Sensors and Actuators B: Chemical最新文献_第7页

Dual-signal amplification via high-entropy alloy nanoparticle catalysis and target DNA recycling for ultrasensitive HPV-16/18 detection in human serum 高熵合金纳米颗粒催化双信号扩增和靶DNA循环用于人血清HPV-16/18的超灵敏检测

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-09 DOI: 10.1016/j.snb.2025.138927

Wang Miao

{"title":"Dual-signal amplification via high-entropy alloy nanoparticle catalysis and target DNA recycling for ultrasensitive HPV-16/18 detection in human serum","authors":"Wang Miao","doi":"10.1016/j.snb.2025.138927","DOIUrl":"10.1016/j.snb.2025.138927","url":null,"abstract":"<div><div>Rapid identification of HPV-16/18 genotypes is critical for cervical cancer prevention, yet remains clinically inaccessible due to inadequate diagnostic sensitivity and specificity. The paper presents an electrochemical DNA biosensor achieving detection of genotypes through an innovative dual-signal amplification cascade. First, an exceptionally active AlCrMnZnAu<sub>0.1</sub> high-entropy alloy was engineered via coordination-driven approach using folic acid and histidine-functionalized boron and nitrogen-doped graphene quantum dot. Synergistic atomic orbital hybridization and tailored support endow unprecedented stability, optimized electron structure and remarkable catalytic activity—outperforming benchmark gold nanoparticle by 6.8-fold. Second, triblock poly-adenine probe (H1) anchored to gold electrode selectively captures HPV-16 or HPV-18 targets. Binding initiates the unfolding of secondary structures: H2 (tagged with AlCrMnZnAu<sub>0.1</sub>/thionine) for HPV-16, and H3 (tagged with AlCrMnZnAu<sub>0.1</sub>/ferrocene) for HPV-18. Crucially, target DNA is regenerated through toehold-mediated strand displacement, enabling geometric signal amplification. Concurrently, AlCrMnZnAu<sub>0.1</sub> intensifies electrochemical responses by catalytically boosting thionine and ferrocene redox reactions. This orchestrated dual-amplification strategy delivers unmatched specificity and sensitivity for HPV-16/18. The platform exhibits an exceptionally broad linear response (10⁻¹⁸ to 10⁻¹³ M) for both targets and achieves ultralow detection limit of 2.9 × 10⁻¹ ⁹ M, representing a transformative advancement over existing state-of-the-art diagnostic sensors for point-of-care deployment.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"448 ","pages":"Article 138927"},"PeriodicalIF":3.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-controlled one-pot RPA-CRISPR/Cas12a biosensor for MRSA detection based on tailed crRNA 基于尾端crRNA的MRSA检测光控单锅式rna - crispr /Cas12a生物传感器

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-09 DOI: 10.1016/j.snb.2025.138925

Zhou Yu , Yan Man , Weilin Li , Cong Shi , Peng Xiao , Qinghai Zhang

{"title":"Light-controlled one-pot RPA-CRISPR/Cas12a biosensor for MRSA detection based on tailed crRNA","authors":"Zhou Yu , Yan Man , Weilin Li , Cong Shi , Peng Xiao , Qinghai Zhang","doi":"10.1016/j.snb.2025.138925","DOIUrl":"10.1016/j.snb.2025.138925","url":null,"abstract":"<div><div>Methicillin-resistant Staphylococcus aureus (MRSA) poses a severe global health threat due to its antibiotic resistance and high mortality rates. Herein, we developed a novel light-controlled one-pot RPA-CRISPR/Cas12a sensing system for rapid, specific, and cost-effective MRSA detection. The sensing system features a \"tailed crRNA\" containing a photocleavable linker (PC-linker), which blocks target recognition through a self-forming hairpin structure, maintaining the CRISPR/Cas system in an inactive state during RPA. Upon ultraviolet irradiation, the PC-linker is cleaved, restoring crRNA activity and enabling one-pot integration of amplification and detection within a single closed reaction tube. The traditional two-step RPA-CRISPR/Cas12a method demonstrated a linear detection range of 8.9 × 10⁰ – 8.9 × 10⁶ CFU/mL with a limit of detection (LOD) of 6.3 CFU/mL, while the light-controlled one-pot RPA-CRISPR/Cas12a system achieved comparable sensitivity (LOD: 34.7 CFU/mL) and specificity with no cross-reactivity against non-target pathogens. Both systems exhibited excellent recovery rates (87.1–110.2 %) and reproducibility (RSD ≤ 6.22 %) in complex food matrices (lettuce, milk, salmon, sauce beef). This light-controlled approach significantly reduces cross-contamination risks while simplifying workflows, providing a sensitive, reliable, and user-friendly platform for point-of-need MRSA detection in food safety and clinical diagnostics.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"448 ","pages":"Article 138925"},"PeriodicalIF":3.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145264210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Baijiu flavor types by MEMS gas sensor based on temperature programmed desorption method 基于程序升温解吸法的MEMS气体传感器识别白酒风味类型

