Sensors and Actuators B: Chemical最新文献_第3页

Quasi-bound states in the continuum empowered terahertz metamaterial sensor for imidacloprid detection in fruits 连续介质准束缚态授权太赫兹超材料传感器用于水果中吡虫啉的检测

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-15 Epub Date: 2026-02-08 DOI: 10.1016/j.snb.2026.139633

Lixin Ma , Xiaonan Yang , Chen Wang , Ruiyun Zhou , Zhikun Yang , Li Sun , Zhiming Guo , Jianrong Cai , Xiaobo Zou

{"title":"Quasi-bound states in the continuum empowered terahertz metamaterial sensor for imidacloprid detection in fruits","authors":"Lixin Ma , Xiaonan Yang , Chen Wang , Ruiyun Zhou , Zhikun Yang , Li Sun , Zhiming Guo , Jianrong Cai , Xiaobo Zou","doi":"10.1016/j.snb.2026.139633","DOIUrl":"10.1016/j.snb.2026.139633","url":null,"abstract":"<div><div>Imidacloprid, a neonicotinoid pesticide commonly found in fruits and vegetables, poses a health hazard when present in excessive residues. This paper designs a terahertz metamaterial sensor based on quasi-bound state in the continuum (QBIC) resonances, achieved by a structure consisting of an external square open-ring and an internal dual-rod structure. Compared with individual components, the coupled meta-atomic array formed by the dual-rod and the open-ring has a stronger electric field intensity. Besides, the effective sensing area of this coupled structure is more than 2.5 times that of the two individual components combined, demonstrating a synergistic “1 + 1 > 2” effect. By adjusting the rod lengths of the dual-rod, a metamaterial exhibiting QBIC resonance at 0.89 THz was obtained, aligning with the absorption peak of imidacloprid and thereby enhancing detection sensitivity. Experimental results show that the QBIC metamaterial sensor exhibits excellent performance, with a linear range of 0.1 mg/kg–1000 mg/kg and a calculated limit of detection of 0.072 mg/kg. Additionally, in spiked orange samples, recovery rates ranged from 92.2 % to 104.19 %, with no significant difference from high-performance liquid chromatography results. These findings provide a novel strategy for sensitive terahertz detection of imidacloprid pesticide in real samples.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"455 ","pages":"Article 139633"},"PeriodicalIF":3.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146139042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep learning enabled magnetic/rare earth hybrid nanorobots for multi-modal bioimaging and temperature sensing with surgical boundary determination 基于深度学习的磁性/稀土混合纳米机器人，可用于多模态生物成像和具有手术边界确定的温度传感

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-15 Epub Date: 2026-02-14 DOI: 10.1016/j.snb.2026.139673

Wenjing Li , Bi Lin , Bixiao Li , Peifu Zhang , Ziyue Ju , Anees A. Ansari , Ruichan Lv

{"title":"Deep learning enabled magnetic/rare earth hybrid nanorobots for multi-modal bioimaging and temperature sensing with surgical boundary determination","authors":"Wenjing Li , Bi Lin , Bixiao Li , Peifu Zhang , Ziyue Ju , Anees A. Ansari , Ruichan Lv","doi":"10.1016/j.snb.2026.139673","DOIUrl":"10.1016/j.snb.2026.139673","url":null,"abstract":"<div><div>Nanorobots, with miniature size, wireless operation, and flexible mobility, can access narrow spaces and are widely used in biomedicine. High-precision transport is vital for targeted drug delivery, disease diagnosis, and treatment, yet current research has limitations like insufficient single-imaging diagnosis and active tumor targeting. In this research, a magnetic nanorobot platform is proposed, combining magnetic ferric oxide substrate with rare earth nanoparticles (RENPs). This magnetic nanorobot features multi-modal imaging including NIR II fluorescence, MRI, and PA with high moving target effect (<5 s). After conjugated with antibodies against MET and VEGF, this platform enables multi-molecular targeting. Under an external magnetic field, the dual-targeting (active and physical magnetic) allows <em>in vitro</em> and <em>in vivo</em> precise tumor cell targeting with tumor imaging. Moreover, its NIR II luminescence enables enhanced real-time temperature detection (Region: 24.6–41.5℃). Especially, the deep learning allows NIR II imaging to simultaneously perform increased fluorescence imaging for surgical boundary definition and temperature sensing display (R<sup>2</sup>= 0.973, RMSE = 1.50℃). With high penetration and spatial resolution, this proposed magnetic/rare earth hybrid nanorobots holds great promise for precision biomedicine.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"455 ","pages":"Article 139673"},"PeriodicalIF":3.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147386183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A highly sensitive NIR-II ratiometric photoacoustic probe activated rapidly by nitric oxide for accurate in vivo imaging of liver injury 一种高灵敏度的NIR-II比率光声探针，由一氧化氮快速激活，用于准确的肝损伤体内成像

