Journal of the ASEAN Federation of Endocrine Societies最新文献

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Efficacy and Safety of Bromocriptine-QR as an Adjunctive Therapy on Glycemic Control in Subjects with Uncontrolled Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis. 溴隐亭-QR 作为辅助疗法对未控制 2 型糖尿病患者血糖控制的有效性和安全性:系统回顾与元分析》。
IF 0.7
Journal of the ASEAN Federation of Endocrine Societies Pub Date : 2024-01-01 Epub Date: 2024-02-21 DOI: 10.15605/jafes.039.01.19
Theo Audi Yanto, Charista Lydia Budiputri, Michelle Patricia Muljono, Shally Chandra
{"title":"Efficacy and Safety of Bromocriptine-QR as an Adjunctive Therapy on Glycemic Control in Subjects with Uncontrolled Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis.","authors":"Theo Audi Yanto, Charista Lydia Budiputri, Michelle Patricia Muljono, Shally Chandra","doi":"10.15605/jafes.039.01.19","DOIUrl":"10.15605/jafes.039.01.19","url":null,"abstract":"<p><strong>Introduction: </strong>There has been an increasing awareness of the effects of combining bromocriptine-QR with other medications for diabetes mellitus type 2. This study aimed to assess the efficacy and safety of bromocriptine-QR as an adjunctive therapy for patients with uncontrolled type 2 diabetes mellitus.</p><p><strong>Methodology: </strong>This systematic review is registered at the International Prospective Register of Systematic Reviews (CRD42022360326). Literature search was done via MEDLINE, NCBI, Google Scholar, Science Direct, Europe PMC and Cochrane Library databases. We included randomized controlled trials with participants 18 years old and above with uncontrolled type 2 diabetes mellitus. The primary outcome of interest is the efficacy and safety of bromocriptine-QR as an adjunctive therapy for glycemic control. Case reports, case series, reviews and animal studies were excluded. The risk of bias was reviewed using the Cochrane Risk of Bias tool. Meta-analysis was performed using Review Manager 5.4 and presented as a weighted mean difference and 95% confidence interval for changes from the baseline level.</p><p><strong>Results: </strong>Nine studies were included in the systematic review with a total of 2709 participants. The baseline HbA1c in the bromocriptine-QR group was 7.42% and 7.51% in the control group. The bromocriptine-QR group was favoured, outperforming the control group in terms of reducing hemoglobin A1c(HbA1c), with a statistically significant difference (weighted mean difference -0.6%; 95% CI [-0.83,-0.36]; p<0.00001). The most common side effects were nausea (33.75% vs 6.92%), fatigue (13.11% vs 5.94%), and headache (11.17% vs 6.87%).</p><p><strong>Conclusion: </strong>Administration of bromocriptine-QR at a dose range of 1.6 to 4.8 mg/day as an adjunctive therapy reduced HbA1c and FBG in patients with uncontrolled type 2 diabetes mellitus (T2DM). However, there were also statistically greater odds of the occurrence of adverse events such as nausea, vomiting, and headache compared to controls.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 1","pages":"95-105"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevailing Food Intake, Physical Activity and Health Beliefs in a Rural Agricultural Community in the Philippines: Factors to Consider Prior to a Diabetes Prevention Program. 菲律宾农村农业社区的普遍食物摄入量、体育活动和健康观念:糖尿病预防计划前应考虑的因素》。
IF 0.7
Journal of the ASEAN Federation of Endocrine Societies Pub Date : 2024-01-01 Epub Date: 2024-01-23 DOI: 10.15605/jafes.039.01.11
Mark Anthony Sandoval, Elizabeth Paz-Pacheco, Edwin Cañete, Perpetua Patal, Monica Therese Cating-Cabral, Frances Lina Lantion-Ang, Elizabeth Paterno, Noel Juban, Cecilia Jimeno
{"title":"Prevailing Food Intake, Physical Activity and Health Beliefs in a Rural Agricultural Community in the Philippines: Factors to Consider Prior to a Diabetes Prevention Program.","authors":"Mark Anthony Sandoval, Elizabeth Paz-Pacheco, Edwin Cañete, Perpetua Patal, Monica Therese Cating-Cabral, Frances Lina Lantion-Ang, Elizabeth Paterno, Noel Juban, Cecilia Jimeno","doi":"10.15605/jafes.039.01.11","DOIUrl":"10.15605/jafes.039.01.11","url":null,"abstract":"<p><strong>Objective: </strong>A diabetes prevention program is being proposed in the rural agricultural town of San Juan, Batangas, Philippines. This study aims to determine the prevailing level of food intake, physical activity, and health beliefs prior to any intervention.