Sensing and Bio-Sensing Research最新文献

{"title":"A data ensemble-based approach for detecting vocal disorders using replicated acoustic biomarkers from electroglottography","authors":"Lizbeth Naranjo ,&nbsp;Carlos J. Pérez ,&nbsp;Daniel F. Merino","doi":"10.1016/j.sbsr.2025.100741","DOIUrl":"10.1016/j.sbsr.2025.100741","url":null,"abstract":"<div><h3>Introduction</h3><div>The relevant prevalence of voice-related pathologies underscores the need for robust computer-aided diagnostic (CAD) systems capable of supporting early detection and continuous monitoring. Electroglottography (EGG), a non-invasive technique measuring vocal fold contact area, has proven valuable in identifying and diagnosing vocal disorders.</div></div><div><h3>Problem statement</h3><div>Traditional diagnostic methods struggle with the dependent nature of EGG measurements within subjects, leading to challenges in managing within-subject variability and supporting multi-class classification.</div></div><div><h3>Objectives</h3><div>This study aims to design, implement, and evaluate two ensemble-based approaches that address the dependency in EGG measurements. The goal is to enhance the detection of vocal disorders by managing within-subject variability and facilitating multi-class classification.</div></div><div><h3>Methods</h3><div>The proposed methods utilize replicated acoustic biomarkers derived from EGG signals. Simulation-based experiments were conducted to assess the robustness and effectiveness of these methods. Additionally, experiments were performed using EGG signals from the Saarbrüecken Voice Database (SVD).</div></div><div><h3>Results</h3><div>Simulation results indicate that integrating replicated data improves accuracy rates compared to non-replicated models. Experiments on SVD demonstrated the robustness of the proposed methodology across different vowels in classifying healthy individuals, patients with laryngitis, and those with vocal fold paralysis.</div></div><div><h3>Conclusion</h3><div>The data ensemble-based approaches developed effectively manage the dependent nature of EGG measurements, enhancing the detection and classification of vocal disorders. These methods can be applied to other data types where replications play a key role. Future research should focus on collecting comprehensive EGG databases and further exploring multi-class classification methods to solidify EGG and machine learning as a valuable tool for non-invasive assessment of laryngeal function.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100741"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of petrochemicals using photonic crystal fiber (PCF) in terahertz domain","authors":"Md. Anowar Kabir ,&nbsp;Md. Selim Hossain ,&nbsp;Ashik Muhammed Arman ,&nbsp;Md. Al-Amin ,&nbsp;Shuvo Sen","doi":"10.1016/j.sbsr.2025.100737","DOIUrl":"10.1016/j.sbsr.2025.100737","url":null,"abstract":"<div><div>A photonic crystal fiber (PCF) with a hexahedron core has been introduced for usage in petrochemical sensing operations. The performance of the proposed sensor has been statistically analyzed in the frequency band of 1.0 to 3.0 THz. Pure petrol, kerosene, and diesel are poured into the hexahedron core hole. The Finite element Method (FEM) is handled for the simulation and precise calculation and investigation. The sensor utilizing PCF exhibits a relative sensitivity of about 97.80 %, 97.45 %, and 96.25 % and a confinement loss of approximately 1.88 × 10⁻⁸ dB/m, 1.90 × 10⁻⁸ dB/m, and 1.85 × 10⁻⁸ dB/m at 2.20 THz for all investigated Petrol, Kerosene, and Diesel petrochemicals. Moreover, effective areas are values of 7.75 × 10⁻⁸ m², 7.80 × 10⁻⁸ m², and 6.98 × 10⁻⁸ m², and the effective material loss for Petrol, Kerosene, and Diesel of 0.0066168 cm⁻¹, 0.0066955 cm⁻¹ and 0.0066988 cm⁻¹, respectively at 2.20 THz. Both 3D printing and extrusion can be used to create this photonic crystal fiber (PCF) sensor. In addition, this heptagonal photonic crystal fiber sensor will be used for biomedical sensing and various industry fields related to sensing sectors.