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-15 Epub Date: 2026-02-12 DOI: 10.1016/j.snb.2026.139654

Yidong Bin, Zongyi He, Lixian Huang, Caiying Li, Fanggui Ye, Shulin Zhao, Yong Huang, Liangliang Zhang

{"title":"A highly sensitive NIR-II ratiometric photoacoustic probe activated rapidly by nitric oxide for accurate in vivo imaging of liver injury","authors":"Yidong Bin, Zongyi He, Lixian Huang, Caiying Li, Fanggui Ye, Shulin Zhao, Yong Huang, Liangliang Zhang","doi":"10.1016/j.snb.2026.139654","DOIUrl":"10.1016/j.snb.2026.139654","url":null,"abstract":"<div><div>Nitric oxide (NO) plays key roles as a signaling molecule and an inflammatory mediator in the pathophysiology of diseases. Real-time, precise visualization of NO dynamics in deep tissues is essential for understanding disease mechanisms and evaluating therapeutic efficacy of drugs. However, existing NO probes, particularly those operating in the first near-infrared (NIR-I) window or single-wavelength “turn-on”, have limitations such as shallow penetration depth, tissue scattering, slow response and low sensitivity. To address these limitations, we used an electron cloud density enhancement strategy to develop NO-activated second near-infrared (NIR-II) window ratiometric photoacoustic (PA) probe (TCF-BA) by replacing the cationic heptamethine cyanine scaffold with an anionic counterpart. This anion-modulated strategy significantly increases electron cloud density, thereby improving the reactivity and sensitivity toward NO. The TCF-BA probe exhibits a significant ratiometric PA response upon NO activation, enabling high-contrast, deep-tissue imaging. Leveraging the high spatiotemporal resolution of PA imaging, the TCF-BA probe was used to quantitatively monitor NO fluctuations in a mouse model of liver injury. Overall, this study provides a reliable molecular imaging tool to investigate NO-related pathological processes and offers a promising strategy for the design of activatable NIR-II ratiometric probes.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"455 ","pages":"Article 139654"},"PeriodicalIF":3.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146169465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lighting up POLRMT: Computational discovery of a selective and " Off–On " fluorescent probe for cancer theranostics 点亮POLRMT：用于癌症治疗的选择性和“Off-On”荧光探针的计算发现

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-15 Epub Date: 2026-02-12 DOI: 10.1016/j.snb.2026.139660

Weiheng Zhang , Yingli Zhu , Yanpeng Fang , Ying Yin , Qiangchao Meng , Qianhui Liu , Pian Yu , Fei Chen , Wenbin Zeng , Jie Dong

