Sensing and Bio-Sensing Research最新文献

{"title":"Electrochemiluminescence ratio sensor for detecting MCP-1 based on s-PdNS","authors":"Weiran Mao ,&nbsp;Xiaoyan Zhang ,&nbsp;Yuanyuan Yin ,&nbsp;Xiaohua Tang ,&nbsp;Qingqing Jiang ,&nbsp;Xia Chen ,&nbsp;Xiaoliang Chen","doi":"10.1016/j.sbsr.2024.100723","DOIUrl":"10.1016/j.sbsr.2024.100723","url":null,"abstract":"<div><div>This study proposes a novel sandwich-based ratio electrochemiluminescence (ECL) immunosensor for detecting monocyte chemotactic protein-1 (MCP-1), a marker of cardiovascular disease. We synthesized sulfur-doped palladium nanosheets (S-PdNS), which possess a stable structure and uniform morphology, and can quench signals generated by the S₂O₈²⁻/O₂ ECL system. Using glutaraldehyde (GA), we conjugated luminol to these nanosheets and combined them with a secondary antibody. This modification enabled the nanomaterial to produce a new luminol signal as an internal reference for detection while quenching the S₂O₈²⁻/O₂ ECL signal. To date, no studies have utilized both mechanisms for detection. Furthermore, the deposition of gold nanoparticles (AuNPs) on the surface of the glassy carbon electrode (GCE) allowed for increased antibody binding and improved electron transmission in the ECL system. When trace analytes are present, the S₂O₈²⁻/O₂ ECL signal decreases, and the luminol ECL signal increases. This setup allowed us to obtain two signals from one measurement and use the ratio to construct a standard curve, significantly reducing the possibility of misjudgment. Under optimal conditions, the linear detection range for MCP-1 is 10^–2.5 pg mL⁻¹ to 10³ pg mL⁻¹, with a detection limit of 1.6 fg mL⁻¹ (S / <em>N</em> = 3). The immunosensor also exhibited excellent selectivity, repeatability, and stability, expanding the application of the dual luminescence mechanism and providing an effective method for early monitoring of cardiovascular disease.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100723"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunable THz supper absorber based on graphene nano ribbons for bio-sensing applications","authors":"Mohamadreza Vatoor,&nbsp;Seyyed Sajjad Tabatabaee,&nbsp;Pejman Shabani","doi":"10.1016/j.sbsr.2025.100776","DOIUrl":"10.1016/j.sbsr.2025.100776","url":null,"abstract":"<div><div>Leveraging periodic arrays of graphene ribbons and a flexible spacer, a highly adjustable THz wave absorber is discussed in the paper. The structure includes two stacked layers while a thick metallic plate covers the structure from beneath. The exploited periodic arrays of graphene ribbons with four different widths are placed on top of the Kapton spacer. The structure is modeled by passive circuit elements as an impedance while numerical full wave simulation is also performed to verify the validity and accuracy of the impedance matching concept. According to simulation results, an acceptable convergence is obtained between two separate simulations while the circuit model is developed by a MATLAB mfile, and full wave analysis is achieved via CST software. Both simulation paths verify multi-band absorption peaks in the THz spectrum with highly reliable and robust absorption peaks. According to the results, six absorption peaks with higher than 90 % adsorption are achieved. The response sensitivity is investigated versus design parameters that show appropriate robustness against geometrical parameters while the response is able to be fully controlled by changing the graphene patterns' chemical potentials. Such an adjustable wave absorber is in great demand for building larger optical systems including medical and security sensors.