{"title":"Isothermal biosensor for highly specific detection of single-base mutations based on peptide nucleic acid and graphene oxide","authors":"Seungmin Park , Woo-keun Kim , Jieon Lee","doi":"10.1016/j.snb.2025.137880","DOIUrl":"10.1016/j.snb.2025.137880","url":null,"abstract":"<div><div>Point mutations serve as critical biomarkers for various cancers and genetic disorders, highlighting the need for precise and reliable detection methods. Various probes, including natural and synthetic oligomers that are often integrated into nucleic acid logic systems, have been utilized for single-base mutation detection. However, achieving high accuracy in distinguishing these mutations using these systems remains challenging because of the high costs and complexity associated with the detection methods. In this study, we developed an isothermal biosensor capable of detecting single-base mutations with a high specificity. The proposed system utilizes a graphene oxide (GO)-based platform combined with toehold-mediated strand displacement and employs peptide nucleic acids (PNA) as key components. The novel PNA-based probe can discriminate single-base mutations with high efficiency, achieving perfect discrimination that surpasses the performance of conventional DNA circuits. This high discrimination efficiency was converted into fluorescence signals through the Förster resonance energy transfer phenomenon, which is facilitated by GO that preferentially binds to PNA rather than DNA. The biosensor effectively identified single-nucleotide variants with a detection limit as low as 4 nM, which is comparable to that of state-of-the-art detection systems, highlighting the potential of PNA-based biosensors as highly specific and sensitive tools for detecting disease-associated point mutations.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137880"},"PeriodicalIF":8.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Youssef Doubi , Bouchaib Hartiti , Abdelkrim Batan , Maryam Siadat , Hicham Labrim , Mounia Tahiri , Ahmed Kotbi , Philippe Thevenin , Mustapha Jouiad
{"title":"Controlled SnO2 nanostructures for enhanced sensing of hydrogen sulfide and nitrogen dioxide","authors":"Youssef Doubi , Bouchaib Hartiti , Abdelkrim Batan , Maryam Siadat , Hicham Labrim , Mounia Tahiri , Ahmed Kotbi , Philippe Thevenin , Mustapha Jouiad","doi":"10.1016/j.snb.2025.137878","DOIUrl":"10.1016/j.snb.2025.137878","url":null,"abstract":"<div><div>Metal oxide semiconductors have garnered increasing attention in gas sensing applications due to their excellent sensitivity and stability under extreme conditions. In this study, we explore the potential of tin oxide (SnO<sub>2</sub>) thin films fabricated via a facile spray coating method to be used as efficient gas sensor devices. Our developed SnO<sub>2</sub>-based devices exhibit superior electrical conductivity, strong optical absorption and robust sensing performances. Specifically, the SnO<sub>2</sub> devices show a rapid and linear sensing response towards NO<sub>2</sub> and H<sub>2</sub>S sour gases, achieving a high relative sensing response of 13.1, with sensing response and recovery times of 17 s and 5 s, respectively. These findings underscore the SnO<sub>2</sub> thin film capabilities as highly efficient and versatile sensing material for next generation gas sensor technologies.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137878"},"PeriodicalIF":8.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A pH-responsive NIR Fluorescent Probe for Precise Cancer Phototheranostics","authors":"Zhuang Hu, Ruihan Li, Xuan Zhang, Zilin Chen","doi":"10.1016/j.snb.2025.137877","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137877","url":null,"abstract":"pH is a key factor of many aspects of daily life and is strongly linked to cancer. Therefore, developing a reliable technique for measuring pH in tumors and looking for novel strategies to enhance tumor treatment efficacy is imperative. A stimulus-responsive phototheranostics platform that integrates imaging and multimodal therapies can effectively improve diagnosis and treatment outcomes. Herein, a pH-responsive and near-infrared (NIR) fluorescent probe featuring Mcl-1 targeting ability was deftly constructed for precise tumor-targeting NIR phototheranostics. The tridentate fluorescent probe, Cy-Nap, was crafted through a comprehensive molecular design strategy that integrated three key components into a single framework. This design included a targeting unit with high affinity for Mcl-1, a NIR-emitting heptamethine cyanine chromophore, and a pH-responsive segment featuring a piperazine ring that serves to link the other two elements within the molecular scaffold. Cy-Nap, an agent designed to be responsive to pH changes, exhibits improved production of reactive oxygen species (ROS) and superior photothermal capabilities under acidic conditions. Additionally, the Cy-Nap probe can be employed to perform intraoperative real-time imaging-guided tumor removal as well as noninvasive, precise NIR imaging of the lymphatic system. Harnessing its tumor-targeting properties, Cy-Nap successfully eliminated tumors in mice with induced tumors when treated with 808<!