</p><p><strong>Methodology: </strong>Adults were recruited via random sampling with proportional allocation. Interviews were done to determine food intake and physical activity. Small group discussions were held to determine prevailing health beliefs.</p><p><strong>Results: </strong>The average energy intake (1,547 kcal/d) is only 72% of the recommended values for Filipinos. Only 12% of the respondents achieved the recommended energy intake. Carbohydrates comprise a large part (71%) of calorie intake. A majority (91%) already have moderate to high levels of physical activity. There are prevailing health beliefs that need to be considered when dietary modifications and physical activity interventions are to be done.</p><p><strong>Conclusion: </strong>Internationally recommended diabetes prevention interventions such as reducing calorie intake and increasing physical activity may not be directly applicable here. We recommend that the features of a diabetes prevention program for this locale must include the following: 1) introduction of affordable plant sources of proteins; 2) decreasing the proportion of rice as a source of carbohydrates in the diet; 3) maintaining the level of physical activity; and 4) being sensitive to the prevailing health beliefs.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 1","pages":"37-44"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between Waist Circumference and IGF-1 Levels in an Elderly Population in Bali, Indonesia.
IF 0.6
Journal of the ASEAN Federation of Endocrine Societies Pub Date : 2024-01-01 Epub Date: 2024-08-31 DOI: 10.15605/jafes.039.02.15
I Made Pande Dwipayana, Wira Gotera, Made Ratna Saraswati, I Made Siswadi Semadi, Ida Bagus Aditya Nugraha, Ketut Suastika, Anak Agung Gede Budhiarta, Padma Amrita, Wahyu Pratama Putra
{"title":"Correlation between Waist Circumference and IGF-1 Levels in an Elderly Population in Bali, Indonesia.","authors":"I Made Pande Dwipayana, Wira Gotera, Made Ratna Saraswati, I Made Siswadi Semadi, Ida Bagus Aditya Nugraha, Ketut Suastika, Anak Agung Gede Budhiarta, Padma Amrita, Wahyu Pratama Putra","doi":"10.15605/jafes.039.02.15","DOIUrl":"https://doi.org/10.15605/jafes.039.02.15","url":null,"abstract":"<p><strong>Background: </strong>Hyperinsulinemia due to insulin resistance is hypothesized to act as a promotor of cancer growth. In addition to the direct effects of hyperinsulinemia on cancer cells, the stimulation of tumor cell growth can also be indirectly mediated through growth factors and receptors such as insulin-like growth factor 1 (IGF-1). Increased cancer risk is also associated with increased adipose tissue, such as in abdominal obesity, due to the higher risk of insulin resistance and hyperinsulinemia. Waist circumference is a parameter that indicates an individual's level of adiposity. In addition, the risk of cancer also increases in the elderly as they age. This study aims to assess the correlation between waist circumference and IGF-1 levels in the elderly population in Bali, Indonesia.</p><p><strong>Methodology: </strong>This study used a cross-sectional analytical design conducted in the Melinggih Village, Gianyar Regency. The study was conducted in September 2023. This study has been approved by the Research Ethics Commission number 2020/UN14.2.2.VII.14/LT/2023. The study population included elderly individuals residing in the Melinggih Village who were willing to participate. Data analysis encompassed descriptive analysis and the Spearman correlation test.</p><p><strong>Result: </strong>A total of 88 subjects participated in the study, consisting of 57 females (64.8%) and 31 males (35.2%). A statistically significant but weak correlation coexists between waist circumference and IGF-1 levels.</p><p><strong>Conclusion: </strong>A weak but statistically significant positive correlation was found between waist circumference and IGF-1 levels in the elderly. However, because of the small sample size, another study with a bigger sample size with enough power to investigate this association needs to be done to validate the results of the current study.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 2","pages":"9-12"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Other Diagnostic Tests for Young-Onset Type 2 Diabetes Mellitus.
