Journal of the ASEAN Federation of Endocrine Societies最新文献

{"title":"Clinical Profile of Non-thyroidal Cancer Patients with Tyrosine Kinase Inhibitor-induced Thyroid Dysfunction in the University of Santo Tomas Hospital, Philippines: A 5-Year Single-center Retrospective Study.","authors":"Nenuel Angelo Luna, Jennilyn Quinitio, Erick Mendoza, Sjoberg Kho, Priscilla Caguioa","doi":"10.15605/jafes.039.02.14","DOIUrl":"https://doi.org/10.15605/jafes.039.02.14","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to determine the clinical profile of non-thyroidal cancer patients with thyroid dysfunction associated with tyrosine kinase inhibitor (TKI) therapy at the University of Santo Tomas Hospital (USTH), Philippines.</p><p><strong>Methodology: </strong>This is a retrospective observational study of TKI-initiated adult non-thyroidal cancer patients with thyroid function testing from 2013 to 2018.</p><p><strong>Results: </strong>Forty percent (95% CI: 26.2% - 58.61%) of the sixty individuals who had thyroid function tests (TFT) had incident thyroid dysfunction. Thirty percent had hypothyroidism (i.e., 25% overt [mean TSH 16.64 uIU/mL]; 5% subclinical [mean TSH 6.62 uIU/mL]). The median time at risk was 8 and 16 months for overt and subclinical hypothyroidism, respectively. Fifty-six percent had persistent hypothyroidism (median TSH 16.75, <i>p</i> = 0.009). The average time to recovery of transient hypothyroidism was 39 months. Ten percent had hyperthyroidism with a median time at risk of 1.5 months. Non-small cell lung cancer and renal cell carcinoma were possible associated risk factors of thyroid dysfunction.</p><p><strong>Conclusion: </strong>TKI-induced thyroid dysfunctions are common. Screening and monitoring for thyroid abnormalities during TKI therapy is important.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 2","pages":"20-26"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiologic Profile and Clinical Outcomes of Patients with Pheochromocytoma at the University of the Philippines Philippine General Hospital (UP-PGH).","authors":"Edrome Hernandez, Cecilia Jimeno, Elizabeth Paz-Pacheco","doi":"10.15605/jafes.039.02.18","DOIUrl":"https://doi.org/10.15605/jafes.039.02.18","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to describe the epidemiologic profile and determine the clinical outcomes of patients with pheochromocytoma at the University of the Philippines Philippine General Hospital (UP-PGH).</p><p><strong>Methodology: </strong>We reviewed the medical records of 30 patients with histopathology-proven, clinical, and biochemical diagnosis of pheochromocytoma. Demographic, clinical characteristics, and clinical outcomes were collected for each patient.</p><p><strong>Results: </strong>The median age at diagnosis of pheochromocytoma was 37.5 years (IQR 28-55) and the most common metabolic comorbidities were glucose intolerance (60%) and hypertriglyceridemia (23.3%). Majority of the patients were hypertensive (90%). Two third of the patients presented with classic features of pheochromocytoma while the remaining third presented as adrenal incidentaloma. Recurrence was found in 17% of subjects, who were significantly younger (25 years vs 46.5 years P = 0.0229), and had higher rates of bilateral pheochromocytoma (0 vs 75%), p = 0.002). Metastatic pheochromocytoma was found in 10% of the subjects.</p><p><strong>Conclusion: </strong>Our study demonstrated that patients with pheochromocytoma in our setting exhibit great variability in terms of clinical behavior. Although majority of the patients presented with symptoms related to catecholamine excess, almost one-third of the patients were only incidentally discovered. Incidence of pheochromocytoma recurrence and metastasis in our setting are comparable with current available foreign studies.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 2","pages":"41-47"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Osteitis Fibrosa Cystica of the Mandible: A Rare Presentation during Pregnancy due to <i>CDC73</i> Mutation.","authors":"Pratibha Pawal, Anand Nikalje, Yash Chauhan, Premlata Varthakavi, Nikhil Bhagwat","doi":"10.15605/jafes.039.02.17","DOIUrl":"https://doi.org/10.15605/jafes.039.02.17","url":null,"abstract":"<p><p>Typically, primary hyperparathyroidism (PHPT) develops as a result of multiglandular hyperplasia, parathyroid cancer, or parathyroid adenoma. Patients usually present with skeletal manifestations such as low-trauma fractures. Osteitis fibrosa cystica (OFC) is a classic yet rare skeletal manifestation of advanced PHPT currently reported in less than 2% of patients. We present a case of a 29-year-old Indian female who presented with a femur fracture and mandibular OFC 20 days after delivery. The painless mandibular swelling gradually progressed from the third month of pregnancy. The biochemical and radiological investigations were indicative of PHPT-associated OFC. After the excision of the three-and-a-half parathyroid gland, histology revealed benign cystic adenomas and hyperplasia. Based on the associated clinical