Sensors and Actuators B: Chemical最新文献_第9页

Biomass-derived graphitic carbon/MoO3 nanosheets-crosslinked tubes for high response and rapid detection of butyl mercaptan at low temperatures

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-20 DOI: 10.1016/j.snb.2025.137655

Shi-Kai Shen, Yu-Ying Xin, Hui-Ye Jiang, Zhao-Peng Deng, Ying-Ming Xu, Li-Hua Huo, Shan Gao

{"title":"Biomass-derived graphitic carbon/MoO3 nanosheets-crosslinked tubes for high response and rapid detection of butyl mercaptan at low temperatures","authors":"Shi-Kai Shen, Yu-Ying Xin, Hui-Ye Jiang, Zhao-Peng Deng, Ying-Ming Xu, Li-Hua Huo, Shan Gao","doi":"10.1016/j.snb.2025.137655","DOIUrl":"10.1016/j.snb.2025.137655","url":null,"abstract":"<div><div>The fabrication of gas sensors for monitoring volatile organic sulfur compounds has currently gained wide concerns, but no related works on butylmercaptan (BM) were reported. Herein, two types of MoO<sub>3</sub> materials were prepared by simple immersion of willow branch slices in ammonium molybdate water/acetonitrile solution followed by air calcination. The GC/MoO<sub>3</sub> nanosheets-crosslinked tubes obtained from calcining precursor at 450 °C involve 5.45 wt% biomass-derived graphitic carbon (GC), and possess multi-level mesopores, large specific surface area and abundant oxygen vacancy defects. These structural features can increase the electroconductivity and percentage of oxygen species adsorbed on sensing surface, promote the rapid transport and adsorption of reducing BM molecules in sensing layer. Under the catalytic synergy of surface Mo<sup>6+</sup> ions, highly sensitive detection of harmful BM gas by semiconductor sensor at different low temperatures is achieved for the first time. At near room temperature of 50 °C, GC/MoO<sub>3</sub> sensor realized a response value (<em>RV</em>) of 174.8 for 50 ppm BM and it also had a good response (<em>RV</em> = 79) to the same concentration of BM at 92 °C. Meanwhile, it possessed reversible response-recovery and other good overall sensing performances. In addition, the low-temperature sensing mechanism of enhanced BM was analyzed in combination with DFT calculation.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"435 ","pages":"Article 137655"},"PeriodicalIF":8.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Empirical enhancement factors for trace moisture in nitrogen and argon: Bridging measurement principles

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-20 DOI: 10.1016/j.snb.2025.137617

Isidora Radičević, Domen Hudoklin

{"title":"Empirical enhancement factors for trace moisture in nitrogen and argon: Bridging measurement principles","authors":"Isidora Radičević, Domen Hudoklin","doi":"10.1016/j.snb.2025.137617","DOIUrl":"10.1016/j.snb.2025.137617","url":null,"abstract":"<div><div>Accurate measurement of trace water vapor concentrations in gases is critical across various industries, specifically in semiconductor manufacturing where moisture impurities affect device reliability. The most sensitive and accurate methods for measuring ultra-low trace humidity concentrations, below 1 ppm, involve chilled mirror hygrometers and cavity ring-down spectroscopy sensors. The former measures dew/frost points directly, while the second detects particle number density or mole fraction. However, comparing measurements from different operating principles is challenging due to limited understanding of water vapor properties in real gases at very low humidity concentrations and elevated pressures.</div><div>The water vapor enhancement factor, which accounts for this non-ideal gas behavior, has so far been empirically determined within a restricted range, with values at low humidity extrapolated. This study extends water vapor enhancement factor measurements below 1 ppm to ultra-low frost points down to −90 °C (corresponding to 100 ppb water amount fraction) and high pressures of up to 1 MPa for carrier gases argon and nitrogen. Our findings reveal significant deviations from existing extrapolated water vapor enhancement factor values. With our measurements achieving lower uncertainties than previous models, this advancement supports the development of reliable, stable, accurate and low-cost humidity sensors essential for industrial applications requiring precise moisture control.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"435 ","pages":"Article 137617"},"PeriodicalIF":8.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coupled cantilever biosensor utilizing a novel approach to gap-method for real-time detection of E. coli in low concentrations

