Perinatology and reproductology: from research to practice最新文献

{"title":"Influence of various methods of treatment of pathology of uterus cervix on obstetric and perinatal outcomes","authors":"I. Kostyuk","doi":"10.52705/2788-6190-2021-3-6","DOIUrl":"https://doi.org/10.52705/2788-6190-2021-3-6","url":null,"abstract":"Today, the frequency of background and precancerous pathology of the cervix of the uterus remains high in the world, the spread of cervical cancer in pregnant women is increasing, and the etiopathogenetic features of the course of sexually transmitted diseases contribute to the threat and development of obstetric and perinatal complications. Therefore, the problem of effective treatment of cervical pathology is one of the most urgent in modern gynecology The condition of the cervix plays an important role in ensuring the normal course of pregnancy and childbirth. In recent years, many methods of treating her diseases have been proposed – both\u0000conservative and surgical. The article presents the advantages and disadvantages of the use of physiosurgical components\u0000aimed at the destruction or extraction of the focus of background and precancerous nature. Analysis of the course of pregnancy and childbirth in women with operated cervix, depending on the method of surgical treatment (diathermocoagulation, cryodestruction, laser vaporization, radio wave coagulation) indicates that with various pathological processes on the cervix, different methods of destructive effects should be used differentially, which must be taken into account when planning pregnancy.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128636089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern state of problem of the combined pathology of uterus and mammary glands at women of perimenopause age","authors":"O. Kruk","doi":"10.52705/2788-6190-2021-3-11","DOIUrl":"https://doi.org/10.52705/2788-6190-2021-3-11","url":null,"abstract":"Among the most common pathological processes in gynecological practice in women of the perimenopausal period are the combined pathology of the uterus and mammary glands. Despite the long history of the study, this problem continues to be the focus of attention of domestic and foreign researchers because of the high risk of malignant degeneration. Particular attention deserves attention to timely quality diagnostics and the development of tactics for the management of patients with combined pathology in perimenopause, since it is during this period of life that women clinicians have the greatest difficulty in choosing the real therapeutic effect.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127062956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and statistical retrospective analysis of the anamnesis of patients with peritoneal pelvic adhesions","authors":"P.F. Shaganov","doi":"10.52705/2788-6190-2021-3-14","DOIUrl":"https://doi.org/10.52705/2788-6190-2021-3-14","url":null,"abstract":"The objective: to identify risk factors for the formation of peritoneal adhesions in women of reproductive age.\u0000Materials and methods. A retrospective analysis of histories of 187 women who were operated by laparoscopic access and diagnosis of peritoneal adhesions was carried out as the main or concomitant. Data on somatic, reproductive and gynecological history, age and social status were assessed. The comparison group consisted of 65 women in which peritoneal adhesions were not detected during surgery.\u0000Results. Analysis of the somatic history of women with and without adhesions in the abdominal cavity showed that women with adhesions had 3.2 (14.97% compared with 4.62%; p <0.05) times more often one or another type of allergy, and 3.5 times more often (10.70% and 3.07% respectively) had autoimmune diseases. Surgical interventions in the past were recorded in both groups, although their number was almost 6 times greater in patients with peritoneal adhesions (53.48% compared to 9.23%; p<0.05). In\u0000women with adhesions in the abdominal cavity, the percentage of operations on the pelvic organs was 2.5 times higher (85.00% compared to 33.33%; p<0.05), and only in this category of patients abdominal drainage was performed during surgery (22.4%; p<0.05). The study of gynecological morbidity in the examined women showed that patients with abdominal adhesions had 3.6 times more often inflammatory diseases of the pelvic organs (61.50% compared to 16.92%; p<0.05), and every third had more than one episode of this pathology in history (33.68%; p<0.05). In addition, every fifth woman with adhesions in the abdominal cavity had endometriosis (17.11% compared with 3.08%; p<0.05). A significant proportion of patients in the main group had 2 or more abortions in the past.\u0000Conclusions. According to the study results, risk factors for the formation of peritoneal adhesions in women of reproductive age include allergic diseases; surgery on the abdominal organs, especially repeated and performed on pelvic organs; drainage of the abdominal cavity after surgery; inflammatory diseases of the pelvic organs and their recurrences; repeated surgical abortions.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128145454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical analysis of somatic and reproductive anamnesis in pregnant with twins after assisted reproductive technologies","authors":"O. Sulimenko","doi":"10.52705/2788-6190-2021-3-15","DOIUrl":"https://doi.org/10.52705/2788-6190-2021-3-15","url":null,"abstract":"The objective: to analyze the somatic and reproductive history in pregnant women with dichorionic, diamniotic twins after the use of assisted reproductive technologies.