Sensors and Actuators B: Chemical最新文献

{"title":"Improving triethylamine vapor detection capabilities of In2O3 via aluminum-mediated isomorphic replacement in the crystalline structure","authors":"Ou Wang ,&nbsp;Jiawei Kong ,&nbsp;Yue Sun,&nbsp;Yu Tang,&nbsp;Heyu Wang,&nbsp;Baoli An,&nbsp;Qingmin Hu,&nbsp;Jiaqiang Xu,&nbsp;Xiaohong Wang","doi":"10.1016/j.snb.2025.137989","DOIUrl":"10.1016/j.snb.2025.137989","url":null,"abstract":"<div><div>Triethylamine (TEA) is one of the most critical raw materials used in the industry. Due to its toxic and harmful characteristics, it is crucial to develop high-performance gas sensors for detecting TEA rapidly and precisely. This study focuses on enhancing the gas sensing performance of In₂O₃ by partially replacing In³⁺ with Al³⁺. The result proved that the introduction of Al³⁺ into In₂O₃ can generate a hollow structure to promote the diffusion of the gas, alter the valence band structure to facilitate the oxidation of TEA, and result in more oxygen vacancies to promote the formation of charge carriers. The combination of these factors leads to the enhanced gas-sensing performance of In₂O₃. The TEA response value of the 5 mol% Al-In₂O₃ reached 2.7 times that of pure In₂O₃ at a relatively low working temperature of 120°C, and the response and recovery time were shortened from 26 s and 147 s to 18 s and 138 s. Moreover, the response values were almost unchanged at high humidity (25°C, 80 % RH) and after 30 days of continuous testing at 120°C. The theoretical detection limit was 31 ppb. This research provides an excellent gas-sensing material for triethylamine detection and a deep understanding of the structure-activity relationship in metal oxide semiconductor materials' gas-sensing mechanisms, thus providing new insights for designing other high-performance gas-sensing materials.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137989"},"PeriodicalIF":8.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Space-confined growth of molecularly imprinted membrane SERS substrate for rapid sample preparation and sensitive food safety analysis all-in-one","authors":"Li Tang ,&nbsp;Jianwei Dong ,&nbsp;Ling Xia,&nbsp;Gongke Li","doi":"10.1016/j.snb.2025.137987","DOIUrl":"10.1016/j.snb.2025.137987","url":null,"abstract":"<div><div>Rapid and accuracy sensing approach is urgent demand in food safety analysis. Development of multifunctional sensing material enabling the integration of molecularly imprinted sample preparation and surface-enhanced Raman scattering (SERS) detection all-in-one is a possible solution. However, the thickness of the molecularly imprinted polymers SERS (MIPs-SERS) substrates is critical to rapidity and sensitivity of analytical method by contributing both the selective enrichment and sufficient Raman signal amplification. A space-confined growth strategy was using for the thickness controllable fabrication of the MIPs-SERS in a microreactor device. As proofs of concept, two types of MIPs-SERS substrates were prepared to realize sample preparation and SERS detection all-in-one. The Au/MIPs membrane was prepared for leucomalachite green (LMG) selective separation, enrichment, chemical conversion and SERS detection with an imprinting factor (<span><math><mi>IF</mi></math></span>) of 18.9 and a Raman enhancement factor (<span><math><mi>EF</mi></math></span>) of 8.5 × 10⁶. Meanwhile, the Au/Ag@MIPs membrane was prepared for forchlorfenuron (CPPU) selective separation, enrichment and Au/Ag nanoparticles synergistic SERS detection with an <span><math><mi>IF</mi></math></span> of 10.5 and a <span><math><mi>EF</mi></math></span> of 2.8 × 10⁶. Based on the MIPs-SERS substrates, selective and sensitive analytical method were established with the limit of detections of 0.49 μg/L for LMG and 6.8 μg/L for CPPU, which meeting the requirement of food safety analysis. In the food safety analysis, LMG and CPPU were detected in a fish and jujube sample, respectively, and the results were verified by recovery tests and standard chromatographic methods. This work provides an alternative approach for rapid complex sample analysis as well as a thickness controllable polymer membrane fabrication strategy.