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100737"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ternary metal oxide of CuNiCo2O4nanorods (1D) distributed on g-C3N4 (2D) nanocomposite for non-enzymatic glucose sensing application","authors":"R. Thenmozhi,&nbsp;R. Navamathavan","doi":"10.1016/j.sbsr.2025.100757","DOIUrl":"10.1016/j.sbsr.2025.100757","url":null,"abstract":"<div><div>Non-enzymatic glucose sensing has a major demand in research community for developing a good glucose sensor. Because enzyme based glucose sensor has several disadvantages such as high cost, difficult fabrication process and instability. To overcome these disadvantages, transition metal oxides (TMO) with g-C₃N₄ nanocomposite are a good choice for non-enzymatic medium for developing a good glucose sensor. Transition metal oxide has multiple oxidation state, different morphology, high conductivity, enhanced catalytic activity and 2D graphitic carbon nitride has a higher stability. In this work, our particular interest in ternary metal oxide (CuNiCo₂O₄) nanorods (1D) distributed on surface of the g-C₃N₄ (2D) nanocomposite were prepared by simple hydrothermal method. The prepared nanocomposite was performed a basic studies such as XRD, FESEM, HRTEM, FTIR, XPS and an electrochemical studies using nickel foam as a current collector. Chronoampermetry analysis produced a sensitivity of 4368 μA Cm⁻² mM⁻¹ and low detection limit (LOD) 1.91 μM. The produced response time is 4 s. The measured results of the CuNiCo₂O₄nanorods (1D) on the surface of g-C₃N₄ (2D) nanocomposite could be a satisfied material for non-enzymatic glucose sensor.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100757"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of nanotechnology in electrochemical sensors for medical diagnostic purposes: A review","authors":"Ali R. Jalalvand,&nbsp;Mohammad Mehdi Karami","doi":"10.1016/j.sbsr.2024.100733","DOIUrl":"10.1016/j.sbsr.2024.100733","url":null,"abstract":"<div><div>The rapid advancements in nanotechnology have significantly enhanced the capabilities of electrochemical sensors, particularly in the realm of medical diagnostics. This review article explores the integration of nanomaterials such as nanoparticles, nanowires, nanotubes, and graphene in electrochemical sensors and their transformative impact on disease detection and health monitoring. Nanotechnology-enhanced sensors offer remarkable improvements in sensitivity, specificity, miniaturization, and making them ideal for point-of-care testing and real-time analysis. This review article provides a comprehensive information about the types and mechanisms of electrochemical sensors, the unique properties of nanomaterials that enhance sensor performance, and the diverse medical applications ranging from biomarker detection to pathogen identification. Despite the promising benefits, several challenges including technical, regulatory, and market barriers are discussed alongside potential strategies to overcome these hurdles. The ongoing research and development in this field promise to revolutionize medical diagnostics by providing rapid, accurate, and accessible testing solutions ultimately improving patient outcomes and healthcare efficiency.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100733"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A label-free gold nanoparticles functionalized peptide dendrimer biosensor for visual detection of breakthrough infections in COVID-19 vaccinated patients","authors":"Naveen Kumar ,&nbsp;Ashutosh Singh ,&nbsp;Preeti Dhaka ,&nbsp;Ankur Singh ,&nbsp;Pragya Agarwala ,&nbsp;Kuldeep Sharma ,&nbsp;Anudita Bhargava ,&nbsp;Sandeep Bhatia ,&nbsp;Thomas Launey ,&nbsp;Rahul Kaushik ,&nbsp;Shailly Tomar ,&nbsp;Aniket Sanyal","doi":"10.1016/j.sbsr.2024.100718","DOIUrl":"10.1016/j.sbsr.2024.100718","url":null,"abstract":"<div><div>Given the global implementation of effective COVID-19 vaccines, which do not confer complete immunity, it is crucial to monitor the occurrence of breakthrough infections, particularly against newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. Hence, we developed a label-free colorimetric assay using gold nanoparticles (GNPs) functionalized with a peptide dendrimer incorporating highly reactive epitopes of the nucleocapsid (N) protein. This assay relies on the tween-20 induced colorimetric changes caused by the aggregation of peptide dendrimer-coated GNPs in the absence of anti- SARS-CoV-2 N antibodies, and <em>vice versa</em>. Transmission electron microscopy, dynamic light scattering, and circular dichroism spectroscopy analyses all showed the formation of a uniform and highly stable coating of the peptide dendrimer over GNPs. Surface plasmon resonance experiments have demonstrated a strong binding affinity for the peptide dendrimer and anti- SARS-CoV-2 N antibodies, with a <em>K</em>_D value of 525 nM. To validate the proof-of-concept, we have tested this assay on seventy human serum samples, and receiver operating characteristic curve analysis demonstrated high diagnostic sensitivity (88.89 %) and specificity (100 %). This approach opens up new avenues for the development of simple and rapid diagnostic assays for identifying antibodies against viral infections and other pathogens.