Clinical characteristics of women with high risk of Great obstetrical syndromes

The objective: to conduct clinical and statistical analyses of somatic and reproductive history of women of Great obstetrical syndromes (GOS) high risk group. Materials and methods. We have conducted clinical and statistical analyses of somatic and reproductive history of 200 pregnant women of GOS high risk group, who were divided by a random selection into 2 groups: I (main) group – 100 pregnant women, that further during research undergone pregravid preparation, obstetrical and perinatal support and delivery according to our method of medical and organization algorithms, prognostication, treatment and prophylactic schemes; II group – 100 pregnant women, who received routine prognostication and treatment and prophylactic measures and III group (control group) -50 almost healthy pregnant women with positive reproductive history and noncomplicated course of this pregnancy. Statistical analyses was conducted using program package StatSoft Statistica 8.0. Results. In I and II groups the age more than 30 was observed in 32,0% and 34,0% respectively, compared to 18% of healthy pregnant, (p <0,05), that corresponds to the data, that indicate higher incidence of GOS in pregnant women of older patients. It should be noted, that pregnant of GOS risk group, had significantly higher incidence of infectious diseases (р<0,05), such as diseases of respiratory tract (pneumonia, bronchitis), renal diseases and also pathology of thyroid gland, diabetes mellitus and arterial hypertension. Later might indicate, that somatic pathology in history can play a role in GOS pathogenesis. The incidence of genital inflammatory diseases was 12,0% compared to 28,0% and 31,0% respectively (р<0,05), cervical intraepithelial neoplasia 4,0% compared to 17,0% and 19,0% respectively (р<0,05). Mentioned data suggest that gynecological diseases play a specific role in early placentation disorders, development of placental disfunction and further to fetal development pathology. High level of complicated somatic and reproductive history, as we suppose, may be GOS risk factors in these pregnant women. Shown data indicate the need of further improvement of measures, aimed on pregnancy planning, pregravid preparation, antenatal fetal guard and decrease of incidence of complications from maternal and fetal side in these pregnant. Conclusions. When analyzing data after conducted research of premorbid background, somatic and reproductive history of women from GOS risk group, no significant difference was found, that gives us the possibility to further compare them in ongoing research.