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100776"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective and simultaneous electrochemical detection of amoxicillin and paracetamol in pharmaceuticals and serum using a mixed-ligand poly(Co(II)-phenanthroline, diresorcinate) modified electrode","authors":"Dereje Birhanu ,&nbsp;Alemu Tesfaye ,&nbsp;Adane Kassa ,&nbsp;Getinet Tamiru Tigineh ,&nbsp;Amare Benor ,&nbsp;Atakilt Abebe","doi":"10.1016/j.sbsr.2025.100746","DOIUrl":"10.1016/j.sbsr.2025.100746","url":null,"abstract":"<div><div>Transition metal coordination compounds are emerging as good alternative electrode modifiers for detection of various electroactive analytes due to their several appropriate features such as that they can provide high sensitivity, selectivity, electrical conductivity, and a larger surface area. This study reports the use of carefully designed and prepared cobalt(II) complex using resorcinolate (HR⁻) and 1,10-phenanthroline(phen) having a formula of Co(HR)₂(phen) (DHRPCo), with electroactivity and a tetrahedral geometry. The later properties are important for its easy polymerization and impart porous surface on the electrode surface. This complex was used for the fabrication of metal complex-based polymer film-modified electrode for the simultaneous analysis of amoxicillin (AMX) and paracetamol (PTM). Using cyclic voltammetric and electrochemical impedance spectroscopy methods, the potentiodynamic (employing a potential range) synthesis of poly(diresorcinate-1,10-phenanthrolinecobalt(II)) modified glassy carbon electrode (poly(DHRPCo)/GCE) was confirmed. The poly(DHRPCo)/GCE in an equimolar combination of AMX and PTM showed adequately separated oxidative peaks with significantly improved peak current, indicating the polymer film's electrocatalytic property towards the oxidation of AMX and PTM, as compared to the unmodified GCE. The poly(DHRPCo)/GCE electrode demonstrated a linear oxidative peak current response to AMX and PTM concentrations ranging from 0.01 to 400.0 μM under optimum pH and square wave voltammetric configurations. The detection limits were 20.50 nM for AMX and 4.03 nM for PTM. While interference recovery errors were less than 4.84 % for both analytes, the range of spike recovery rates for AMX and PTM was 99.00 % to 100.45 % and 99.33 % to 100.05 %, respectively. The technique showed outstanding electrode stability and a high degree of agreement between the detected and nominal values of AMX and PTM in tablet samples. These results confirm the reliability of the developed approach for simultaneous quantification of AMX and PTM in diverse real-world samples. Its application to pharmaceutical tablets and human blood serum further highlights its potential as an effective analytical tool.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100746"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methane detection approach based on THz wave absorber","authors":"Alireza Barati Haghverdi ,&nbsp;Ilghar Rezaei ,&nbsp;Amir Ali Mohammad Khani ,&nbsp;Toktam Aghaee","doi":"10.1016/j.sbsr.2025.100758","DOIUrl":"10.1016/j.sbsr.2025.100758","url":null,"abstract":"<div><div>A simple and efficient methane detection approach has been developed in this paper. A THz wave absorber sensitive to refractive index is designed. The proposed absorber mainly uses nested graphene rings and continuous graphene sheets. Two scenarios are followed in this paper. Firstly, a simple single layer including graphene rings on top of the Kapton dielectric and backside coated gold is suggested. The graphene rings face free space or polluted air with a known refractive index in this situation. The second scenario considers the sample (probably toxic polluted air) in the middle layer and also in free space. Both states are mathematically modeled in terms of referred impedance. Additionally, full-wave simulations are also performed. The equivalent impedance can reveal the absorption response of the structure with the aim of impedance matching or maximum power transmission theorem. Interestingly, the impedance modeling converges to the numerical full-wave simulation, verifying efficient mathematical modeling. Furthermore, ample simulation results are provided to investigate the robustness and reliability of the proposed methane optical detector. Based on the findings, the proposed detector is highly appropriate for gas detection, specifically for the healthcare industry due to using Kapton which makes it flexible and wearable.