Perinatology and reproductology: from research to practice最新文献

{"title":"Efficacy of Clinical and Pathogenetic Treatment of Patients with Alopecia Areata Associated with Metabolic Syndrome","authors":"I. Horda","doi":"10.52705/2788-6190-2023-03-14","DOIUrl":"https://doi.org/10.52705/2788-6190-2023-03-14","url":null,"abstract":"Alopecia areata (HA) is an autoimmune inflammatory disease of hair follicles (HF) with a nonscarring pattern of hair loss on a scalp and/or other areas of skin. The objective: to assess the efficacy of the developed complex pathogenetically justified method of treatment of patients with AA associated with MS using drugs for the correction of dyslipidaemia and insulin resistance. Materials and methods. 59 patients with alopecia areata of moderate severity associated with metabolic syndrome underwent complex pathogenetic treatment with correction of lipid and carbohydrate indicators. In the course of the study, patients were divided into 4 groups: 1A (n=16) – patients with AA, burdened with MS (3 components), who underwent basic therapy of AA and treatment of metabolic disorders with rosuvastatin at a dose of 10 mg per day; 1B (n=14) – patients with AA with MS (3 components), who were prescribed basic therapy and correction of metabolic disorders through diet; 1C (n=14) – patients with AA with MS (4–5 components), who received basic therapy, as well as rosuvastatin 10 mg per day and thioctacid 600 mg per day; 1D (n=15) – patients with AA, burdened with MS (4–5 components), who received basic therapy and followed a diet. Results. As a result of the study, the following predicted patterns were revealed: - the level of blood glucose in patients of group 1A after 6 months of treatment decreased by 5%, in patients of group ǀB – by 2%; in group 1A, the acceleration of the improvement dynamics of the HOMA index and triglycerides was determined, in contrast to group ǀB; the level of total cholesterol in group 1A compared to group ǀB was statistically significantly lower (p<0.05%); - statistically significant differences (p<0.05%) were found regarding the improvement of blood glucose and LDL levels after 6 months of treatment in patients of groups 1C and 1D in favour of group 1C, taking into account the improvement of these indicators in both groups during the study period; - compared to patients of group 1D, patients of group 1C after 6 months of treatment showed a statistically significant improvement in all the studied indicators that determine the severity of MS; - after 6 months of treatment of patients with AA, statistically more cases of recovery were found in group 1C compared to group 1A (p=0.041); after 12 months in group 1C, the frequency of cases of clinical recovery was statistically significantly higher (p=0.069) compared to group 1D (p=0.035) and group 1B (p=0.017); - the number of cases of a diagnosed positive effect (clinical recovery and partial effect), which began to manifest itself after 6 months and intensified after 12 months, prevailed in group 1A in contrast to group 1B, in which, on the contrary, an increase in the number of cases with no effect or deterioration was recorded; - the number of cases of a positive effect in group 1C after 6 months of dermatosis treatment statistically significantly exceeded the number of such cases","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139318485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological features of erdometrium for women with reproductive losses on a background chronic endometritis","authors":"O.M. Susidko","doi":"10.52705/2788-6190-2023-03-12","DOIUrl":"https://doi.org/10.52705/2788-6190-2023-03-12","url":null,"abstract":"The objective. Analysis to investigate the morphological features of endometrium in patients without aphids with chronic endometritis. Materials and methods. Conducted a prospective investigation in women with a history of chronic endometritis and infertility. The main group - 100 women of reproductive age with chronic endometritis, the control group - 40 women of reproductive age, with supra-temporal menstruation, with a medical history of history of pregnancy and childbirth. To study the morphological characteristics of endometrium in patients with chronic endometritis, an assessment of the results of endometrial biopsy, viconanization on the 5th-7th day of the menstrual cycle was carried out using an additional aspiration curette Pipelle de Cornier (France). Statistically significant differences were taken as p<0.05. Results. Pathomorphological examination of the endometrium revealed characteristic signs of chronic inflammation - the presence of a large number of plasma cells in the stroma of the endometrium, lymphoid infiltrates