\u0000Materials and methods. This article presents the clinical characteristics with anamnestic data of 70 women whose pregnancies occurred as a result of assisted reproductive technologies (ART), namely by in vitro fertilization (IVF) using five-day cryoembryos, and in some cases by ICSI (intracytoplasmic) injection of a single sperm) in the classical version. When calculating the results, the methods adopted by medical and biological statistics, described in the manual Glanz [1]. Data processing was performed using StatSoft Statistica 8.0 software package.\u0000Results. According to the data obtained in the groups, primary infertility was 67.1%, secondary 32.9%, the average age of infertility was from 4 to 7 years. The main cause of infertility was a tubular-peritoneal factor of 34.3% in both groups, also a significant share was occupied by male and combined factors without significant differences. In both groups there was a low level of artificial abortions (4.4% vs. 8.7%) and involuntary early abortions (13% vs. 8.7%) (p>0.05). Among genital pathologies the main place is occupied by chronic inflammatory diseases of appendages (40% of group I and 38.1% of group II), endometriosis (31.4% in group I and 38.1% of group II). Analysis of extragenital pathology showed a predominance of hypertensive disorders 25.7% vs. 31.4%, thyroid pathology 42.9% vs. 40%, anemia 25.7% vs. 22.9%.\u0000Conclusions. When comparing the data obtained after analysis of the premorbid background, somatic and reproductive history in pregnant women with twins, significant differences between the main and the comparison group were absent, which allows us to compare them in a further study.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126597346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and anamnestical aspects of very early preterm birth","authors":"O. Mosendz","doi":"10.52705/2788-6190-2021-3-4","DOIUrl":"https://doi.org/10.52705/2788-6190-2021-3-4","url":null,"abstract":"The objective: determine risk factors, causes and clinical features of patients with very early preterm birth.\u0000Materials and methods. The study analyzed the data of anamnesis, the course of pregnancy, childbirth and perinatal outcomes of 166 women of reproductive age with very early preterm birth at 22–27 weeks of gestation. The fact of childbirth at these stages of pregnancy is the main criterion of inclusion. The patients were divided into two groups depending on the criteria of live\u0000birth: group 1 – 79 women, whose labor was regarded as late miscarriage (retrospective study); group 2 – 87 women, whose labor occurred as a very early preterm (prospective study). Exclusion criteria: congenital malformations of the fetus. Patients of both groups have got a comprehensive examination using clinical, instrumental and laboratory research methods. Results. During the management of pregnancy of patients of these groups, special attention was paid to the assessment of risk factors for the development of very early preterm labor, among which the main ones were urogenital infections (83,7% and 78,9% in groups 1 and 2, respectively), which caused perinatal mortality in both groups (p˂0,05). A combination of pathogens was found in almost half of the subjects (43% in group 1,44% in group 2). Patients of both groups had a serious general and obstetric anamnesis, high frequency of inflammatory processes of the genitals, surgery and hormonal disorders with diseases caused by them. The main complications\u0000of gestation of pregnant women of both groups in the second trimester were the miscarriage risk (43% and 30%, respectively) and dysfunction of the fetoplacental complex (FPC) (22,7% and 21,8%, respectively), which caused the syndrome of delayed fetal development in both groups of subjects - in 66% and 63% of children, respectively.\u0000Conclusion. Analysis of general and obstetric history, the presence of infectious factor in combination with extragenital pathology confirm the polyetiology of the causes that leads to very early preterm birth. Considering the main risk factors of preterm birth, a thorough examination for urogenital infections in women at the stage of pre-pregnancy and during pregnancy, followed by treatment and restoration of normal vaginal biocenosis, as well as study of fetoplacental system function from early pregnancy.\u0000Preventive measures and timely treatment of fetoplacental disorders should promote prolonging pregnancy to longer gestations, which is the best way to improve perinatal outcomes.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122539458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive aspects of long-term consequences of ovarian apoplexy","authors":"O.M. Ishak","doi":"10.52705/2788-6190-2021-3-9","DOIUrl":"https://doi.org/10.52705/2788-6190-2021-3-9","url":null,"abstract":"The objective: to determine the long-term consequences of surgical treatment of ovarian apoplexy, taking into account the risk factors of this urgent pathology.\u0000Materials and methods. The study included 112 women (main group, n=112), who underwent surgery for ovarian apoplexy, and 40 patients in the control group (n=40), who had no history of this pathology. All patients underwent a comprehensive examination using clinical, instrumental and laboratory research methods. The groups were homogeneous in age (mean age was 23,6±4,2) and statistically comparable.