{"title":"Lighting up POLRMT: Computational discovery of a selective and \" Off–On \" fluorescent probe for cancer theranostics","authors":"Weiheng Zhang , Yingli Zhu , Yanpeng Fang , Ying Yin , Qiangchao Meng , Qianhui Liu , Pian Yu , Fei Chen , Wenbin Zeng , Jie Dong","doi":"10.1016/j.snb.2026.139660","DOIUrl":"10.1016/j.snb.2026.139660","url":null,"abstract":"<div><div>Human mitochondrial RNA polymerase (POLRMT), a critical enzyme for mitochondrial DNA transcription, is frequently overexpressed in various tumors, including colorectal cancer, where it drives cancer progression. Specific targeting of POLRMT not only holds promise for suppressing cancer cell growth but also provides a novel molecular tool for cancer diagnosis through direct visualization. However, imaging strategies for POLRMT are currently underdeveloped, which restricts its translational potential. To address this gap, we present the rational design and characterization of a novel fluorescent probe based on the Folding-Photoinduced Electron Transfer (PET) mechanism. Our approach integrated structure-driven drug design with molecular dynamics simulations. The resulting probe, <strong>BMXan–ImPy</strong>, was constructed by combining the pharmacophore recognition unit <strong>BMXan</strong> with the optical module <strong>ImPy</strong>, and its fluorescence mechanism was validated through quantum chemical calculations. In the free state, <strong>BMXan–ImPy</strong> adopts a folded conformation that facilitates PET, leading to quenched fluorescence. Upon binding to POLRMT, the interaction induces conformational unfolding, which blocks the PET process and restores fluorescence, enabling highly specific “Off–On” imaging. Experimental studies in colorectal cancer cells demonstrated that <strong>BMXan–ImPy</strong> exhibits strong biological activity and favorable optical properties. This work introduces the first POLRMT-targeted theranostic small-molecule probe, underscoring its potential as a promising strategy and technical platform for the early diagnosis and precision therapy of colorectal cancer.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"455 ","pages":"Article 139660"},"PeriodicalIF":3.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146169861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-mode PEF/SERS detection of Riboflavin based on TA-AuNSF/AgNS@PVA plasmonic hybrid substrate 基于TA-AuNSF/AgNS@PVA等离子体杂交底物的核黄素双模PEF/SERS检测

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-15 Epub Date: 2026-02-10 DOI: 10.1016/j.snb.2026.139647

Ziheng Song , Wenxuan Liu , Wenjie Hu , Yingying Deng , Meiqin Ni , Yingdong Han , Qingru Wang , Dong Zhang

{"title":"Dual-mode PEF/SERS detection of Riboflavin based on TA-AuNSF/AgNS@PVA plasmonic hybrid substrate","authors":"Ziheng Song , Wenxuan Liu , Wenjie Hu , Yingying Deng , Meiqin Ni , Yingdong Han , Qingru Wang , Dong Zhang","doi":"10.1016/j.snb.2026.139647","DOIUrl":"10.1016/j.snb.2026.139647","url":null,"abstract":"<div><div>Riboflavin (RF), a photosensitive and water-soluble vitamin, is critical for cellular redox metabolism and serves as an indicator for food quality monitoring. Herein, we present a thermally annealed self-assembled gold nanosphere film/silver nanosphere@polyvinyl alcohol (TA-AuNSF/AgNS@PVA) hybrid substrate that integrates plasmon-enhanced fluorescence (PEF) and surface-enhanced Raman scattering (SERS) for ultrasensitive RF detection. The substrate exploits localized surface plasmon resonance (LSPR) coupling between gold nanosphere arrays and silver nanospheres, generating high-density electromagnetic hot spots that markedly amplify local electric fields. It reveals a PEF detection limit of 7 nM with an approximately 300-fold fluorescence enhancement, as well as a SERS detection limit of 32 nM with a 0.8 × 10⁶ fold enhancement at 1344 cm⁻¹ under 633 nm excitation. In addition, the substrate demonstrates excellent uniformity, high selectivity against common interferents, and thermal stability. Its successful application to the analysis of commercial vitamin B₂ tablets further confirms the reliability and practical applicability. This dual-mode sensing platform provides a powerful and versatile tool for pharmaceutical quality control and the analysis of complex biological samples.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"455 ","pages":"Article 139647"},"PeriodicalIF":3.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146153226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supra-carbon dots as smart surface-enhanced Raman scattering material for tumor monitoring 超碳点作为智能表面增强拉曼散射材料用于肿瘤监测

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-15 Epub Date: 2026-02-13 DOI: 10.1016/j.snb.2026.139664