near blood vessels and the mouth of glands, unevenly expressed fibrosis of the stroma, sclerotic changes in the walls of spiral arteries. All examinees had two or more morphological signs of chronic endometritis. The most common morphological sign of chronic endometritis in the main group was inflammatory infiltrates, consisting mainly of lymphoid elements, which occurred in 94.0%, respectively, and were absent in patients of the control group (p<0.001). Focal fibrosis of the endometrial stroma covered large areas in the vast majority of women in the main group and accounted for 93.0% (р<0,01). In the stroma of the endometrium, the appearance of capillary-type vessels was noted, the intensity of their development had a strong correlation with the degree of severity of inflammatory changes (r=0.69: p<0.05). Conclusions. A morphological study of the endometrium in patients with infertility, against the background of chronic endometritis, shows that inflammatory changes in the tissues have clear morphological criteria, which are most pronounced on the 5-7th day of the menstrual cycle - the presence of plasma cells, stroma fibrosis, and sclerosis of the vessel walls","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139336398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound examination of mammary glands in patients with infertility on background violations of menstrual function","authors":"S. Gladenko","doi":"10.52705/2788-6190-2023-03-6","DOIUrl":"https://doi.org/10.52705/2788-6190-2023-03-6","url":null,"abstract":"The objective. Іs to investigate the state of the mammary glands in patients with infertility of endocrine genesis. Materials and methods. The study was conducted in 110 patients with endocrine infertility who underwent an ultrasound examination of the mammary glands. The first group (n=52) consisted of patients with a regular menstrual cycle against the background of luteal phase insufficiency, the second group (n=58) consisted of patients with a menstrual cycle disorder with anovulation. Statistical processing of the research results was carried out using the standard programs \"Microsoft Excel 5.0\" and \"Statistica 8.0\". Results and their discussion. Changes in the mammary glands according to the type of PCH in the studied group were found in 44 out of 110 patients (40.0%), underdevelopment of the structural elements of the mammary glands - in 19 out of 110 (17.3%), early involutional changes - in 6 out of 110 (65, 4%), focal formations – in 4 out of 110 (3.6%). The frequency of fibrocystic disease in patients of the II group was 1.3 times higher compared to the I group - 24 (41.3%) versus 20 (38.4%), respectively, p<0.01. At the same time, focal mammary gland formations of the fibroadenoma type were diagnosed 3.5 times more often in patients of the I group - 3 (5.8%) versus 1 (1.7%) in the II group, p<0,01. Conclusions. In infertility of endocrine genesis, the first place in the structure of mammary gland pathology is diffuse fibrocystic disease - 40.0%. The frequency of underdevelopment of mammary glands is 17.3%, early involutional changes 10.3%, and focal formations like fibroadenoma are 3.6% of cases.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139336555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated laparoscopy is at complication after gynaecological endoscopic operations","authors":"Valery Kostikov","doi":"10.52705/2788-6190-2023-03-7","DOIUrl":"https://doi.org/10.52705/2788-6190-2023-03-7","url":null,"abstract":"The objective. To analyze the results of repeated laparoscopy for patients of gynecological type with suspicion of intra-abdominal postoperative complications. Materials and methods. 42 patients (middle age - 46±11,3 years) with postoperative abdominal complications after surgical treatment of different gynecological diseases needed repeated operations took part in the research. Depending on the method of the repeated interference patients are up-diffused into 2 groups: basic (n=20) are women for the correction of postoperative complications laparoscopy only; control (n=22) are women in which for the correction of postoperative complications during diagnostic laparoscopy there were the proposed testimonies to relaparotomy. In 8 patients of the control group relaparotomy is executed at once. A complex inspection was conducted on all patients with the application of clinical, instrumental, and laboratory methods of research. Groups were homogeneous in age and by the structure of operations, executed on the organs of the small pelvis, and statistically comparative. Results. During research, the analyzed results of repeated laparoscopy of 34 patients of gynecological type are suspicion of intra-abdominal