Sensors and Actuators B: Chemical最新文献

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An automated scanning contactless conductivity detection device for microfluidic isoelectric focusing 用于微流体等电聚焦的自动扫描式非接触电导检测装置
IF 8 1区 化学
Sensors and Actuators B: Chemical Pub Date : 2025-01-27 DOI: 10.1016/j.snb.2025.137308
Haozheng Dai , Youli Tian , Zhimin Tao , Ke-Er Chen , Weiwen Liu , Qiang Zhang , Chengxi Cao
{"title":"An automated scanning contactless conductivity detection device for microfluidic isoelectric focusing","authors":"Haozheng Dai ,&nbsp;Youli Tian ,&nbsp;Zhimin Tao ,&nbsp;Ke-Er Chen ,&nbsp;Weiwen Liu ,&nbsp;Qiang Zhang ,&nbsp;Chengxi Cao","doi":"10.1016/j.snb.2025.137308","DOIUrl":"10.1016/j.snb.2025.137308","url":null,"abstract":"<div><div>Isoelectric focusing (IEF) is widely used for protein separation and enrichment, with various methods available for detecting focused protein bands. While conventional capacitively coupled contactless conductivity detection (C<sup>4</sup>D) reduced costs and enhanced portability by eliminating optical equipment, it still required an additional mobilization step due to its single-point detection method. To address this limitation, herein we designed a novel device of scanning C<sup>4</sup>D (sC<sup>4</sup>D) for microfluidic IEF. At first, we developed an automated device of sC<sup>4</sup>D which was integrated with IEF chip for protein separation. Second, we designed the relevant software for system control and real-time conductivity measurement. Third, by using equine myoglobin as a model protein we achieved quantitative detection with a linear range of 0.2–2.5 mg/mL and a limit of detection (LOD) of 0.05 mg/mL, demonstrating the feasibility of the method and platform. In contrast to the conventional C<sup>4</sup>D with single-point detection, the developed sC<sup>4</sup>D could reduce the detection time of protein band from 760 sec to 25 sec without chemical or pressure mobilization of pH gradient, and without significant deterioration of resolution, and particularly could monitor the dynamic process of IEF and cathode drift of pH gradient. These results indicate that the designed sC<sup>4</sup>D device might serve as a reliable alternative for microfluidic IEF detection and holds significant potential for applications in various electrophoretic analysis fields in the future.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"430 ","pages":"Article 137308"},"PeriodicalIF":8.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-atom transition metals doping in N-doped hollow carbon spheres for high-performance organic gas sensing 在掺杂 N 的中空碳球中掺入单原子过渡金属,实现高性能有机气体传感
IF 8 1区 化学
Sensors and Actuators B: Chemical Pub Date : 2025-01-27 DOI: 10.1016/j.snb.2025.137328
Ming Hong , Xuzi Cong , Likai Wang , Yeong Don Park
{"title":"Single-atom transition metals doping in N-doped hollow carbon spheres for high-performance organic gas sensing","authors":"Ming Hong ,&nbsp;Xuzi Cong ,&nbsp;Likai Wang ,&nbsp;Yeong Don Park","doi":"10.1016/j.snb.2025.137328","DOIUrl":"10.1016/j.snb.2025.137328","url":null,"abstract":"<div><div>Organic gas sensors have attracted considerable interest owing to their promising applications in environmental monitoring and industrial operations. However, the inherent low mobility and stability of conjugated polymers limit their effectiveness in gas sensing. In this study, we explore the enhancement of organic gas sensor performance by doping transition metals (Ni and Cu) into nitrogen-doped 3D hollow carbon spheres (NHCS). NHCS, a carbon-based material, stands out for its exceptional electrical conductivity, extensive surface area, and robust chemical stability, positioning it as a promising choice for sensor applications. Its gas-sensing efficiency can be further enhanced through the incorporation of single-atom transition-metal dopants. Our experimental results demonstrate that the high porosity of NHCS serves as an efficient gas diffusion channel, enabling enhanced penetration of gas molecules into the active layer. Moreover, the single-atom transition-metal sites exhibit strong chemisorption properties, surpassing the binding strength of physical adsorption. The NHCS-blended sensor co-doped with Ni and Cu exhibited the most promising gas-sensing performance. This improvement is attributed to the synergistic effects of nitrogen doping and the dual transition-metal dopants, which contribute to selective NO<sub>2</sub> detection. These results indicate a valuable direction for advancing gas-sensing devices with enhanced sensitivity and selectivity.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"430 ","pages":"Article 137328"},"PeriodicalIF":8.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PEC-EC dual-mode biosensing platform for PFOA assay based on competitive binding between HSA and PFOA or hemin
