Hanyang Ji , Renze Zhang , Lu Kong , Zhenyu Yuan , Fanli Meng
{"title":"A detection method for industrial methanol and ethanol two-component gas leakage based on transient response sequence","authors":"Hanyang Ji , Renze Zhang , Lu Kong , Zhenyu Yuan , Fanli Meng","doi":"10.1016/j.snb.2026.139563","DOIUrl":"10.1016/j.snb.2026.139563","url":null,"abstract":"<div><div>This study addresses the challenge of rapid methanol and ethanol leakage monitoring during coke oven gas conversion by proposing a transient response sequence method based on a semiconductor gas sensor for fast qualitative and quantitative analysis of binary mixtures. Using programmed temperature ramping (0–6 V, 50 s, 0.12 V/s), distinct characteristic peaks were identified at 4.70 V for methanol and 4.38 V for ethanol, enabling reliable gas discrimination. First-order differential processing enhanced methanol detection specificity in mixtures. A two-dimensional concentration estimation model based on dual peak amplitudes was established using Rational2D fitting, achieving average errors of 5.74 % for methanol and 1.64 % for ethanol. The method exhibits high speed and accuracy, showing strong potential for rapid multi-component gas analysis in industrial settings.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139563"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146098443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lipeng Zhong , Kun Liang , Weifeng Liu , Zhijie Tang , Lanbo Wang , Sheng Hu , Feng Wang
{"title":"Short-period temperature modulation for drift suppression and enhanced recognition performance in gas sensor","authors":"Lipeng Zhong , Kun Liang , Weifeng Liu , Zhijie Tang , Lanbo Wang , Sheng Hu , Feng Wang","doi":"10.1016/j.snb.2026.139617","DOIUrl":"10.1016/j.snb.2026.139617","url":null,"abstract":"<div><div>Temperature modulation (TM) techniques have been widely employed in semiconductor gas sensors to enhance gas selectivity. However, inappropriate temperature control during TM can lead to drift-like effects, negatively impacting the accuracy of gas detection and concentration estimation. Existing drift-compensation methods exhibit high sensitivity to parameter tuning and limited adaptability, restricting their effectiveness in real-time sensing applications. In this study, we propose a hardware-level control strategy based on short-period temperature modulation, aiming to fundamentally suppress drift by compressing reaction time windows, thereby reducing thermal accumulation and residual formation. Experimental results indicate that, without any additional post-processing, the short-period (1 s) modulation achieves superior classification accuracy and concentration regression performance compared with the conventional long-period (40 s) modulation. Specifically, concentration regression error is reduced by approximately 68% on average. Even when compared with the algorithmically compensated 40 s dataset, regression error is further decreased by around 10%. This research provides not only a systematic parameter-optimization framework for TM cycle design but also a practical hardware solution for developing artificial olfactory systems characterized by high stability and minimal drift.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139617"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chuanxuan Zhou , Jun Min , Linchuan Zuo , Fuchao Yang , Zhiguang Guo
{"title":"Corrigendum to “Defect-engineered WO3-X pollen-like architectures for highly sensitive and selective detection of Listeria biomarkers” [Sens. Actuators B Chem. 451 (2026) 139331]","authors":"Chuanxuan Zhou , Jun Min , Linchuan Zuo , Fuchao Yang , Zhiguang Guo","doi":"10.1016/j.snb.2026.139609","DOIUrl":"10.1016/j.snb.2026.139609","url":null,"abstract":"","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139609"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146153227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiwoo Choi , Sungmin Kim , Qute Choi , Hyun Jin Kim , Hyun Kyu Yoon , In Hyuk Chung , Junho Maeng