Yu Su , Xia Xiao , Jiale Chen , Yuqian Tian , Jieyi Chen , Kali Xie , Zhouyi Guo , Bo Xu , Huiqing Zhong , Haolin Chen , Zhiming Liu

{"title":"Supra-carbon dots as smart surface-enhanced Raman scattering material for tumor monitoring","authors":"Yu Su , Xia Xiao , Jiale Chen , Yuqian Tian , Jieyi Chen , Kali Xie , Zhouyi Guo , Bo Xu , Huiqing Zhong , Haolin Chen , Zhiming Liu","doi":"10.1016/j.snb.2026.139664","DOIUrl":"10.1016/j.snb.2026.139664","url":null,"abstract":"<div><div>Supra-carbon dots (supra-CDs) fundamentally expand the optical performance of carbon dot systems beyond just photoluminescence. Here, we report the first evidence of surface-enhanced Raman scattering (SERS) phenomenon in supra-CDs, discovered from a lamellar nano-assembly formed by polyphenol carbon dot coordinated with metal ions in a layered architecture (denoted as CML). Metal coordination remarkably alters the Fermi level that enables efficient charge transfer between CML and analyte, realizing the maximum Raman enhancement factor of 1.15 × 10<sup>4</sup>. CML also retains the outstanding adhesive and reductive capabilities of polyphenol structure, which allows the <em>in situ</em> formation of CML@Au nanocomposites on the medical needle to fabricate SERS needle. The nanocomposites integrate electromagnetic and chemical enhancement mechanisms which endows the optical needle with coupling SERS effect. Then real-time <em>in vivo</em> tumor SERS monitoring is achieved via label and label-free modes utilizing this SERS needle as minimally invasive probe. In label-free mode, metabolic markers are extracted from tumor SERSome assisted by the deep learning algorithm, facilitating the precise evaluation of molecular components in tumorigenesis. Finally, the needle is functionalized with 5,5′-Dithiobis-(2-nitrobenzoic acid) (DTNB) to serve as glutathione (GSH)-responsive SERS probe, enabling real-time monitoring of tumor microenvironment dynamics.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"455 ","pages":"Article 139664"},"PeriodicalIF":3.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146169463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A one-dimensional covalent organic framework for dual-mode sensing and photocatalytic recovery of gold ions from electronic waste 用于电子废弃物中金离子双模传感和光催化回收的一维共价有机框架

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-15 Epub Date: 2026-02-16 DOI: 10.1016/j.snb.2026.139649

Si-Meng Chen , Zhen-Wen Zhang , Sai-Jin Xiao , Ru-Ping Liang , Li Zhang , Jian-Ding Qiu

{"title":"A one-dimensional covalent organic framework for dual-mode sensing and photocatalytic recovery of gold ions from electronic waste","authors":"Si-Meng Chen , Zhen-Wen Zhang , Sai-Jin Xiao , Ru-Ping Liang , Li Zhang , Jian-Ding Qiu","doi":"10.1016/j.snb.2026.139649","DOIUrl":"10.1016/j.snb.2026.139649","url":null,"abstract":"<div><div>The detection and recovery of gold from electronic waste (e-waste) are crucial for environmental protection and resource sustainability. Herein, we report the synthesis of a novel one-dimensional (1D) fluorescent covalent organic framework (DABI-COF) from 1,3,6,8-tetra(4-formylphenyl)pyrene (TFPPy) and 5,6-diaminobenzimidazol-2-one (DABI) for dual-mode detection and photocatalytic recovery of gold from e-waste. DABI-COF with abundant recognition sites enables rapid and specific responses to gold ions, with fluorescence quenching <em>via</em> a photoinduced electron transfer mechanism and a visible color change from bright yellow to dark green, achieving fluorescent and colorimetric sensing with a low detection limit of 13.33 nM. Furthermore, under visible light irradiation, DABI-COF demonstrates exceptional photocatalytic recovery of gold with shorter equilibration time (10 min) and higher adsorption capacity (up to 3906.5 mg g<sup>−1</sup>) than those in the dark condition. Practical applications in real e-waste leachate confirm its excellent selectivity and high efficiency (> 90 %) for gold recovery. This work highlights the great potential of 1D COFs in the dual-functional detection and photocatalytic recovery of precious metals from e-waste.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"455 ","pages":"Article 139649"},"PeriodicalIF":3.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147386171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A dual-gated detection system for pathogen diagnosis: Integrating nanozyme-based visual screening with duplex-specific nuclease-assisted specific verification 一种用于病原体诊断的双门检测系统：整合基于纳米酶的视觉筛选与双特异性核酸酶辅助特异性验证