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137987"},"PeriodicalIF":8.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A colorimetric and fluorometric dual-mode biosensor for point-of-care testing of β-lactoglobulin in milk based on DNAzyme and carbon dots","authors":"Zheng Liu ,&nbsp;Qiqi Dang ,&nbsp;Wenyi Yang ,&nbsp;Yufan Feng ,&nbsp;Chunyan Sun","doi":"10.1016/j.snb.2025.137976","DOIUrl":"10.1016/j.snb.2025.137976","url":null,"abstract":"<div><div>β-Lactoglobulin (BLG) is a major allergen in milk and has proven to be a valuable biomarker for the assessment of milk quality. Herein, a colorimetric and fluorometric dual-mode biosensor was first constructed for detecting BLG based on the G-quadruplex/hemin DNAzyme and orange-emitting carbon dots (O-CDs). The BLG aptamer was employed to generate G-quadruplex/hemin DNAzyme, which exhibits peroxidase-like (POD-like) activity and serves as a specific recognition probe. The DNAzyme efficiently catalyzes the conversion of 3,3′,5,5′-Tetramethylbenzidine (TMB) into its blue oxidation product (oxTMB) and simultaneously quenches the fluorescence of O-CDs through the internal filter effect (IFE). Upon the presence of BLG, the aptamer specifically binds to BLG, thereby destroying the structure of the DNAzyme. Consequently, the POD-like activity of the DNAzyme is decreased, leading to an inhibition of oxTMB production and a restoration of the fluorescence of O-CDs. The BLG can be accurately measured by observing the changes in the colorimetric signal of oxTMB at 370 nm and the fluorescence signal of O-CDs at 580 nm. The developed biosensor demonstrates excellent linearity over a concentration range spanning from 1 μg·mL⁻¹ to 500 μg·mL⁻¹. Integrated with the smartphone platform, it could realize convenient quantitative analysis without instruments and meet the requirements of point-of-care testing (POCT). This study holds significant potential for ensuring food security.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137976"},"PeriodicalIF":8.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced ammonia gas sensing performance of in situ-polymerised ZnO/PANI–HCl-doped emeraldine base: Experimental and theoretical investigations","authors":"Ekasiddh Wongrat ,&nbsp;Ittirit Moonmuang ,&nbsp;Narong Chanlek ,&nbsp;Niyom Hongsith ,&nbsp;Sittichain Pramchu ,&nbsp;Supab Choopun","doi":"10.1016/j.snb.2025.137981","DOIUrl":"10.1016/j.snb.2025.137981","url":null,"abstract":"<div><div>Ammonia (NH₃) detection has an essential role in environmental monitoring, industrial safety, and medical diagnostics, particularly in the early-stage detection of possible diseases from human breath. In this study, we comprehensively investigated various gas sensors, focusing on the characteristics of an NH₃ gas sensor prepared using pure ZnO and polyaniline (PANI) and their nanocomposites at room temperature. Bare ZnO nanostructures were synthesised via electrical current heating, while PANI and ZnO/PANI were produced through in situ polymerisation. The prepared nanostructures were characterised using X-ray diffraction, field-emission scanning electron microscopy, transmission electron microscopy, energy-dispersive spectrometry, Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, photoluminescence spectroscopy, and Raman spectroscopy. The ZnO/PANI with 95.1 %/4.9 % by weight ratio sensor (SZP3) demonstrated a notable performance with responses of 5990 and 5.5 at NH₃ concentrations of 500 ppm and 100 ppb, respectively. Density functional theory calculations helped elucidate the sensing mechanisms of the PANI, ZnO, and ZnO/PANI nanocomposites. The PANI sensor exhibited a deprotonation activation energy of 0.53 eV, correlating with the pre-adsorbed <span><math><mrow><msubsup><mrow><mi>O</mi></mrow><mrow><mn>2</mn></mrow><mrow><mo>–</mo></mrow></msubsup></mrow></math></span> and OH⁻ mechanisms on ZnO surfaces. ZnO/PANI nanocomposites showed increased resistance due to charge settlement effects. The sensors displayed high selectivity toward NH₃ over other gases, with sustained performance and stability over 40 days. This comparative study of the gas sensing mechanisms provides both experimental and theoretical insights into the response of ZnO/PANI nanocomposites to NH₃, underscoring the potential for developing a highly selective NH₃ sensor. Our findings can help produce NH₃ sensor prototypes for non-invasive medical diagnostics using human breath.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137981"},"PeriodicalIF":8.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tartaric acid-assisted synthesis and acetone gas sensing properties of hierarchical WO3 phase junctions","authors":"Bohao Liu ,&nbsp;Daocheng Hong ,&nbsp;Lin Li ,&nbsp;Tianci Su ,&nbsp;Luping Che ,&nbsp;XiuLi Yang ,&nbsp;Ning Xu ,&nbsp;Lu Yue ,&nbsp;Wenhui Zhang","doi":"10.1016/j.snb.2025.137965","DOIUrl":"10.1016/j.snb.2025.137965","url":null,"abstract":"<div><div>Acetone is a hazardous substance that can directly impact vital human organs. Accurate detection is crucial for ensuring air quality, monitoring the environment, and conducting medical diagnostics. Herein, hierarchical WO₃ phase junctions assembled with nanoparticals and nanosheets were synthesized by a simple tartaric acid-assisted hydrothermal method. The morphology, phase, and band gap of WO₃ are influenced by the use of different chiral tartaric acids (L(+)-tartaric acid, D(-)-tartaric acid, DL-tartaric acid). Compared with the sample prepared with L(+)-tartaric acid, D(-)-tartaric acid, hierarchical WO₃ phase junctions prepared with DL-tartaric acid have the higher exposed crystal faces, and the sensor with this structure shows the highest response (<em>R</em>_a/<em>R</em>_g = 162.3), short response/recovery time (16 s/15 s) to 50 ppm acetone, along with low practical detection limit (300 ppb) at the operating temperature of 180 °C. Additionally, it possesses favorable selectivity, satisfactory reproducibility, stability, and resistance to moisture. The reaction process of acetone is revealed using in situ diffuse reflectance infrared fourier transform spectroscopy (DRIFT) and validated through density functional theory (DFT) calculations. Such enhanced acetone sensing mechanism mainly roots from its unique structure, the narrow band gap, high exposed crystal faces, phase junctions and oxygen vacancies. This work provides a novel design method to construct hierarchical WO₃ phase junctions with high gas-sensing performance.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137965"},"PeriodicalIF":8.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective intracellular delivery of mRNA by progressive cell deformation in viscoelastic microfluidics","authors":"Qiang Zhao,&nbsp;Minhui Liang,&nbsp;Ye Ai","doi":"10.1016/j.snb.2025.137953","DOIUrl":"10.1016/j.snb.2025.137953","url":null,"abstract":"<div><div>Intracellular delivery of exogenous biomolecules is crucial in the fields of biology and medicine. However, a significant challenge in intracellular delivery is balancing cell viability with delivery efficiency due to the wide distribution of cell sizes. In this study, we have developed a microfluidic device with viscoelastic fluids to implement highly efficient intracellular delivery and maintain high cell viability after delivery. This method utilizes a micro-constriction array that generates progressive shear forces on the cell membrane via the viscoelastic fluids, facilitating the delivery of exogenous biomolecules into cells. Additionally, the constriction width is greater than the cell diameter to avoid physical squeezing by the device structures, which allows to maintain high cell viability and eliminate channel clogging issue. Without altering the constriction width, we have successfully delivered a wide range of molecule sizes to MDA-MB-231 and Jurkat cells. We have also demonstrated the intracellular delivery of mRNA to Jurkat cells with high efficiency (&gt;99 %), high viability (90 %), and high throughput (500,000 cells/min). This method holds significant potential for applications in biological sciences and medicine.