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-09 DOI: 10.1016/j.snb.2025.138921

Renjun Si , Hongze Jiang , Jinbo Yang , Renminxi Ou , Shaofeng Chen , Xin Guo , Shunping Zhang

引用次数: 0

Colorimetric sensing platform based on persulfate activation on fluorine-modified metal-organic frameworks for fast and selective detection of perfluorooctane sulfonic acid 基于过硫酸盐活化氟修饰金属-有机骨架的比色传感平台快速选择性检测全氟辛烷磺酸

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-09 DOI: 10.1016/j.snb.2025.138926

Qi An , Yi Tan , Xinze Du , Heyun Fu , Pedro J.J. Alvarez , Xiaolei Qu

{"title":"Colorimetric sensing platform based on persulfate activation on fluorine-modified metal-organic frameworks for fast and selective detection of perfluorooctane sulfonic acid","authors":"Qi An , Yi Tan , Xinze Du , Heyun Fu , Pedro J.J. Alvarez , Xiaolei Qu","doi":"10.1016/j.snb.2025.138926","DOIUrl":"10.1016/j.snb.2025.138926","url":null,"abstract":"<div><div>Widespread environmental pollution by highly-persistent and toxic perfluorooctane sulfonic acid (PFOS) underscores the need for a low-cost, high-throughput detection method to assess exposure risks and regulatory compliance. Herein, we developed a novel colorimetric sensing platform, based on peroxymonosulfate (PMS) activation by fluorine-modified metal-organic frameworks (MOFs), for sensitive and selective PFOS detection. Specifically, PCN-222(Fe) and its fluorinated counterpart, PCN-222(Fe)-3F, efficiently activate PMS, leading to the oxidation of the chromogenic substrate 3,3’,5,5’-tetramethylbenzidine (TMB) into its blue oxidized form. The oxidation is primarily mediated by high-valent iron-oxo species rather than free radicals, offering high selectivity. PFOS binds to the catalytic sites of MOFs, effectively inhibiting TMB oxidation. PCN-222(Fe)-3F exhibits superior PFOS selectivity compared to PCN-222(Fe) owing to specific fluorine-fluorine interactions. The developed colorimetric sensor has a low detection limit of 12.6 nM, fast detection within 30 min, and a broad linear range. It exhibits excellent selectivity against common interferents and performs reliably in real water sample analysis. The reported colorimetric sensor based on persulfate activation offers a promising approach for the development of low-cost, high-throughput, and on-site screening of per-and perfluorinated alkyl substances.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"448 ","pages":"Article 138926"},"PeriodicalIF":3.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amplified broad-spectrum detection of tetracyclines in surface water using CdTe@PVP@ZIF-8-accelerated cation exchange reactions and TMSDR-driven self-protective DNAzyme 利用CdTe@PVP@ zif -8加速阳离子交换反应和tmsdr驱动的自保护DNAzyme对地表水中四环素类药物的放大广谱检测

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-09 DOI: 10.1016/j.snb.2025.138914

Shuangyu Meng , Bowen Li , Chunyuan Huo , Wentong Yu , Ziyan Zhao , Runlong Ma , Zhiqiang Guo , Xinru Ren , Haiping Zhang , Jiadong Huang , Yu Wang , Su Liu