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100718"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing sensitivity with laser-scribed graphene interdigitated electrodes in water quality monitoring","authors":"Ceren Durmus ,&nbsp;Abdullah Bukhamsin ,&nbsp;José Ilton de Oliveira Filho ,&nbsp;Khaled Nabil Salama","doi":"10.1016/j.sbsr.2024.100731","DOIUrl":"10.1016/j.sbsr.2024.100731","url":null,"abstract":"<div><div>Conventional methods for monitoring water quality are often time-consuming, expensive, and lack sensitivity, making it difficult to detect contaminants before they enter the environment. Therefore, it is essential to develop sensing platforms that address these issues and that are capable of performing on-site detection. As such, in this study, we developed an electrochemical sensing platform for detecting pharmaceutical pollutants in water, particularly paracetamol (PCM) and acetylsalicylic acid (ASP). By minimizing the gap distance between the working and auxiliary electrodes of laser-scribed graphene interdigitated electrodes (LSG-IDEs), the sensitivity of the sensors was improved. The developed platform was compared to a standard LSGE design, and the LSG-IDEs achieved an 18.6-fold and 70-fold improvement in detection limits for PCM and ASP, respectively. The system was tested with real wastewater samples spiked with ASP and PCM, demonstrating its effectiveness in practical scenarios. Additionally, the system was successfully integrated with an on-site detection device, demonstrating its potential for real-time, portable water quality monitoring. The high sensitivity and low-cost of LSG-IDEs make them a suitable option for the monitoring of water quality and protecting public health.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100731"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on roles of electrochemical approaches in drug delivery","authors":"Ali R. Jalalvand,&nbsp;Mohammad Mehdi Karami","doi":"10.1016/j.sbsr.2025.100742","DOIUrl":"10.1016/j.sbsr.2025.100742","url":null,"abstract":"<div><div>The advancement of drug delivery systems (DDS) has significantly enhanced the efficacy and safety of therapeutic agents addressing limitations such as poor bioavailability and non-specific distribution associated with traditional methods. This article provides a comprehensive review of the role of electrochemical approaches in DDS, highlighting their precision, minimally invasive nature and ability to provide targeted and localized therapy. Electrochemical methods including voltammetry, amperometry and potentiometry offer unparalleled control over drug release kinetics and distribution, presenting significant advantages for the treatment of chronic and complex diseases like cancer, cardiovascular disorders, and neurological conditions. The integration of biotechnology, materials science and nanotechnology has led to the development of sophisticated DDS that respond to specific biological signals. This review discusses the fundamental principles of electrochemistry, various electrochemical techniques, and their applications in DDS alongside current innovations and future research directions in the field. The potential of electrochemical approaches to revolutionize drug delivery by providing precise, controlled, and targeted therapeutic interventions is emphasized, underscoring their growing importance in personalized medicine and future biomedical applications.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100742"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-sensitivity creatine detection using doped ZnO nanoribbon biosensors: A density functional theory approach","authors":"A. Shahriyari ,&nbsp;Sh. Bagherzadeh-Nobari ,&nbsp;M. Yousefizad ,&nbsp;N. Manavizadeh ,&nbsp;H. Pourfarzad ,&nbsp;Z. GolshanBafghi ,&nbsp;H. Ahmadi ,&nbsp;F. Gholipour","doi":"10.1016/j.sbsr.2025.100767","DOIUrl":"10.1016/j.sbsr.2025.100767","url":null,"abstract":"<div><div>Determining creatine concentration in the liver and kidneys is crucial for diagnosing health status due to its role as a significant biomarker in biosynthesis and muscle energy metabolism. This study proposes a two-terminal device made of hydrogen-passivated armchair ZnO nanoribbons connected between ZnO nanoribbon electrodes to explore its potential as a creatine biosensor. Using Transiesta, Tbtrans, and Density Functional Theory (DFT) calculations, the study evaluates the sensing capabilities of doped AZnONR for the first time. It involves hydrogen passivation, detailed doping analysis, and