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-20 DOI: 10.1016/j.snb.2025.137665

Syed Ali Raza Bukhari, Elham Alaei, Yongjun Lai

{"title":"Coupled cantilever biosensor utilizing a novel approach to gap-method for real-time detection of E. coli in low concentrations","authors":"Syed Ali Raza Bukhari, Elham Alaei, Yongjun Lai","doi":"10.1016/j.snb.2025.137665","DOIUrl":"10.1016/j.snb.2025.137665","url":null,"abstract":"<div><div>Biosensors have become indispensable for rapid detection of pathogens and play a vital role in the monitoring of bioparticles in healthcare, environmental monitoring and food safety. This paper presents a novel microsensor consisting of a pair of coupled cantilevers. During testing, the cantilevers are immersed in a sample solution and one of the cantilevers is actively actuated to vibrate while the other is passively driven through the sample solution. To accelerate pathogen capture, dielectrophoresis (DEP) is used to concentrate the sparse bacteria in the sample solution to the gap region between the cantilevers. The captured bacteria cause frequency shifts for both cantilevers. The limit of detection (LOD) of the sensor is determined to be 15 cells/ml and signal-to-noise ratio (SNR) reaches to 12.8 and higher. For stagnant samples, high frequency shifts of up to 3.1 kHz are observed for 10<sup>5</sup> cells/ml while even for a low concentration of 100 cells/ml a substantial frequency shift of 914 Hz is recorded. Performance is also characterized at different flowrates, and significant frequency shifts up to 1.7 kHz are observed for 10<sup>5</sup> cells/ml concentration at 1 µl/min. These advancements establish the proposed biosensor as a highly sensitive, and versatile tool for detecting pathogens in diverse applications.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"435 ","pages":"Article 137665"},"PeriodicalIF":8.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gas classification system based on hybrid waveform modulation technology on FPGA

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-20 DOI: 10.1016/j.snb.2025.137637

Jiade Zhang , Mingzhi Jiao , Liangsong Duan , Lina Zheng , VanDuy Nguyen , Chu Manh Hung , DucHoa Nguyen

{"title":"Gas classification system based on hybrid waveform modulation technology on FPGA","authors":"Jiade Zhang , Mingzhi Jiao , Liangsong Duan , Lina Zheng , VanDuy Nguyen , Chu Manh Hung , DucHoa Nguyen","doi":"10.1016/j.snb.2025.137637","DOIUrl":"10.1016/j.snb.2025.137637","url":null,"abstract":"<div><div>With the growing global emphasis on environmental protection, new energy vehicles have become essential for reducing carbon emissions in the transportation sector. However, safety issues related to lithium-ion batteries, particularly thermal runaway, remain a critical concern. Different stages of thermal runaway produce distinct gas compositions, necessitating sensors with high selectivity for targeted detection of specific gases or gas categories. Dynamic measurement technology using temperature modulation can enhance the selectivity of semiconductor gas sensors. However, most dynamic measurements yield limited data features for gas categories, complicating subsequent classification algorithms and making them less suitable for deployment in embedded devices. To address these challenges, this study proposes an electronic nose system based on hybrid waveform modulation technology. By employing multi-waveform superposition heating, this approach enriches data features corresponding to gas responses and optimizes sensor technology and data processing algorithms using ARM+FPGA architectures, significantly improving system accuracy. The system collects gas sensor data via a sensor array and achieves a recognition rate of 95.82 % using the MLP algorithm, successfully deployed on Xilinx’s System-on-Chip (SoC) platform.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"435 ","pages":"Article 137637"},"PeriodicalIF":8.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultra-high response and selectivity of triethylamine sensor based on NiO/Pd/SnO2 multiple heterojunctions composite

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-20 DOI: 10.1016/j.snb.2025.137652

Gaojie Li , Xueyang Li , Linqi Zhang , Zemin Zhou , Yihui Li , Hui Li , Ke Ning , Xuedong Chen