IF 8 1区 化学
Sensors and Actuators B: Chemical Pub Date : 2025-01-27 DOI: 10.1016/j.snb.2025.137326
Hejie Zheng , Linghe Bai , Cuicui Du, Xiaohua Zhang, Jinhua Chen
{"title":"PEC-EC dual-mode biosensing platform for PFOA assay based on competitive binding between HSA and PFOA or hemin","authors":"Hejie Zheng ,&nbsp;Linghe Bai ,&nbsp;Cuicui Du,&nbsp;Xiaohua Zhang,&nbsp;Jinhua Chen","doi":"10.1016/j.snb.2025.137326","DOIUrl":"10.1016/j.snb.2025.137326","url":null,"abstract":"<div><div>Perfluorooctanoic acid (PFOA), a typical persistent per- and poly-fluoroalkyl substance (PFAS), may accumulate in the body and cause various human health problems. Herein, a novel photoelecrochemical (PEC)-electrochemical (EC) dual-mode biosensing platform has been developed for PFOA assay based on the competitive binding between amino-modified magnetic beads (MB)@human serum albumin (HSA) (MB@HSA) and hemin or PFOA. Through co-incubation of MB@HSA with PFOA and hemin, the MB@HSA-hemin-PFOA conjugates were obtained and collected by magnetic separation and then introduced onto the surface of the ZnCdS@ZnIn<sub>2</sub>S<sub>4</sub>-modified ITO electrode. After that, the PEC and EC measurements were carried out to achieve sensitive and accurate dual-mode detection of PFOA, based on the hemin-induced photocurrent enhancement of the ZnCdS@ZnIn<sub>2</sub>S<sub>4</sub> heterojunction and the electrochemical properties of hemin. The developed PEC-EC dual-mode biosensing platform exhibited good selectivity, reproducibility and sensitivity with linear response ranges of 10 nM – 1 μM (PEC)/5 nM – 1 μM (EC) and detection limits of 8.71 nM (PEC)/1.46 nM (EC). The magnetic-assisted PEC-EC dual-mode sensing platform provides a new analytical route for the detection of PFOA in water samples and a new reference for environmental monitoring of PFOA.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"429 ","pages":"Article 137326"},"PeriodicalIF":8.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quartz crystal tuning fork enhanced spectroscopy with self-calibration algorithms
IF 8 1区 化学
Sensors and Actuators B: Chemical Pub Date : 2025-01-27 DOI: 10.1016/j.snb.2025.137344
Junya Du, Siyuan Xia, Keren Cheng, Minghui Zhang, Jingsong Li
{"title":"Quartz crystal tuning fork enhanced spectroscopy with self-calibration algorithms","authors":"Junya Du,&nbsp;Siyuan Xia,&nbsp;Keren Cheng,&nbsp;Minghui Zhang,&nbsp;Jingsong Li","doi":"10.1016/j.snb.2025.137344","DOIUrl":"10.1016/j.snb.2025.137344","url":null,"abstract":"<div><div>In this paper, a gas sensing technique based on quartz crystal tuning fork (QCTF) enhanced spectroscopy was reported with self-calibration algorithms by combing two key factors of resonant frequency and quality factor. To demonstrate this proposed gas sensing technique, methane (CH<sub>4</sub>) was selected as the target gas, a gas sensor system based on near-infrared distributed feedback (DFB) diode laser near 1653 nm was developed by combining wavelength modulation spectroscopy (WMS) with second harmonic (2 f) signal detection technique. A hybrid single-frequency modulation algorithm was developed for real-time tracking the QCTF resonance profile, and a quality factor-based calibration algorithm model was developed for calibrating the 2 f signal amplitude on pressure of the QCTF detector working environment. Comparing to traditional scanning modulation frequency method (typical 30 s), the proposed self-calibration algorithms can realize resonant frequency calibration with 1 s response time, and a measurement error less than 1 % can be achieved within a large dynamic pressure change of 320 mbar, which shows a time resolution improvement of 30 times and a good adaptability to the field application.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"430 ","pages":"Article 137344"},"PeriodicalIF":8.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic organoiridium nanocatalysts activate fluorescence biosensors
