Sensors and Actuators B: Chemical最新文献_第10页

Structure modulation based on SnO2/In2O3 heterojunction to improve ethanol sensitivity at room temperature 基于SnO2/In2O3异质结的结构调制提高室温下乙醇敏感性

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-01-23 DOI: 10.1016/j.snb.2025.137310

Tao Wang , Ruixiong Zhai , Taihong Huang , Dehao Kong , Yuxu Bao , Peng Song

{"title":"Structure modulation based on SnO2/In2O3 heterojunction to improve ethanol sensitivity at room temperature","authors":"Tao Wang , Ruixiong Zhai , Taihong Huang , Dehao Kong , Yuxu Bao , Peng Song","doi":"10.1016/j.snb.2025.137310","DOIUrl":"10.1016/j.snb.2025.137310","url":null,"abstract":"<div><div>The development of semiconductor sensors for real-time monitoring of ethanol gas concentration changes is an important requirement for environmental governance and human health protection. In this paper, a new type of plasma fusion method is used to prepare a unique SnO<sub>2</sub>/amorphous/In<sub>2</sub>O<sub>3</sub> ternary heterostructure, which has excellent performance in ethanol detection. Its response value (41) is several or even tens of times higher than that of pure SnO<sub>2</sub> and In<sub>2</sub>O<sub>3</sub>, and its short response/recovery time indicates fast gas-sensitive reaction kinetics, while at the same time, having ultra-high selectivity and anti-interference capability. In-situ tests and First-principles density functional theory (DFT) calculations prove that its unique heterogeneous structure is the key to its performance. The highly crystalline SnO<sub>2</sub> and amorphous structures have good adsorption effects on ethanol and oxygen molecules, respectively. Therefore, the interface becomes the best place for gas-sensitive reactions. The small size of the nanomaterials prepared by us increases the number of phase boundaries and provides further guarantee for excellent performance. All the results show that this is a promising structural material.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"429 ","pages":"Article 137310"},"PeriodicalIF":8.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bionic synapses for real-time epileptic seizure control 实时控制癫痫发作的仿生突触

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-01-22 DOI: 10.1016/j.snb.2025.137304

Chen Liu , Yuting Jiang , Xingda Mu , Xuling Chang , Ye Zhang , Xiaoxiao He , Xiaojuan Zhu , Wenbo Sun , Lehui Lu

{"title":"Bionic synapses for real-time epileptic seizure control","authors":"Chen Liu , Yuting Jiang , Xingda Mu , Xuling Chang , Ye Zhang , Xiaoxiao He , Xiaojuan Zhu , Wenbo Sun , Lehui Lu","doi":"10.1016/j.snb.2025.137304","DOIUrl":"10.1016/j.snb.2025.137304","url":null,"abstract":"<div><div>Real-time optogenetic devices that can intelligently react to abnormal changes in the electrophysiological signals of epilepsy patients are crucial for timely seizure control. Inspired by electrical synapses, we report a bionic synapse built with entirely transparent ionic conductors. This system forms a soft, flexible network that allows free ionic movement, mimicking natural synaptic behavior. The bionic conductive technology is demonstrated in the application for brain signal recording-an emotion detection sensor. We also explore the potential of this technology for use in neural activity detections during optogenetic stimulation and emphasize its advantages in compromising optical recording. Furthermore, we have implemented this device for epileptic seizure control by real-time optogenetic modulation, which offers good potential for brain-machine interfaces in the monitoring and treatment of diseases. Our work highlights the advantages of transparent ionic conductors in combining electrophysiological recording and neural modulation, advancing both neurotechnology and bioelectronics.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"429 ","pages":"Article 137304"},"PeriodicalIF":8.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel multifunctional fluorescent probe for imaging the regulatory effects of pregnane X receptor on ferroptosis and carboxylesterase in atherosclerosis 一种新型多功能荧光探针成像孕烷X受体对动脉粥样硬化中铁下沉和羧酸酯酶的调节作用