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137953"},"PeriodicalIF":8.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-planar boron-oxygen multiple resonance thin-film fluorescent sensor for high-performance vapor phase BTEX detection","authors":"Wenya Wang,&nbsp;Jiaman Li,&nbsp;Jianting Liu,&nbsp;Haitao Yu,&nbsp;Yanyu Qi","doi":"10.1016/j.snb.2025.137986","DOIUrl":"10.1016/j.snb.2025.137986","url":null,"abstract":"<div><div>BTEX vapors, comprising benzene, toluene, ethylbenzene, <em>ortho</em>-xylene, <em>meta</em>-xylene, and <em>para</em>-xylene, are classified as volatile organic compounds (VOCs) and present a considerable risk to human health. The sensitive, real-time, rapid and room temperature detection and identification of BTEX vapors through vapor sampling continues to pose a significant challenge within the field. In this study, we creatively have integrated boron-oxygen multiple resonance units with <em>ortho</em>-carborane groups to fabricate film-based fluorescent sensors (FFSs) that demonstrates rapid response, excellent selectivity, repeatability, and high sensitivity towards BTEX vapors at room temperature. The response time is as short as 4 s, and the recovery time is less than 80 s, and after conducting the tests more than 30 times, no discernible deterioration was detected. The experimental detection limits are 30.9 ppm, 44.8 ppm, 34.7 ppm, 44.6 ppm, 30.86 ppm and 69.4 ppm, for benzene, toluene, ethylbenzene, <em>ortho</em>-xylene, <em>meta</em>-xylene, and <em>para</em>-xylene, respectively. The exceptional performance of the sensor was attributed to the non-planar configuration and microenvironmental sensitivity of the sensing fluorophore, as it facilitates the formation of micro-channels within the film. We firmly believe that our work not only achieves reversible fluorescence sensing of BTEX vapors, offering vast potential for applications in air quality assessment, industrial environmental monitoring, and the analysis of photoelectronically inactive VOCs, but also underscores that the integration of a non-planar structure with microenvironmentally sensitive groups represents a highly effective strategy for developing advanced fluorescent sensing films with superior performance.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137986"},"PeriodicalIF":8.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Equipment-free detection of saccharin based on the confined space enhanced AIE effect of a novel ratiometric fluorescent Zn-MOF: Probe design, sensing performance, and practical applications","authors":"Ensheng Zhang ,&nbsp;Guixue Zhang ,&nbsp;Wenhui Lu ,&nbsp;Dezheng Liu ,&nbsp;Anzhang Li ,&nbsp;Qingxiang Zhang ,&nbsp;Long Jiang ,&nbsp;Ping Ju ,&nbsp;Fengli Qu","doi":"10.1016/j.snb.2025.137985","DOIUrl":"10.1016/j.snb.2025.137985","url":null,"abstract":"<div><div>Saccharin (SAC) is a widely used low-calorie sweetener, which is also classified as a Group 2B carcinogen. However, fluorescent probes for SAC sensing are rarely reported. Herein, we reveal the first equipment-free method for the highly selective detection of saccharin based on a novel ratiometric fluorescent probe, MOF-1@RhB. MOF-1@RhB was obtained by physically encapsulating RhB in MOF-1 as an internal self-calibration through the one-pot solvothermal synthesis. A naked-eye distinguishable color change from orange to green could be observed for MOF-1@RhB in the presence of SAC. MOF-1@RhB exhibits a fast response speed (30 seconds), a wide linear range (0–160 μM), and a good limit of detection (LOD = 109 nM) in the detection of SAC. Taking advantage of MOF-1@RhB, paper-based sensors were prepared and used for on-site detection. A portable device integrating a smartphone and paper sensors for point-of-care testing has been developed. In real-sample detection, the photograph of the paper sensors could be taken using a smartphone and then analyzed with a dedicated smartphone app to derive the SAC concentration. Moreover, the proposed method has been successfully applied to monitor SAC in food samples and its accuracy has been verified with the HPLC method.