\u0000Results. Based on the analysis of clinical and anamnestic data of patients who underwent surgical treatment of ovarian apoplexy, we identified the main risk factors for this pathology: chronic diseases of the urinary, respiratory and digestive systems, genital infantilism, ovarian retention cysts, chronic salpingo-oophoritis, menstrual disorders by type of hyperpolymenorrhea and/or algodysmenorrhea, family thrombophilic history, bleeding of various localizations in the anamnesis, artificial abortions, weight loss, smoking. Our proposed comprehensive two-stage rehabilitation system included treatment and prevention measures from the acute period of ovarian apoplexy to the time of reproductive function. The first stage of the treatment complex (early postoperative period) helped to eliminate the effects of ovarian injury, pain relief and hypercoagulable changes in the blood coagulation system,\u0000improving the quality of life during inpatient treatment. The second stage (2 months after surgery) provided the restoration of ovarian function and balance of the hemostasis system, thus preparing a woman’s reproductive system for future pregnancy and childbirth. In the remote postoperative period, the complex stage of rehabilitation in 23 treated patients resulted in the birth of healthy children and the absence of obstetric complications in 22 of them.\u0000Conclusion. Identification and structuring of risk factors for ovarian apoplexy is an important step for comprehensive treatment and prevention of recurrence of this disease. Eliminating or reducing the impact of these factors will help restore the reproductive system and improve quality of life. A comprehensive assessment of the state of the whole organism in the remote postoperative period indicates the need for rehabilitation measures aimed at increasing the natural resistance of the macroorganism and the effective restoration of reproductive function.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125090335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the degree of bacteriuria on perinatal results for asymptomatic urinary tract infection","authors":"Dmytro Gavryushov, T. Andriychuk, Anatoliy Senchuk, Volodymyr Chermak Chermak","doi":"10.52705/2788-6190-2021-3-1","DOIUrl":"https://doi.org/10.52705/2788-6190-2021-3-1","url":null,"abstract":"The objective: to conduct a comparative analysis of the outcomes of pregnancy, childbirth and the postpartum period in women with varying degrees of asymptomatic bacteriuria (AB) and to assess its role in the development of perinatal complications.\u0000Materials and methods. To identify the features of the course of childbirth and the postpartum period in BB, a comprehensive clinical study of 182 pregnant women was carried out, divided into 3 groups. Group I (main) included 85 pregnant women with asymptomatic bacteriuria >105 CFU/ml («severe» bacteriuria), group II included 52 pregnant women with АB 102–104 CFU/ml («moderate» bacteriuria) who did not receive treatment. Group III (control) consisted of 45 pregnant women without urinary tract\u0000infection. Statistical analysis of the research results was carried out using computer processing of the data obtained using the «Excell-5.0» and «Statistica» programs.\u0000Results. The age of the surveyed ranged from 16 to 42 years, while the average age was the same in the studied groups. In the first group it was 27.2±0.63 years, in the second group – 26.2±0.75 years, in the third (control) – 26.7±0.42 years. Premature birth was observed significantly more often in АB. Thus, pregnancy against the background of asymptomatic infection urinary tract ended in premature birth in 10.6% and 11.5% of observations in women of groups I and II, which did not exceed the general population indicator, however, in comparison with healthy patients, it increased in 4.8 and 5 times, respectively (p<0.05).\u0000Conclusion.The results of our study showed that АB affects the development of preterm labor, premature rupture of membranes, increases the frequency of pathological births, caesarean sections and pyoinflammatory diseases in the postpartum period. In pregnant women with asymptomatic infection urinary tract, regardless of the severity of bacteriuria, it is advisable to use antibiotic\u0000therapy to reduce intranatal and postnatal complications, reduce the severity and duration of recurrent infection urinary tract and reduce purulent-inflammatory diseases of puerperium.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126299579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current state of problem of disturbances of menstrual function at women with diffuse dysplasia of mammary glands","authors":"S. Gladenko","doi":"10.52705/2788-6190-2021-3-8","DOIUrl":"https://doi.org/10.52705/2788-6190-2021-3-8","url":null,"abstract":"Diffuse benign dysplasia of the mammary glands is one of the frequent pathologies that practitioners almost daily encounter. Studying the mechanisms of development of pathological gynecological conditions, the researchers concluded that there is a pathogenetic connection between cyclic changes in the reproductive system and the physiological processes occurring in the mammary glands. This makes it possible to assume a high probability of occurrence of pathological changes in the mammary glands in various gynecological diseases, developing as a result of disorders of the hypothalamic-pituitary-ovarian system. The general inhibition and unity of the reaction of the reproductive organs to hormonal imbalance is the main prerequisite for the\u0000development of benign hyperplastic and the risk of malignant processes. The relevance of studying the reproductive health of patients with dyshormonal non-inflammatory pathology of the genital organs is due to the steady increase in the proportion of this pathology in recent years in the structure of gynecological morbidity, the rejuvenation of the patient population, and the lack of a single algorithm for rehabilitation measures. On the one hand, effective treatment reduces symptoms, guarantees quality of life, on the other hand, mastopathy is a risk factor for the development of a malignant tumor in the future. Therefore, timely correction of dysplasia can be considered as a variant of primary prevention of breast cancer. The choice of an adequate tactic to manage such patients from the existing variety of dosage forms is the key to the success of treatment.