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-01-22 DOI: 10.1016/j.snb.2025.137306

Wen Gao , Jiawei Chang , Yinkao Zhou , Xiaoqing Huang , Guanghan Li , Bo Tang

{"title":"A novel multifunctional fluorescent probe for imaging the regulatory effects of pregnane X receptor on ferroptosis and carboxylesterase in atherosclerosis","authors":"Wen Gao , Jiawei Chang , Yinkao Zhou , Xiaoqing Huang , Guanghan Li , Bo Tang","doi":"10.1016/j.snb.2025.137306","DOIUrl":"10.1016/j.snb.2025.137306","url":null,"abstract":"<div><div>Ferroptosis is closely associated with the macrophage foam cells formation during early-stage of atherosclerosis (AS). To date, the effect of ferroptosis-induced inflammatory response on lipid metabolism remains incompletely elucidated. Carboxylesterase (CES) plays an important role in lipid metabolism in macrophages. We speculated from previous reports that during the process of foam cell formation, the reduction in CES activity induced by inflammation leads to excessive lipid accumulation and exacerbates AS. However, it was still unknown whether there was a bidirectional regulation between CES or its agonists and ferroptosis. This was due to the lack of effective tools for simultaneous presentation of intracellular ferroptosis processes and CES levels. To address this situation, we designed a multifunctional fluorescent probe (CAS-FC) to simultaneously detect CES and Fe<sup>2+</sup>, enabling to monitor the interaction between ferroptosis and CES during the early-stage of AS. By employing fluorescence imaging, we confirmed the inhibitory effect of ferroptosis on CES. More significantly, we demonstrate for the first time that pregnane X receptor (PXR), an activator of CES, has a significant anti-ferroptosis effect. These findings are expected to contribute to the development of new strategies for the inhibition of ferroptosis and provide innovative insights into the diagnosis and treatment of AS.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"429 ","pages":"Article 137306"},"PeriodicalIF":8.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging convolutional neural networks for enhancing performance of Cs3Cu2I5/TiO2 nanocrystal-based carbon monoxide gas sensor 利用卷积神经网络增强Cs3Cu2I5/TiO2纳米晶一氧化碳气体传感器的性能

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-01-22 DOI: 10.1016/j.snb.2025.137311

Xinjian He , Yuyan Zhuang , Danhong Gao , Hongwei Liu , Jintuo Zhu , Sheng Huang

{"title":"Leveraging convolutional neural networks for enhancing performance of Cs3Cu2I5/TiO2 nanocrystal-based carbon monoxide gas sensor","authors":"Xinjian He , Yuyan Zhuang , Danhong Gao , Hongwei Liu , Jintuo Zhu , Sheng Huang","doi":"10.1016/j.snb.2025.137311","DOIUrl":"10.1016/j.snb.2025.137311","url":null,"abstract":"<div><div>Carbon monoxide is a colorless, odorless gas that can cause irreversible effects on the brain if inhaled in excess. Accurate measurement of carbon monoxide is very important for human health. The current carbon monoxide sensors work with long response time and narrow detection range. Therefore, in this work, TiO<sub>2</sub> was coated on perovskite nanocrystals Cs<sub>3</sub>Cu<sub>2</sub>I<sub>5</sub> by solution method to obtain high performance carbon monoxide gas sensitive material Cs<sub>3</sub>Cu<sub>2</sub>I<sub>5</sub>/TiO<sub>2</sub> nanocrystals. Moreover, high precision and anti-interference measurement of carbon monoxide was realized by combining with machine learning. The carbon monoxide sensor based on Cs<sub>3</sub>Cu<sub>2</sub>I<sub>5</sub>/TiO<sub>2</sub> has a short response/recovery time of 3.8/17.5 s and a sensitivity of 0.36 at 10 ppm. Then, an intelligent classification algorithm is used to quickly identify the concentration of carbon monoxide gas, and the recognition accuracy is as high as 99.5 %, which is higher than that of traditional sensitivity determination of gas concentration methods, due to the fact that machine learning involves multiple features of the electrical response curve, rather than the single feature of traditional sensitivity determination methods. Finally, the sensor was integrated into the self-rescuer for coal mine to realize the intelligent opening in the presence of CO, and improved the rescue efficiency. We believe that this sensor will be promising in the field of carbon monoxide, and the idea of using machine learning to intelligently recognize gas concentrations can be extended to other gas sensors.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"429 ","pages":"Article 137311"},"PeriodicalIF":8.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing the surface activity of Co3O4 by gallium doping to increase the sensitivity of conductometric CO gas sensors 通过掺杂镓提高Co3O4的表面活性，提高电导CO气体传感器的灵敏度