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-15 Epub Date: 2026-02-09 DOI: 10.1016/j.snb.2026.139641

Lulu Guo , Dalong Shi , Taotao Sui , Ting Xu , Xinrui Liu , Hong Liu , Xuguang Zhang , Zhimin Yang

{"title":"A dual-gated detection system for pathogen diagnosis: Integrating nanozyme-based visual screening with duplex-specific nuclease-assisted specific verification","authors":"Lulu Guo , Dalong Shi , Taotao Sui , Ting Xu , Xinrui Liu , Hong Liu , Xuguang Zhang , Zhimin Yang","doi":"10.1016/j.snb.2026.139641","DOIUrl":"10.1016/j.snb.2026.139641","url":null,"abstract":"<div><div>Targeting the challenge of achieving a balance among portability, low cost, and high specificity in pathogen nucleic acid detection, we developed a dual-gated detection system (DGDS) that integrates nanozyme-based colorimetric screening with duplex-specific nuclease (DSN)-mediated fluorescence verification. The first gate enables rapid, instrument-free visual triage by exploiting the inhibition of the peroxidase-like MIL-101(Fe) nanozyme by pyrophosphate (PPi), a byproduct of loop-mediated isothermal amplification (LAMP). The second gate ensures high-fidelity confirmation through DSN cleavage of a TaqMan probe only upon perfect hybridization with target amplicons, effectively circumventing nonspecific amplification artifacts common to isothermal methods. Using monkeypox virus (Mpox) as a model, DGDS demonstrated single-copy sensitivity and excellent specificity, and could simultaneously differentiate multiple pathogens via multiplexed probes. Validation with 72 clinical samples showed complete concordance with PCR, confirming its diagnostic reliability. In contrast to CRISPR/Cas systems, the DSN-based strategy operates without PAM sequence constraints or in vitro transcription steps, accommodating both DNA and RNA targets with enhanced compatibility and storage stability. Furthermore, we designed a proof-of-concept microfluidic device that integrates \"amplification-screening-verification\" into a single workflow, demonstrating the potential for fully enclosed, field-deployable detection. Through its logically tiered signal output and verification mechanism, DGDS achieves an optimal balance among sensitivity, accuracy, and operational simplicity, offering a translatable platform for rapid and precise pathogen diagnosis at the point of care and in resource-limited settings.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"455 ","pages":"Article 139641"},"PeriodicalIF":3.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The design of β-carboline–8-aminoquinoline tethered probes for nanomolar Zn²⁺ sensing and cell imaging 用于纳米锌2 +传感和细胞成像的β-氨基喹啉系留探针的设计

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-15 Epub Date: 2026-02-10 DOI: 10.1016/j.snb.2026.139645