IF 0.6
Journal of the ASEAN Federation of Endocrine Societies Pub Date : 2024-01-01 Epub Date: 2024-08-28 DOI: 10.15605/jafes.039.02.11
Katty Huamán-Chavarry, Jorge Pacco-Valdivia, Andrea Salvador-Carrillo
{"title":"Other Diagnostic Tests for Young-Onset Type 2 Diabetes Mellitus.","authors":"Katty Huamán-Chavarry, Jorge Pacco-Valdivia, Andrea Salvador-Carrillo","doi":"10.15605/jafes.039.02.11","DOIUrl":"https://doi.org/10.15605/jafes.039.02.11","url":null,"abstract":"","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 2","pages":"126"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Combination of Curcumin and Piperine Supplementation on Glycemic Profile in Patients with Prediabetes and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis. 姜黄素和胡椒碱联合补充剂对糖尿病前期和 2 型糖尿病患者血糖谱的影响:系统回顾与元分析》。
IF 0.7
Journal of the ASEAN Federation of Endocrine Societies Pub Date : 2024-01-01 Epub Date: 2024-02-17 DOI: 10.15605/jafes.039.01.18
Nicolas Daniel Widjanarko, Erich Tamio, Louis Fabio Jonathan Jusni, Steven Alvianto, Erlangga Saputra Arifin, Maria Riastuti Iryaningrum
{"title":"Effects of Combination of Curcumin and Piperine Supplementation on Glycemic Profile in Patients with Prediabetes and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis.","authors":"Nicolas Daniel Widjanarko, Erich Tamio, Louis Fabio Jonathan Jusni, Steven Alvianto, Erlangga Saputra Arifin, Maria Riastuti Iryaningrum","doi":"10.15605/jafes.039.01.18","DOIUrl":"10.15605/jafes.039.01.18","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effects of the combination of curcumin and piperine supplementation on Fasting Plasma Glucose (FPG), Homeostatic Model of Insulin Resistance (HOMA-IR), and Body Mass Index (BMI) in patients with prediabetes and type 2 Diabetes Mellitus (T2DM). This review was done to identify potential herbal remedies that may help improve glycemic parameters, leading to better health outcomes in combination with current antidiabetic treatment.</p><p><strong>Methodology: </strong>This systematic review was based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). It was conducted in 2023 with sources and databases from MEDLINE, EBSCO-Host, ScienceDirect and ProQuest. This paper included randomized-controlled trials exploring the effects of the combination of curcumin and piperine on patients with prediabetes and T2DM. Systematic reviews, observational studies, case reports, case series, conference abstracts, book sections, commentaries/editorials, non-human studies and articles with unavailable full-text and written in non-English language, were excluded. The key terms for the literature search were \"curcumin,\" \"piperine,\" \"prediabetes\" and \"Type 2 Diabetes Mellitus.\" We use Cochrane Risk of Bias (RoB) 2 for quality assessment of the included studies and Review Manager (RevMan) 5.4 to do the meta-analysis.</p><p><strong>Results: </strong>A total of three studies were included in this systematic review. Two studies from Neta et al., and Cicero et al., showed no significant difference in HOMA-IR, BMI and FPG levels between the curcumin, piperine and placebo groups. One study from Panahi et al. demonstrated a significant difference in BMI levels between the curcumin and piperine and placebo groups (<i>p</i> <0.01). The meta-analysis showed that FPG levels, HOMA-IR and BMI improved among patients with diabetes given in curcumin and piperine with reported mean differences (MD) of = -7.61, 95% CI [-15.26, 0.03], <i>p</i> = 0.05, MD = -0.36, 95% CI [-0.77 to 0.05], <i>p</i> = 0.09, and MD = -0.41, 95% CI [-0.85 to 0.03], <i>p</i> = 0.07, respectively).</p><p><strong>Conclusions: </strong>The supplementation of curcumin and piperine showed a numerical reduction in FPG, HOMA-IR and BMI, but were not statistically significant. Further research is needed as there is a paucity of studies included in the review.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 1","pages":"106-114"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fructosamine and HbA1c: A Correlational Study in a Southeast Asian Population. 果糖胺与 HbA1c:一项针对东南亚人群的相关研究。
