Sensing and Bio-Sensing Research最新文献

{"title":"A wireless instrumented insole for monitoring plantar pressure during human locomotion","authors":"Mariana Alegria ,&nbsp;Mariana Ballesteros ,&nbsp;David Cruz-Ortiz","doi":"10.1016/j.sbsr.2025.100752","DOIUrl":"10.1016/j.sbsr.2025.100752","url":null,"abstract":"<div><div>This work proposes a wireless instrumented insole for monitoring plantar pressure (PP) during human locomotion. The insole is composed of two elements. The first is a mold manufactured with thermoplastic polyurethane using tridimensional printing techniques. The second one is a soft cover fabricated with a liquid polymer Ecoflex™ 00–30 from Smooth-On. The insole considers a microcontroller Arduino Nano and 24 force-sensing resistors located in ten anatomic regions of the foot with a sampling frequency of 70 Hz. The device sends the data through wireless communication based on a Bluetooth module to a graphical user interface in a computer where the data is received, displayed, and stored. A test was carried out with ten healthy volunteers (five men and five women) to validate the PP measured with the device. The data obtained were analyzed and compared with the literature, considering relevant characteristics in the PP analysis.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100752"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143353638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DPV and EIS-based ultrasensitive aptasensor for VEGF165 detection based on nanoporous gold platform modified with SH-aptamer","authors":"Bahareh Pourbahram ,&nbsp;Samira Mansouri Majd ,&nbsp;Mojtaba Shamsipur","doi":"10.1016/j.sbsr.2025.100766","DOIUrl":"10.1016/j.sbsr.2025.100766","url":null,"abstract":"<div><div>The sensitive detection of trace amounts of vascular endothelial growth factor (VEGF₁₆₅) in samples holds significant potential for clinical cancer diagnosis across various cancer types. This work introduces a novel and cost-effective dual strategy for developing an ultrasensitive electrochemical aptasensor based on the self-assembly of SH-aptamer onto a nanoporous gold electrode for VEGF₁₆₅ detection. SEM and electrochemical characterization confirmed the formation of the nanoporous structure and the increase of the surface area of the gold electrode from 0.1199 cm² to 0.1875 cm². The sensing method relied on the interaction between the DNA probe and VEGF₁₆₅, which increased the charge transfer resistance of Fe(CN)₆^3−/4- in the (signal-on) strategy, as determined by EIS. Conversely, it diminished the reduction peak current of the methylene blue probe in the (signal-off) strategy, as assessed by Differential Pulse Voltammetry (DPV). The limit of detection and linear dynamic range of the prepared electrode were found to be 0.25 pM and 2.5 to 140 pM, respectively, using DPV, and 0.18 pM and 5 to 200 pM, respectively, using EIS. The aptasensor demonstrated desirable stability after storing the aptasensor in a buffer solution for one week. Furthermore, analogous proteins did not exhibit significant interference. Also, detecting the VEGF₁₆₅ cancer marker in undiluted human serum samples had excellent recovery with relatively low standard deviation percentages. Therefore, the findings indicate that the proposed aptasensor could potentially be utilized in the future design of a non-invasive cancer diagnostic kit using a blood or interstitial fluid test instead of the painful and aggressive biopsy method.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100766"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Miniaturized multispectral imaging for microfluidic pH sensing","authors":"Yushan Meng ,&nbsp;Dechuan Sun ,&nbsp;Bryce Widdicombe ,&nbsp;Dina Thankom Jacob ,&nbsp;Yiling Yang ,&nbsp;Xumei Gao ,&nbsp;Alastair G. Stewart ,&nbsp;Ranjith Rajasekharan Unnithan","doi":"10.1016/j.sbsr.2025.100764","DOIUrl":"10.1016/j.sbsr.2025.100764","url":null,"abstract":"<div><div>Multispectral lab-on-chip imaging based on complementary metal-oxide semiconductor (CMOS) is an innovative technology that supports portable microfluidic platforms and enables the extraction of spectral information from specimens under multiple wavelengths. Accurate pH sensing is essential across a diverse range of chemical, biological, medical, and environmental applications. In this paper, we presented a new approach for pH sensing using the CMOS-based multispectral lab-on-chip imaging. Using a six-band color filter array that spans the optical spectrum in the visible and near-infrared range and a U-shape PDMS microfluidic channel, images of solutions with specific pH values were captured by a monochrome CMOS image sensor. To predict pH values, we developed a Support Vector Regression (SVR) model, which was trained using captured images of the six bands. Predicted pH values were obtained by the model with an RMSE of 0.364. Our research demonstrates that multispectral lab-on-chip imaging represents a miniature and rapid method to achieve pH sensing with high sensitivity and accuracy.