{"title":"MOFs-derived In2O3 hollow microtubes/ZnCo2O4 microflowers for fast and sensitive detection of n-butanol","authors":"Wangchang Geng, Pengfei Song, Libing Duan, Tingyue Luan","doi":"10.1016/j.snb.2024.136803","DOIUrl":"https://doi.org/10.1016/j.snb.2024.136803","url":null,"abstract":"Metal-organic frameworks (MOFs)-derived metal oxides have a high specific surface area and porous structure, making them promising for gas sensing applications. In this paper, MOFs-derived In<sub>2</sub>O<sub>3</sub>/ZnCo<sub>2</sub>O<sub>4</sub> composites were synthesized using a two-step solvothermal method. Through a series of characterization strategies, it is revealed that the morphology of the In<sub>2</sub>O<sub>3</sub>/ZnCo<sub>2</sub>O<sub>4</sub> composites consists of hollow microtubes and microflowers. The gas sensing performance of In<sub>2</sub>O<sub>3</sub>/ZnCo<sub>2</sub>O<sub>4</sub> composites was significantly enhanced compared to pure In<sub>2</sub>O<sub>3</sub>. Among them, the In<sub>2</sub>O<sub>3</sub>/ZnCo<sub>2</sub>O<sub>4</sub>-2 sensor exhibited superior performance towards 100 ppm <em>n</em>-butanol gas, with a lower operating temperature of 200℃, a higher response value of 208.7, a lower detection limit of 4.2 ppb, shorter response/recovery times of 152<!-- --> <!-- -->s/223<!-- --> <!-- -->s, higher selectivity, and better repeatability. Furthermore, the improved gas response can be attributed to the utilization of MOFs as self-sacrificial templates, the high specific surface area of the sensing materials, and the formation of <em>p-n</em> heterojunctions. This study provides a valuable reference for synthesizing <em>n</em>-butanol sensing materials with a high specific surface area, strong response, and excellent selectivity.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gas classification and concentration prediction in open environments using class anchor clustering-initialized temporal convolutional network","authors":"","doi":"10.1016/j.snb.2024.136793","DOIUrl":"10.1016/j.snb.2024.136793","url":null,"abstract":"<div><div>Identifying target gases and predicting their concentrations in open environments are critical tasks, particularly due to fluctuating environmental conditions and the presence of unknown gases. This study aims to address these challenges by developing a model that improves both gas classification and concentration prediction. We introduce two key components: Quantile-Dynamic Associated Features (Q-DAF) and the Class Anchor Clustering-Initialized Temporal Convolutional Network (CAC-InitTCN). Q-DAF dynamically enhances gas signal feature extraction, optimizing the ability of CAC-InitTCN to handle complex and changing gas environments. CAC-InitTCN is designed to efficiently process time-series data, allowing it to manage gas concentration fluctuations while mitigating the interference of unknown gases. CAC-InitTCN was evaluated on two distinct datasets, achieving classification accuracy rates of 93.62 % and 98.05 %, respectively. In gas concentration prediction tasks, the model demonstrated RMSE values of 0.2102 and 0.0392, and R<sup>2</sup> scores of 0.9085 and 0.9784, after data normalization. These results demonstrate the capability of CAC-InitTCN in handling real-time gas fluctuations and recognizing unknown gases, making it a promising approach for open-environment gas detection.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Introduction of Lewis acid sites to endow cobalt phosphide with peroxidase-like and oxidase-like activities and application in colorimetric sensing analysis","authors":"","doi":"10.1016/j.snb.2024.136790","DOIUrl":"10.1016/j.snb.2024.136790","url":null,"abstract":"<div><div>With more and more attention to health, developing a simple and effective method for detecting phenolic compounds is an urgent and challenging task. In this context, Mn-doped CoP (referred to as Mn-CoP) with a nanocage interior architecture has been successfully constructed. The formation of a hollow structure exposes more active sites, while the incorporation of Mn ion reduces the charge transfer resistance and accelerates the charge transfer. Consequently, Mn-CoP effectively provides electrons to activate H<sub>2</sub>O<sub>2</sub> and O<sub>2</sub> producing OH<sup>•</sup> and O<sub>2</sub><sup>•<img></sup>, demonstrating excellent peroxidase-like and oxidase-like activities. Given its strong oxidase-like activity, Mn-CoP enables a straightforward colorimetric assay for detecting hydroquinone using 3,3′,5,5′-tetramethyl benzidine (TMB) as colorimetric substrate. Interestingly, the developed colorimetric detection method exhibits a broad linear range and a low limit of detection (LOD) for hydroquinone, showing good potential for application even in real samples. Detailed analyses reveal that the doped Mn ions serve as Lewis acid sites directly reacting with the amino functional group in TMB. The Lewis acid-base reaction between Mn-CoP and TMB is crucial for the chromogenic reaction of TMB. Moreover, doping Mn ion to enhance the oxidase-like activity of the nanozyme is a simple and feasible modification strategy with universal applicability. This work provides a valuable reference for designing nanozymes with oxidase-like activity.