Clinical analysis of somatic and reproductive anamnesis in pregnant with twins after assisted reproductive technologies

Abstract

The objective: to analyze the somatic and reproductive history in pregnant women with dichorionic, diamniotic twins after the use of assisted reproductive technologies. Materials and methods. This article presents the clinical characteristics with anamnestic data of 70 women whose pregnancies occurred as a result of assisted reproductive technologies (ART), namely by in vitro fertilization (IVF) using five-day cryoembryos, and in some cases by ICSI (intracytoplasmic) injection of a single sperm) in the classical version. When calculating the results, the methods adopted by medical and biological statistics, described in the manual Glanz [1]. Data processing was performed using StatSoft Statistica 8.0 software package. Results. According to the data obtained in the groups, primary infertility was 67.1%, secondary 32.9%, the average age of infertility was from 4 to 7 years. The main cause of infertility was a tubular-peritoneal factor of 34.3% in both groups, also a significant share was occupied by male and combined factors without significant differences. In both groups there was a low level of artificial abortions (4.4% vs. 8.7%) and involuntary early abortions (13% vs. 8.7%) (p>0.05). Among genital pathologies the main place is occupied by chronic inflammatory diseases of appendages (40% of group I and 38.1% of group II), endometriosis (31.4% in group I and 38.1% of group II). Analysis of extragenital pathology showed a predominance of hypertensive disorders 25.7% vs. 31.4%, thyroid pathology 42.9% vs. 40%, anemia 25.7% vs. 22.9%. Conclusions. When comparing the data obtained after analysis of the premorbid background, somatic and reproductive history in pregnant women with twins, significant differences between the main and the comparison group were absent, which allows us to compare them in a further study.