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100764"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface acoustic waves (SAW) sensor for the active detection of Microcystin-LR (Cyanobacteria)","authors":"Debdyuti Mandal ,&nbsp;Tally Bovender ,&nbsp;Robert D. Geil ,&nbsp;Debabrata Sahoo ,&nbsp;Sourav Banerjee","doi":"10.1016/j.sbsr.2024.100724","DOIUrl":"10.1016/j.sbsr.2024.100724","url":null,"abstract":"<div><div>Cyanobacteria are a family of prokaryotic bacteria whose death causes the release of harmful toxins. Upon ingestion, these toxins produce symptoms similar to food poisoning and are dangerous to humans, as well as livestock. As there is no easily accessible way to remove cyanotoxins from water sources, thus detection before consumption is vitally important. In this article, we report a shear horizontal surface acoustic wave (SH-SAW) based sensor for the active detection of the microcystin congener, microcystin-LR (MC-LR). The sensing platform was devised on 36° YX cut-LiTaO₃ which is a piezoelectric substrate. The sensor system was designed based on delay line configuration and was actively coated with silicon dioxide as a waveguide layer for better mass-load sensitivity. Unlike conventional SAW, the sensing platform utilizes a 5-count tone burst signal, enhancing sensitivity due to its sensitive coda waves. Signal transformation and analysis were made for distinct detection in the frequency domain. The sensor also incorporates the functionalization of gold nanospheres for a high surface-to-volume ratio and enhanced degree of orientation leading to better sensitivity. The sensor detection limit was down to 5.13 nM. Further evidence was provided by selectivity analysis and the sensor could identify MC-LR from the other biomarkers.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100724"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecularly imprinted polymers-based electrochemical sensors for tracking vitamin B12 released from spray-dried microcapsules during in vitro simulated gastrointestinal digestion","authors":"Seyed Mohammad Taghi Gharibzahedi ,&nbsp;Gauri Kishore Hasabnis ,&nbsp;Eda Akin ,&nbsp;Zeynep Altintas","doi":"10.1016/j.sbsr.2025.100759","DOIUrl":"10.1016/j.sbsr.2025.100759","url":null,"abstract":"<div><div>Highly sensitive detection of vitamin B₁₂ (VB₁₂) is crucial for assessing its bioavailability and diagnosing deficiency-related disorders. VB₁₂ with 87.69 % efficiency was microencapsulated by spray drying complex coacervation-based emulsions of Arabic gum and sonicated insect protein, forming 5.4 μm semi-spherical microcapsules with smooth or wrinkled surfaces. The optimized VB₁₂-specific o-aminophenol (AP)-based molecularly imprinted polymer (MIP) film demonstrated efficient molecular recognition and significant electrochemical responsiveness, enabling VB₁₂ detection in PBS buffer with an LOD of 0.5 μM within a linear range of 0.5–10 μM (R² = 0.991). Surface characterization revealed remarkable property changes during sensor fabrication. A significant reduction in the hydrophilicity of the VB₁₂-AP-MIP film after template removal (TR) was observed due to the increased contact angle from 33.1° to 55.82° (<em>p</em> &lt; 0.05). Morphological analysis using atomic force microscopy (AFM) showed the highest roughness (90.57 nm) for the VB₁₂-AP-MIP film, decreasing after TR (30.56 nm) and increasing upon VB₁₂ capture (46.04 nm). Scanning electron microscopy (SEM) revealed smoother, more uniform surfaces for MIP films than non-imprinted polymer (NIP) films, indicating the template's critical role in polymerization. The developed electro-MIP sensor exhibited good template-selectivity and a 15-day storage stability at 4 °C. The electrochemical VB₁₂-AP-MIP sensor successfully detected VB₁₂ in digested microcapsules under simulated salivary (3.30 ± 0.46 μM), gastric (64.87 ± 2.66 μM), and intestinal (76.68 ± 2.16 μM) conditions. The VB₁₂ analysis using HPLC and UV–Vis spectrophotometry showed that the electro-MIP sensor outcomes were comparable to those obtained with HPLC. The developed electro-MIP sensor would be a promising tool for determining VB₁₂ levels in complex biological samples.