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121873746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of clinical and anamnestic characteristics of patients with different ovary reserve","authors":"O. Chayka","doi":"10.52705/2788-6190-2021-3-16","DOIUrl":"https://doi.org/10.52705/2788-6190-2021-3-16","url":null,"abstract":"The objective: conduct a clinical and statistical analysis of anamnestic data in infertile women with a predicted weak response of the ovaries to gonadotropins stimulation.\u0000Materials and methods. A prospective study of the clinical and statistical analysis of anamnestic data in infertile women with a predicted weak response of the ovaries to gonadotropins stimulation was carried out on the base of CRT USIR Shupyk National Healthcare University of Ukraine, for the period from 2020–2021. Group I consisted of 55 of reproductive aged women with chronic\u0000endometritis and repeated unsuccessful attempts of IVF, and control group consisted of 40 reproductive aged women without impaired fertility.\u0000Scope of research: pH-metric of vaginal discharge, assessment of vaginal microbiocenosis by microscopic data of a smear stained by Gram, endometrial biopsy and examination of polymerase chain reaction (PCR) of vaginal discharge culture and cervical canal microflora.\u0000Results. According to obtained data, in both groups, primary infertility was 43.6% and 55.5%, secondary – 53.4% and 44.4%, respectively. In both groups, there was a high level of artificial abortions (21.8% and 31.1%) and spontaneous early abortions (14.5% and 13.3%) (p<0.05). Among gynecological pathology, the main place is occupied by chronic inflammatory diseases (56.3% of women in group I and 62.2% in group II) and endometriosis (29.1% in the first group and 26.7% in group II). All women with a predicted weak ovarian response to gonadotropin stimulation had surgical interventions on the pelvic organs in anamnesis; 78.0% (78/100) of cases were performed laparoscopic approach. Analysis of surgical intervention structure in women of both groups revealed high frequency of ovarian resection due to the presence of functional cysts and benign formations (27.0%, 27/100).\u0000Conclusions. Thus, the predisposing factors for a «weak» response in IVF programs were an older reproductive age, a high frequency of surgical interventions on the pelvic organs and, as a consequence, a change in the blood supply of the ovarian cortical layer, a decrease in stroma volume and follicular reserve reduction. According to main clinical and anamnestic characteristics, groups were comparable and revealed intergroup differences were statistically insignificant that allows us to compare them with each other in a further study.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126872102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of lipid peroxidation processes and antioxidant protection system in pregnant women with type I diabetes mellitus and their newborns","authors":"Оlexandr Тітоv, A. Senchuk, Victoria Titova, I. Doskoch, V. Chermak","doi":"10.52705/2788-6190-2021-3-5","DOIUrl":"https://doi.org/10.52705/2788-6190-2021-3-5","url":null,"abstract":"The objective: to determine the characteristics of lipid peroxidation processes and the antioxidant defense system in pregnant women with type I diabetes mellitus and their newborns.\u0000Materials and methods. 160 patients at 12–41 weeks of gestation were examined. The main group included 110 pregnant women with type I diabetes mellitus, the control group – 50 healthy pregnant patients. Evaluation of lipid peroxidation activity was determined by the content of diene conjugates, lipid hydroperoxide, malondialdehyde in blood serum and erythrocytes, superoxideanion O2 in blood plasma.\u0000Results. Analysis of the results in patients with diabetes mellitus showed a significant activation of lipid peroxidation processes. In the first half of pregnancy, the content of lipid hydroperoxide, malondialdehyde of plasma and erythrocytes, as well as superoxide anion in patients with diabetes mellitus was higher than in healthy pregnant women. In the second half, all lipid peroxidation\u0000indicators in patients with diabetes mellitus exceeded the corresponding indicators in healthy pregnant women.\u0000The dynamics of antioxidant defense system indices in diabetes mellitus indicates a compensatory tension of its main links with a subsequent decrease in their activity, in contrast to healthy pregnant women, where the antioxidant defense system activity increases adequately to the growth of lipid peroxidation activity.\u0000Conclusion. Disorders in the lipid peroxidation system in pregnant women with diabetes mellitus should be regarded as such that negatively affect the development and functioning of the fetoplacental complex. The results indicate the need to include the pregnant women with diabetes mellitus in the risk group of the placental dysfunction development, with the aim of its timely\u0000prevention, thereby reducing perninatal morbidity and mortality.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128894900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}