postoperative complications. For all patients of the basic group (47,6%) laparoscopy appeared the unique and eventual method of treatment of postoperative complications, in 7 women repeated реlaparoscopy was used from 2 to 4 times, and in 13 laparoscopies it was conducted singly. In the group control (52,3%) 10 patients during diagnostic laparoscopy were exposure to testimony to relaparotomy, 4 patients of the possibility of an operating brigade and laparoscopic technique allowed to execute some elements of operation and complete mini-laparotomy access, and 8 patients relaparotomy is executed at once. Peritonitis and intra-abdominal bleeding predominate in the structure of early abdominal complications. Application of videolaparoscopic method allowed in 28,6% patients with the poured out peritonitis successfully to liquidate the developed complication, remove his source and conduct санацію of abdominal region. Laparoscopic hemostasis is successfully executed in 7 patients. By comparison to standard, the use of videoendoscopic method allowed to improve the indexes of diagnostic value: to increase the level of sensitiveness in 1,07 times, in 1,39 times of specificity and in 1,11 times of exactness of diagnostics. Conclusion. On the whole in an early postoperative period concerning the suspected complications it is executed 47 реlaparoscopy, that is explained by the leadthrough of programmable sanation of abdominal region by application of dynamic laparoscopy for control of motion of intra-abdominal complication. On the basis of analysis of the investigated material we are offer general testimonies and contra-indications to the leadthrough of реlaparoscopy in an early postoperative period with the purpose of diagnostics and treatment of postoperative co","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139336574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency and structure of thyroid disfunction is at gynaecological diseases","authors":"I.P. Netskar","doi":"10.52705/2788-6190-2023-03-8","DOIUrl":"https://doi.org/10.52705/2788-6190-2023-03-8","url":null,"abstract":"The objective. Women have a study of frequency and structure of thyroid violations with gynaecological diseases. Materials and methods. The screening estimation of pathology of thyroid is conducted was mine-out in 298 women with infertility (basic group) and in 50 fertility of women which appealed to the clinic for the selection of method of contraception (control group). The selection of patients was carried out by the opened cohort method as far as handling of patients infertility in the separation of maintainance and proceeding in a reproductive function. A questionnaire is conducted in 205 women with infertility. The inspection of patients with infertility was conducted in accordance with the generally accepted diagnostic algorithm, including endoscopic methods, and treatment – depending on found out reasons of infertility. Results. Prevalence of thyroid pathology women with infertility had at 3,8 time higher as compared to fertility women (48,0% and 12,5% respectively, p<0,05). In the structure of thyroid pathology at infertility prevailed the transmitter of antibodies to thyroperoxidase in combination with the signs of echo of autoimmune thyroiditis (24,0%); hypothyroidism as a result of autoimmune thyroiditis (9,4%), including manifest (0,8%) and subclinical (8,6%) women and euthyroid goitre (7,8%), while part of patients with infertility and thyrotoxicosis was low (0,6%). The estimation of the state of the reproductive system for women with infertility depending on found out pathology of thyroid rotined that a leading place in the structure of reasons of infertility for women external genital endometriosis occupied with autoimmuny thyroiditis - 34,4%, for women with found out a hypothyroidism is an endocrine factor of infertility (polycystic ovary syndrome) – 29,8%, for patients with the compensated hypothyroidism is external genital endometriosis (26,6%), for women with a euthyroid goitre and for patients without pathology of thyroid - pipe peritoneal factor (33,3% and 39,8%, respectively). Conclusion. The results of questionnaire, conducted for women with infertility, showed the low diagnostic value of clinical symptoms of hypothyroidism as compared to laboratory diagnostics in verification of this diagnosis. A sensitiveness of symptoms was low and hesitated from 16,1% to 27,8%, while specificity of symptoms was considerable and varied from 85,1% to 94,5%. A leading place in the structure of reasons of infertility for women with autoimmuny thyroiditis occupies external genital endometriosis (34,4%); for patients with a hypothyroidism is endocrine infertility (29,8%), for women with a euthyroid goitre and without pathology of thyroid - pipe peritoneal factor of infertility (33,3% and 39,8%). The got results must be taken into account at development of algorithm of diagnostic and treatment-and-prophylactic measures.