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-01-22 DOI: 10.1016/j.snb.2025.137288

Cong Qin , Zhanxiang Wei , Xiaoyan Zhao , Junjun Sun , Jianliang Cao , Yan Wang

{"title":"Enhancing the surface activity of Co3O4 by gallium doping to increase the sensitivity of conductometric CO gas sensors","authors":"Cong Qin , Zhanxiang Wei , Xiaoyan Zhao , Junjun Sun , Jianliang Cao , Yan Wang","doi":"10.1016/j.snb.2025.137288","DOIUrl":"10.1016/j.snb.2025.137288","url":null,"abstract":"<div><div>Increasing the surface activity of p-type oxide semiconductors, especially for Co<sub>3</sub>O<sub>4</sub>, is essential but challenging to improve the sensing performances toward CO. Herein, a strategy is proposed aiming to increase the surface activity of Co<sub>3</sub>O<sub>4</sub> toward the oxidation of CO through gallium doping by utilizing the wet impregnation and freeze-drying approach. The synthesized Ga-doped Co<sub>3</sub>O<sub>4</sub> (Ga-Co<sub>3</sub>O<sub>4</sub>) features a hierarchical structure assembled by nanosheets and a large surface area (65.39 m<sup>2</sup>/g), which ensures high-efficiency gas interaction and high response to CO. Moreover, the results demonstrate that this strategy promotes the formation of oxygen vacancies and increases the ratio of Co<sup>3+</sup>/Co<sup>2+</sup> in Co<sub>3</sub>O<sub>4</sub>, resulting in an enhanced response of 5.8 toward 100 ppm CO, which is markedly higher than that of the bare Co<sub>3</sub>O<sub>4</sub> (1.08). The sensor based on Ga-Co<sub>3</sub>O<sub>4</sub> also presents excellent selectivity toward CO in various interfering gases and a wide concentration detection range of 1–900 ppm. The improved CO sensing performance can be put down to the increased surface activity of Co<sub>3</sub>O<sub>4</sub> via tailoring the content of oxygen vacancy and Co<sup>3+</sup> active sites. This study provides new perspectives and strategies for improving the gas-sensing properties of p-type oxide semiconductors.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"429 ","pages":"Article 137288"},"PeriodicalIF":8.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visualization of carboxylesterase 2 regulation in kidney injury via an enzyme-activated fluorescent probe 酶激活荧光探针观察羧酸酯酶2在肾损伤中的调节作用

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-01-22 DOI: 10.1016/j.snb.2025.137309

Yue-Yang Zhang , Le-Yu Huang , Huiling Wang , Sixuan Meng , Fei Yang , Shi-Yu Liu

