Sensors and Actuators B: Chemical最新文献

{"title":"Self-templated fabrication of shuttle-like WO3 functionalized with Co3O4 nanobox for efficient detection of acetone","authors":"Xinzhi Wang ,&nbsp;Jie Hu ,&nbsp;Wangwang Guan","doi":"10.1016/j.snb.2025.137603","DOIUrl":"10.1016/j.snb.2025.137603","url":null,"abstract":"<div><div>In this work, a self-template in situ etching strategy was applied to fabricate a hollow shuttle-like WO₃-Co₃O₄ heterojunction. The morphology and nanostructure were investigated comprehensively by a series of techniques. Notably, the hollow shuttle-like WO₃-Co₃O₄ shows a large specific area and promising architecture, which can efficiently promote the gas adsorption-desorption process and provide more active sites in whole composites. Compared to other sensing devices, the WO₃-Co₃O₄ sample with hollow shuttle-like architecture shows the best gas sensing characterizations, and the response to 100 ppm acetone is as high as 52 under optimum working temperature. Moreover, it also presents good repeatability, high against moisture, fast response-recovery speed and long-term stability. The enhanced gas sensing characterizations can be ascribed to the synergistic effect of a unique hollow shuttle-like structure and the p-n heterojunction at the interface of WO₃ and Co₃O₄. These admirable properties make it an excellent candidate for constructing high-performance acetone sensors. In addition, the relative sensing mechanism of shuttle-like WO₃-Co₃O₄ composites-based sensors will be discussed in detail.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"434 ","pages":"Article 137603"},"PeriodicalIF":8.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual readout biosensor based on AIE-type immunomagnetic ZIF-8: From sample pretreatment to multi-residue detection","authors":"Shuai Zhang ,&nbsp;Jincheng Xiong ,&nbsp;Boyan Sun ,&nbsp;Chunchao Yin ,&nbsp;Yongjun Zheng ,&nbsp;Xingxing Liu ,&nbsp;Yanchen Gao ,&nbsp;Xiaomei Wang ,&nbsp;Sihan Wang ,&nbsp;Haiyang Jiang","doi":"10.1016/j.snb.2025.137601","DOIUrl":"10.1016/j.snb.2025.137601","url":null,"abstract":"<div><div>Emerging contaminants seriously jeopardize food safety and even human health. This study presents the formation of all-in-one aggregation-induced emission (AlE)-type immunomagnetic ZlF-8 (AlMZ) through an ultra-simple self-assembly method in an aqueous phase, successfully harnessing the functions of immuno-recognition, luminescence, and magnetism, Here, we have achieved a dual enhancement in detection efficiency rapidly enriching targets and performing a triple lateral flow immunoassay (LFlA) for ractopamine, diethylstilbestrol, and chloramphenicol within 40 minutes, The dual readout biosensor was then configured to automatically extract the color intensity values of the three test lines using a smartphone. A portable sensing platform ensures stable temperature and light intensity in non-laboratory environments, providing favorable conditions for immunological detection. This study demonstrated low detection limits of 0.11, 0.14, and 0.01ug/L for ractopamine, diethylstilbestrol, and chloramphenicol, respectively, Applications in pork and tap water showed excellent practicality and stability, with recovery rates ranging from 87.2 % to 112.7 %, emphasizing the potential for applications in food and environmental safety.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"434 ","pages":"Article 137601"},"PeriodicalIF":8.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A label-free fluorescent aptasensor for AFB1 and AFM1 based on the aptamer tailoring strategy and synergistic signal amplification of HCR and MoS2 nanosheets","authors":"Yifeng Lan ,&nbsp;Yingqi Ma ,&nbsp;Yingwen Xu ,&nbsp;Yuan Zhang ,&nbsp;Rujia Deng ,&nbsp;Lulu Liu ,&nbsp;Boya Hou ,&nbsp;Haiyan Cui ,&nbsp;Keming Yun ,&nbsp;Zhiwen Wei ,&nbsp;Yanli Wei","doi":"10.1016/j.snb.2025.137591","DOIUrl":"10.1016/j.snb.2025.137591","url":null,"abstract":"<div><div>Effective truncation and mutation can obtain highly active nucleic acid aptamers for the target, especially avoiding non-specific binding, uncertainty to the tertiary structure and low binding affinity of the lengthy aptamer. In this work, a new aptamer, T-AF28 (28 nt) with better affinity to AFB1 was obtained by truncating 22 bases and mutating 3 bases of the reported AFB1 aptamer (50 nt), and the thermodynamic information, structural changes and binding domains of aptamer T-AF28 in the presence of AFB1 or AFM1 were further investigated by isothermal titration calorimetry, circular dichroism, and molecular dynamics. On this basis, Using