IF 0.6
Journal of the ASEAN Federation of Endocrine Societies Pub Date : 2024-01-01 Epub Date: 2024-02-08 DOI: 10.15605/jafes.039.01.14
Kurumbian Chandran, See Muah Lee, Liang Shen, Eng Loon Tng
{"title":"Fructosamine and HbA1c: A Correlational Study in a Southeast Asian Population.","authors":"Kurumbian Chandran, See Muah Lee, Liang Shen, Eng Loon Tng","doi":"10.15605/jafes.039.01.14","DOIUrl":"10.15605/jafes.039.01.14","url":null,"abstract":"<p><strong>Objectives: </strong>Fructosamine correlates well with glycated haemoglobin (HbA1c) in Caucasians. This study investigates this correlation and whether fructosamine can reliably estimate glycated haemoglobin in Southeast Asians.</p><p><strong>Methods: </strong>We recruited 193 participants based on 4 HbA1c bands (<6.0%; 6.0 - 7.9%; 8.0- 9.9%; ≥10%) from a secondary hospital in Singapore between August 2017 and December 2021. Blood samples for fructosamine, glycated haemoglobin, albumin, haemoglobin, thyroid stimulating hormone and creatinine were drawn in a single setting for all participants. Scatter plot was used to explore correlation between fructosamine and glycated haemoglobin. Strength of linear correlation was reported using Pearson's correlation coefficient. Simple linear regression was used to examine the relationship between fructosamine and glycated haemoglobin.</p><p><strong>Results: </strong>We performed simple linear regression to study the relationship between fructosamine and HbA1c in the research participants (R<sup>2</sup> = 0.756, <i>p</i><0.01). Further analysis with natural logarithmic transformation of fructosamine demonstrated a stronger correlation between HbA1c and fructosamine (R<sup>2</sup> = 0.792, <i>p</i><0.01).</p><p><strong>Conclusions: </strong>Fructosamine is reliably correlated with HbA1c for the monitoring of glycaemic control in Southeast Asians.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 1","pages":"26-30"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insulin Autoimmune Syndrome - An After-Meal Roller Coaster Ride. 胰岛素自身免疫综合征--餐后过山车。
IF 0.6
Journal of the ASEAN Federation of Endocrine Societies Pub Date : 2024-01-01 Epub Date: 2024-01-07 DOI: 10.15605/jafes.039.01.07
Chee Koon Low, Hui Chin Wong, Saraswathy Apparow, Sy Liang Yong
{"title":"Insulin Autoimmune Syndrome - An After-Meal Roller Coaster Ride.","authors":"Chee Koon Low, Hui Chin Wong, Saraswathy Apparow, Sy Liang Yong","doi":"10.15605/jafes.039.01.07","DOIUrl":"10.15605/jafes.039.01.07","url":null,"abstract":"<p><p>Hypoglycemic disorders are rare in persons without diabetes, and clinical evaluation to identify its etiology can be challenging. We present a case of insulin autoimmune syndrome induced by carbimazole in a middle-aged Chinese man with underlying Graves' disease, which was managed conservatively with a combination of dietary modification and alpha-glucosidase inhibitor.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 1","pages":"125-128"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cushing Disease in a Patient with Double Pituitary Adenomas Complicated with Diabetes Insipidus: A Case Report.