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100759"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-pot green synthesis of BSA-capped O-CQDs as an effective fluorescent sensing platform for sensitive and selective detection of promethazine drug","authors":"S. Viji ,&nbsp;A. Dinesh ,&nbsp;K. Radhakrishnan ,&nbsp;L. Srimathi Priya ,&nbsp;C. Sivasankari ,&nbsp;Madhappan Santhamoorthy ,&nbsp;Manikandan Ayyar ,&nbsp;V. Mohanavel ,&nbsp;Mohamed Hashem ,&nbsp;Hassan Fouad ,&nbsp;G. Ramachandran ,&nbsp;S. Santhoshkumar","doi":"10.1016/j.sbsr.2025.100756","DOIUrl":"10.1016/j.sbsr.2025.100756","url":null,"abstract":"<div><div>Reliability in biosensing technologies is crucial for the accurate detection and measurement of target molecules, prompting strategies to minimise non-specific binding events that may result in inaccurate findings. This work reports on bovine serum albumin (BSA)-capped oxygen rich carbon quantum dots (O-CQDs) to improve the accuracy of promethazine sensing. The CQDs were produced utilizing a hydrothermal technique with apple juice as a sustainable carbon source. BSA-Caped O-CQDs improve their biocompatibility and stability in physiological conditions while also reducing non-specific interactions with other biomolecules. Several spectroscopic methods, such as fluorescence, X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR), were used to evaluate this enhanced specificity and sensitivity. Obtained results show that BSA-O-CQDs had higher specificity for promethazine Furthermore, their ability to resolve non-specific binding was assessed under simulated physiological backgrounds, demonstrating their promise for robust biosensing applications. This sensor method achieved a high selectivity with LOD of 0.2 μM from range of 10–90 μM indicating its suitability for precise promethazine measurement in environmental samples. The primary advantages of this technique include simplified sample preparation together with economic advantages which make it a critical instrument for public health monitoring as well as cutting-edge pharmaceutical research. Sustainable O-CQDs demonstrate the potential for creating environmentally friendly biosensors.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100756"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress and application prospects of flexible wearable sensor in spacesuit","authors":"Aiming Bu ,&nbsp;Wanxin Zhang ,&nbsp;Qian Ran ,&nbsp;Dongyue Liu ,&nbsp;Jialu Ma ,&nbsp;Rongqing Wang ,&nbsp;Kun Shang ,&nbsp;Hongrui Yang ,&nbsp;Zhiqiang Mei","doi":"10.1016/j.sbsr.2025.100750","DOIUrl":"10.1016/j.sbsr.2025.100750","url":null,"abstract":"<div><div>Spacesuit provide the basic life support for astronauts in the space environment. Astronauts in extravehicular operations need spacesuit for pressure to form a vacuum protection. However the suit pressure caused greater joint activity resistance impact on the operation of astronauts. The wearable sensors have drawn more and more attention because its operations are simple and real-time detections are available. It can realize the benefits of heart rate, breathing, sweat, action recognition and date acquisition, etc. The joint resistance characteristics of spacesuit is revealed under pressure were studied by wearing flexible wearable sensors, which provides a theoretical basis for improving the performance of spacesuit. Based on the above problems, this paper summarizes the latest research progress of wearable flexible sensor category and application of different types of flexible sensors. Finally, the challenges in the application of flexible wearable sensors in the spacesuit were discussed. It provides a theoretical basis for the research in related fields.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100750"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy efficiency enhancement of ethanol electrooxidation based on zinc molybdate nanostructures in direct fuel cells","authors":"Asma Khoobi","doi":"10.1016/j.sbsr.2025.100769","DOIUrl":"10.1016/j.sbsr.2025.100769","url":null,"abstract":"<div><div>Today, environmental pollution and energy shortages have become two main crisis for future of the world. Also, the synthesis of novel nanostructures by sonochemical methods is a promising option because of their non-toxicity and environmental friendliness. In the present study, a sonochemical method was used to synthesis novel zinc molybdate nanopowders with different precursors. The synthesis of the nanostructures was performed using sodium zinc molybdate and different salts of zinc such as zinc nitrate, zinc acetate, and zinc sulfate, as a precursor. Also, the effect of instrumental factors containing sonication power and time irradiation was optimized by the sonochemical method for synthesis of the nanostructures. The characterization of the products was accomplished by various techniques containing field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and energy dispersive X-ray spectroscopy (EDX). The results showed zinc nitrate precursor can be produce homogeneous nanostructures in