{"title":"Amplified broad-spectrum detection of tetracyclines in surface water using CdTe@PVP@ZIF-8-accelerated cation exchange reactions and TMSDR-driven self-protective DNAzyme","authors":"Shuangyu Meng , Bowen Li , Chunyuan Huo , Wentong Yu , Ziyan Zhao , Runlong Ma , Zhiqiang Guo , Xinru Ren , Haiping Zhang , Jiadong Huang , Yu Wang , Su Liu","doi":"10.1016/j.snb.2025.138914","DOIUrl":"10.1016/j.snb.2025.138914","url":null,"abstract":"<div><div>Tetracyclines (TCs) are important in animal husbandry, aquaculture and medical fields, which pose environmental residues and potential health risks. Consequently, the detection of TCs is important for environmental safety. However, traditional detection methods are time-consuming and laborious, and the sensitivity needs to be improved. Accordingly, it is necessary to establish a highly specific and accurate approach for the detection of TCs. Herein, based on CdTe@PVP@ZIF-8 material, a fluorescent biosensor combined with self-locking allosteric hypersensitive DNAzyme (SAH-Dz) was developed for the broad-spectrum detection of TCs in surface water. During the detection process, TCs first bind to the aptamer to activate the toehold-mediated strand displacement reaction (TMSDR), which generates a large amount of P. Subsequently, the binding region of SAH-Dz can change the self-locking conformation by complementary pairing with the base of P, release the DNAzyme binding arm, bind to the substrate chain H, cleave the rA site in the presence of Mg<sup>2</sup><sup>+</sup> , and release Ag<sup>+</sup> diffusing into the porous ZIF-8. Cation exchange reactions (CER) occur between Ag<sup>+</sup> and CdTe QDs, inducing fluorescence quenching. The extent of the fluorescence signal's weakening is utilized for the quantitative determination of TCs concentrations. Under optimized conditions, the detection limit of this method for TCs reached 0.0987 nM. This method can achieve sensitive, specific and broad-spectrum detection of four TCs, and is suitable for the identification of antibiotics in surface water.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"448 ","pages":"Article 138914"},"PeriodicalIF":3.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid, sensitive and wide-spectrum colourimetric detection of viable Staphylococcus aureus in food using phage cocktail 利用噬菌体鸡尾酒快速、灵敏、广谱比色法检测食品中活菌金黄色葡萄球菌

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-09 DOI: 10.1016/j.snb.2025.138910

Wenyuan Zhou , Wenjuan Li , Aiping Deng , Yelin Han , Yajie Li , Yajun Gao , Qin Hu , Guoqiang Zhu , Zhenquan Yang

{"title":"Rapid, sensitive and wide-spectrum colourimetric detection of viable Staphylococcus aureus in food using phage cocktail","authors":"Wenyuan Zhou , Wenjuan Li , Aiping Deng , Yelin Han , Yajie Li , Yajun Gao , Qin Hu , Guoqiang Zhu , Zhenquan Yang","doi":"10.1016/j.snb.2025.138910","DOIUrl":"10.1016/j.snb.2025.138910","url":null,"abstract":"<div><div>Although bacteriophages (phages) are ideal biorecognition elements employed for <em>Staphylococcus aureus</em> detection, existing single-phage-based approaches are limited by the specific affinity of phages and false-negative results. To develop an improved phage-based colourimetric detection system and investigate its detection mechanism, we prepared a phage cocktail composed of three <em>S. aureus</em> phages (SapYZU10, SapYZU11, and SapYZUM13), immobilised it on Co-Mn nanozymes, and applied it to <em>S. aureus</em> for evaluation. The phage cocktail@Co-Mn demonstrated a sensitive, specific, and fast colourimetric evaluation of live <em>S. aureus</em> counts in approximately 17 min, with a detection limit of 92 CFU/mL. Moreover, the phage cocktail@Co-Mn was successfully used to detect <em>S. aureus</em> in food samples, with recovery rates ranging from 92.21 % to 105.56 %. The phage cocktail@Co-Mn also exhibited resilience to changes in pH (3–9), five food additives, and NaCl concentration (2 %–10 %). The detection mechanism of the phage cocktail@Co-Mn involves blockage of the active sites of the nanozyme producing O<sub>2</sub><sup>•–</sup>. Notably, owing to the synergistic recognition spectra of the three phages in the cocktail, the recognition rate for the strains was a remarkable 100 %, compared with the much lower recognition rates of individual phages (between 74.7 % and 76.9 %). The recognition mechanism involves adsorption between phage tail fibres and <em>S. aureus</em> hosts. This pioneering study revealed that the phage cocktail is an effective biorecognition element suitable for the rapid, sensitive, specific, reliable, and colourimetric detection of viable <em>S. aureus</em> strains in the food industry, providing innovative directions for the phage-based detection methods.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"448 ","pages":"Article 138910"},"PeriodicalIF":3.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methylamine gas sensing by optical array 光学阵列甲胺气体传感