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139336087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical and non­surgical methods of penis enlargement","authors":"Olena Lytvak, V. Shaprynskyi, Marianna Markova, Yurii Zasieda","doi":"10.52705/2788-6190-2023-03-13","DOIUrl":"https://doi.org/10.52705/2788-6190-2023-03-13","url":null,"abstract":"Abstract. In this scientific study we reviewed the literature on non-invasive and invasive methods of male genital enhancement. A non-systematic review of current scientific evidence was conducted to obtain reliable data on surgical and non-surgical penile procedures, which may form the basis of possible indications and recommendations for the future. To achieve this goal, we conducted a systematic search for scientific medical information in English-language databases such as MEDLINE, Embase, AMED (Allied and Complementary Medicine) and HMIC (Health Management Information Consortium). We analyzed all articles that met the specified search parameters. In addition, a manual search for relevant references in the found texts was conducted. The study conducted in this paper examined and recorded the main results related to changes in penis size in men who used both non-surgical and surgical methods of penis enlargement. One of the key goals of this study was to examine in detail the impact of different methods on the length and girth of the penis, as well as to analyze possible complications after these procedures. The principles of choosing treatment methods for patients who express a desire to increase the size of the penis are based on the individual characteristics of the patient, his medical indicators and personal preferences. Doctors should take into account the patient's general health status, possible risks of complications, and his realistic expectations of the procedure. Based on the results of the literature analysis, a strategy for working with patients before penis enlargement procedures was generalized. This strategy includes detailed counseling of the patient about possible methods, their benefits and risks, as well as taking into account his personal wishes. An important step is to prepare the patient for the procedure, including all the necessary examinations and tests to determine his suitability for the intervention.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139336066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of preconception care in the program of miscarriage prevention in patients with reduced reproductive potential due to endometrial hyperplasia and obesity","authors":"O. Makarchuk, Oksana Ostrovska, Mariana Rymarchuk, I. Orishchak, N. Henyk, Pavlo Prudnikov, S. Ostafiichuk","doi":"10.52705/2788-6190-2023-03-11","DOIUrl":"https://doi.org/10.52705/2788-6190-2023-03-11","url":null,"abstract":"Summary. One of the most severe consequences of endometrial hyperplasia in the reproductive age is infertility, and the fact of miscarriage and an increase in the rate of spontaneous abortions in obesity is currently proven. The aim of the study is to evaluate the effectiveness of an optimized program of preconception care and pregnancy monitoring in patients with impaired reproductive function against the background of endometrial hyperplasia and obesity. Research materials and methods. All 100 women with impaired reproductive function against the background of endometrial hyperplasia and BMI>30 kg/m2 underwent a comprehensive clinical and laboratory examination and were divided into two groups by the method of blind sampling: the main group included 50 patients, who were offered an optimized program of preconception care, and the comparison group consisted of 50 women who received traditional folate therapy. The effectiveness of therapeutic options and rehabilitation measures was evaluated 3 months after the completion of the endometrial pathology treatment program and monitored during the year based on the results of natural fertility cycles, cycles of the IVF program, taking into account the proportion of pregnancy complications, its consequences and the percentage of live births. Research results and their discussion. Pregnancy in overweight women is accompanied by a higher percentage of early reproductive loss (20.0%), preterm birth (16.0%), preeclampsia, especially severe form (45.0%), placental dysfunction, and low birth weight babies (15.0%), as well as failed IVF program attempts. Out of 100 examined patients with endometrial hyperplasia