optimized conditions. Therefore, the nano-structured zinc molybdate compound was applied for modification of a carbon paste electrode (CPE). The oxidation reaction of ethanol was selected for investigation of the electrocatalytic performance of the nano-structured modified electrode. Cyclic voltammetry (CV) and chronoamperometry were applied for the electrochemical characterization as well as stability and repeatability studies. The nano-structured modified electrode showed an improved catalytic performance for the oxidation of ethanol than the CPE. Therefore, the nanostructures can show potential applications or directions for future work. The potential applications of the modified electrode in fuel cells, sensors, and energy storage fields can be considered and also suggest areas for further research.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100769"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A robust and highly sensitive electrochemical probe for detection of trace levels of NH3/NH4+ in water based on Berthelot's reaction","authors":"H. Alwael ,&nbsp;A.S. Alharthi ,&nbsp;A. Alsolami ,&nbsp;M. Oubaha ,&nbsp;B. Duffy ,&nbsp;R.M. Elshafey ,&nbsp;M.S. El-Shahawi","doi":"10.1016/j.sbsr.2025.100760","DOIUrl":"10.1016/j.sbsr.2025.100760","url":null,"abstract":"<div><div>Traditional spectrochemical methods for quantifying NH₃/NH₄⁺ based on the colored oxidation product of Berthelot or Nessler reactions, face challenges due to spectral overlap, auto-self absorbance, background scattering noise and high limits of detection. Thus, the current study introduces a new electrochemical sensing platform utilizing an <em>ex-situ</em> Bi film-plated glassy carbon electrode (BiF/GCE) combined with Berthelot's reaction for detecting trace levels of NH₃/NH₄⁺ in water. The primary advantage of Bi as a surface modifier of GCE is its ability to provide a selective and explicit probe for NH₃/NH₄⁺ detection at trace levels. This platform employs an <em>ex-situ</em> BiF/GCE, square wave-adsorptive anodic stripping voltammetry (Ads SW-ASV), and the oxidation product of Berthelot's reaction for precise indirect detection of NH₃/NH₄⁺ in aqueous solutions at pH 10–11. The probe demonstrated excellent electrochemical performance for NH₃/NH₄⁺ detection over a concentration range of 3.2 nM to 20.0 μM, with detection and quantitation limits of 0.95 and 3.2 nM, respectively. It showed good selectivity towards detection of NH₃/NH₄⁺ in water with favorable repeatability (RSD = ±3.2 %) and reproducibility (RSD = ±4.1 %). The probe's measurements were validated against standard ion chromatography (IC) and microspectrophotometry methods, demonstrating high reliability for detecting NH₃/NH₄⁺ in environmental and Red Sea water samples. This assay is precise and versatile for ammonia detection, enabling measurement of trace levels of N-containing organic compounds in foodstuffs and their degradation products.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100760"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simplified optical monitoring systems for detecting leukocyte-derived hypochlorite ions using small amounts of whole blood","authors":"Kozo Takeuchi ,&nbsp;Toshiyuki Miwa ,&nbsp;Takayuki Sato ,&nbsp;Takahiro Shikayama ,&nbsp;Hiroshi Tsuchiya ,&nbsp;Kimiko Kazumura","doi":"10.1016/j.sbsr.2024.100722","DOIUrl":"10.1016/j.sbsr.2024.100722","url":null,"abstract":"<div><div>Here, we developed two simplified optical systems, FLP-H3200 and FLP-H4200, designed to detect leukocyte-derived hypochlorite ions via fluorescence (FL-OCl⁻) using only three microliters of whole blood. First, the new systems employed a lower-cost photodiode as the photodetector instead of a photomultiplier tube in their preceding system CFL-H2200. The systems featured a simplified optical configuration optimized for the blood measurement fluidic chip, enabling efficient focusing of the desired FL-OCl⁻ signal and obtaining a signal intensity comparable to that obtained with CFL-H2200. These improvements made the new systems more compact, lightweight, and cost-effective than CFL-H2200. Additionally, in FLP-H4200, the intensity of the excitation light source, the light-emitting diode, was set higher than that in FLP-H3200, further enhancing the FL-OCl⁻ signal. Using the fluorescent reagent fluorescein, we confirmed that the fluorescence sensitivity of the new systems was comparable to that of CFL-H2200. Finally, blood analysis data using FLP-H3200 and FLP-H4200 showed a high correlation. This study broadens the scope of clinical examinations by providing accessible and efficient tools for monitoring leukocyte activity using whole blood.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100722"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}