optimized aptamers as recognition elements, a novel label-free and enzyme-free fluorescent aptasensor for AFB1 and AFM1 was developed by synergistic amplification effect of hybridization chain reaction (HCR) coupled molybdenum disulfide nanosheets and copper nanoparticles in situ synthesized (CuNPs) on an extra-long double-stranded template generated by HCR as the fluorescent probe. Under the optimal experimental conditions, sensitive and selective fluorescent detection of AFB1 and AFM1 was achieved with wide linear detection ranges of 0.030 ng/mL-46.8 ng/mL and 0.030 ng/mL-32.8 ng/mL, respectively. And this aptasensor can be applied to accurate detection of AFB1 and AFM1 in grains, edible oil, tea, and milk with the recovery in the range of 85.20 %-117.0 %. This work not only provides a theoretical basis for the design of AFB1 and AFM1 aptasensors and expands the application of AFB1 aptasensors in the field of food safety, but also breaks a new path for the development of HCR-MoS₂Ns CuNPs aptasensors.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"434 ","pages":"Article 137591"},"PeriodicalIF":8.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distance-based lateral flow immunoassay for quantitative detection of C-reactive protein in cardiovascular risk assessment","authors":"Sirowan Ruantip ,&nbsp;Umaporn Pimpitak ,&nbsp;Songchan Puthong ,&nbsp;Sirirat Rengpipat ,&nbsp;Abdulhadee Yakoh ,&nbsp;Mohini M. Sain ,&nbsp;Kittinan Komolpis ,&nbsp;Sudkate Chaiyo","doi":"10.1016/j.snb.2025.137602","DOIUrl":"10.1016/j.snb.2025.137602","url":null,"abstract":"<div><div>C-reactive protein (CRP) is a key biomarker of inflammation, widely utilized for predicting cardiovascular disease (CVD) risk. Conventional detection methods often require sophisticated equipment and skilled personnel, limiting their accessibility in point-of-care testing (POCT). This study presents a novel distance-based lateral flow immunoassay (Dist-LFIA) for semi-quantitative CRP detection, offering a simple, portable, and cost-effective alternative. The device visually categorizes CRP levels into risk groups—low (&lt;1 mg/L), intermediate (1–3 mg/L), and high (4–10 mg/L)—based on the length of a colorimetric signal, enabling easy interpretation without the need for advanced instrumentation. The Dist-LFIA demonstrated excellent analytical performance, achieving a detection limit of 0.12 mg/L, comparable recovery rates to immunoturbidimetry, and sustained stability over prolonged periods. Observer reliability tests confirmed strong intra- and inter-reader agreements, ensuring consistent and reproducible results. Additionally, the device features a straightforward fabrication process, making it highly scalable and suitable for resource-limited settings. Unlike traditional methods, which often depend on auxiliary devices or complex protocols, the Dist-LFIA provides immediate, equipment-free results. This innovation enhances accessibility to CRP-based diagnostics, facilitating early CVD risk assessment in home settings, remote areas, and under-resourced healthcare environments. Its versatility promises broader applications in diagnostics beyond CVD prediction.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"434 ","pages":"Article 137602"},"PeriodicalIF":8.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “SnO2-Co3O4 nanocomposite sensor: Achieving ultra-selective hydrogen detection in mixed gas environments” [Sens. Actuators B. Chem. 422 (2025) 136521]","authors":"Yuxiang Qin ,&nbsp;Yizhe Zhang ,&nbsp;Peilun Qiu ,&nbsp;Songyuan Lei","doi":"10.1016/j.snb.2025.137582","DOIUrl":"10.1016/j.snb.2025.137582","url":null,"abstract":"","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"434 ","pages":"Article 137582"},"PeriodicalIF":8.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced yolk-shell Pt@In2O3 nanoreactor: Achieving selective and ppb-level acetone detection","authors":"Zicheng Zheng ,&nbsp;Hanwen Chi ,&nbsp;Jingmin Wu ,&nbsp;Liyuan Zhang ,&nbsp;Denghui Huang ,&nbsp;Zhizhen Ye ,&nbsp;Jie Jiang ,&nbsp;Liping Zhu","doi":"10.1016/j.snb.2025.137599","DOIUrl":"10.1016/j.snb.2025.137599","url":null,"abstract":"<div><div>Acetone is commonly used in industry and laboratories but can harm human organs at high concentrations. It also serves as a biomarker for fat metabolism. The accurate detection of acetone using chemiresistive gas sensors holds great promise for applications in human exhaled breath analysis. It remains a hurdle to overcoming challenges with metal oxide-based sensors in detecting acetone selectively at parts per billion (ppb) levels, especially in