Muhammad Ashraf , Mochamad Lutfi Firmansyah , Safwat Abdel-Azeim , Nisar Ullah

{"title":"The design of β-carboline–8-aminoquinoline tethered probes for nanomolar Zn²⁺ sensing and cell imaging","authors":"Muhammad Ashraf , Mochamad Lutfi Firmansyah , Safwat Abdel-Azeim , Nisar Ullah","doi":"10.1016/j.snb.2026.139645","DOIUrl":"10.1016/j.snb.2026.139645","url":null,"abstract":"<div><div>Maintaining optimal Zn²⁺ concentrations are essential for various physiological and environmental systems. Despite many reported Zn²⁺ sensors, their selectivity and operational simplicity often remain inadequate. In this work, two newly engineered β-carboline–derived fluorescent probes (<strong>S1</strong> and <strong>S2</strong>) are presented as efficient and sensitive Zn²⁺ recognition platforms. The probes integrate 8-aminoquinoline with a β-carboline framework to form half-ring confined binding cavities that enable selective Zn²⁺ coordination. These probes can selectively detect Zn²⁺ with fluorescence enhancement upon binding with Zn²⁺, due to PET suppression mechanism, yielding strong signal amplification and nanomolar-level detection with limit of detection of 1.3 nM and 2.2 nM, respectively. DFT analyses suggested hexacoordinate geometries with square bipyramidal arrangements for Zn²⁺–probe complexes with favourable thermodynamic stability. Moreover, ¹H NMR spectra provided evidence for the formation of probe/Zn²⁺ complexes, as distinct changes were observed between the free probe and the complexed form. The probes also demonstrate high biocompatibility, reversible fluorescence modulation, and successfully applied to monitor Zn²⁺ in WiDr cells that validate their potential for Zn²⁺ imaging in cellular environments.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"455 ","pages":"Article 139645"},"PeriodicalIF":3.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146153085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning-assisted LIBS for quantitative determination of heavy metals in surfactant-enhanced adsorption on PMMA nanoplastics 机器学习辅助LIBS在PMMA纳米塑料表面活性剂增强吸附中的重金属定量测定

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2026-05-15 Epub Date: 2026-02-12 DOI: 10.1016/j.snb.2026.139653

Rongling Zhang , Jingzhong Liu , Qiao Li , Mengfan Zhang , Tianlong Zhang , Hongsheng Tang , Hua Li

{"title":"Machine learning-assisted LIBS for quantitative determination of heavy metals in surfactant-enhanced adsorption on PMMA nanoplastics","authors":"Rongling Zhang , Jingzhong Liu , Qiao Li , Mengfan Zhang , Tianlong Zhang , Hongsheng Tang , Hua Li","doi":"10.1016/j.snb.2026.139653","DOIUrl":"10.1016/j.snb.2026.139653","url":null,"abstract":"<div><div>Surfactant molecules can alter the hydrophobicity of nanoplastics (NPs), thereby influencing the adsorption of heavy metals onto them. In this study, a systematic comparison was conducted on the enhancement effects of three surfactants, namely cetyltrimethylammonium bromide (CTAB), sodium dodecylbenzene sulfonate (SDBS), and sodium dodecyl sulfate (SDS), on the adsorption of Cr, Pb, and Cu by poly(methyl methacrylate) (PMMA). Using laser-induced breakdown spectroscopy (LIBS), surfactant type, concentration and adsorption time were optimized, and the impact of coexisting ions was examined. Following the identification of the optimal surfactant and experimental conditions, quantitative analysis of the heavy metal adsorption capacity of PMMA was conducted using machine learning-assisted LIBS. LIBS spectra of 21 contaminated PMMA samples were collected, and wavelet transform (WT) and Savitzky-Golay (SG) were applied to remove noise and matrix effects from the spectra. Five variable selection methods were further employed to eliminate redundant variables and enhance the predictive performance of the model. SDS exhibited the most prominent enhancement among the three surfactants. The signal-to-noise ratios (SNRs) of Cr, Pb, and Cu were enhanced by 4.41, 10.58, and 3.26 times, respectively. Based on optimized input variables and model parameters, the SG-competitive adaptive reweighted sampling (CARS)-PLS calibration model demonstrated superior performance in quantitative analysis of three metal elements in PMMA: Cr (R<sup>2</sup><sub>p</sub> = 0.9153, MRE<sub>p</sub> = 0.1201), Pb (R<sup>2</sup><sub>p</sub> = 0.9419, MRE<sub>p</sub> = 0.0756), and Cu (R<sup>2</sup><sub>p</sub> = 0.9317, MRE<sub>p</sub> = 0.2496). This study improves understanding of heavy metal adsorption by NPs in the presence of surfactants, facilitating effective control of NPs-induced risks.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"455 ","pages":"Article 139653"},"PeriodicalIF":3.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146160617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0