IF 0.6
Journal of the ASEAN Federation of Endocrine Societies Pub Date : 2024-01-01 Epub Date: 2024-07-31 DOI: 10.15605/jafes.039.02.05
Waye Hann Kang, Ida Ilyani Adam, Norasyikin A Wahab
{"title":"Cushing Disease in a Patient with Double Pituitary Adenomas Complicated with Diabetes Insipidus: A Case Report.","authors":"Waye Hann Kang, Ida Ilyani Adam, Norasyikin A Wahab","doi":"10.15605/jafes.039.02.05","DOIUrl":"https://doi.org/10.15605/jafes.039.02.05","url":null,"abstract":"<p><p>Managing a patient with both pituitary hypersecretory and hyposecretory manifestations may be perplexing. We report a 14-year-old female who presented with weight gain, polyuria and polydipsia. Biochemical results were consistent with Cushing disease with central diabetes insipidus. Pituitary magnetic resonance imaging showed a right adenoma with stalk thickening. The immunohistochemistry staining of both adenomas was positive for adrenocorticotropic hormone, thyroid stimulating hormone, growth hormone and luteinizing hormone. Postoperatively, the patient developed panhypopituitarism with persistent diabetes insipidus. The coexistence of double adenomas can pose diagnostic and management challenges and is a common cause of surgical failure. Intraoperative evaluation is important in the identification of double or multiple pituitary adenomas in a patient presenting with multiple secretory manifestations.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 2","pages":"97-102"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endocrine Disorders in Childhood Brain Tumour Survivors: A Single-Centre Study. 儿童脑肿瘤幸存者的内分泌失调:单中心研究
IF 0.7
Journal of the ASEAN Federation of Endocrine Societies Pub Date : 2024-01-01 Epub Date: 2023-12-22 DOI: 10.15605/jafes.039.01.05
Nurul Wahidah Ramezan, Suhaimi Hussain, Norsarwany Mohamad, Najib Majdi Yaacob
{"title":"Endocrine Disorders in Childhood Brain Tumour Survivors: A Single-Centre Study.","authors":"Nurul Wahidah Ramezan, Suhaimi Hussain, Norsarwany Mohamad, Najib Majdi Yaacob","doi":"10.15605/jafes.039.01.05","DOIUrl":"10.15605/jafes.039.01.05","url":null,"abstract":"<p><strong>Objective: </strong>The study aims to determine the prevalence and risk factors for endocrine disorders in childhood brain tumour survivors.</p><p><strong>Methodology: </strong>Included in the study were 124 childhood brain tumour survivors aged 18 years old or younger with either stable disease or in remission, and had survived for at least 2 years after diagnosis. Demographic data (age at diagnosis, gender, ethnicity, socioeconomic status), clinical clues for endocrine disorders, anthropometrics (weight, height, midparental height), pubertal staging, tumour-related characteristics, treatment modalities and endocrine laboratory measurements at diagnosis and during follow up were obtained. Logistic regression was applied to evaluate risk factors for endocrine disorders in childhood brain tumour survivors.</p><p><strong>Results: </strong>The prevalence of endocrine disorders in childhood brain tumour survivors was 62.1%. The risk factors were high BMI [adjusted odds ratio (OR) 1.29, 95% CI: 1.12 to 1.5], high-risk site [adjusted odds ratio (OR) 7.15, 95% CI: 1.41 to 36.3] and chemotherapy [adjusted odds ratio (OR) 0.18, 95% CI: 0.05 to 0.62].</p><p><strong>Conclusion: </strong>The prevalence of endocrine disorders in childhood brain tumour survivors in our centre was 62.1%. The significant risk factors were high BMI, tumour location (suprasellar and intrasellar) and chemotherapy.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 1","pages":"12-17"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interrelationship of Sarcopenia and Cardiovascular Diseases: A Review of Potential Mechanisms and Management. 肌肉疏松症与心血管疾病的相互关系:潜在机制与管理综述。
IF 0.7
Journal of the ASEAN Federation of Endocrine Societies Pub Date : 2024-01-01 Epub Date: 2023-10-27 DOI: 10.15605/jafes.039.01.03
Frederick Berro Rivera, Bettina Therese Escolano, Frances Micole Nifas, Sarang Choi, Genquen Philip Carado, Edgar Lerma, Krishnaswami Vijayaraghavan, Marc Gregory Yu
{"title":"Interrelationship of Sarcopenia and Cardiovascular Diseases: A Review of Potential Mechanisms and Management.","authors":"Frederick Berro Rivera, Bettina Therese Escolano, Frances Micole Nifas, Sarang Choi, Genquen Philip Carado, Edgar Lerma, Krishnaswami Vijayaraghavan, Marc Gregory Yu","doi":"10.15605/jafes.039.01.03","DOIUrl":"10.15605/jafes.039.01.03","url":null,"abstract":"<p><p>Sarcopenia refers to an age-related reduction of lean body mass. It showed a reciprocal relationship with cardiovascular diseases. Thus, it is imperative to explore pathophysiological mechanisms explaining the relationship between sarcopenia and cardiovascular diseases, along with the clinical assessment, and associated management. In this review, we discuss how processes such as inflammation, oxidative stress, endothelial dysfunction, neural and hormonal modifications, as well as other metabolic disturbances influence sarcopenia as well as its association with cardiovascular diseases. Moreover, this review provides an overview of both non-pharmacological and pharmacological management for patients with sarcopenia and cardiovascular diseases, with a focus on the potential role of cardiovascular drugs to mitigate sarcopenia.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 1","pages":"69-78"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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