high-humidity environments. We synthesised a Pt@In₂O₃ yolk-shell nanoreactor that ensures gas sensing performance while protecting noble metal nanoparticles from oxidation. It has a 20-ppb detection limit, a good response of 5.13 at 1.8 ppm under a high relative humidity of 90 %, and outstanding selectivity for acetone. Chemical state analyses and first-principles calculations reveal that the nanoreactor has abundant oxygen vacancy and strong acetone adsorption, facilitating enhanced charge transfer during sensing. Exhaled breath tests confirm that our sensors can differentiate individuals with abnormal respiratory acetone levels. Our study opens a new path for developing high-performance gas-sensitive materials and structures for a wide range of applications.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"434 ","pages":"Article 137599"},"PeriodicalIF":8.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New label-free serum exosomes detection method based on hierarchical SERS substrate for diagnosis of pancreatic cancer using AI","authors":"Hu Wang ,&nbsp;Yanru Li ,&nbsp;Shuai Chen ,&nbsp;Jie Yan ,&nbsp;Jinkai Zhang ,&nbsp;Peilong Li ,&nbsp;Helgi B. Schioth ,&nbsp;Chengpeng Zhang ,&nbsp;Yang Yang ,&nbsp;Juan Li ,&nbsp;Lutao Du","doi":"10.1016/j.snb.2025.137588","DOIUrl":"10.1016/j.snb.2025.137588","url":null,"abstract":"<div><div>Early diagnosis significantly enhances the 5-year survival rate of pancreatic cancer (PaC) patients. Obtaining information on molecular phenotypic changes in exosomes provides prospects for early non-invasive diagnosis of PaC. Unfortunately, current detection modes are time-consuming and still not sensitive enough, so methods that can directly obtain exosome information in complex biological fluids are urgently needed. In this study, we developed a new method for early diagnosis of PaC by obtaining a spectral set of serum exosomes on a hierarchical surface-enhanced Raman scattering (SERS) substrate. Then these spectra were analyzed with artificial intelligence (AI). Specifically, we designed a micro-lens array/silver nanowires/silver nanoparticles hierarchical SERS substrate (MLA/AgNWs/AgNPs H-SERS substrate) that exhibited a minimum detection concentration of 10⁻⁹ M and a minimum relative standard deviation of 7.68 %. The performance of the substrate increased the strength and stability of exosome biological information acquisition. Furthermore, through the spectral analysis of exosome from 149 serum samples using AI, we performed PaCs diagnosis with an area under the receiver operating curve (AUROC) of 0.96 and successfully classified 24 cases of early PaCs. Moreover, the maximum diagnostic positive rate of 161 cases of non-pancreatic cancer was 4.44 %, supporting the fact that the model was specific. This label-free Raman spectral analysis can potentially be extended to identify multiple cancers, offering a non-invasive diagnostic approach for clinic.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137588"},"PeriodicalIF":8.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly-sensitive photoacoustic gas sensor with dual resonant modalities for simultaneous NO and NO2 detection","authors":"Zhiyu Feng ,&nbsp;Chaotan Sima ,&nbsp;Tailin Li ,&nbsp;Wenzhe Wang ,&nbsp;Yufeng Pan ,&nbsp;Lihua Wang ,&nbsp;Zhiwen Ming ,&nbsp;Ping Lu","doi":"10.1016/j.snb.2025.137596","DOIUrl":"10.1016/j.snb.2025.137596","url":null,"abstract":"<div><div>Photoacoustic spectroscopy (PAS) gas sensors based on acoustic resonators have high detection sensitivity and are widely used for trace gas detection. However, there are challenges such as difficult time/frequency separation, low signal-to-noise ratio of higher-order modes, and high sample consumption in multi-gas detection. Here, we present a dual-modality PAS (DM-PAS) gas sensor for simultaneous detection of NO_x. The sensor incorporates two integrating spheres and a cylindrical tube to excite both Helmholtz and longitudinal resonances within a single cell. LED and QCL light sources are modulated to generate PA signals originated from the dual resonant modalities, which are detected by the array of MEMS microphones. Allan deviation analysis shows a minimum detection limit (MDL) of 61.5 ppb for nitrogen dioxide (NO₂) and 2.0 ppb for nitric oxide (NO) at over 450 s integration time. Furthermore, experimental results demonstrate the favorable repeatability and response performance of this sensor. The proposed sensor configuration provides a novel approach to realize the simultaneous detection of multiple gases.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"434 ","pages":"Article 137596"},"PeriodicalIF":8.