Sensors and Actuators B: Chemical最新文献_第3页

Preparation and application of EpCAM electrochemiluminescent aptamer sensor based on porous UiO-66(Ce) loading CdTe/CdS quantum dots 基于多孔 UiO-66(Ce)负载 CdTe/CdS 量子点的 EpCAM 电化学发光适配体传感器的制备与应用

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-29 DOI: 10.1016/j.snb.2025.137708

Yanqing Ran , Rui Dai , Xiaoshuo Zhang , Faqiong Zhao , Baizhao Zeng

{"title":"Preparation and application of EpCAM electrochemiluminescent aptamer sensor based on porous UiO-66(Ce) loading CdTe/CdS quantum dots","authors":"Yanqing Ran , Rui Dai , Xiaoshuo Zhang , Faqiong Zhao , Baizhao Zeng","doi":"10.1016/j.snb.2025.137708","DOIUrl":"10.1016/j.snb.2025.137708","url":null,"abstract":"<div><div>Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein and its detection is important for diagnosis and therapeutic prognostic assessment of many cancers. Herein, a highly sensitive electrochemiluminescence (ECL) sensor was developed for its detection. In the ECL sensor, dimercaptosuccinic acid-capped core/shell structured CdTe/CdS quantum dot (QD) was loaded on metal-organic framework material UiO-66(Ce) as electrochemical luminophore; Ti<sub>3</sub>C<sub>2</sub>/Ag composite was introduced for immobilizing EpCAM aptamer. Due to the well immobilization of QD and catalysis of UiO-66(Ce), the obtained luminophore CdTe/CdS QDs@UiO-66(Ce) displayed a strong and stable ECL signal. Furthermore, the Ti<sub>3</sub>C<sub>2</sub>/Ag could act as a co-reactant accelerator to boost the ECL signal. Thus, the resulted sensor had quite strong initial ECL signal for signal-off detection. Further experiment showed that it exhibited good linear response to EpCAM over the concentration range of 1 pg mL<sup>−1</sup>− 10 ng mL<sup>−1</sup> in pH 7.4 Tris buffer, with a detection limit low to 0.66 pg mL<sup>−1</sup>. Additionally, the ECL sensor also presented high selectivity and satisfying reproducibility; its practicability was demonstrated by the successful determination of EpCAM in serum samples.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"436 ","pages":"Article 137708"},"PeriodicalIF":8.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-response fluorescent probe for real-time super-resolution imaging of mitochondrial nucleoprotein dynamics in Parkinson's disease

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-29 DOI: 10.1016/j.snb.2025.137703

Wei Huang , Dong Wang , Po Hu , Yaping Zhu , Yafei Zhou , Yinyin Chen , Zhiwen Yu , Tao Zhang , Na Hu , Xiaohe Tian , Zhongping Zhang

{"title":"Dual-response fluorescent probe for real-time super-resolution imaging of mitochondrial nucleoprotein dynamics in Parkinson's disease","authors":"Wei Huang , Dong Wang , Po Hu , Yaping Zhu , Yafei Zhou , Yinyin Chen , Zhiwen Yu , Tao Zhang , Na Hu , Xiaohe Tian , Zhongping Zhang","doi":"10.1016/j.snb.2025.137703","DOIUrl":"10.1016/j.snb.2025.137703","url":null,"abstract":"<div><div>Monitoring the dynamics of mitochondrial nucleoprotein complexes in real-time and at super-resolution is crucial for elucidating their role in Parkinson’s disease, a challenge compounded by the inadequacy of existing fluorescent probes and the complexity of distinguishing mitochondrial proteins and nucleic acids simultaneously. This study introduces a quinolinium derivative probe, selectively enriched in mitochondria and capable of distinct dual fluorescence activation in response to nucleic acids and proteins. This dual-mode function allows for the concurrent visualization of mitochondrial nucleic acids, proteins, and their dynamics. Our super-resolution imaging demonstrates that proteins, primarily localized at mitochondrial cristae, interact with nucleic acids to form and maintain nucleoproteins in a dynamic equilibrium. This equilibrium regulates essential mitochondrial processes such as physiological stress. Notably, we found that Parkinson’s disease progression is marked by the disruption of these nucleoproteins. This research not only paves the way for advanced probe design for detailed mitochondrial imaging but also lays the groundwork for exploring mitochondrial dynamics as therapeutic targets in Parkinson’s disease.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"436 ","pages":"Article 137703"},"PeriodicalIF":8.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-triggered-potential electrochemiluminescence platform based on anodic-emitting Yb-MOF for sensitive detection of APE1