-- --> <!-- -->nm laser irradiation, and this was achieved with minimal observable side effects. This work offers novel insights into the development of advanced, multifunctional phototheranostic agents for the therapeutic management of cancer.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"7 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yawen Liu , Hezhen Liu , Wenyi Yang , Chengcheng Xu , Qiang Xie , Hongzhi Song , Xiaojun Hu , Hongxia Chen
{"title":"Cell membrane biomimetic nanoparticle-enhanced SPR biosensor for facile and sensitive detection of circulating tumor cells","authors":"Yawen Liu , Hezhen Liu , Wenyi Yang , Chengcheng Xu , Qiang Xie , Hongzhi Song , Xiaojun Hu , Hongxia Chen","doi":"10.1016/j.snb.2025.137872","DOIUrl":"10.1016/j.snb.2025.137872","url":null,"abstract":"<div><div>Circulating tumor cells (CTCs) released from solid tumors into the peripheral blood are valuable in assessing the risk of breast cancer metastasis and guiding precision therapy. This study proposes a surface plasmon resonance (SPR) strategy utilizing functionalized red blood cell membranes (RBCM-PPP) and CTCs membranes functionalized gold nanoparticles (AuNPs@Mem) for the highly sensitive detection of CTCs. The RBCM-PPP was modified on the surface of the gold chip by sulfhydryl groups on DSPE-PEG-SH, and the ERBB2 protein expressed on the membrane surface of CTCs specifically bound to the ERBB2 palmitoylated polypeptide (PP) in the RBCM-PPP, while the AuNPs in AuNPs@Mem acted as signal amplifying molecules to achieve the sensitive detection of AuNPs@Mem. The constructed biosensor achieved a linear detection range of 5 × 10<sup>3</sup> to 1 × 10<sup>6</sup> particles/mL, with a detection limit as low as 868.11 particles/mL. This novel biosensing strategy possesses excellent selectivity, sensitivity, and stability, and offers potential applications for clinical CTCs detection.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137872"},"PeriodicalIF":8.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jingting Zhan, Huawei Huang, Wei Quan, Weiying Lin
{"title":"Innovative two-dimensional fluorescent probe of viscosity and ONOO- for high-throughput screening of antioxidant drugs and its application in epilepsy","authors":"Jingting Zhan, Huawei Huang, Wei Quan, Weiying Lin","doi":"10.1016/j.snb.2025.137887","DOIUrl":"10.1016/j.snb.2025.137887","url":null,"abstract":"<div><div>Epilepsy is a neurodegenerative disease closely associated with oxidative stress and neuronal damage, posing a grave threat to human health. Unfortunately, the prompt diagnosis and effective treatment of epilepsy currently remain a substantial challenge. Here, a novel two-dimensional fluorescent probe, <strong>NIR-VO</strong>, has been rationally developed for the detection of LDs viscosity and ONOO<sup>-</sup> changes in epilepsy models. It is worth noting that the high-throughput screening of common antioxidants has been achieved using the probe's non-interfering dual-channel feedback signals, and the experimental results indicate that melatonin has the optimal antioxidant stress response and neuroprotective effects. More significantly, melatonin has also exhibited tremendous antiepileptic potential in the imaging of cell, zebrafish and mice epilepsy models. It is expected that this work will provide new insights for the construction of innovative multidimensional fluorescent probes, and boost the advancement of diagnosis and treatment research for epilepsy and related neurological diseases.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137887"},"PeriodicalIF":8.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhiren Zhou, Lina Zou, Ping Zhang, Chunmei Li, Ye Zhu, Huanyu Ren, Zheng Li, Huiru Niu, Hao Liao, Xiaojing Zhang, Shanshan An, Fei Ren, Xiuhong Ge, Lang Cheng, Feiyan Yang, Hongzhi Pan, Shengzhong Rong, Dong Chang, Hongkun Ma