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing subtle features of gas detection signals using MFD_attention mechanism for improved detection in complex environments","authors":"Jingfeng Li ,&nbsp;Zhenyu Yuan ,&nbsp;Yannan Wang ,&nbsp;Fanli Meng","doi":"10.1016/j.snb.2025.137597","DOIUrl":"10.1016/j.snb.2025.137597","url":null,"abstract":"<div><div>Hydrogen is widely used in industrial environments as a clean energy source. However, hydrogen leaks can easily lead to fires and explosions. Real-time monitoring of gas types and concentrations is essential to ensure industrial safety. When using semiconductor gas sensors to detect gas mixtures, the sensitivity of the sensors to different gases is often similar. As a result, subtle features of low concentration gases or gases with low sensitivity are easily masked or overlapped, and thus ignored in the algorithmic recognition process, greatly reducing the detection accuracy. To address this problem, this paper proposes a novel model that combines multi-scale filtering decomposition (MFD), kernel convolution, and an attention mechanism (AM) to extract subtle features from the data and enhance the useful information while suppressing redundant signals through adaptive weight assignment. We validated the model using commonly used regression algorithms: BP neural network and support vector machine. The results show that the total mean absolute error (MAE) root-mean-square error (RMSE) for predicting the concentration of hydrogen-methane mixtures showed a reduction of more than 50 %. In addition, to test the generalization ability of the model, we applied it to hydrogen-carbon monoxide mixtures and hydrogen-methane mixtures under different humidity conditions, and the results improved the prediction accuracy for both.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"434 ","pages":"Article 137597"},"PeriodicalIF":8.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143599586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulating the hydrophobic part in amphiphilic triphenylamino-diarylethene fluorophores for ultrasensitive and portable detection of urinary albumin","authors":"Caiqiang Liao ,&nbsp;Xianwen Liang ,&nbsp;Tianyi Qin ,&nbsp;Xinfeng Du ,&nbsp;Haoyan Xiong ,&nbsp;Quan Chen ,&nbsp;Cuizhen Lu ,&nbsp;Zhongyang Zhang ,&nbsp;Zhongyong Xu ,&nbsp;Taoyuze Lv ,&nbsp;Zhaohui Wang ,&nbsp;Yalong Wang ,&nbsp;Bin Liu ,&nbsp;Mingqiang Zhu","doi":"10.1016/j.snb.2025.137592","DOIUrl":"10.1016/j.snb.2025.137592","url":null,"abstract":"<div><div>Sensitive and accurate detection of urinary albumin (<em><strong>u-ALB</strong></em>), preferably by user-friendly smartphone-based portable devices, is essential for the prevention and regular evaluation of chronic kidney disease (CKD). Here, we present a class of ionic aggregation-induced emission fluorogens (AIEgens) containing triphenylamine pyridinium skeleton and extended alkyl chains (<em><strong>TPA-Ps</strong></em>) as novel probes for <em><strong>u-ALB</strong></em>. Different from the previous studies focusing on regulating the number of ionic moieties, we for the first time investigated the effect of extending the hydrophobic tails on enhancing the sensitivity. Specifically, the <em><strong>TPA-P-C6</strong></em> with one ionic moiety yet a n-hexyl chain exhibited the highest fluorescent increasing fold (&gt; 3450) on responding to <em><strong>u-ALB</strong></em>, which has also been the highest degree among the reported ionic AIEgen-based <em><strong>u-ALB</strong></em> probes. Different stages of albuminuria (A1-A3) represented by varying <em><strong>u-ALB</strong></em> concentrations could be clearly revealed through fluorescence spectral signal readout. Additionally, the <em><strong>TPA-P-C6</strong></em> exhibited a restored fluorescence at longer wavelength area in real urine samples, enabling fluorocolorimetric sensing and point-of-care testing by naked eye. With the assistance of smartphones for signal capturing and analysis, portable devices based on test papers, 96-well plate, and 3D-printing technique have been constructed for the on-site detection of <em><strong>u-ALB</strong></em>. Compared with the commercial dye based <em><strong>u-ALB</strong></em> indicator (G250) and test papers, the multi-color sensing signals of our probe can clearly reveal the different stages of albuminuria and offer useful proofs for early diagnosis of CKD.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"434 ","pages":"Article 137592"},"PeriodicalIF":8.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}