{"title":"GenHome®: Development of a next-generation all-in-one molecular point-of-care testing platform with high sensitivity and accessibility","authors":"Jiwoo Choi , Sungmin Kim , Qute Choi , Hyun Jin Kim , Hyun Kyu Yoon , In Hyuk Chung , Junho Maeng","doi":"10.1016/j.snb.2026.139590","DOIUrl":"10.1016/j.snb.2026.139590","url":null,"abstract":"<div><div>SARS-CoV-2 (COVID-19) pandemic has highlighted the need for rapid and accurate molecular point-of-care testing (mPOCT). Here, we describe the development of GenHome®, a fully integrated, single-use cartridge platform that performs sample loading, direct nucleic-acid preparation, loop-mediated isothermal amplification (LAMP), and lateral-flow readout within a closed-system workflow, minimizing user intervention and providing results within 30 min. As the first cartridge of its type, we validated the GenHome® SARS-CoV-2 cartridge targeting the ORF1ab gene from SARS-CoV-2. Under optimized conditions (65 °C, 20 min), GenHome® achieved a limit of detection (LoD) of 194 copies/µL by probit analysis. Furthermore, analytical specificity testing revealed no cross-reactivity against a respiratory panel consisting of 33 viruses. Lastly, clinical evaluation of 466 nasopharyngeal specimens pre-verified by RT-PCR revealed a positive percentage agreement (PPA) of 94.7 %, negative percentage agreement (NPA) of 92.6 %, and overall agreement of 92.8 %. Moreover, Ct-stratified analysis demonstrated PPA of 100 % for Ct < 30, 88.9 % for 30 ≤ Ct ≤ 35, and 30 % for Ct > 35. These findings highlight the potential of GenHome® to deliver high clinical concordance with RT-PCR while retaining the ease-of-use and rapid turnaround critical for mPOCT. With its cartridge-integrated design and room-temperature-stable workflow, GenHome® is well-suited for widespread applications across diverse infectious-disease diagnostic applications.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139590"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dehao Jia , Yu Du , Jingshuai Li , Shu-yuan Liu , Jingui Chen , Binnan Shi , Xuejing Liu , Rui Feng , Qin Wei
{"title":"Silver aerogel-confined gold nanoclusters as electrochemiluminescence emitter and co-reaction promoter integrated with enzyme-free catalytic DNA amplification for ultrasensitive detection of aflatoxin B1","authors":"Dehao Jia , Yu Du , Jingshuai Li , Shu-yuan Liu , Jingui Chen , Binnan Shi , Xuejing Liu , Rui Feng , Qin Wei","doi":"10.1016/j.snb.2026.139599","DOIUrl":"10.1016/j.snb.2026.139599","url":null,"abstract":"<div><div>Gold nanoclusters (AuNCs) have garnered attention for their unique optical properties and biocompatibility, positioning them as promising electrochemiluminescence (ECL) emitters. However, the low ECL efficiency resulting from ligand rotation significantly hinders their broader application in biosensing technologies. Herein, AuNCs were loaded into silver aerogels (Ag AGs) via the synergistic aggregation of Ag AGs and citric acid (CA), yielding the ECL emitter (CA/AuNCs@Ag AGs) with integrated catalytic and luminescent properties. Firstly, Ag AGs could effectively aggregate AuNCs, which hindered the free rotation of AuNCs ligands, thereby reducing nonradiative energy dissipation and enhancing ECL efficiency. Secondly, Ag AGs could act as a co-reactant accelerator by catalyzing the conversion of more persulfate ions (S<sub>2</sub>O<sub>8</sub><sup>2-</sup>) to sulfate radicals (SO<sub>4</sub><sup>•-</sup>), thereby further enhancing the ECL intensity. Additionally, an enzyme-free dual-cycle strategy was designed to efficiently correlate trace amounts of aflatoxin B1 (AFB1) with the generation of abundant quencher-bearing DNA strands through the catalytic hairpin assembly reaction, while simultaneously achieving ultrasensitive detection of AFB1 via highly efficient ECL resonance energy transfer. The developed biosensor exhibited a wide linear range from 1 pg/mL to 100 ng/mL and an impressive low detection limit of 0.23 pg/mL. This method not only provides a new idea for the development of high-performance ECL emitters but also possesses potential application in the field of trace biomarker detection.