{"title":"Visualization of carboxylesterase 2 regulation in kidney injury via an enzyme-activated fluorescent probe","authors":"Yue-Yang Zhang , Le-Yu Huang , Huiling Wang , Sixuan Meng , Fei Yang , Shi-Yu Liu","doi":"10.1016/j.snb.2025.137309","DOIUrl":"10.1016/j.snb.2025.137309","url":null,"abstract":"<div><div>Carboxylesterase 2 (CES2), an extensively expressed serine esterase which widely distributed in various organs and tissues, exerts important roles in maintaining normal physiological function while abnormal expression of CES2 was correlated with many metabolic diseases and cancers. Thus, to develop efficient tool for detection of CES2 activity is of great importance in related clinical diagnosis and research of physiological function of CES2. To date, several enzyme-activated fluorescent probes were developed for CES2 sensing. Among which regulation of CES2 in diseases such as diabetics, colitis, cancers and liver injury could be visualized. However, even though CES2 displayed relatively high expression level in kidney, its regulation in pathological process of kidney injury was rarely studied, and thus related preliminary investigation is in urgent demand. Herein, by rational design and construction of an enzyme-activated fluorescent probe (named as <strong>DDXB</strong>) with high catalytic efficacy, sensitivity and specificity toward CES2, down-regulation of CES2 activity in acetaminophen (APAP)-induced liver injury and dextran sulfate sodium (DSS)-induced colitis model was successfully visualized. Most importantly, aberrant up-regulation of CES2 in streptozotocin (STZ), renal ischemia reperfusion (IR) injury (RIRI) and cisplatin (CDDP)-induced kidney injury model was first revealed via <strong>DDXB-</strong>based fluorescence imaging and further confirmed by immunohistochemistry (IHC) staining. Thus, preliminary evidence for identifying CES2 as potential biomarker of kidney injury were first provided, and the newly developed probe could serve as an efficient tool for related diagnosis or further investigation of CES2 physiological function in more diseases.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"429 ","pages":"Article 137309"},"PeriodicalIF":8.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pd nanoparticles on Zn/Co zeolitic imidazolate frameworks: A H2O2-free oxidase mimic for dual colorimetric and fluorescent detection of glutathione 锌/Co沸石咪唑盐框架上的钯纳米粒子：用于谷胱甘肽双比色和荧光检测的无h2o2氧化酶模拟物

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-01-22 DOI: 10.1016/j.snb.2025.137294

Fei-Fei Li, Yu Liu, Wen-Li Jia, Rong-Na Ma, Wei Zhang, Lei Shang, Xiao-Jian Li, Huai-Sheng Wang, Li-Ping Jia

{"title":"Pd nanoparticles on Zn/Co zeolitic imidazolate frameworks: A H2O2-free oxidase mimic for dual colorimetric and fluorescent detection of glutathione","authors":"Fei-Fei Li, Yu Liu, Wen-Li Jia, Rong-Na Ma, Wei Zhang, Lei Shang, Xiao-Jian Li, Huai-Sheng Wang, Li-Ping Jia","doi":"10.1016/j.snb.2025.137294","DOIUrl":"10.1016/j.snb.2025.137294","url":null,"abstract":"<div><div>Glutathione (GSH), a key antioxidant and free radical scavenger, plays a crucial role in enhancing the activity of the human immune system and detoxification. The abnormal expression of GSH has been linked to several diseases. In this study, a Pd nanoparticles (PdNPs)-decorated Zn/Co zeolitic imidazole framework (ZIF) nanocomposite (Zn/Co-ZIF@PdNPs) was synthesized. Doping with Zn<sup>2 +</sup> greatly enhanced the stability of Co-ZIF. Due to the synergy between Zn/Co-ZIF and PdNPs, the obtained Zn/Co-ZIF@PdNPs exhibited excellent oxidase-like activity. Zn/Co-ZIF@PdNPs could effectively catalyze the oxidation of colorless 3,3′,5,5′-tetramethylbenzidine (TMB) and nonfluorescent thiamine (TH) into blue 3,3′,5,5′-tetramethylbenzodiimine (TMBDI) and fluorescent thiochrome, respectively, without requiring an additional oxidizer. Based on this mechanism, a dual-mode colorimetric–fluorescent detection method for GSH was developed, utilizing the inhibitory effect of GSH on the oxidation of TMB and TH. The colorimetric and fluorescent sensing demonstrated wide linear ranges of 0.3–12 μM and 0.5–60 μM, with detection limits of 0.12 μM and 0.015 μM, respectively. In addition, the developed biosensor exhibited promising feasibility using human serum and cucumber samples.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"429 ","pages":"Article 137294"},"PeriodicalIF":8.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Versatile Tb3+–carbon-dot nanoplatform for fluorescence detection and in situ inactivation of bacterial spores 用于荧光检测和原位灭活细菌孢子的多功能Tb3+ -碳点纳米平台