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-29 DOI: 10.1016/j.snb.2025.137687

Ruiyan Liu , Yike Xu , Zhuoxin Ye , Yuxuan Chen , Yan Zhang , Mo Ma , Pinyi Ma , Qiong Wu , Daqian Song

{"title":"Low-triggered-potential electrochemiluminescence platform based on anodic-emitting Yb-MOF for sensitive detection of APE1","authors":"Ruiyan Liu , Yike Xu , Zhuoxin Ye , Yuxuan Chen , Yan Zhang , Mo Ma , Pinyi Ma , Qiong Wu , Daqian Song","doi":"10.1016/j.snb.2025.137687","DOIUrl":"10.1016/j.snb.2025.137687","url":null,"abstract":"<div><div>Porphyrins possess excellent electrochemiluminescence (ECL) properties but suffer from aggregation-induced quenching (ACQ) in aqueous solutions. Metal-organic frameworks (MOFs) can effectively mitigate this issue by restricting porphyrin aggregation. However, existing studies predominantly focus on cathodic ECL emission at highly negative trigger potentials, which often leads to undesirable hydrogen evolution side reactions. To overcome this challenge, we developed a novel Yb-based MOF (Yb-TCPP) with anodic ECL emission and a low triggering potential. Yb-TCPP was synthesized via the hydrothermal reaction, using 5,10,15,20-tetra(4-carboxyphenyl)-porphyrin (H<sub>2</sub>TCPP) as the organic linker. Among a series of Yb-MOFs (Yb-ETTC, Yb-CTTB, Yb-BCPP), Yb-TCPP had the strongest ECL emission, with an intensity reaching ∼ 11000 a.u. Further modification with gold nanoparticles (AuNPs) significantly enhanced its conductivity and ECL performance. The resulting Yb-TCPP@AuNPs exhibited a low triggering potential of + 0.47 V, effectively avoiding oxygen evolution side reactions. With the Φ<sub>ECL</sub> of [Ru(bpy)<sub>3</sub>]<sup>2 +</sup>/triethylamine (TEA) set as 1, it also achieved a high ECL efficiency (Φ<sub>ECL</sub>) of 11 %. These results highlight the potential of Yb-TCPP@AuNPs as a robust anodic ECL material for biosensing applications. Based on this material, we constructed an “on-off” ECL biosensor for the sensitive detection of apurinic/apyrimidinic endonuclease 1 (APE1) using catalytic hairpin amplification (CHA). The sensor had a linear detection range of 1 × 10<sup>−8</sup> U/mL to 1 × 10<sup>−2</sup> U/mL and a detection limit of 1.58 × 10<sup>−9</sup> U/mL. In summary, this study presents the successful development of Yb-TCPP@AuNPs as a promising anodic ECL platform, providing new insights into the development of advanced ECL materials for clinical diagnostics.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"436 ","pages":"Article 137687"},"PeriodicalIF":8.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced room-temperature NO₂ sensing via abundant edge interfaces on graphene oxide-decorated silicon

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-28 DOI: 10.1016/j.snb.2025.137724

Hua Li , Yuan Li , Wenjing Wang , Xiaolong Liu , Suwan Zhu , Binbin Dong , Yurui Huang , Xijing Ning , Li Zhao , Jun Zhuang

{"title":"Enhanced room-temperature NO₂ sensing via abundant edge interfaces on graphene oxide-decorated silicon","authors":"Hua Li , Yuan Li , Wenjing Wang , Xiaolong Liu , Suwan Zhu , Binbin Dong , Yurui Huang , Xijing Ning , Li Zhao , Jun Zhuang","doi":"10.1016/j.snb.2025.137724","DOIUrl":"10.1016/j.snb.2025.137724","url":null,"abstract":"<div><div>NO<sub>2</sub> gas sensing properties of the graphene oxide-decorated silicon (GO/Si) materials with abundantly exposed edge interfaces are studied. GO sheets are intermittently covered on the silicon surface treated with hydrophilic agents through a spin-coating process, enabling the formation of a sensing layer with optimized active surface area and diversified adsorption sites, which facilitate gas sensing. As the sensitive material in a conductometric gas sensor, far different from the respective planar Si and pristine GO, which exhibit poor repeatability and an undesirable n- to p-type response transition, the GO/Si brings about a qualitative change in sensing behavior, showing consistent p-type response to all tested concentrations and exhibiting good reproducibility. More interestingly, the coverage of GO can be simply adjusted by the hydrophilic treatment time. At an optimal hydrophilic treatment time ∼ 1 second, the GO/Si sensor demonstrates an ultra-low theoretical detection limit of 188 ppt, along with high response, good selectivity, and long-term stability. The mechanisms behind the outstanding sensing performance are discussed, considering the exposed GO/Si edge interface and the synergistic effect of GO and Si.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"436 ","pages":"Article 137724"},"PeriodicalIF":8.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From simulation to experiment: A Sagnac interference-based double holes optical fiber sensor for ultrasensitive Cu(II) detection