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139599"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A local symmetric pattern-based actuation algorithm (L-SPAA) for contact charge electrophoresis-based digital microfluidic systems","authors":"Seo Jun Bae, Seon Jun Lee, Do Jin Im","doi":"10.1016/j.snb.2026.139618","DOIUrl":"10.1016/j.snb.2026.139618","url":null,"abstract":"<div><div>To address the challenges of traditional electrode polarity control algorithms and to propose a standardized framework for droplet manipulation in contact charge electrophoresis-based digital microfluidic systems that has not been previously established, to the best of our knowledge, we developed a local symmetric pattern-based electrode polarity control algorithm founded on a generalized, streamlined, and efficient control framework. This algorithm employs an initial electrode polarity arrangement in which positive and negative polarities alternate across the array. A simple modification of this initial state generates a unique configuration that consistently maintains a centrally focused and symmetrically aligned polarity arrangement, enabling direction- and path-independent manipulation of droplets. By generalizing this unique configuration, the developed algorithm significantly improves the efficiency and reliability of droplet manipulation by reducing the complexity associated with the numerous polarity assignment cases inherent to traditional algorithms. In addition, to achieve generalized manipulation of multiple droplets, an actuation strategy based on assigning priorities to individual droplets was introduced. Furthermore, we successfully demonstrated multi-droplet coalescence using the developed algorithm, and performed quantitative performance comparisons with existing algorithms to verify its usefulness and practical applicability. Finally, the generalization of droplet manipulation enabled by the developed algorithm is expected to expand the applicability of contact charge electrophoresis technology across a wide range of research fields.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139618"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146153229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Systematic optimization of aptamer self-assembly on graphene transistor gates for rapid detection of chloramphenicol residues in milk","authors":"Songjia Luo , Xianzhi Dou , Lu Wang , Lei Zheng","doi":"10.1016/j.snb.2026.139574","DOIUrl":"10.1016/j.snb.2026.139574","url":null,"abstract":"<div><div>Chloramphenicol (CAP) residues in milk pose severe health risks, yet current detection methods (e.g., chromatography-mass spectrometry) suffer from complexity and high costs. In this work, we address this gap by developing an ultrasensitive aptamer-gated graphene Field-effect biosensor. A self-assembled Aptamer-functionalized solution-gated graphene transistor (Apt-SGGT) was engineered via systematic optimization of aptamer surface density to overcome spatial-confinement limitations and enhance conformational switching efficiency. We applied the Apt-SGGT biosensor to the analytical determination of CAP in actual skim milk samples, achieving a detection limit as low as 21.5 pM with a spiked recovery rate of 97.65 % ± 5.72 %. This study not only presents a promising platform for the rapid, on-site detection of antibiotic residues in complex food matrices but also provides a generalizable interfacial engineering strategy to enhance the performance of aptamer-based field-effect biosensors.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139574"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sensitive label-free SERS detection of cTnI enabled by epitope molecularly imprinted polymer based on host-guest interaction of cyclodextrin and ferrocene","authors":"Yitong Xu , Yaming Zhao , Qiong Jia","doi":"10.1016/j.snb.2026.139601","DOIUrl":"10.1016/j.snb.2026.139601","url":null,"abstract":"<div><div>Cardiac troponin I (cTnI) is a key disease biomarker for acute myocardial infarction; therefore, it is crucial to selectively enrich cTnI in complex samples and accurately detect it. Molecularly imprinted polymers combined with surface-enhanced Raman scattering (MIP-SERS) hold promise for applications in protein detection. However, the technology often suffers from low imprinting efficiency and detection complexity. Herein, we developed an epitope-oriented MIP based on host-guest interaction (hg-EMIP) between <em>β-</em>cyclodextrin and ferrocene, as well as constructed a novel hg-EMIP-label-free SERS assay. The template immobilization was achieved through host-guest recognition, followed by imprinted layer synthesis using multiple functional monomers. The resulting hg-EMIP exhibits high specificity toward cTnI, with superior imprinting factor and reusability. The developed hg-EMIP-label-free SERS assay enables sensitive and rapid detection of cTnI without extrinsic nanotags, possesses a wide linear range (10<sup>−3</sup>-10<sup>3</sup> ng/mL), and can be successfully used for the detection of cTnI in human serum samples. hg-EMIP is promising for the isolation of targets, and label-free SERS assay based on hg-EMIP is highly potential in the area of disease biomarker detection.