{"title":"A sandwich-configuration ratiometric electrochemical immunosensor based on dual signal amplification of NH2-GO/Fe-Ni@Ti0033C2Tx/NH2-GO/Fc@AuNPs and BPNPs/AuPt-MB for the detection of survivin","authors":"Zhiren Zhou, Lina Zou, Ping Zhang, Chunmei Li, Ye Zhu, Huanyu Ren, Zheng Li, Huiru Niu, Hao Liao, Xiaojing Zhang, Shanshan An, Fei Ren, Xiuhong Ge, Lang Cheng, Feiyan Yang, Hongzhi Pan, Shengzhong Rong, Dong Chang, Hongkun Ma","doi":"10.1016/j.snb.2025.137882","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137882","url":null,"abstract":"Survivin serves as a crucial biomarker for bladder cancer, so exploring the detection method is essential. Therefore, a sensitive ratiometric electrochemical immunosensor was developed. In brief, a double-layered amino graphene oxide (NH<sub>2</sub>-GO) sandwich enhanced by Fe-Ni@Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> (NH<sub>2</sub>-GO/Fe-Ni@Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>/NH<sub>2</sub>-GO) significantly amplified the detection signal. ferrocene@Au nanoparticles (Fc@AuNPs) provided a reference signal, and Ab<sub>1</sub> was anchored via an Au-N bond. Moreover, AuPt-methylene blue (AuPt-MB) served not only as a secondary signal but also anchored Ab<sub>2</sub> through Au-NH<sub>2</sub> and Pt-NH<sub>2</sub> bonds. Black phosphorus nanoplates (BPNPs) improved conductivity and provided additional binding sites for AuPt-MB. The immunosensor exhibited a broad detection range (0.001~1000<!-- --> <!-- -->ng/mL) and a low detection limit (0.00065<!-- --> <!-- -->ng/mL), facilitating successful survivin detection in human urine samples with promising clinical analysis applications.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"73 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A dual-mode paper-based humidity sensor: Optical and electrical dual-signal sensing platform for multifunctional applications","authors":"Jinyong Hu , Chentian Wu , Bohao Liu , Yong Zhang","doi":"10.1016/j.snb.2025.137890","DOIUrl":"10.1016/j.snb.2025.137890","url":null,"abstract":"<div><div>Developing dual-signal sensing system that enables simultaneous optical and electrical humidity detection holds significant application foreground in the realm of real-time environmental humidity monitoring. In this work, utilizing cobalt chloride (CoCl<sub>2</sub>) hybridized with polyvinyl alcohol (PVA) as sensitive materials, and cellulose paper with pencil-drawn graphite electrodes as the substrate, a paper-based humidity sensor capable of dual-signal sensing with colorimetric visualization and electrical readout is proposed for the monitoring of environment humidity across multiple application scenarios. This designed dual-mode humidity sensor exhibits superior electrical sensing properties, with a three-order-of-magnitude change in impedance over a relative humidity range from 11 % to 95 %, and a desired maximum hysteresis of only 3.5 %. Additionally, the sensor reveals remarkable electrical long-term stability and reliability, with a response variation of merely 5.11 % after one month of operation. Furthermore, this designed dual-mode humidity sensor also manifests outstanding optical sensing performance with reversible naked-eye readable color change in different humidity environments, without significant degradation in colorimetric performance even after 30 days. The designed dual-signal humidity sensor is further explored as wearable devices, demonstrating its potential practicality in multi-scenario fields such as respiration monitoring, non-contact sensing, and smart diapers. The proposed dual-mode humidity sensor allows for the simultaneous visualization and precise electrical quantification of humidity changes, offering a significant contribution to the field of environmental sensing and opening new avenues for the development of multifunctional sensing technologies.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137890"},"PeriodicalIF":8.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shihui Ding , Wenyong Ding , Xuan Wang , Zeyao Li , Yanping Fan , Francis Lin , Jiandong Wu
{"title":"Sorting and characterization of cancer cells with different migration phenotypes using a microfluidic platform","authors":"Shihui Ding , Wenyong Ding , Xuan Wang , Zeyao Li , Yanping Fan , Francis Lin , Jiandong Wu","doi":"10.1016/j.snb.2025.137875","DOIUrl":"10.1016/j.snb.2025.137875","url":null,"abstract":"<div><div>Cancer metastasis is the primary cause of poor prognosis and high mortality in patients, and the chemotactic migration of cancer cells is closely related to the metastasis process. Isolating cancer cells with different migration phenotypes is crucial for understanding the mechanisms of cancer cell migration and cancer metastasis. However, current methods for sorting cancer cells based on migration phenotypes often suffer from low efficiency, long operation times, and complex procedures. Additionally, cell migration and sorting experiments often rely on live cell imaging systems, which are generally costly and lack portability. In this study, we developed an automated microfluidic platform for sorting cancer cells based on their migration phenotypes. The platform was validated using two breast cancer cell lines, MDA-MB-231 and MCF-7, with the sorting process completed within 6.5 hours. The sorted cells with high and low migration phenotypes could be further cultured and had similar proliferative capacities. Through SMART-seq2 analysis, we identified several significantly differentially expressed genes closely related to cell migration and tumor metastasis across different migration phenotypes. Functional validation experiments revealed that the knockdown of the GADD45B gene in MDA-MB-231 cells reduced the migration rate of high-chemotactic cells. Enrichment analyses revealed that the differentially expressed genes were associated with multiple migration-related pathways, including the mitogen-activated protein kinases (MAPK) signaling pathway. Protein expression assays indicated an upregulation of phosphorylated p38 in high-chemotactic cells. In conclusion, this sorting platform provides an efficient and robust solution for investigating the migration heterogeneity of cancer cells.