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A fluorescent probe for rapid staining and real-time detection of autophagy in single cells by lighting-up G-quadruplexes","authors":"","doi":"10.1016/j.snb.2024.136768","DOIUrl":"10.1016/j.snb.2024.136768","url":null,"abstract":"<div><div>Autophagy is a crucial physiological mechanism in eukaryotes for maintaining metabolic balance, and its dysregulation is closely linked to human neurodegenerative diseases, tumors, and others. Real-time tracking of autophagy in live cells is essential for elucidating pathogenesis and developing new therapeutics. Here, a supramolecular assembly, <strong>SCY-3</strong>, has been designed to monitor autophagy by selectively lighting-up the G-quadruplex structures entering the lysosomes. <strong>SCY-3</strong> exhibits low cytotoxicity, long optical detection wavelength, and excellent photostability, making it ideal for prolonged tracking in single cells and living organisms. Notably, <strong>SCY-3</strong> can rapidly penetrate lysosomes, offering significant advantages in fast staining. These attributes position <strong>SCY-3</strong> as a promising universal tool for autophagy tracking with broad applicability.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"α-Linolenic acid from Mori Folltfm found as Choloylglycine hydrolase inhibitor by the developed fluorescent probe to alleviate type 2 diabetes","authors":"","doi":"10.1016/j.snb.2024.136789","DOIUrl":"10.1016/j.snb.2024.136789","url":null,"abstract":"<div><div>Choloylglycine hydrolase (CH), also known as bile salt hydrolase, is expressed by intestinal microbiota and plays a key role in the hydrolysis of conjugated bile acids, influencing the composition and levels of various bile acids. In this study, a conjugate (<strong>CA-ACDI</strong>) of cholic acid and a semi-cyanine derivative was developed as an enzyme-activated fluorescent probe for detecting CH activity, showing potential applications in this area. By the high-throughput screening of CH activity using <strong>CA-ACDI</strong>, <em>Mori Folium</em> was identified as a significant CH inhibitor from a collection of 95 traditional herbal medicines. Further analysis using various chromatographic techniques and spectroscopic data identified α-linolenic acid as the key bioactive component in <em>Mori Folium</em> responsible for inhibiting CH activity. Importantly, α-Linolenic acid, as a natural CH inhibitor, was shown to significantly regulate glucose metabolism in a type 2 diabetes mellitus (T2DM) mouse model via the FXR signaling pathway. This work not only developed a novel fluorescent probe for CH detection but also discovered potential CH inhibitors that may help alleviate type 2 diabetes.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yanwei Wang, Qinghua Li, Jinyue Zhang, Chongbo Yin, Qinglun Zhang, Yan Shi, Hong Men
{"title":"A gas detection system combined with a global extension extreme learning machine for early warning of electrical fires","authors":"Yanwei Wang, Qinghua Li, Jinyue Zhang, Chongbo Yin, Qinglun Zhang, Yan Shi, Hong Men","doi":"10.1016/j.snb.2024.136801","DOIUrl":"https://doi.org/10.1016/j.snb.2024.136801","url":null,"abstract":"Overheating failures in electrical equipment can lead to fires, making advanced fire warning technologies essential for preventing or limiting the spread of such incidents. In this work, we develop a gas detection system designed to identify volatile gases emitted from various overheated materials in electrical equipment at different heating stages. By integrating the Global Extension Extreme Learning Machine (GEELM), the system effectively classifies gas information related to overheating materials across multiple time intervals. The gas detection system consists of an odor generation equipment and an external high-current generator. Without producing soot particles of smoke, it collects gas information for six types of plastics, including four boards and two cables. Finally, GEELM achieves the optimal performance in classifying gas information from various overheated materials at different heating times. This confirms the system’s feasibility and effectiveness, offering a powerful technical solution for early detection of overheating issues in electrical equipment.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Internal-driven DNA nanowindmill: Multi-fulcrum mediated amplified rolling nanomachine for fast and ultrasensitive electrochemical detection of tau","authors":"","doi":"10.1016/j.snb.2024.136797","DOIUrl":"10.1016/j.snb.2024.136797","url":null,"abstract":"<div><div>Inspired by the wind driving windmill rolling to generate electrical energy, we have fabricated a multi-fulcrum mediated amplified rolling nanomachine (MFN) for Tau detection with the internal drive. The MFN backbone is DNA nanowindmill (DM) self-assembled from DNA, which is initially ineffective and finally activated into an effective DM through interaction with Tau followed by the magnetic separation. The DM is introduced to the electrode interface where it continues rolling under the drive of the multi-fulcrum and signal probe to achieve signal amplification. On one hand, the modular design and DM rolling feeds the impediment of signal transduction and amplification due to spatial hindrance during protein detection. On the other hand, it endows fast response and high sensitivity. The proposed MFN electrochemical biosensor is successfully applied to detect Tau ranging from 10 pg/mL to 2 μg/mL with low detection limit of 127 fg/mL, which is much lower than the pathological state concentration of Tau ∼400 pg/mL. Furthermore, our findings proves that MFN can successfully differentiate normal individuals from Alzheimer’s disease (AD) patients based on clinical samples analysis.