An integrated kirigami-patterned skin patch for multiplexed detection of inflammatory biomarkers along with transdermal drug delivery

IF 5.4 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research Pub Date : 2025-02-01 DOI:10.1016/j.sbsr.2025.100772

Tanzila Noushin , Nafize Ishtiaque Hossain , Rhythem Tahrin , Md Najmul Islam , Shawana Tabassum

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引用次数: 0

Abstract

Detecting, monitoring, and managing chronic pain levels in real-time remains a critical and challenging aspect of medical practice. Chronic pain is associated with an increased production of inflammatory biomarkers, such as Interleukin-6 and Interleukin-10. Accurately detecting the levels of these biomarkers with a highly sensitive sensor can facilitate real-time monitoring of pain severity and enable the administration of appropriate medication based on the patient's needs. In this context, transdermal drug delivery offers a significant advantage in pain management by delivering targeted opioids, such as Fentanyl, to alleviate chronic pain in a non-invasive and long-term manner. This work presents a kirigami-patterned skin patch that combines multiplexed sensors with a drug delivery module to detect inflammatory biomarker levels in sweat with high sensitivity and precision, while also enabling on-demand drug delivery for pain relief. By correcting response variations caused by changes in body temperature and sweat pH, the device ensures accurate sensing while maintaining strain-insensitive performance—an essential feature for wearable sensors. This system has the potential to significantly impact healthcare by providing an innovative, reliable solution for chronic pain management.

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一种集成的基里伽米图案皮肤贴片，用于多重检测炎症生物标志物以及透皮给药

实时检测、监测和管理慢性疼痛水平仍然是医疗实践的一个关键和具有挑战性的方面。慢性疼痛与炎症生物标志物如白细胞介素-6和白细胞介素-10的产生增加有关。用高灵敏度传感器准确检测这些生物标志物的水平，可以促进对疼痛严重程度的实时监测，并根据患者的需要给予适当的药物治疗。在这种情况下，经皮给药在疼痛管理中提供了显著的优势，通过递送靶向阿片类药物，如芬太尼，以非侵入性和长期的方式缓解慢性疼痛。这项工作提出了一种kirigami图案的皮肤贴片，它结合了多路传感器和药物递送模块，以高灵敏度和精度检测汗液中的炎症生物标志物水平，同时还可以按需给药以缓解疼痛。通过纠正由体温和汗液pH值变化引起的反应变化，该设备确保了准确的传感，同时保持了对应变不敏感的性能——这是可穿戴传感器的基本功能。该系统通过为慢性疼痛管理提供创新、可靠的解决方案，具有显著影响医疗保健的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sensing and Bio-Sensing Research Engineering-Electrical and Electronic Engineering

CiteScore

10.70

自引率

3.80%

发文量

审稿时长

87 days

期刊介绍： Sensing and Bio-Sensing Research is an open access journal dedicated to the research, design, development, and application of bio-sensing and sensing technologies. The editors will accept research papers, reviews, field trials, and validation studies that are of significant relevance. These submissions should describe new concepts, enhance understanding of the field, or offer insights into the practical application, manufacturing, and commercialization of bio-sensing and sensing technologies. The journal covers a wide range of topics, including sensing principles and mechanisms, new materials development for transducers and recognition components, fabrication technology, and various types of sensors such as optical, electrochemical, mass-sensitive, gas, biosensors, and more. It also includes environmental, process control, and biomedical applications, signal processing, chemometrics, optoelectronic, mechanical, thermal, and magnetic sensors, as well as interface electronics. Additionally, it covers sensor systems and applications, µTAS (Micro Total Analysis Systems), development of solid-state devices for transducing physical signals, and analytical devices incorporating biological materials.