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"440 ","pages":"Article 137875"},"PeriodicalIF":8.0,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xinghan Mi, Chengpeng Zhang, Nianqiang Zhang, Ziran Wang, Jilai Wang
{"title":"Recyclable flexible pressure, temperature, and humidity multimodal sensors based on micro-pyramidal structures and PVA/Choline Chloride/Ethylene Glycol","authors":"Xinghan Mi, Chengpeng Zhang, Nianqiang Zhang, Ziran Wang, Jilai Wang","doi":"10.1016/j.snb.2025.137866","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137866","url":null,"abstract":"Flexible sensors are a commonplace wearable electronic device. The development of flexible sensors that can detect multiple signals and are recyclable is necessary to meet the requirements of practical wearability and environmental friendliness. This paper reports a recyclable flexible pressure, temperature, and humidity multimodal sensor based on micro-pyramidal structures and polyvinyl alcohol (PVA), choline chloride (ChCl), ethylene glycol (EG) material systems (MPCE-sensor). PVA/ChCl/EG (PCE) films with micro-pyramidal structures were prepared using a template-assisted transfer process and an evaporative solvent method, and the sensors were obtained by assembling the structural faces of the two films face-to-face. The sensor exhibits a high pressure sensitivity (13.49 kPa<sup>-1</sup>), a rapid response time (39 ms), and remarkable durability (5000 cycles). The sensor has a temperature sensitivity of -5.95%/°C (30-40 °C) and can detect subtle temperature changes. Furthermore, the high water absorption capacity of PVA endows the sensor with exceptional humidity sensing capabilities, achieves a fast humidity response time of 2.1<!-- --> <!-- -->s and a sensitivity of 4.71 MΩ/%RH. More interestingly, the sensing material exhibits excellent recyclability. It dissolves in water and the solution is used to reprepare the sensing material (repeated five times). The sensor can also be used to detect breathing status and recognize speech, enabling applications in real-time health monitoring and human-computer interaction.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"6 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dan Li , Mao Li , Zijia Huang , Xiaolong Li , Xiaoming Chen , Na Li , Yong Zhao
{"title":"Ultrasensitive, online detection of endogenous H2S by a novel ratiometric fluorescent approach","authors":"Dan Li , Mao Li , Zijia Huang , Xiaolong Li , Xiaoming Chen , Na Li , Yong Zhao","doi":"10.1016/j.snb.2025.137874","DOIUrl":"10.1016/j.snb.2025.137874","url":null,"abstract":"<div><div>Endogenous hydrogen sulfide (H<sub>2</sub>S) is a crucial biological signaling molecule in the mammals. Numerous H<sub>2</sub>S sensing methods have been developed, yet there remains an urgent need for portable, online and sensitive detection of H<sub>2</sub>S in complex samples. Herein, a ratiometric fluorescent optical fiber sensor was designed for ultrasensitive, online detection of H<sub>2</sub>S, using nanohybrids electrostatically self-assembled from silicon quantum dots and gold nanoclusters (AuNCs@SiQDs nanohybrids). The nanohybrids, acting as a ratiometric fluorescent probe, exhibited a specific response to H<sub>2</sub>S. The mechanism involved static quenching effect of H<sub>2</sub>S on AuNCs and fluorescence resonance energy transfer between SiQDs and AuNCs. The sensor showed a good linear response to H<sub>2</sub>S concentration of 0.01 ∼ 100 μM, with an ultralow detection limit of 4.33 nM. The sensor was also successfully employed for rapid detection of H<sub>2</sub>S in real serum samples, without tedious preprocessing. This approach offers a portable and efficient technique for on-line ultrasensitive measurement of H<sub>2</sub>S in complex biological samples, as well as the determination of H<sub>2</sub>S-mediated biomolecules. This method boasts high sensitivity and selectivity, strong anti-interference capability, portability, practicality, and ease of production, making it significant for disease research and emergency analysis.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"439 ","pages":"Article 137874"},"PeriodicalIF":8.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}