"},"PeriodicalIF":8.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143940546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel 2H-MoS2/MoO3/1T-MoS2 ternary heterojunction SERS sensor with high carrier concentration and mobility for highly sensitive and highly selective detection of bilirubin in urine","authors":"Yimin Tang ,&nbsp;Weijie Di ,&nbsp;Rui Wang ,&nbsp;Huizhu Zhang ,&nbsp;Libin Yang ,&nbsp;Xin Jiang ,&nbsp;Xiuwen Wang ,&nbsp;Bing Zhao","doi":"10.1016/j.snb.2025.137961","DOIUrl":"10.1016/j.snb.2025.137961","url":null,"abstract":"<div><div>Constructing a semiconductor heterojunction with high carrier concentration and mobility is an effective strategy to boost the surface-enhanced Raman scattering (SERS) performance of semiconductor. Here, a novel ternary molybdenum-based compound heterojunction 2H-MoS₂/MoO₃/1T-MoS₂ was developed as an excellent semiconducting SERS substrate for ultrasensitive detection of bilirubin in urine. Theoretical calculation and experimental results prove the contribution of charge transfer mechanism to SERS enhancement. The high carrier concentration in the substrate and the high electron mobility induced by the heterostructure are together responsible for its huge SERS enhancement effect. The substrate has a limit of detection (LOD) of 1.05 × 10⁻¹⁰ M and a SERS enhancement factor (EF) of 1.48 × 10⁹ for methylene blue probe. More meaningfully, the developed heterojunction substrate can achieve an ultrasensitive and high-selectivity detection for bilirubin in human urine, and the LOD is as low as 9.94 × 10⁻⁹ M.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137961"},"PeriodicalIF":8.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dual colorimetric-electrochemical platform based on bromocresol green for the selective detection of atropine","authors":"Larissa M.A. Melo ,&nbsp;Elena Bernalte ,&nbsp;Robert D. Crapnell ,&nbsp;Rodrigo M. Verly ,&nbsp;Rodrigo A.A. Muñoz ,&nbsp;Wallans T.P. dos Santos ,&nbsp;Craig E. Banks","doi":"10.1016/j.snb.2025.137962","DOIUrl":"10.1016/j.snb.2025.137962","url":null,"abstract":"<div><div>Atropine is crucial in forensic investigations due to its role in poisoning cases, requiring precise detection methods. We propose a novel dual-mode analytical platform that combines screen-printed graphite electrodes with square-wave voltammetry and a colorimetric reaction using bromocresol green. This dual platform provides three distinct analytical responses: a colour change via the colorimetric reaction and electrochemical responses before and after the colorimetric reaction, allowing robust atropine identification. For the first time, the electrochemical behaviour of atropine in the presence of bromocresol green has been investigated, with mechanistic insights elucidated through NMR analysis. Although atropine alone undergoes an irreversible oxidation process, the colorimetric reaction facilitates a redox process involving bromocresol green, allowing indirect atropine detection. The real-world applicability of this dual-sensing platform is demonstrated by detecting atropine in drink and biological samples for potential spiking and poisoning diagnosis. Importantly, the platform is shown to function within solutions containing quinine, proving its suitability to analysing strong and bitter tonic water drink with low atropine concentrations, overcoming this known analytical problem. The developed method exhibited a wide linear range (0.001–0.4 mg mL⁻¹), a low limit of detection (0.255 μg mL⁻¹), and excellent stability with relative standard deviation lower than 7 %. Interference studies confirm the method’s selectivity, and atropine recoveries from drink and biological samples were close to 100 %. The proposed platform is a simple, rapid, and selective screening tool, and shows significant potential for forensic applications in atropine detection.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137962"},"PeriodicalIF":8.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143940534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}