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-01-21 DOI: 10.1016/j.snb.2025.137296

Xinxin Wang , Shan Sun , Ke Cheng , Tao Lin , Henggang Wang , Haoyi Sun , Hengwei Lin , Peng Wang

{"title":"Versatile Tb3+–carbon-dot nanoplatform for fluorescence detection and in situ inactivation of bacterial spores","authors":"Xinxin Wang , Shan Sun , Ke Cheng , Tao Lin , Henggang Wang , Haoyi Sun , Hengwei Lin , Peng Wang","doi":"10.1016/j.snb.2025.137296","DOIUrl":"10.1016/j.snb.2025.137296","url":null,"abstract":"<div><div>Pathogenic bacterial spores pose a considerable threat to human health due to their ability to survive extreme environmental conditions. Thus, sensitive detection and efficient inactivation of these spores are essential for preventing disease transmission. However, most existing studies have predominantly concentrated on detection alone. Herein, we developed a versatile nanoplatform that integrates sensitive bacterial spore sensing and <em>in situ</em> spore inactivation capabilities by assembling terbium ions (Tb<sup>3+</sup>) with photosensitizing carbon dots (CDs), referred to as Tb-CDs nanoassemblies (NAs). By leveraging the unique optical properties of CDs and Tb<sup>3+</sup> ions, along with the antenna effect of lanthanides, Tb-CDs NAs demonstrated highly sensitive visual detection of the key bacterial spore biomarker, pyridinedicarboxylic acid (DPA), achieving a low detection limit of 0.68 μM and excellent selectivity. Additionally, Tb-CDs NAs exhibited practical sensing capabilities in various environments, including spore suspensions and real samples, while monitoring bacterial spore germination. Further studies confirmed that the DPA-triggered disassembly of Tb-CDs NAs led to the release of CDs, enabling higher affinity for spores and <em>in situ</em> inactivation through singlet oxygen generation. This work underscores the potential of CDs-based assemblies for simultaneous pathogen detection and inactivation, providing promising tools for preventing bacterial spread and contamination.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"429 ","pages":"Article 137296"},"PeriodicalIF":8.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ruthenium oxide electrode integrated with molecularly imprinted polymer for direct electrochemical sensing of a neurotrophic factor protein 氧化钌电极与分子印迹聚合物集成用于神经营养因子蛋白的直接电化学传感

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-01-21 DOI: 10.1016/j.snb.2025.137301