manifestations, OFC was suspected. Clinical exome sequencing revealed <i>CDC73</i>(+) c.687_688dupAG heterogenous pathogenic autosomal dominant mutation. Undiagnosed PHPT in mothers during pregnancy led to neonatal hypocalcaemic convulsions. With adequate supplementation, the infant recovered completely from transient congenital hypoparathyroidism. OFC is an important diagnosis to consider in a young patient with swelling of the neck and jaw. Simultaneous high levels of PTH and serum calcium should raise a high index of suspicion for OFC. Parathyroidectomy helps manage the biochemical abnormalities and causes regression of the jaw mass that causes facial disfigurement and attenuates the declining BMD. Children born to mothers with PHPT should be evaluated for neonatal hypoparathyroidism and supplemented appropriately to reduce the risk of hypocalcaemic manifestations that can be life-threatening. If the <i>CDC73</i> mutation is detected, the offspring should be monitored for signs of PHPT due to the high probability of inheritance and parathyroid malignancy.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 2","pages":"112-118"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intentional Hyperglycemia at work, Glycemic Control, Work-related Diabetes Distress and Work Ability among Workers with Diabetes.","authors":"Samah Saleh Elhadidy, Abdel-Hady El-Gilany, Mohamed Roshdi Abdel Ghani Badawi, Aya Mohamed Elbialy","doi":"10.15605/jafes.039.02.09","DOIUrl":"https://doi.org/10.15605/jafes.039.02.09","url":null,"abstract":"<p><strong>Background: </strong>Work life of individuals with diabetes differs from that of those without diabetes. Work may interfere with diabetes self-management tasks, resulting in intentional hyperglycemia at work (IHW) and poor glycemic control. Diabetes affects work productivity due to work-related diabetes distress (WRDD) and impaired work ability (WA).</p><p><strong>Objectives: </strong>To estimate the prevalence and identify the predictors of always high, poor/very poor glycemic control, high WRDD and poor/moderate WA among workers with diabetes.</p><p><strong>Methodology: </strong>A cross-sectional study was done at the Specialized Medical Hospital Mansoura University, which included 323 working patients with diabetes. They were subjected to personal interviews to collect socio-demographic data, occupational, diabetes and other pertinent medical histories. Questionnaires for measuring IHW, WRDD and WA were completed. Clinical and A1c data were obtained from their records.</p><p><strong>Results: </strong>The prevalence of always high IHW, poor/very poor glycemic control, high WRDD and poor/moderate work ability was: 23.8%, 60.1%, 34.7% and 74.6%, respectively. The predictors of always high IHW were: 1) Below university education; 2) Treatment with insulin only or combined with oral drugs; and 3) High WRDD. The predictors of poor/very poor glycemic control were urban residence, always and almost high IHW. The predictors of high WRDD were mentallyrequiring jobs or both mentally- and physically-requiring jobs, duration of diabetes greater than 14 years and treatment with insulin. The predictors of poor/moderate WA were 'high' WRDD, 'almost high' and 'high a few times' IHW ratings.</p><p><strong>Conclusions: </strong>Most of the studied population suffered mainly from poor/very poor glycemic control and poor/moderate work ability, while a lower proportion had high WRDD. This highlighted the need for workplace modifications and interventions to help workers with diabetes control their diabetes, improve their work ability and reduce WRDD to increase productivity.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 2","pages":"70-78"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Maternal Iodine Excess during Pregnancy on Neonatal Thyroid Function and Neurodevelopmental Status at 12 Weeks.","authors":"Deepashree K Rao, Ankur Jindal, Aashima Dabas, Haseena Sait, Sangeeta Yadav, Seema Kapoor","doi":"10.15605/jafes.039.02.12","DOIUrl":"https://doi.org/10.15605/jafes.039.02.12","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to determine the effect of iodine excess in pregnant mothers on thyroid function, growth and neurodevelopment in the neonates when assessed at 12 weeks of age.</p><p><strong>Methodology: </strong>This prospective study enrolled term neonates with birth weight >2500 gm of mothers having urine iodine concentration (UIC) ≥500 µg/L documented in the third trimester of the peripartum period. Neonatal TSH was collected by heel prick on dried blood spots within 24-72 hours of age and measured by time-resolved fluroimmunoassay. Neonates with TSH ≥11 mIU/L at birth were followed up at 2 and 12 weeks to monitor thyroid dysfunction, growth and development.</p><p><strong>Results: </strong>A total of 2354 (n = 1575 in the delivery room) maternal urine samples were collected of which 598 (25.4%) had elevated UIC. Forty-nine (12.2%) neonates had TSH ≥11mIU/L on newborn screening of whom 18 and 3 neonates had residual elevated TSH at 2 and 12 weeks of life, respectively. Maternal iodine levels correlated weakly with TSH at 2 weeks (<i>rho</i> = 0.299; <i>p</i> = 0.037). No child required treatment for congenital hypothyroidism. Eight babies additionally had TSH >5 mIU/L at 12 weeks of life. The growth and development of babies with or without TSH elevation was comparable at three months (<i>p</i> >0.05).