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A simplified antibody-responsive fluorescence biosensor by proximity ligation-induced quasi-Y-DNA assembly to illuminate emissive DNA looped-Ag nanocluster","authors":"","doi":"10.1016/j.snb.2024.136781","DOIUrl":"10.1016/j.snb.2024.136781","url":null,"abstract":"<div><div>Exploring the proximity ligation-induced quasi-Y-DNA assembly (<em>plq</em>YDA) for creating label-free fluorescence biosensor might be intriguing based on DNA loop-hosted red Ag nanocluster (<em>lr</em>AgNC) as a signaling reporter. For proof-of-concept, a bivalent digoxigenin antibody (anti-Dig) with two identical binding sites was used as an analyte model, and it can specifically distinguish two Dig haptens that were separately modified in two modular split strands (SS1 and SS2) with complements each other and invading domains. The strong and robust anti-Dig-Dig binding guided the proximity ligation of SS1 and SS2 to construct geometric-structure <em>plq</em>YDA with a paired stem and two sticky linkers. After introducing a dsDNA duplex from a reporting strand (RS) with seven-polycytosine template (C<sub>7</sub>) of <em>lr</em>AgNC and a blocking strand (BS), entropy-driven hybridization and cooperative displacement occurred. As a result, RS was rationally immobilized in <em>plq</em>YDA to crimp single-coil C<sub>7</sub> as a closed and extruded loop, which preferably favored the development of emissive <em>lr</em>AgNC when adding AgNO<sub>3</sub> and NaBH<sub>4</sub>. By collecting the distinct fluorescence signal, the label- and enzyme-free assay of anti-Dig was readily achieved, exhibiting good specificity and high sensitivity. This would be the first example of our best understanding of integrating <em>plq</em>YDA and <em>lr</em>AgNC for applicable biosensing and bioanalysis.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Monolayer-fluorescence counting for ultrasensitive detection of tumour cell-derived extracellular vesicles using a step-wedge microfluidic platform","authors":"","doi":"10.1016/j.snb.2024.136786","DOIUrl":"10.1016/j.snb.2024.136786","url":null,"abstract":"<div><div>Extracellular vesicles have emerged as significant noninvasive tumour biomarkers, and ultrasensitive detection methods are important for early cancer diagnosis. Here, a monolayer-fluorescence counting strategy was developed for the ultrasensitive detection of extracellular vesicles using a microfluidic platform. Extracellular vesicles were specially captured and separated from complex matrix by immune magnetic microbeads (IMBs). With an enhancing acoustic wave microfluidic channel, the magnetic-extracellular vesicles immune complex was adequately mixed and reacted with antibody-modified fluorescence microbeads (IFBs). Using a newly designed step-wedge microfluidic structure, micrometer-size particles were trapped in large numbers with monolayer in the step zone, and the fluidic resistance was reduced through the wedge structure. This detection signal of the fluorescence-labelled immune sandwich complex could be read by counting, avoiding background interference and achieving an ultrasensitive detection with a detection limit of 850 particles/mL. Moreover, this method showed strong reliability and specificity in clinic samples. In addition, a miniaturized detection device was developed based on this microfluidic platform, improving this detection automation.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metal-organic framework-derived hierarchical flower-like DyCo-layered double hydroxide amalgamated nitrogen-doped graphene for diphenylamine detection in fruit samples: Theoretical density functional theory interpretation","authors":"","doi":"10.1016/j.snb.2024.136782","DOIUrl":"10.1016/j.snb.2024.136782","url":null,"abstract":"<div><div>Diphenylamine (DPA) is an environmental pollutant that can be potentially toxic. As a result, it is crucial to use basic and affordable analytical techniques to detect DPA. Electrochemical detection of DPA is a cost-effective and simple method. Modifying the electrodes with nanomaterials can enhance the electrochemical characteristics and sensitivity of the sensor. Herein, metal-organic framework (MOF) derived dysprosium cobalt-layered double hydroxide integrated nitrogen-doped graphene (DyCo-LDH/NG) is reported for the fabrication of the DPA sensing platform. The electrochemical oxidation of DPA is enhanced by the exceptional electrocatalytic activity and electron transfer properties of the DyCo-LDH/NG nanocomposite. Interestingly, the glassy carbon electrode (GCE) modified with DyCo-LDH/NG nanocomposite demonstrates a large linear detection range (0.05–470 μM) and a low limit of detection (0.012 µM). The density functional theory (DFT) study is employed to examine the energy levels and electron transfer sites of DPA during the electro-oxidation process. Furthermore, the practical efficiency test of the developed DPA sensor demonstrates a substantial recovery in fruit samples.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}