{"title":"Ultra-high response and selectivity of triethylamine sensor based on NiO/Pd/SnO2 multiple heterojunctions composite","authors":"Gaojie Li , Xueyang Li , Linqi Zhang , Zemin Zhou , Yihui Li , Hui Li , Ke Ning , Xuedong Chen","doi":"10.1016/j.snb.2025.137652","DOIUrl":"10.1016/j.snb.2025.137652","url":null,"abstract":"<div><div>Multiple heterojunctions composite may be an effective way to simultaneously improve the selectivity and response of metal oxide semiconductor-based sensors, as well as reduce the working temperature. In this study, the NiO/Pd/SnO<sub>2</sub> composite including PN heterojunction (NiO/SnO<sub>2</sub>) and Schottky junction (Pd/SnO<sub>2</sub>) was successfully prepared through three steps. The morphology, structure, and chemical state of surface elements were characterized by XRD, SEM, TEM, and XPS. Gas sensing performance displayed that the NiO/Pd/SnO<sub>2</sub> sensor exhibited ultra-high response (1320) and selectivity (>4.1), low detect limit (0.1 ppm) and excellent long-term stability to 100 ppm of TEA at 275°C. Compared with SnO<sub>2</sub> and NiO/SnO<sub>2</sub>, Pd/SnO<sub>2</sub> and NiO/Pd/SnO<sub>2</sub> sensors exhibited higher response and lower working temperature. Compared with Pd/SnO<sub>2</sub>, the NiO/Pd/SnO<sub>2</sub> sensor exhibited higher selectivity. In addition, the adsorptions of oxygen and TEA on the surface of samples have also been simulated through DFT calculations. Based on the characterization and calculation results, the excellent sensing performance of the NiO/Pd/SnO<sub>2</sub> sensor can be attributed to the multiple heterojunctions and strong activation effect of Pd on oxygen and TEA molecules.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"435 ","pages":"Article 137652"},"PeriodicalIF":8.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mn-doped ZnS quantum dots@dendritic mesoporous silica phosphorescent nanocomposites for antimicrobial susceptibility testing

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-20 DOI: 10.1016/j.snb.2025.137664

Shiqing Luo , Xiaojie Sun , Lifang Zhang , Yanming Miao , Guiqin Yan

{"title":"Mn-doped ZnS quantum dots@dendritic mesoporous silica phosphorescent nanocomposites for antimicrobial susceptibility testing","authors":"Shiqing Luo , Xiaojie Sun , Lifang Zhang , Yanming Miao , Guiqin Yan","doi":"10.1016/j.snb.2025.137664","DOIUrl":"10.1016/j.snb.2025.137664","url":null,"abstract":"<div><div>The excessive use of antibiotics has accelerated the rise of antimicrobial resistance (AMR), and rapid antimicrobial susceptibility testing (AST) is very important for the early detection, early prevention and treatment of AMR. On this basis, we combined manganese-doped zinc sulfide quantum dots (Mn-ZnS QDs) with aminated dendritic mesoporous silica nanoparticles (DMSNs-NH<sub>2</sub>) to prepare Mn-ZnS QDs@DMSNs-NH<sub>2</sub> room-temperature phosphorescent (RTP) nanocomposites·H<sub>2</sub>O<sub>2</sub> can quench the RTP of Mn-ZnS QDs@DMSNs-NH<sub>2</sub> nanocomposites, while catalase-positive bacteria can cause the hydrolysis of H<sub>2</sub>O<sub>2</sub>. Hence, RTP detection of different antibiotic tolerance for <em>Staphylococcus aureus</em> (<em>S. aureus</em>) and methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) was achieved. This sensing system can achieve rapid bacterial detection and AST through the difference in RTP intensity. Experimental results demonstrated that the linear detection range for bacteria is 0 × 10<sup>5</sup>-64 × 10<sup>5</sup> CFU·mL<sup>−1</sup>, with a limit of detection (LOD) of 1 × 10<sup>5</sup> CFU·mL<sup>−1</sup> for MRSA and 0.7 × 10<sup>5</sup> CFU·mL<sup>−1</sup> for <em>S. aureus</em>. The pore confinement effect of DMSNs-NH<sub>2</sub> can induce the aggregation of Mn-ZnS QDs, which strengthens the RTP of Mn-ZnS QDs@DMSNs-NH<sub>2</sub> nanocomposites and improves the sensitivity of RTP detection. This method is not only free from sample background fluorescence interference, but also shortens the AST time (less than 90 min), making antibacterial treatment more time-saving and efficient and reducing patient pains. This nanosensor provides a new strategy for rapid clinical bacterial detection and effective assessment of antimicrobial susceptibility.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"435 ","pages":"Article 137664"},"PeriodicalIF":8.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucose selective textile OECT based on molecularly imprinted nanoparticles functionalized channel for in vivo plants monitoring