against the background of a violation of fat metabolism, 15 patients (15.0%) decided to postpone reproductive plans, 32 women (32.0%) were offered an IVF program after two unsuccessful ovulation inductions in a natural fertility cycle, 43 patients (43.0%) had a spontaneous pregnancy, 10 women (10.0%) did not get pregnant. At the time of the analysis of the final conclusions, it should be noted a 1.9 times higher share of spontaneous pregnancy, a 2.1 times higher share of successful IVF attempts, a 1.5 times higher share of live births, and 4.2 times less reproductive failures. The risk of retrochorial hematoma in the comparison group increases 4.1 times (OR=4.14, 95% CI: (1.30-13.21; p<0.05), as well as the risk of early reproductive losses (OR= 3.12, 95% CI: (1.21-8.02; p<0.05), and the possibility of successful termination of pregnancy in the main group exceeds such data in the comparison group by 6.0 times (OR=6.0, 95%, CI: (1.75-20.62; p<0.05). Conclusions. Careful monitoring and diagnostic algorithm in patients with endometrial hyperplasia, as a significant factor in subfertility, allows choosing a rational personalized approach to the use of minimally invasive visual techniques and rehabilitative therapeutic options for restoring the morphofunctional state of the endometrium and metabolic para","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139336412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic aspects of laboratory research of amniotic fluid are at premature births","authors":"Anastasiya Padchenko","doi":"10.52705/2788-6190-2023-02-3","DOIUrl":"https://doi.org/10.52705/2788-6190-2023-02-3","url":null,"abstract":"The objective: to learn a diagnostic value clinical-and-laboratory research of amniotic fluid atpremature births. Materials and methods. Under our supervision in clinical terms was 142 puerpera which actedon births to maternity establishments of different level. All the inspected acted with beginning ofchildbirth. From an incurrence there were eliminated puerpera with a multifetation, pelvic fetal presentation, anomalies of development of fetus and antenatal fetal death. Most inspected was inactive reproductive age. Middle age of inspected made 24,9±0,3 year.A complex clinical inspection was conducted all pregnant at a receipt in permanentestablishment. The clinical inspection of women was included by the study of anamnesisof life, including also to anamnesis of disease, the features of motion of pregnancy werestudied, the generally accepted laboratory and functional methods of research wereconducted. To the complex of additional methods researches were included echographic,cardiotocographic and Doppler. Results. The study of hormonal status of amniotic fluid rotined in births, that content ofestradiol during a childbirth had hesitated within the limits of 30–180 ng/ml. Found out areliable difference between maintenance of this hormone in a amniotic fluid at birth of boysand girls. So at birth of girls the index of estradiol arrived at 21,4±2,3 ng/ml, while at birthof boys a middle index of estradiol was at the level of 16,5±2,3 ng/ml. Although found out adifference and did not carry reliable character (р>0,05), this fact specifies on participating offetus in making a amniotic fluid.Meantime, level of estradiol in a amniotic fluid at birth of boys and girls identically for certainrose at presence of obstetric pathology, such as a weakness of childbirth in combination withfetal distress (p<0,05). An analogical picture is marked in maintenance of cortisol in a amnioticfluid. Indexes of cortisol in a amniotic fluid in births were within the limits of 200–450 nmol/ml.Thus at birth of girls the middle level of cortisol made 180,4±8,4 nmol/ml and at birth of boys –265,4±10,2 nmol/ml, that also testifies to participating of fetus in making of amniotic fluid.Between two hormones found out direct cross-correlation connection (r=0,64; p<0,05). Atpathological motion of births index of estradiol, as well as to the cortisol, rose for certain, thathad testified to the intrauterine fetal distress (p<0,01). The found out intercommunication oflevels of estradiol and cortisol is with other parameters of amniotic fluid and state of fetus inbirths. An index of estradiol was in direct dependence on the indexes of resistance of bloodstream at dopplerometry, namely – systolic-diastolic ratio and index of resistance (r=0,64).The indexes of estradiol and cortisol appropriately rose at the decline of pH in a amnioticfluid (r=-0,71; p<0,01) and at the decline of basale rhythm of cardiac activity of fetus oncardiotocogram (r=-0,69). Conclusion. The results of the conduct","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features of the autonomic