IF 8 1区 化学
Sensors and Actuators B: Chemical Pub Date : 2025-01-27 DOI: 10.1016/j.snb.2025.137333
Li-Jun Zhao , Qing Zhou , Na Zhou , Shixin Zhang , Yue Yang , Chao Shi , Yanhong Li , Feng Luan , Chunyuan Tian , Peng Xiao , Xuming Zhuang
{"title":"Magnetic organoiridium nanocatalysts activate fluorescence biosensors","authors":"Li-Jun Zhao ,&nbsp;Qing Zhou ,&nbsp;Na Zhou ,&nbsp;Shixin Zhang ,&nbsp;Yue Yang ,&nbsp;Chao Shi ,&nbsp;Yanhong Li ,&nbsp;Feng Luan ,&nbsp;Chunyuan Tian ,&nbsp;Peng Xiao ,&nbsp;Xuming Zhuang","doi":"10.1016/j.snb.2025.137333","DOIUrl":"10.1016/j.snb.2025.137333","url":null,"abstract":"<div><div>Here, we developed the cyclodextrin-organoiridium-functionalized magnetic nanocatalyst <strong>MBs@CD@Ir</strong> by assembling highly active adamantane-functionalized pyridinamide organoiridium complexes <strong>PicPh-Ada-Ir</strong> and cyclodextrin-modified magnetic nanoparticles <strong>MBs@CD</strong>, which could efficiently catalyze quinone hydrogenation using the cofactor NADH as a hydrogen source under physiological conditions. Furthermore, by combining the developed catalysts <strong>MBs@CD@Ir</strong> and the quinone hydrogenation-triggered Rhodamine 110-type fluorescence probe <strong>Q-Rho 110</strong>, we successfully established a sensitive cofactor NADH fluorescence sensor, which showed superior hydrogenation performance for quinone when NADH was used as a hydrogen source. The established sensor presented excellent detection performance for NADH with a limit of detection (LOD) of 4.18 nM and was successfully applied to NADH detection in <em>Escherichia coli</em> fermentation broth. The established sensor has successfully expanded the application of organometallic catalysts in biosensing and provides a new approach for the design of other sensors.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"430 ","pages":"Article 137333"},"PeriodicalIF":8.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellulose acetate and reduced graphene oxide (rGO)-based flexible humidity sensor for monitoring human respiration
IF 8 1区 化学
Sensors and Actuators B: Chemical Pub Date : 2025-01-27 DOI: 10.1016/j.snb.2025.137291
Ruiyang Zhao , Dong Xie , Sun Qing , Baolong Zhu , Wei Shen , Lixin Wang , Xiangmin Meng , Jinhui Pang
{"title":"Cellulose acetate and reduced graphene oxide (rGO)-based flexible humidity sensor for monitoring human respiration","authors":"Ruiyang Zhao ,&nbsp;Dong Xie ,&nbsp;Sun Qing ,&nbsp;Baolong Zhu ,&nbsp;Wei Shen ,&nbsp;Lixin Wang ,&nbsp;Xiangmin Meng ,&nbsp;Jinhui Pang","doi":"10.1016/j.snb.2025.137291","DOIUrl":"10.1016/j.snb.2025.137291","url":null,"abstract":"<div><div>Humidity plays a vital role in our daily life and various agro-industrial productions, and humidity sensors have been widely applied in various fields. In this study, flexible, rapid-response, and directly readable composite humidity sensing films were fabricated, employing cellulose (water-soluble cellulose acetate (WSCA)) as moisture sensing layers and reduced graphene oxide (rGO) as resistive conductive layers. The rGO/WSCA composite film can be used as a new type of humidity-sensitive material for the development of humidity sensors. It has been confirmed that abundant hydroxyl groups in WSCA provided abundant adsorption sites and made the composite film highly sensitive to moisture. In addition, WSCA also be used as the dispersant, which could efficiently reduce lamellar accumulation of rGO during the reduction to form a tightly ordered brick-mortar microstructure of rGO/WSCA composite film. The ordered microstructure makes the composite films exhibit a satisfactory mechanical strength (339.5 MPa). Moreover, the rGO/WSCA film sensor could respond quickly within seconds and exhibited low hysteresis towards changes in RH from 23 % to 97 %, and the repeatable error was less than 2.3 % after 6 cycles. Further, the rGO/WSCA humidity sensor could monitor and recognize human respiratory frequency in different states, indicating its potential application in versatile noncontact humidity sensing fields.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"429 ","pages":"Article 137291"},"PeriodicalIF":8.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CRISPR/dCas9-assisted SERS sensing for transgenic crops based on two-factor verification of 35S promoter and Nos terminator
