Perinatology and reproductology: from research to practice最新文献

{"title":"Influence of excess body weight on tactics of maintaining women of reproductive age with hyperplastic processes an endometrium","authors":"Yurii Sadugov","doi":"10.52705/2788-6190-2021-3-12","DOIUrl":"https://doi.org/10.52705/2788-6190-2021-3-12","url":null,"abstract":"The objective: decline of frequency of relapses of hyperplastic processes of endometrium for the women of reproductive age with surplus mass of body on the basis of improvement and introduction of algorithm of treatment-and-prophylactis and prognostic measures.\u0000Materials and methods. The conducted researches carried stage-by-stage character. So, on I stage the analysis of clinical – anamnestic, hormonal and metabolic features of patients of reproductive age with surplus mass of body and hyperplastic processes of endometrium is a 1 group (n=90), patients with surplus mass of body, but without the hyperplastic processes of endometrium – 2 group (n=60). On II stage progressive, randomized, opened, comparative research of efficiency of hormonotherapy of hyperplastic processes of endometrium was conducted in 90 women of reproductive age with surplus mass of body (1 group) by the agonist of gonadotropin-releasing hormone (sub-group of 1.1, n=30), progestine (sub-group of 1.2, n=30), by estrogen-gestagenic preparation (sub-group of 1.3, n=30) and means that it is powerful enough. On III stage were found out the factors of risk of uneffectiveness of treatment and recurrent flow of hyperplastic processes of endometrium for the women of reproductive age with obesity. Method of incremental discriminant analysis (n=90): patients with recurrent motion of hyperplastic processes of endometrium (3 group of, n=40), patients without the relapse of hyperplastic processes of endometrium (4 group of, n=50).\u0000Results. At the comparative estimation of efficiency of treatment of hyperplastic processes of endometrium for women it was set with surplus mass of body, that frequency of relapses in 24 months takes place for 6,7% patients after therapy of а-GRG, at 46,7% patients which got norethisterone, and for 63,3% women, treated the combined oral contraceptives. A level of the forced operative treatment (hysterectomia) is 3,3% for women which got а-GRG and 23,3% – norethisterone and combined oral contraceptives.\u0000Conclusion. For the women of reproductive age with the hyperplastic processes of endometrium and surplus mass of body for treatment most effective and safe in relation to operating there is application of а-GRG on metabolic processes and hormonal status. The use of norethisterone and combined oral contraceptives is possibly in default of found out the factors of risk.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"138 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131246064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of women with high risk of Great obstetrical syndromes","authors":"N. Lemish","doi":"10.52705/2788-6190-2021-3-3","DOIUrl":"https://doi.org/10.52705/2788-6190-2021-3-3","url":null,"abstract":"The objective: to conduct clinical and statistical analyses of somatic and reproductive history of women of Great obstetrical syndromes (GOS) high risk group.\u0000Materials and methods. We have conducted clinical and statistical analyses of somatic and\u0000reproductive history of 200 pregnant women of GOS high risk group, who were divided by a random selection into 2 groups: I (main) group – 100 pregnant women, that further during research undergone pregravid preparation, obstetrical and perinatal support and delivery according to our method of medical and organization algorithms, prognostication, treatment and prophylactic schemes; II group – 100 pregnant women, who received routine prognostication and treatment and prophylactic measures and III group (control group) -50 almost healthy pregnant women with positive reproductive history and noncomplicated course of this pregnancy. Statistical analyses was conducted using program package StatSoft Statistica 8.0.\u0000Results. In I and II groups the age more than 30 was observed in 32,0% and 34,0% respectively, compared to 18% of healthy pregnant, (p <0,05), that corresponds to the data, that indicate higher incidence of GOS in pregnant women of older patients. It should be noted, that pregnant of GOS risk group, had significantly higher incidence of infectious diseases (р<0,05), such as\u0000diseases of respiratory tract (pneumonia, bronchitis), renal diseases and also pathology of thyroid gland, diabetes mellitus and arterial hypertension. Later might indicate, that somatic pathology in history can play a role in GOS pathogenesis. The incidence of genital inflammatory diseases was 12,0% compared to 28,0% and 31,0% respectively (р<0,05), cervical intraepithelial neoplasia\u00004,0% compared to 17,0% and 19,0% respectively (р<0,05). Mentioned data suggest that gynecological diseases play a specific role in early placentation disorders, development of placental disfunction and further to fetal development pathology. High level of complicated somatic and reproductive history, as we suppose, may be GOS risk factors in these pregnant women. Shown data indicate the need of further improvement of measures, aimed on pregnancy planning, pregravid preparation, antenatal fetal guard and decrease of incidence of complications from maternal and fetal side in these pregnant.\u0000Conclusions. When analyzing data after conducted research of premorbid background, somatic and reproductive history of women from GOS risk group, no significant difference was found, that gives us the possibility to further compare them in ongoing research.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130012192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}