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100758"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel electrochemical aptasensor for L-tryptophan detection utilizing photoluminescent covalent organic polymer","authors":"Farzaneh Mohammadi ,&nbsp;Mahmoud Roushani ,&nbsp;Mina Nasibipour ,&nbsp;Mehrangiz Bahrami ,&nbsp;S. Jafar Hoseini","doi":"10.1016/j.sbsr.2025.100773","DOIUrl":"10.1016/j.sbsr.2025.100773","url":null,"abstract":"<div><div>A novel method was developed for the sensitive detection of L-tryptophan (Trp) utilizing an imine-linked covalent organic polymer (COP) with inherent photoluminescent properties. The COP was synthesized through the reaction of aminoclay (AC) with terephthalaldehyde (TPA). This COP incorporates building blocks featuring a large conjugated aromatic skeleton, high stability, a rough surface, and uniform morphology, facilitating effective binding with aptamers. Electrochemical testing results demonstrated that the aptasensor based on the COP significantly enhanced the detection of Trp, achieving an exceptionally low detection limit of 0.03 fM within a Trp concentration range of 0.1 fM to 500 nM. This detection limit surpasses those of most other reported Trp sensors. Furthermore, the aptamer-based biosensor exhibited remarkable stability and repeatability. This study introduces a new electrochemical sensing approach for Trp detection based on the COP, showcasing a comprehensive understanding of COP-based biosensor design that can be extended to detect various target compounds. The proposed method presents an innovative and cost-effective solution for the swift and accurate identification of Trp using the COP.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100773"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pressure sensor made of laser-induced graphene@carbon ink in a waste sponge substrate using novel and simple fabricaing process for health monitoring","authors":"Aoxun Liang ,&nbsp;Weijie Liu ,&nbsp;Yuanrui Cui ,&nbsp;Peihua Zhang ,&nbsp;Xinkun Chen ,&nbsp;Junlong Zhai ,&nbsp;Wenhao Dong ,&nbsp;Xueye Chen","doi":"10.1016/j.sbsr.2024.100730","DOIUrl":"10.1016/j.sbsr.2024.100730","url":null,"abstract":"<div><div>This paper presents a laser-induced graphene (LIG)@ carbon ink sponge (GCS) pressure sensor. This sensor has the advantage of low cost, significantly reducing the manufacturing cost by using simple materials (carbon ink and sponge) and processes. It has a high linearity with R² = 0.996, a high sensitivity S = 3.68 kPa⁻¹, a response time of 400 ms, and a recovery time of 300 ms. Meanwhile, to reduce the interference of sweat and water vapor in a high-humidity environment, the hydrophobic Ecoflex material is selected and improved by using SiO₂ for packaging, enhancing the practicability of the sensor. The sensor is soft in texture and suitable for human health monitoring, and can be attached to different parts of the human body to monitor various physiological signals. By monitoring the click frequency of the mouse and keyboard, the bending of the arm, the cough at the neck (analyzing its frequency, intensity, and time pattern), the mechanical parameters when walking at the center of the sole, the physiological signal of clenching the fist, and the pressure change when holding a water cup at the center of the palm, it provides a assistance for related fields such as motor function assessment, diagnosis of respiratory system diseases, disease diagnosis and rehabilitation treatment.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100730"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of novel oligomeric Co(II) complexes of 4,4′-bipyridine and 1,10-phenanthroline modified glassy carbon electrode for differential pulse voltammetric determination of ciprofloxacin","authors":"Mezgebu Biresaw ,&nbsp;Adane Kassa ,&nbsp;Getinet Tamiru Tigineh ,&nbsp;Atakilt Abebe","doi":"10.1016/j.sbsr.2024.100721","DOIUrl":"10.1016/j.sbsr.2024.100721","url":null,"abstract":"<div><div>Two new oligomer mixed ligand complexes, comprising 21 ([Co₂₁(phen)₄₂(bipy)₂₁]Cl₄₂ (C2)) and 100 monomer units ([Co₁₀₀(phen)₂₀₀(bipy)₁₀₀]Cl₂₀₀ (C3)) were synthesized. These complexes, designated as [Co₂₁(phen)₄₂(bipy)₂₁]Cl₄₂ (C2) and [Co₁₀₀(phen)₂₀₀(bipy)₁₀₀]Cl₂₀₀ (C3), were employed for the modification of a glassy carbon electrode (GCE) to detect ciprofloxacin (CPF) in tablet formulations and human urine samples. By potentiodynamic deposition, the modified electrodes (poly(C2)/GCE) and (poly(C3)/GCE) were prepared, forming