Akinrinade George Ayankojo, Jekaterina Reut, Roman Boroznjak, Vitali Syritski

{"title":"Ruthenium oxide electrode integrated with molecularly imprinted polymer for direct electrochemical sensing of a neurotrophic factor protein","authors":"Akinrinade George Ayankojo, Jekaterina Reut, Roman Boroznjak, Vitali Syritski","doi":"10.1016/j.snb.2025.137301","DOIUrl":"10.1016/j.snb.2025.137301","url":null,"abstract":"<div><div>In the pursuit of precision diagnostics and analytical methodologies, electrochemical devices have emerged as a promising frontier. This article presents the synergy between a molecularly imprinted polymer (MIP) layer and the ruthenium dioxide (RuO<sub>2</sub>) electrode as components of an electrochemical sensor designed for direct detection of disease biomarkers. For this purpose, brain-derived neurotrophic factor (BDNF), a potential biomarker for neurodegenerative disorder, was selected as the target analyte. By anchoring a BDNF-selective MIP (BDNF-MIP) layer to RuO<sub>2</sub> electrode functioning as both a substrate transducer and a redox-active internal probe, a direct electrochemical analysis of BDNF was achieved. Following the optimization of the template elution, rebinding time, and BDNF-MIP layer thickness, linear sweep voltammetry (LSV) analysis of the BDNF sensor demonstrated low detection limit, 0.1 ng/mL in buffer and an effective functionality within two linear analytical ranges (0–15 ng/mL and 15–40 ng/mL) in serum. Additionally, exceptional discriminatory selectivity for the target was confirmed in comparison with other neurotrophic factors, as well as other proteins. Importantly, an outstanding reusability of the BDNF sensor during at least 8 rebinding-regeneration cycles was achieved. Thus, the resulting sensing platform offers rapid and precise analysis of biological samples, paving the way for enhanced diagnostics and analytical methodologies across various scientific disciplines.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"429 ","pages":"Article 137301"},"PeriodicalIF":8.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescent-SERS dual-mode strategy combined with mussel-inspired molecularly imprinted polymers for ultrasensitivity and high selectivity detection of 4-Nitrophenol 荧光- sers双模策略结合贻贝启发的分子印迹聚合物用于超灵敏度和高选择性检测4-硝基苯酚

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-01-21 DOI: 10.1016/j.snb.2025.137299

Yuanyuan Yang , Xiaohui Liu , Bofang Mu , Shuang Meng , Xiaohan Wu , Shun Mao , Wenquan Tao , Zhuo Li

{"title":"Fluorescent-SERS dual-mode strategy combined with mussel-inspired molecularly imprinted polymers for ultrasensitivity and high selectivity detection of 4-Nitrophenol","authors":"Yuanyuan Yang , Xiaohui Liu , Bofang Mu , Shuang Meng , Xiaohan Wu , Shun Mao , Wenquan Tao , Zhuo Li","doi":"10.1016/j.snb.2025.137299","DOIUrl":"10.1016/j.snb.2025.137299","url":null,"abstract":"<div><div>A novel surface molecularly imprinted polymers-based dual-mode nanoprobe, NH<sub>2</sub>-MIL-53(Al)@PDA-MIPs/AuNPs, was developed for fluorescence (FL) and surface-enhanced Raman scattering (SERS) detection of 4-Nitrophenol (4-NP) in real water samples. By integrating the advantage of rapid visual detection in FL mode with the advantage of ultrasensitive sensing in SERS mode, the FL-SERS dual-modal approach offers cross-verification of results and extends the detection range. The incorporation of NH<sub>2</sub>-MIL-53(Al) as carriers not only improved the MIPs stability and prevented the deformation of the imprinting cavity, but also provided stable emission signals, eliminating the need for complex fluorescence sources preparation. The PDA-based MIPs layer isolated NH<sub>2</sub>-MIL-53(Al) from the external interferences, providing selective cavities for improved specificity. Additionally, the functional groups on the surface of PDA-based MIPs facilitated the in-situ reduction of AuNPs to create the SERS substrate. The FL-SERS dual-mode nanoprobe exhibited excellent performance, with limits of detection (LOD) of 2.56 nM for FL mode and 1.3 pM for SERS mode. The imprinting factors were calculated to be 13.15 for FL mode and 6.06 for SERS mode, indicating the strong imprinting efficiency. Moreover, real sample applications demonstrated satisfactory recoveries ranging from 96.38 % to 101.78 %, underscoring the practical utility of the sensor in environmental monitoring. The FL-SERS dual-mode nanoprobe thus holds great potential as a versatile tool for future practical application in the sensitive detection of 4-NP in complex water environment.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"429 ","pages":"Article 137299"},"PeriodicalIF":8.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0