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139601"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146139045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Runqiu Wang , Ying He , Shunda Qiao , Chu Zhang , Haiyue Sun , Jinxing Liang , Yufei Ma
{"title":"Quartz-enhanced laser spectroscopy based on grooved quartz tuning forks: Design, optimization, and characterization","authors":"Runqiu Wang , Ying He , Shunda Qiao , Chu Zhang , Haiyue Sun , Jinxing Liang , Yufei Ma","doi":"10.1016/j.snb.2026.139581","DOIUrl":"10.1016/j.snb.2026.139581","url":null,"abstract":"<div><div>Quartz-enhanced laser spectroscopy, including quartz-enhanced photoacoustic spectroscopy (QEPAS) and light-induced thermoelastic spectroscopy (LITES), has become a research focus in the trace gas sensing field. This study developed a systematic approach for designing, optimizing, and characterizing grooved quartz tuning forks (QTFs) for quartz-enhanced laser spectroscopy. We combined theoretical modeling, finite element simulation, and experimental investigation to develop a comprehensive method for designing high-performance grooved QTFs by controlling the groove dimensions, including its depth, width, and shape. Experimental investigations revealed that rectangular grooves with a depth of 22 μm and a width of 1237.5 μm produced the strongest signals in both QEPAS and LITES systems, achieving SNR improvements of 1.45 times and 1.75 times, respectively, compared to conventional ungrooved QTFs. For isosceles-trapezoidal grooves, the positive isosceles-trapezoidal (PI) configuration consistently surpassed the inverted isosceles-trapezoidal (II) design across all tested depths. The 44 μm-deep PI grooved QTF demonstrated particularly notable performance, exhibiting the SNR value 1.71 times higher than the ungrooved QTF and 1.18 times greater than the II grooved QTF at the same depth. The 44 μm-deep PI grooved QTFs enabled detection limits of 0.56 ppm in QEPAS and 0.15 ppm in LITES systems for methane sensing. These experimental observations aligned well with theoretical predictions, confirming that groove geometry determines QTF behavior by modulating the balance between effective stiffness and mass.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139581"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Super-Nernstian graphene ion-sensitive field-effect transistor for Nickel(II) detection","authors":"Yingming Xu, Peng Zhou, Tianhong Cui","doi":"10.1016/j.snb.2026.139588","DOIUrl":"10.1016/j.snb.2026.139588","url":null,"abstract":"<div><div>We report a graphene ion-sensitive field-effect transistor (G-ISFET) integrated with a nickel-selective ion-selective membrane (ISM). This device enables ultrasensitive detection of Ni²⁺ in water and reveals an unprecedented super-Nernstian response. Two distinct sensitivity regions are observed, with a Nernstian slope of −30.7 mV/decade from 0.1 ppt to 10 ppb and a detection limit of 0.1 ppt, and a super-Nernstian slope of −232 mV/decade from 10 ppb to 10 ppm with a detection limit of 10 ppb. The lower-range response arises from reversible Ni²⁺ binding at the membrane-analyte interface, whereas the upper-range response originates from irreversible complexation, producing a persistent positive surface charge and uncompensated potential shift. Successive calibrations, Dirac-point drift, and X-ray photoelectron spectroscopy confirm these binding kinetics, showing reversible interactions below 10 ppb and irreversible trapping above this threshold. The device also discriminates Ni²⁺ against sixteen common ions, demonstrating strong selectivity. This sensor achieves record-high sensitivity for Ni²⁺ detection, establishing a compact platform for real-time monitoring of toxic metals in environmental systems.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139588"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}