IF 8 1区 化学
Sensors and Actuators B: Chemical Pub Date : 2025-01-27 DOI: 10.1016/j.snb.2025.137293
Ailing Su , Ziqi Chen , Weiqing Xu , Chongyang Liang , Xiangguo Liu , Shuping Xu
{"title":"CRISPR/dCas9-assisted SERS sensing for transgenic crops based on two-factor verification of 35S promoter and Nos terminator","authors":"Ailing Su ,&nbsp;Ziqi Chen ,&nbsp;Weiqing Xu ,&nbsp;Chongyang Liang ,&nbsp;Xiangguo Liu ,&nbsp;Shuping Xu","doi":"10.1016/j.snb.2025.137293","DOIUrl":"10.1016/j.snb.2025.137293","url":null,"abstract":"<div><div>A nucleic acid analysis platform was built based on the combination of the recombinase polymerase amplification (RPA)-aided CRISPR/dCas9 and surface-enhanced Raman scattering (SERS) technologies, which enables the simultaneous detection of dual nucleic acid fragments, for the purpose of identifying transgenic crops. Two SERS-active nanoprobes (AgNP@Ra@dCas9/sgRNA) were fabricated by grafting the single RNA (sgRNA)-activated dCas9 protein to silver nanoparticles that have been decorated with two different Raman reporters (Ra). RPA primers endow target genes with biotin end that can be captured by the streptavidin-modified magnetic bead (MB@SA), followed by the conjugation of SERS nanoprobes. Thus, strong SERS signals would be detected above the MBs. This SERS platform has been applied for identifying transgenic crops based on the sequence designs specifically for the 35S promoter and Nos terminator simultaneously. Double confirmation of target genes can ensure the accuracy of detection. The whole sensing process, including RPA, dCas9 activation, and target gene identification, can be completed in one tube, within 80 min. This CRISPR/dCas9-SERS analytical platform has been proved to be feasible in detecting plant samples, indicating one successful attempt of the CRISPR/dCas9-SERS systems in multi-target detection.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"429 ","pages":"Article 137293"},"PeriodicalIF":8.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Solvatochromic Aluminum-1,8-Naphthalimide Complex 2D Nanostructure as a Versatile Probe for Sudan III Detection and Forensic Analysis 溶解变色的 1,8-萘二甲酰亚胺铝络合物二维纳米结构作为苏丹 III 检测和法医分析的多功能探针
IF 8.4 1区 化学
Sensors and Actuators B: Chemical Pub Date : 2025-01-27 DOI: 10.1016/j.snb.2025.137336
Priyanka Rana, Deepak Dabur, Hui-Fen Wu
{"title":"A Solvatochromic Aluminum-1,8-Naphthalimide Complex 2D Nanostructure as a Versatile Probe for Sudan III Detection and Forensic Analysis","authors":"Priyanka Rana, Deepak Dabur, Hui-Fen Wu","doi":"10.1016/j.snb.2025.137336","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137336","url":null,"abstract":"This study focuses on the development of a 2D nanostructure-based aluminum complex with 1,8-naphthalimide (Al-Nap) that exhibits negative solvatochromism and bright green fluorescence, emitting around 500<!-- --> <!-- -->nm when excited at 390<!-- --> <!-- -->nm. The Al-Nap complex was applied for the detection of Sudan III dye, a potential Class III carcinogen still illegally used in cosmetics and food, with a detection limit of 11<!-- --> <!-- -->nM and a linear range of 100<!-- --> <!-- -->nM to 250<!-- --> <!-- -->µM. The quenching of fluorescence is driven by a distinct interaction between Al-Nap NSs and Sudan III, primarily due to the Inner Filter Effect (IFE) followed by the reduction of Sudan III. Importantly, the Al-Nap complex also functions as a reductase, catalyzing the Sudan III into its reduced form, which further enhances the quenching effect. This dual functionality not only facilitates highly sensitive detection but also underscores the versatility of the Al-Nap complex in chemical sensing. Additionally, the derived fluorescent powder shows promise in latent fingerprint detection, highlighting its potential for advanced fluorescence-based sensors in both chemical sensing and forensic analysis.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"14 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Respirometric sensor vials for rapid and selective detection of coliforms in raw milk
IF 8 1区 化学