a conductive electroactive film on the GCE surface. The modified electrodes were characterized using cyclic voltammetry and electrochemical impedance spectroscopy, which revealed an increased effective surface area and a significant reduction in charge transfer resistance of the electrode. An oxidative peak at a lower potential with a six-fold increase in peak current was observed at the poly(C2)/GCE. The absence of a reductive peak in the reverse scan indicated the irreversibility of the electrochemical oxidation of CPF. The correlation coefficient between the peak current and the square root of the scan rate indicated that CPF oxidation at the poly(C2)/GCE was primarily controlled by diffusion mass transport. With a detection limit of 3.4 × 10⁻⁹ M, the voltammetric current response of CPF at the poly(C2)/GCE under optimal circumstances showed a linear trend with concentrations ranging from 5.0 × 10⁻⁸ to 2.0 × 10⁻⁴ M. It was discovered that the CPF levels in the examined tablet brands fell between 98.35 % and 101.30 % of their stated ranges. The recovery results for tablet and urine samples ranged from 99.44 % to 99.95 % and 99.25 % to 100.51 %, respectively, with interference recovery showing an error of less than 4.73 %. When it came to determining CPF in tablet formulations and human urine samples, the new approach outperformed recently published voltammetric methods. This superiority can be attributed to the simplicity of the electrode modification step, the lowest limit of detection, and a reasonably wide linear dynamic range.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100721"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in hazardous gases detection: Using dual structures of photonic crystal fiber-based sensor","authors":"Pratishtha Pandey ,&nbsp;Sapana Yadav ,&nbsp;Adarsh Chandra Mishra ,&nbsp;D.K. Dwivedi ,&nbsp;Pooja Lohia ,&nbsp;R.K. Yadav ,&nbsp;Upendra Kulshrestha ,&nbsp;Vipin Kumar ,&nbsp;Prabhu Paramasivam ,&nbsp;R. Bousbih ,&nbsp;M. Khalid Hossain","doi":"10.1016/j.sbsr.2025.100738","DOIUrl":"10.1016/j.sbsr.2025.100738","url":null,"abstract":"<div><div>This paper presents a comparative analysis of two distinct nonlinear elliptical hollow-core photonic crystal fiber (PCF) based sensors designed for the detection of three gaseous analytes, namely CCl₄ (<em>n</em> = 1.461), SnCl₄ (<em>n</em> = 1.5086) and C₁₀H₁₆ (<em>n</em> = 1.472). A comprehensive examination is conducted across a wide wavelength range (1.2 μm–2.6 μm). In order to enhance both the fabrication tolerance and sensing performance of the proposed sensors, investigations have been conducted on the diameter of circular and elliptical-shaped air holes, as well as the dimensions of struts and the core size. Silica works as background material for both the sensors. The sensing parameters including relative sensitivity, effective area, birefringence, and dispersion, have been obtained for two different sensors proposed for evaluation. The numerical investigation employs the finite element method based on Comsol Multiphysics. When comparing both sensors, sensor design-2 stands out with an impressive nonlinear coefficient value of 15.470 W⁻¹Km⁻¹, a higher relative sensitivity of 98.386 %, enhanced effective area of 1.134× 10⁻¹¹ m², comparable effective refractive index of 1.496 and significant birefringence −4.701 × 10⁻⁵, along with low confinement loss for SnCl₄ followed by CCl₄ and C₁₀H₁₆ at 1.2 μm operating wavelength, owing to its higher refractive index compared to sensor design-1 for same sensing analyte. The designed model holds potential applications in sensing, bio-sensing research, and related fields.