nervous system and their correlation with psycho-emotional disorders in women with hypertensive states during pregnancy","authors":"Yaroslav Zadorozhniy, S. Ostafiichuk","doi":"10.52705/2788-6190-2023-02-1","DOIUrl":"https://doi.org/10.52705/2788-6190-2023-02-1","url":null,"abstract":"The objective: to evaluate the clinical characteristics and correlation between signs of autonomic nervous system (ANS) dysfunction and psychoemotional disorders in pregnant women with gestational hypertension/preeclampsia and pregnant women with hypertensive states during the previous pregnancy. Materials and methods. The study involved 124 women pregnant women with gestational hypertension/preeclampsia (first group), 48 pregnant women with hypertensive states during the previous pregnancy (second group), and 35 women with a physiological pregnancy (control group). The study of ANS status was conducted by Wein questionnaires for subjective and objective assessment of autonomic status, the evaluation of the Kerdo informative index, and the study of psychoemotional state based on well-being, activity, and mood assessment questionnaire and Spielberger–Khanin scale of reactive and personal anxiety. Data were analyzed using Statistica 10.0 (StatSoft Inc., USA). Results. Сlinical characteristics of autonomic dysfunction were detected in all pregnant women of the first group with an increase of sympathetic activity in association with psycho-emotional disorders, which were proved based on increasing points on the scales of subjective (36,03±4,08) and objective assessment of autonomic status (44,28±5,45), a 6,1-fold increase in the percentage of patients with sympathicotonia due to Kerdo informative index compared to control, the presence of asthenic disorders was associated with a bad mood and an increased level of high anxiety. In the second group, significant autonomic dysfunction was diagnosed at an early stage, and asthenic disorders associated with high levels of situational anxiety were diagnosed in a higher percentage of patients compared to the control. A significant correlation was proved between the number of points of the Wein objective scale and the scores of well-being, activity, and mood assessment questionnaire(r= – 0,76; p<0,001), the levels of personal (r=0,33; p<0,001) and reactive anxiety (r=0,41; p<0,001). Conclusions. Therefore, hypertensive states during pregnancy are considered a syndrome of psycho-emotional and autonomic-vascular dysadaptation, caused by the personal characteristics of a woman before the onset of complications against the background of persistent insufficient autonomic support of pregnancy, which indicates the importance of studying the psychological status of a woman and the dysfunction of the ANS in the early stages of pregnancy to find out the expressiveness deviations for monitoring and optimization of treatment and preventive measures.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian tumors in women after hysterectomy for benign diseases","authors":"Maryan Halandzhiy","doi":"10.52705/2788-6190-2022-03-4","DOIUrl":"https://doi.org/10.52705/2788-6190-2022-03-4","url":null,"abstract":"Varian cancer is one of the most common malignant neoplasms of the female reproductive systemand ranks first as the cause of women’s mortality from oncogynecological pathology. Over thepast 10 years, the increase in the incidence of ovarian cancer was 11.5% and remains high todaywithout a clear downward trend. According to the United Kingdom Collaborative Study, for one woman with a confirmed diagnosisof ovarian cancer, ten women underwent unnecessary surgical interventions and manipulationsbased on the results of imaging methods.Hysterectomy without accompanying ovariectomy has traditionally been considered one of theways to protect against ovarian cancer. But the latest data, which includes a large numberof contemporary studies of women recently diagnosed with ovarian cancer, did not find asimilar correlation. These findings may be related to changes in surgical practice, the use ofmenopausal hormone therapy, or perhaps improved reporting of oophorectomy.The risk of detecting epithelial ovarian cancer after hysterectomy has been repeatedly studied,but summarizing the data of most studies, no statistically reliable data were found that wouldindicate an increase in the risk of developing a malignant disease after this surgical intervention.However, the question needs further study in terms of the rapid development of modern oncology.","PeriodicalId":419861,"journal":{"name":"Perinatology and reproductology: from research to practice","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123711415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}