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-28 DOI: 10.1016/j.snb.2025.137692

Qiang Chen , Yi Cai , Tianyu Jiang , Qing Chen , Jianhua Wang , Yong Zhao

{"title":"From simulation to experiment: A Sagnac interference-based double holes optical fiber sensor for ultrasensitive Cu(II) detection","authors":"Qiang Chen , Yi Cai , Tianyu Jiang , Qing Chen , Jianhua Wang , Yong Zhao","doi":"10.1016/j.snb.2025.137692","DOIUrl":"10.1016/j.snb.2025.137692","url":null,"abstract":"<div><div>Double-hole optical fiber (DHF) exhibits considerable potential for sensing applications due to its distinctive structural characteristics. In this study, a Sagnac interference (SI) optical fiber sensor based on a corroded DHF shows high refractive index (RI) sensitivity, allowing for the detection of copper ions, Cu(II), at very low concentrations. The dependence of DHF corrosion on the birefringence and RI sensitivity are investigated by the optical simulation. Experimental results illustrate that the RI sensitivity reaches 3267 nm/RIU within the range of 1.3333–1.3743, exhibiting good linearity. A chitosan derivative (CSD) with ion-imprinted (IIM) treatment is coated on the surface of the corroded DHF for Cu(II) detection. It is demonstrated that within the concentration range of Cu(II) from 10<sup>−15</sup> to 10<sup>−6</sup> M, both the maximum and average sensitivities can reach 12.08 × 10<sup>9</sup> and 129.96 nm/μM, respectively, without interference from other metal ions or temperature (25.3–44.0 ℃). The proposed corroded DHF sensor is a good candidate for RI and Cu(II) concentration detection due to its simple structure, high sensitivity, and selectivity.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"436 ","pages":"Article 137692"},"PeriodicalIF":8.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrothermally grown WO3-SnO2 nanocomposites for efficient NO2 detection at low concentration

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-28 DOI: 10.1016/j.snb.2025.137711

Muhammad Javed Liaqat , Shahid Hussain , Arslan Shahid , Jesse Nii Okai Amu-Darko , Talib K. Ibrahim , Sobhy M. Ibrahim , Rajesh Kumar Manavalan , Xiangzhao Zhang , Guanjun Qiao , Guiwu Liu

{"title":"Hydrothermally grown WO3-SnO2 nanocomposites for efficient NO2 detection at low concentration","authors":"Muhammad Javed Liaqat , Shahid Hussain , Arslan Shahid , Jesse Nii Okai Amu-Darko , Talib K. Ibrahim , Sobhy M. Ibrahim , Rajesh Kumar Manavalan , Xiangzhao Zhang , Guanjun Qiao , Guiwu Liu","doi":"10.1016/j.snb.2025.137711","DOIUrl":"10.1016/j.snb.2025.137711","url":null,"abstract":"<div><div>Detecting trace amounts of hazardous gases at diverse temperature is crucial to protect both human health and the environment. In this study, WO<sub>3</sub>-SnO<sub>2</sub> nanocomposites were prepared using a hydrothermal method. The gas-sensing characteristics of the prepared sensors for NO<sub>2</sub> have been investigated at temperatures ranging from 75 to 200°C. The results demonstrated that WO<sub>3</sub>-SnO<sub>2</sub> nanocomposites exhibited a remarkable response of 1167, response/recovery time of 39.51 s/98.07 s towards 10 ppm NO<sub>2</sub> gas at an optimal temperature of 150°C. The development of n-n heterojunctions and higher available surface areas for chemisorbed NO<sub>2</sub> species could be responsible for the improved NO<sub>2</sub> sensing capabilities. This research demonstrates that the WO<sub>3</sub>-SnO<sub>2</sub> composites is an attractive option for environmental NO<sub>2</sub> monitoring applications.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"436 ","pages":"Article 137711"},"PeriodicalIF":8.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasensitive probe-type hydrogen sensor based on dual liquid-filled silica capillary fibers with Pt-WO3 coating