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-08 DOI: 10.1016/j.snb.2025.138936

Alessia Cavallaro , Rossella Santonocito , Andrea Pappalardo , Nunzio Tuccitto , Giuseppe Trusso Sfrazzetto

引用次数: 0

Integrated microfluidic immunoassays for point-of-care diagnostic measurement of human serum cystatin C in chronic kidney disease 集成微流控免疫分析法用于慢性肾脏疾病患者血清胱抑素C的即时诊断测量

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-08 DOI: 10.1016/j.snb.2025.138880

Dumitru Tomsa , Yang Liu , Amir Hossein Abolfathi , Xiaoou Ren , Amanda Stefanson , Nicholas Palmerley , AbdulRazaq A.H. Sokoro , Paul Komenda , Navdeep Tangri , Rene P. Zahedi , Claudio Rigatto , Francis Lin

{"title":"Integrated microfluidic immunoassays for point-of-care diagnostic measurement of human serum cystatin C in chronic kidney disease","authors":"Dumitru Tomsa , Yang Liu , Amir Hossein Abolfathi , Xiaoou Ren , Amanda Stefanson , Nicholas Palmerley , AbdulRazaq A.H. Sokoro , Paul Komenda , Navdeep Tangri , Rene P. Zahedi , Claudio Rigatto , Francis Lin","doi":"10.1016/j.snb.2025.138880","DOIUrl":"10.1016/j.snb.2025.138880","url":null,"abstract":"<div><div>Cystatin C (CYS-C) is considered superior to creatinine as a serum biomarker of estimated glomerular filtration rate (eGFR) for chronic kidney disease (CKD) assessment. It is minimally influenced by non-filtration-specific factors such as muscle mass, age and gender. However, currently CYS-C testing is limited to specialized diagnostic labs and no point-of-care (PoC) tools are clinically available. To address this gap, we leveraged the enabling power of microfluidic devices for PoC tests of CYS-C. Among the microfluidic devices, PDMS-based wet chips and paper-based dry chips have been widely used for disease biomarker measurements with their respective advantages and limitations. Therefore, in this study, we developed a PDMS-based microfluidic immunoturbidity chip allowing side-scattering optical measurement and a paper-based microfluidic lateral flow immunoassay chip plus a novel electric field-assisted antibody loading protocol for quantitative CYS-C tests. We demonstrated that both chips meet the clinical requirements of the serum CYS-C detection range and limit. Importantly, each type of microfluidic chip is integrated with a custom-developed portable reader as PoC test prototypes. In validation studies using serum samples from CKD patients, both chip tests showed a similar agreement level with the traditional well plate-based immunoturbidity assay test results. As an integrated PoC test system, the microfluidic CYS-C paper chip test showed higher accuracy in determining the eGFR range based on several clinically relevant grouping criteria compared to the turbidity chip test. Collectively, these integrated microfluidic assays offer practical solutions for decentralized PoC diagnostic tests of CKD with competitive advantages over existing methods.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"448 ","pages":"Article 138880"},"PeriodicalIF":3.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI-enabled self-powered humidity sensors based on PVA/CNTs/Mg(NO3)2 composites for smart applications 基于PVA/CNTs/Mg(NO3)2复合材料的人工智能自供电湿度传感器，用于智能应用

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-08 DOI: 10.1016/j.snb.2025.138932