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100738"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid crystal template-assisted electrodeposition of nanoporous nickel microspheres: A sensitive electrochemical sensing platform for electrocatalytic oxidation and quantitative determination of l-carnitine","authors":"R. Dehdari Vais ,&nbsp;M. Negahdary ,&nbsp;S.R. Rasouli Nasrabadi ,&nbsp;A. Rahi ,&nbsp;S.A. Dastgheib ,&nbsp;H. Heli","doi":"10.1016/j.sbsr.2025.100743","DOIUrl":"10.1016/j.sbsr.2025.100743","url":null,"abstract":"<div><div><span>l</span>-carnitine (LC) is a vital constituent of mammalian tissues, has a significant role in the function of different biological systems, and its determination is of great interest. Electrochemical sensing using nickelaceous nanostructured electrocatalysts offers potential interests and advantages. In the present study, nanoporous nickel microspheres (NNiMs) were electrodeposited and then utilized as an electrode modifier for the electrocatalytic oxidation and determination of LC. NNiMs were electrodeposited on a nickel substrate from a liquid crystal medium containing nickel (II) chloride, and Triton X-100 under a potentiostatic condition. The surface morphological characterization of the obtained nanoporous microspheres was followed by field emission scanning electron microscopy. NNiMs were transformed into the corresponding oxides by applying consecutive potential cycles in an alkaline medium, and the electron transfer coefficient and apparent charge transfer rate constant of the redox species present on the modified electrode surface were calculated as 0.59 and 0.54 s⁻¹, respectively. Cyclic voltammetry, chronoamperometry, and steady-state polarization measurements were used for assessing the electrocatalytic oxidation mechanism and kinetics of LC on the NNiMs surface. Based on these measurements, an LC diffusion coefficient of 4.1 × 10⁻⁶ cm² s⁻¹, a catalytic rate constant of 4.0 × 10⁴ cm³ mol⁻¹ s⁻¹, and an electron transfer coefficient of 0.41 were achieved. The proposed sensor was then employed as a sensitive amperometric sensor for determination of LC with a linear dynamic range of 25 to 217 μmol L⁻¹, a calibration sensitivity of 67.85 mA L mol⁻¹, and a detection limit of 3.2 μmol L⁻¹. The designed sensing platform depicted a stable and reproducible response and insignificant interference from the common species found in the biological fluids and pharmaceutical formulations. Taking all these features together, the developed determination method can be satisfactorily exploited as a simple and quick tool for direct analysis of LC in pharmaceutical oral solutions and human serum samples.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100743"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced point-of-care biomarker testing for the diagnosis of cardiovascular diseases","authors":"Wenjun Ming ,&nbsp;Yidan Zhu ,&nbsp;Wenjun Jiang ,&nbsp;Jing Zhang ,&nbsp;Jinxia Liu ,&nbsp;Li Wu ,&nbsp;Yuling Qin","doi":"10.1016/j.sbsr.2025.100747","DOIUrl":"10.1016/j.sbsr.2025.100747","url":null,"abstract":"<div><div>Cardiovascular disease (CVD) stands as the primary cause of global mortality, necessitating early diagnosis for mitigating death rates and improving quality of life. Conventional CVD diagnostic techniques necessitate the use of bulky hospital instruments for electrocardiogram recording and immunoassay, resulting in time-consuming and inconvenient limitations. Point-of-care testing (POCT) presents unique benefits compared to traditional central laboratory (CLT) methods, such as accelerated turnaround times for results, enhanced portability, and ease of use, which are especially beneficial in resource-constrained healthcare environments. As a result, POCT is increasingly recognized as an innovative diagnostic strategy for the management of CVD, achieving significant standing across a variety of healthcare scenarios. The present review offers a comprehensive overview of the prevailing categories of cardiovascular diseases and emphasizes the diagnostic application of cardiac biomarkers detected through blood tests. The focus of this study is specifically on POCT devices used for the detection of biomarkers related to cardiovascular disease. Additionally, their performance will be compared and evaluated against traditional CLT methods and commercially available equipment. With the growing implementation of hierarchical medical policies and increasing demand for health management services, the market for POCT cardiac biomarkers testing is expected to expand further as a crucial development direction within the field of medicine.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"47 ","pages":"Article 100747"},"PeriodicalIF":5.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}