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-20 DOI: 10.1016/j.snb.2025.137640

Filippo Vurro , Elena Dembech , Riccardo Manfredi , Gabriele Debbi , Manuele Bettelli , Alice Marinangeli , Alessandra Maria Bossi , Nadia Palermo , Vittoria Martini , Michela Janni , Nicola Coppedè

{"title":"Glucose selective textile OECT based on molecularly imprinted nanoparticles functionalized channel for in vivo plants monitoring","authors":"Filippo Vurro , Elena Dembech , Riccardo Manfredi , Gabriele Debbi , Manuele Bettelli , Alice Marinangeli , Alessandra Maria Bossi , Nadia Palermo , Vittoria Martini , Michela Janni , Nicola Coppedè","doi":"10.1016/j.snb.2025.137640","DOIUrl":"10.1016/j.snb.2025.137640","url":null,"abstract":"<div><div>Organic electrochemical transistors (OECTs) have been used as flexible biosensors, in organic bioelectronics, with high sensitivity and high transconductance but limited selectivity. OECTs can measure metabolic biomarkers, also continuously with real-time monitoring applications, in different biofluids of interest, with applications in sports, healthcare, biology and agriculture. In this study we developed an OECTs biosensor based on the functionalization of the active channel of the OECT with a biomimetic recognition element, namely molecularly imprinted nanoparticles (nanoMIPs), to selectively bind the target analyte D-glucose. Two configurations based on textile absorbent materials (nanoMIP fiber wire) or on polymer microfibers (nanoMIP microwire) were prepared and tested for D-glucose sensing and for D-fructose interference. The results show that the nanoMIPs improved the sensitivity and selectivity towards D-glucose. The nanoMIP fiber D-glucose wire sensor was used to monitor tomato plants in the field together with the conventional OECT based biosensor bioristor, providing new insights into the dynamics of the drought defense response.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"436 ","pages":"Article 137640"},"PeriodicalIF":8.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly-sensitive ultra-thin dental patches assisted with artificial-intelligence recognition for mapping hidden periodontitis lesions

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-20 DOI: 10.1016/j.snb.2025.137648

Ying Liu , Siyuan Wang , Xinyi Qu , Yuanfang Li , Cuiping Zhou , Dong Xie , Jianpei Dong , Li Ji , Jincheng Xu , Jianhua Zhou

{"title":"Highly-sensitive ultra-thin dental patches assisted with artificial-intelligence recognition for mapping hidden periodontitis lesions","authors":"Ying Liu , Siyuan Wang , Xinyi Qu , Yuanfang Li , Cuiping Zhou , Dong Xie , Jianpei Dong , Li Ji , Jincheng Xu , Jianhua Zhou","doi":"10.1016/j.snb.2025.137648","DOIUrl":"10.1016/j.snb.2025.137648","url":null,"abstract":"<div><div>Accurate detection and early diagnosis of periodontitis can be potentially achieved by detecting volatile sulfur compounds (VSCs) produced by pathogenic bacteria beneath the gingiva. However, current methods for detecting VSCs face limitations due to their reliance on expensive and bulky instruments, long testing times, or the requirement of customized mouthguards. Herein, we propose a simple yet effective strategy to improve the sensitivity of ZnO quantum dots (QDs) to VSCs by modulating surface defects of ZnO QDs and report the development of the as-prepared highly sensitive fluorescent ZnO-PDMS wearable dental patch sensor. With the assistance of artificial intelligence (AI) recognizing the fluorescence quenching areas, the ZnO-PDMS dental patches are demonstrated to accurately detect the local release of VSCs (e.g., H<sub>2</sub>S) <em>in vivo</em> within 15 min, thereby enabling convenient mapping and screening for hidden periodontitis lesions. Due to its facile preparation, ease of use, and rapid and accurate mapping ability, the ZnO-PDMS dental patches demonstrate significant potential in routine screening, treatment assisting, and the monitoring of periodontitis.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"435 ","pages":"Article 137648"},"PeriodicalIF":8.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-mode detection of malathion under neutral conditions: Integrated application of specific nanozyme and time-resolved europium probe