Galang Eryanto , Shih-Feng Tseng , Chien-Yao Huang

{"title":"AI-enabled self-powered humidity sensors based on PVA/CNTs/Mg(NO3)2 composites for smart applications","authors":"Galang Eryanto , Shih-Feng Tseng , Chien-Yao Huang","doi":"10.1016/j.snb.2025.138932","DOIUrl":"10.1016/j.snb.2025.138932","url":null,"abstract":"<div><div>This research introduces the creation and thorough assessment a flexible self-powered humidity sensor based on a PVA/CNTs/Mg(NO<sub>3</sub>)<sub>2</sub> composite, designed in a sandwich configuration with aluminum and copper adhesive tape electrodes, synthesized via the freeze-thaw technique to enhance mechanical stability and flexibility. The sensor leverages the hydrophilic and degradable properties of polyvinyl alcohol (PVA), the conductive pathways of carbon nanotubes (CNTs), and the high ionic conductivity of magnesium nitrate (Mg(NO<sub>3</sub>)<sub>2</sub>) to achieve efficient moisture adsorption and ion migration, generating stable voltage outputs with range of 11–97 %. Material characterization through XRD, SEM, FTIR, and water contact angle measurements confirms the composite structural integrity, uniform morphology, and controlled hydrophilicity, while electrochemical analysis reveals a peak voltage of 0.6 V at 97 % RH and response/recovery times of 12 and 16 s, respectively, with minimal hysteresis (3.5 % RH) and sustained stability over 500 min. The sensor demonstrates recyclability through water dissolution of the composite within 180 min, albeit with a 12.1 % performance reduction (from 0.58 V to 0.51 V), and versatility in applications such as touch sensing, non-contact detection up to 8 mm, and differentiation of bare versus gloved hand interactions. Integration of machine learning, with the Gated Recurrent Unit (GRU) model achieving an MSE of 0.0001 and R² of 0.9991, enhances humidity prediction accuracy by leveraging the sensor dynamic voltage responses. These findings establish the PVA/CNTs/Mg(NO<sub>3</sub>) sensor as a robust, eco-friendly platform for wearable and environmental monitoring, with significant implications for sustainable sensing technologies and opportunities for further optimization in recycling efficiency and predictive modeling.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"448 ","pages":"Article 138932"},"PeriodicalIF":3.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-functionality in one MOF: Tailored AuNC@MOF hybrids with synergistic oxidase-mimetic activity and fluorescence amplification for multi-modal tannic acid sensing 一个MOF的双重功能：量身定制的AuNC@MOF杂交品种，具有协同氧化酶模拟活性和荧光扩增，可用于多模态单宁酸感应

IF 3.7 1区化学

Sensors and Actuators B: Chemical Pub Date : 2025-10-08 DOI: 10.1016/j.snb.2025.138935

Shun Wang , Beibei Han , Guoming Sun , Mengke Wang , Qing Li

{"title":"Dual-functionality in one MOF: Tailored AuNC@MOF hybrids with synergistic oxidase-mimetic activity and fluorescence amplification for multi-modal tannic acid sensing","authors":"Shun Wang , Beibei Han , Guoming Sun , Mengke Wang , Qing Li","doi":"10.1016/j.snb.2025.138935","DOIUrl":"10.1016/j.snb.2025.138935","url":null,"abstract":"<div><div>The development of multi-mode sensors for target detection has gained significant attention due to their enhanced accuracy and versatility. In this study, a fluorescent nanozymes composite (AuNC@CeMOF) was fabricated via self-assembly, combining orange-emitting gold nanoclusters (AuNC) with the cerium-based metal-organic framework (CeMOF) exhibiting intrinsic oxidase-like activity. Notably, the fluorescence properties of AuNC were significantly enhanced due to the confinement effect of CeMOF, improving sensor performance. Under optimized conditions, the dual-mode sensing platform, leveraging both the oxidase-mimicking activity and the enhanced fluorescence of AuNC@CeMOF, enabled the highly sensitive detection of tannic acid (TA). The sensor demonstrated a linear response range and an ultra-low detection limit, surpassing many conventional methods. Furthermore, the integration of smartphone-based analysis facilitated portable, on-site TA detection. This work highlights the feasibility of designing multifunctional nanozyme composites by synergizing fluorescence enhancement and enzyme-mimicking properties, offering a promising strategy for the discrimination and quantification of TA in complex samples.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"448 ","pages":"Article 138935"},"PeriodicalIF":3.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0