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-27 DOI: 10.1016/j.snb.2025.137696

Mengqi Ding , Ben Xu , Yaxin Chen , Enlei Gao , Huaping Gong , Minghong Yang , Yan Zhang , Xianfeng Chen , Huifang Chen , Chunliu Zhao

{"title":"Ultrasensitive probe-type hydrogen sensor based on dual liquid-filled silica capillary fibers with Pt-WO3 coating","authors":"Mengqi Ding , Ben Xu , Yaxin Chen , Enlei Gao , Huaping Gong , Minghong Yang , Yan Zhang , Xianfeng Chen , Huifang Chen , Chunliu Zhao","doi":"10.1016/j.snb.2025.137696","DOIUrl":"10.1016/j.snb.2025.137696","url":null,"abstract":"<div><div>A highly sensitive optical fiber hydrogen sensor is proposed and experimentally verified. It consists of dual liquid-filled silica capillary fibers (SCFs) with Pt-WO<sub>3</sub> coating. The cedar oil filled in SCFs can be considered liquid-core of theirs, and light is confined and transmitted within it. The SCFs with different inner diameter form a structure like a liquid-in-glass thermometer, resulting in the thermal expansion effect of the sealed cedar oil is significantly amplified, which ensures the proposed sensor highly sensitive to hydrogen since it operates on the exothermic reaction between WO<sub>3</sub> and hydrogen. Due to the long interference length, the reflection spectrum of the sensor exhibits highly dense fringes in wavelength domain, then optical path difference demodulation is adopted. The experimental results reveal that the hydrogen sensor has an ultrahigh OPD sensitivity of 560.583 µm/% (vol%), corresponding to an equivalent sensitivity of 109.597 nm/% (vol%) in wavelength domain, which is 1–2 orders of magnitude higher than most optical fiber hydrogen sensors. Additionally, the proposed sensor features with compact size (less than 4 mm in total length), good repeatability, fast response speed and humidity immunity for hydrogen sensing.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"436 ","pages":"Article 137696"},"PeriodicalIF":8.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active methane gas imaging and leakage quantification based on standoff TDLAS and pan-tilt units

IF 8 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-27 DOI: 10.1016/j.snb.2025.137698

Senyuan Wang , Shouzheng Zhu , Yicong Jiang , Xi Lan , Jiacheng Dong , Shijie Liu , Guoliang Tang , Xin He , Chunlai Li , Yuwei Chen , Jianyu Wang

{"title":"Active methane gas imaging and leakage quantification based on standoff TDLAS and pan-tilt units","authors":"Senyuan Wang , Shouzheng Zhu , Yicong Jiang , Xi Lan , Jiacheng Dong , Shijie Liu , Guoliang Tang , Xin He , Chunlai Li , Yuwei Chen , Jianyu Wang","doi":"10.1016/j.snb.2025.137698","DOIUrl":"10.1016/j.snb.2025.137698","url":null,"abstract":"<div><div>Methane (CH<sub>4</sub>) is the main component of natural gas. Natural gas leakage can cause economic losses and safety hazards, making its accurate detection and quantification a critical issue in the natural gas industry. We developed a non-cooperative target-based, low-cost active standoff gas sensor for imaging and quantifying CH<sub>4</sub> leaks. The sensor is developed based on tunable diode laser absorption spectroscopy (TDLAS) to measure the path-integrated concentration of atmospheric CH<sub>4</sub>. The wavelength modulation spectroscopy with first harmonic normalized second harmonic detection (WMS-2f/1 f) method is applied to reduce the measurement errors caused by the variation of the echo laser intensity. The key to active imaging is a pan-tilt unit integrating the standoff CH<sub>4</sub> sensor, a laser rangefinder, and a visible camera. With 2D scanning, CH<sub>4</sub> concentration data, ranging data, and pan-tilt angular data are fused to generate a pseudo-color map of CH<sub>4</sub> concentration. Further, the CH<sub>4</sub> leakage rate is estimated by a mass balance algorithm based on the wind speed data collected by an anemometer. The imaging quality and quantification accuracy were evaluated by targeting calibrated CH<sub>4</sub> gas bags and controlled CH<sub>4</sub> gas release at different concentrations. The experiments show that the developed sensor can detect CH<sub>4</sub> leaks down to 0.1 g/s at 30 m range and quantify leaks with accuracy better than 10 % at 10 m range, which demonstrates its potential for application in the natural gas industry.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"436 ","pages":"Article 137698"},"PeriodicalIF":8.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous Tracing of Protein Vicinal Dithiols in Live Cells Using an “Off-on” Fluorescent Probe