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-20 DOI: 10.1016/j.snb.2025.137650

Jing-Jing Zhu , Huai-Yuan Niu , Cong Yi , Kai-Xin Wang , Cheng-Gang Niu

{"title":"Dual-mode detection of malathion under neutral conditions: Integrated application of specific nanozyme and time-resolved europium probe","authors":"Jing-Jing Zhu , Huai-Yuan Niu , Cong Yi , Kai-Xin Wang , Cheng-Gang Niu","doi":"10.1016/j.snb.2025.137650","DOIUrl":"10.1016/j.snb.2025.137650","url":null,"abstract":"<div><div>This study develops a dual-mode colorimetric-fluorescent sensor for malathion detection, capable of functioning directly under neutral conditions. The sensor integrates the highly specific Cu-MIL-53(Fe)-2 nanozyme and a long-lifetime europium-based probe. Unlike traditional acetylcholinesterase catalytic systems, this method utilizes an alkaline hydrolysis strategy to generate thiol groups, which significantly reduces detection costs and avoids the common issues of enzyme instability and false positives associated with conventional biological enzyme systems. Unlike traditional methods relying on acetylcholinesterase inhibition, the hydrolysis process is based on a \"multiple condition tandem protection\" mechanism, offering higher specificity. The hydrolysis products simultaneously trigger a broad-range visible colorimetric \"off\" signal and a highly sensitive fluorescent \"on\" signal, with the two signals cross-verifying each other to greatly enhance detection accuracy. The Cu-MIL-53(Fe)-2 nanozyme demonstrates exclusive peroxidase activity under neutral conditions, effectively solving the issue of conventional nanozymes only working in acidic environments, thus ensuring compatibility with practical detection settings. Its specific enzyme activity also effectively mitigates interference from nonspecific enzyme reactions. Additionally, combining the long-lifetime Eu(PDA)<sub>3</sub> probe with time-resolved properties significantly eliminates background fluorescence interference, enhancing the signal-to-noise ratio. Through this design, the study provides a reliable, cost-effective method for malathion detection with high specificity and precision.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"435 ","pages":"Article 137650"},"PeriodicalIF":8.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multifunctional fluorescent probe: Selective visualization of mitochondria and tumor cells with viscosity/polarity responsiveness

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-20 DOI: 10.1016/j.snb.2025.137644

Fengjun Hu , Fawei Zhu , Lei Yang , Xiaobo Wang , Shusheng Zhang

{"title":"A multifunctional fluorescent probe: Selective visualization of mitochondria and tumor cells with viscosity/polarity responsiveness","authors":"Fengjun Hu , Fawei Zhu , Lei Yang , Xiaobo Wang , Shusheng Zhang","doi":"10.1016/j.snb.2025.137644","DOIUrl":"10.1016/j.snb.2025.137644","url":null,"abstract":"<div><div>The generation of cancer cells is often accompanied by significant changes in their microenvironment, including increased viscosity, decreased polarity, elevated levels of reactive oxygen species and reduced pH. These alterations are significantly distinct from the microenvironment of normal cells. In response to the characteristics of cancer cells, we designed and synthesized a red fluorescent probe that responds to mitochondrial viscosity and polarity. The positively charged pyridine group facilitates targeting of the mitochondria, while the sulfonic acid group enhances water solubility. The probe exhibits favorable spectral properties, demonstrating significant aggregation-induced emission (<strong>AIE</strong>) characteristics, excellent water solubility, responsiveness to viscosity changes, and strong photostability. Through cellular experiments and mouse imaging technology, this probe displayed high localization to the mitochondrial membrane and effectively monitored changes in mitochondrial polarity and viscosity. More importantly, due to the differences in mitochondrial viscosity and polarity between normal and cancer cells, the probe can selectively identify cancer cells, offering potential for tumor-specific imaging. This groundbreaking discovery paves the way for advancements in tumor diagnosis, contributing to more accurate tumor identification.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"435 ","pages":"Article 137644"},"PeriodicalIF":8.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0