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137985"},"PeriodicalIF":8.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous quantification of intracellular pH and lactate at the single-cell level using a genetically encoded fluorescence lifetime biosensor","authors":"Huangmei Zhou ,&nbsp;Yejun Zou ,&nbsp;Yike Song ,&nbsp;Zhuo Zhang ,&nbsp;Kai Chen ,&nbsp;Lunhua Deng ,&nbsp;Xie Li ,&nbsp;Sanjun Zhang ,&nbsp;Yuzheng Zhao","doi":"10.1016/j.snb.2025.137979","DOIUrl":"10.1016/j.snb.2025.137979","url":null,"abstract":"<div><div>Metabolism plays an essential role in supporting physiological functions and maintaining a stable intracellular environment, including pH homeostasis. It is of biological significance to dynamically track metabolites and pH simultaneously in living cells. Genetically encoded fluorescent protein biosensors are extensively used to monitor metabolites; however, their fluorescence intensity—the commonly used readout—is often responsive to pH fluctuations, rendering analyte quantification challenging. In this study, we report a novel method that involves the steady-state fluorescence, time-resolved fluorescence and occupancy of the biosensor, called biosensor occupancy-enabled absolute quantification (BOEAQ) method, for simultaneous measurement of pH and analyte concentrations. We first demonstrate that FiLa (a recently reported lactate biosensor) can serve as a high performance fluorescence lifetime biosensor for lactate with a large intensity-weighted lifetime response (∼1.1 ns and ∼1.2 ns at 405 nm and 470 nm excitation, respectively). In a proof-of-principle, we simultaneously quantify pH and lactate concentration with our BOEAQ method both <em>in vitro</em> and in living cells at the single-cell resolution. In principle, the BOEAQ methodology holds promise for applications to other metabolite biosensors, thereby expanding the possibilities for multiplexed imaging.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137979"},"PeriodicalIF":8.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced ferroptosis in triple-negative cancer cells achieved by a type-I cell membrane-targeted tetrabenzophenazine photosensitizer","authors":"Zhuo-Liang Zhou ,&nbsp;Xiao Zhang ,&nbsp;Ming-Hao Hu","doi":"10.1016/j.snb.2025.137978","DOIUrl":"10.1016/j.snb.2025.137978","url":null,"abstract":"<div><div>Triggering ferroptosis emerges as a promising anticancer therapeutic strategy. Photodynamic therapy based on cell membrane-targeted agents presents a chance to facilitate ferroptosis. However, there have been limited reports on this topic. In this study, we introduced a type-I cell membrane-targeted photosensitizer capable of inducing ferroptosis (<strong>FQ2</strong>). The study demonstrated that <strong>FQ2</strong> was located on cell membrane, and the <strong>FQ2</strong>-mediated PDT could promote ferroptosis, which was attributed to GSH depletion, NADH oxidation, and GPX4 downregulation, ultimately causing lipid peroxidation (LPO) accumulation. Moreover, <strong>FQ2</strong> was capable to induce apoptosis, as well as immunogenic cell death (ICD) upon irradiation. Finally, <strong>FQ2</strong> exhibited good anticancer activity in vivo using a 4T1 tumor-bearing mouse model. Overall, this work provided an example for the development of cell membrane-targeted ferroptosis inducers.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"441 ","pages":"Article 137978"},"PeriodicalIF":8.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}