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-27 DOI: 10.1016/j.snb.2025.137685

Tongxia Jin, Luling Wu, Ti Jia, Rongrong Zhao, Chusen Huang, Mengfang Tang, Weiping Zhu, Yufang Xu, Tony D. James, Xuhong Qian

{"title":"Simultaneous Tracing of Protein Vicinal Dithiols in Live Cells Using an “Off-on” Fluorescent Probe","authors":"Tongxia Jin, Luling Wu, Ti Jia, Rongrong Zhao, Chusen Huang, Mengfang Tang, Weiping Zhu, Yufang Xu, Tony D. James, Xuhong Qian","doi":"10.1016/j.snb.2025.137685","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137685","url":null,"abstract":"Vicinal dithiol-containing proteins (VDPs) are of considerable importance due to their role in regulating cellular functions through the reversible dithiol/disulfide inter-conversion reaction. However, there are currently no effective tools for the simultaneous tracing of endogenous VDPs in live cells. Here, we report an “off-on” fluorescent probe (<strong>RhQ</strong>) for the selective detection of VDPs and illustrate its utility for the long-term tracing of protein vicinal dithiols with simultaneous fluorescence imaging in various cell lines. Importantly, our study provides valuable insight into the localization of VDPs in whole cells, dynamically visualizing the presence of cell-surface protein vicinal dithiols in MCF-7 cells. Significantly, proteomic analysis confirms that MCF-7 cells exhibit functional cell-surface VDPs. As such our technology exhibits great promise as a visualization tool for revealing the role of cellular protein vicinal dithiols, especially VDPs on the cell-surface, and stimulating the design of VDP related drug candidates and vectors.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"183 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Rare Earth Doped Metal-Organic Framework for Fluorescent Detection of Uranyl in Real Seawater

IF 8.4 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-03-27 DOI: 10.1016/j.snb.2025.137643

Yifei Sun, Long Yu, Kaili Wu, Mengyu Yin, Yunfei Lu, Zhaojing Yuan, Wenyuan Jiang, Jiaqi Wang, Xiangxue Wang, Suhua Wang

{"title":"Non-Rare Earth Doped Metal-Organic Framework for Fluorescent Detection of Uranyl in Real Seawater","authors":"Yifei Sun, Long Yu, Kaili Wu, Mengyu Yin, Yunfei Lu, Zhaojing Yuan, Wenyuan Jiang, Jiaqi Wang, Xiangxue Wang, Suhua Wang","doi":"10.1016/j.snb.2025.137643","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137643","url":null,"abstract":"Rare-earth doped fluorescent metal-organic frameworks (MOFs) are widely used for the fluorescence quenching detection of uranyl ions. However, few existing studies have developed red fluorescence-enhanced, non-rare-earth doped MOF probes with anti-background interference capabilities. Therefore, it is of great significance to develop a UO<sub>2</sub><sup>2+</sup> fluorescent probe with higher specificity and sensitivity, while maintaining long-wavelength fluorescence properties similar to those of rare-earth doped materials. Herein, we prepared a porphyrin-based MOF with nickel chloride hexahydrate as the nickel source, and tetrakis (4-carboxyphenyl) porphyrin as the organic ligand, called Ni-TCPP, which could be used as a fluorescence probe for simultaneous visual detection and removal of the common pollutant uranyl in seawater. Specifically, Ni-TCPP responds to ultra-low concentrations of uranyl ions (16.59 nM) and, through an efficient fluorescence \"turn-on\" mechanism, has become one of the most sensitive MOF-based fluorescent sensing materials. In addition, the material was demonstrated for the removal capability of uranyl for its suitable pore size and large surface areas. By merging the optical and adsorption properties of Ni-TCPP, we have creatively developed a dual-functional platform for sensing and removing uranyl in actual seawater samples, demonstrating significant potential for practical applications.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"19 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0