the assessment of electronic structure and adsorption properties to optimize biosensor performance. Measurements of PDOS, transmission coefficient, conductance, charge transfer, and electrostatic potential elucidate detection mechanisms, focusing on Al, Ga, and N doping effects. Findings reveal that creatine adsorption leads to the disappearance of some states near the conduction band edge due to charge transfer from the Al-doped ZnO nanoribbon. The projected density of states and transmission shift to higher energies because of creatine's negative electrostatic gating effect, significantly reducing transmission at 0.7 eV. A gate voltage of 0.7 V drastically alters the device's conductance, enabling creatine detection with 99.9 % sensitivity. The study highlights Al-doped ZnO nanoribbons' potential as highly sensitive creatine biosensors with an adsorption energy of −3.07 eV.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100767"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrated kirigami-patterned skin patch for multiplexed detection of inflammatory biomarkers along with transdermal drug delivery","authors":"Tanzila Noushin ,&nbsp;Nafize Ishtiaque Hossain ,&nbsp;Rhythem Tahrin ,&nbsp;Md Najmul Islam ,&nbsp;Shawana Tabassum","doi":"10.1016/j.sbsr.2025.100772","DOIUrl":"10.1016/j.sbsr.2025.100772","url":null,"abstract":"<div><div>Detecting, monitoring, and managing chronic pain levels in real-time remains a critical and challenging aspect of medical practice. Chronic pain is associated with an increased production of inflammatory biomarkers, such as Interleukin-6 and Interleukin-10. Accurately detecting the levels of these biomarkers with a highly sensitive sensor can facilitate real-time monitoring of pain severity and enable the administration of appropriate medication based on the patient's needs. In this context, transdermal drug delivery offers a significant advantage in pain management by delivering targeted opioids, such as Fentanyl, to alleviate chronic pain in a non-invasive and long-term manner. This work presents a kirigami-patterned skin patch that combines multiplexed sensors with a drug delivery module to detect inflammatory biomarker levels in sweat with high sensitivity and precision, while also enabling on-demand drug delivery for pain relief. By correcting response variations caused by changes in body temperature and sweat pH, the device ensures accurate sensing while maintaining strain-insensitive performance—an essential feature for wearable sensors. This system has the potential to significantly impact healthcare by providing an innovative, reliable solution for chronic pain management.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100772"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical aptasensor for ultrasensitive detection of glycated hemoglobin (HbA1c) using gold-modified SPCE","authors":"Serly Zuliska ,&nbsp;Irkham ,&nbsp;Salma Nur Zakiyyah ,&nbsp;Yeni Wahyuni Hartati ,&nbsp;Yasuaki Einaga ,&nbsp;Iman Permana Maksum","doi":"10.1016/j.sbsr.2025.100765","DOIUrl":"10.1016/j.sbsr.2025.100765","url":null,"abstract":"<div><div>Accurate monitoring of diabetes mellitus (DM) biomarkers, particularly glycated hemoglobin (HbA1c), is essential for assessing long-term blood glucose control, optimizing therapeutic strategies, and preventing diabetes-related complications. To enhance the efficiency of this monitoring, electrochemical aptasensors based on screen-printed carbon electrodes (SPCE) modified with gold nanoparticles (AuNP) have been developed. The results demonstrate that the electrodeposition technique produces a uniform AuNP distribution and significantly increases the current responses of K₃[Fe(CN)₆] compared to bare SPCE. Aptamer immobilization using a streptavidin-biotin system via linker-mediated attachment exhibits high affinity for HbA1c, as evidenced by a significant decrease in current upon target binding.The analytical performance of the aptasensor shows a low detection limit of 8.34 pg/mL, with a linear detection range of 1 to 10⁴ pg/mL. Moreover, the aptasensor exhibits good selectivity for HbA1c over hemoglobin, glucose, and palmitic acid, with a selectivity value of 82.56 %. Stability tests indicate that the sensor retains 90.38 % of its activity after 70 days of storage, confirming its reliability for HbA1c detection. This study contributes to the advancement of effective electrochemical biosensors for diabetes monitoring, enabling early diagnosis and improved disease management.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100765"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}