Sensors and Actuators B: Chemical Pub Date : 2025-01-27 DOI: 10.1016/j.snb.2025.137300
Ali Abdallah , Sophia Elisseeva , Loris Pinto , Federico Baruzzi , Dmitri B. Papkovsky , Elisa Santovito
{"title":"Respirometric sensor vials for rapid and selective detection of coliforms in raw milk","authors":"Ali Abdallah ,&nbsp;Sophia Elisseeva ,&nbsp;Loris Pinto ,&nbsp;Federico Baruzzi ,&nbsp;Dmitri B. Papkovsky ,&nbsp;Elisa Santovito","doi":"10.1016/j.snb.2025.137300","DOIUrl":"10.1016/j.snb.2025.137300","url":null,"abstract":"<div><div>Traditional microbiological methods for coliforms detection, such as the Most Probable Number (MPN) assays, are as essential for food hygiene and safety as they are time-consuming and labor-intensive. We propose a new methodology for the rapid and sensitive detection and enumeration of coliforms in raw milk, which uses disposable 30 mL respirometric vials with built-in oxygen sensors and a handheld autonomous reader. Milk samples are added in sensor vials containing selective media and incubated at 37 °C with hourly readings of the sensor signals with FirestingO2 (Pyroscience) until the preset sensor signal threshold is reached, thus indicating cell growth and viability. The resulting time to threshold (TT, h) is then calculated and used to determine coliforms load in the milk sample by applying pre-determined calibration equation(s). Three versions of the sensor vial based coliform test were assessed: one-step assay in M-lauryl sulphate Broth (LSB), one-step assay in Brilliant Green Bile Lactose Broth (BGB) and the two-step sequential assay in LSB followed by BGB broths. The results of the sensor vials tests were benchmarked against the standard MPN ISO4831:2006 method for coliform detection, showing strong statistical correlation (demonstrated by correlation analysis), and time to result reduced more than 2-fold (≤11 h vs 24–72 h). Microbial isolates from the sensor vial tests were also analyzed by 16S rRNA sequencing, confirming the selectivity and accuracy of the respirometry technique. Thus, offering rapid results, ease of use, real-time monitoring, on-site deployment, cost and labor-saving capabilities, the sensor vial test provides an attractive alternative to traditional methods of coliform testing in milk and dairy products.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"429 ","pages":"Article 137300"},"PeriodicalIF":8.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vibration induced flow facilitating immunoagglutination for rapid detection and quantification of nanoparticles
IF 8 1区 化学
Sensors and Actuators B: Chemical Pub Date : 2025-01-27 DOI: 10.1016/j.snb.2025.137312
Kanji Kaneko , Mamiko Tsugane , Taku Sato , Takeshi Hayakawa , Yosuke Hasegawa , Hiroaki Suzuki
{"title":"Vibration induced flow facilitating immunoagglutination for rapid detection and quantification of nanoparticles","authors":"Kanji Kaneko ,&nbsp;Mamiko Tsugane ,&nbsp;Taku Sato ,&nbsp;Takeshi Hayakawa ,&nbsp;Yosuke Hasegawa ,&nbsp;Hiroaki Suzuki","doi":"10.1016/j.snb.2025.137312","DOIUrl":"10.1016/j.snb.2025.137312","url":null,"abstract":"<div><div>The detection of bioactive nanoparticles (NPs) plays an important role in the medical and diagnostic fields. Conventional techniques for the sensitive detection of target NPs must overcome challenges such as long processing time, complex sample preparation, and high cost. Here, we show that vibration-induced flow (VIF), in which a local flow is induced around microscopic objects by applying small periodic vibrations, can facilitate immunoagglutination to realize rapid, facile, sensitive, and low-cost detection of NPs in a minute sample. In the proposed system, the presence of NPs in a minute sample fluid is detected by the formation of aggregates of affinity microparticles (MPs) stirred by the VIF within a short time (approximately 15 min). The concentration of NPs can be quantified using the average area of aggregates observed in bright-field microscopic images. Finally, we demonstrate the detection of extracellular vesicles (EVs) to validate the applicability of the proposed system in diagnostic applications.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"430 ","pages":"Article 137312"},"PeriodicalIF":8.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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