</p><p><strong>Conclusion: </strong>Maternal iodine excess in pregnancy and peripartum period causes transient hyperthyrotropinemia in neonates that did not affect the growth and development at 3 months of age.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 2","pages":"27-32"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Acute Coronary Syndrome Risk in Medically Managed Subjects with Type 2 Diabetes Mellitus - Is the ASCVD Risk Score Failing Here?","authors":"Ameya Joshi, Harminder Singh, Sanjay Kalra","doi":"10.15605/jafes.039.01.15","DOIUrl":"10.15605/jafes.039.01.15","url":null,"abstract":"<p><strong>Objectives: </strong>Type 2 Diabetics have elevated risk for acute coronary syndrome (ACS). The current management algorithm focuses on atherosclerotic cardiovascular (ASCVD) risk score to stratify this risk. However, in medically managed subjects, this algorithm may not be accurate. This study compares the ASCVD risk score in an Indian population with T2DM under medical supervision and the actual incidence of ACS. It also compared the ASCVD risk scores in cases with T2DM who developed ACS to controls and tried to estimate whether the ASCVD risk score is different in the two subsets, evaluating the utility of the ASCVD risk score in predicting ACS.</p><p><strong>Methodology: </strong>This is an electronic medical record (EMR) based case-control study. Only records of subjects with T2DM where details of age, sex, body mass index, blood pressure, duration of diabetes, family history of ACS, lipid profile, renal and liver function tests were included. The incidence of ACS was calculated in the selected records, and the records of subjects with ACS were compared with age and sex-matched subjects without ACS. Data are summarized as median and interquartile range (IQR). Wilcoxon rank-sum test was used for checking differences in continuous variables and Pearson's Chi-squared test for categorical data. Univariate and multivariate logistic regression analyses were used to check the effect of ASCVD scores and other variables on the occurrence of ACS.Statistical data analyses were performed using JASP, version 0.16.4 (JASP Team [2022]) for MS Windows.</p><p><strong>Results: </strong>Of the 1226 EMRs included in the analysis, 207 had ACS. The actual incidence of ACS was 16.85% in 6 years, higher than the mean predicted 10-year incidence of 14.56 percent (<i>p</i> <0.05). The cases were age and sex-matched with controls and the ASCVD incidence was estimated in the two groups. The mean ASCVD score in the cases was 14.565 ± 8.709 (Min: 1.5, Max: 38.3) and controls 13.114 ± 8.247 (Min: 1.4, Max: 45). The chance of development of ACS increases with elevated systolic blood pressure (per mmHg rise OR: 1.04, 95% CI: 1.03, 1.06; <i>p</i> <0.001), positive family history (OR: 5.70, 95% CI: 3.41, 9.77; <i>p</i> <0.001), statin use (OR: 2.26, 95% CI: 1.46, 3.52; <i>p</i> <0.001), and longer duration of diabetes (for every year increase OR: 1.19, 95% CI: 1.13, 1.25; <i>p</i> <0.001).</p><p><strong>Conclusion: </strong>The ASCVD risk score underestimates the ACS risk in subjects with T2DM under medical supervision and may not differ in those who developed and did not develop ACS. We also conclude that factors like a negative family history (30% less risk), longer duration of diabetes, and higher SBP are relevant in those who developed ACS.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 1","pages":"31-36"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uric Acid Crystalluria following the Recovery Phase of Diabetic Ketoacidosis (DKA): A Lesser-known Complication of DKA.","authors":"Yotsapon Thewjitcharoen, Nopparath Tongpoo, Worawit Kittipoom","doi":"10.15605/jafes.039.01.20","DOIUrl":"10.15605/jafes.039.01.20","url":null,"abstract":"","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 1","pages":"129-130"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Hyperparathyroidism during Pregnancy: Two Tales with Different Outcomes.","authors":"Yoon Doong Loh, Masliza Hanuni Mohd Ali","doi":"10.15605/jafes.039.01.17","DOIUrl":"10.15605/jafes.039.01.17","url":null,"abstract":"<p><p>Primary hyperparathyroidism (PHPT) is rare in pregnancy. This condition is challenging to diagnose and manage due to the limited diagnostic and therapeutic options that are safe during pregnancy. If not diagnosed and managed in a timely manner, serious maternal and foetal complications may occur. We report two cases, one with surgical intervention and one without, to show the importance of timely surgical intervention and discuss the challenges in the management of PHPT in pregnancy.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 1","pages":"115-119"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Gestational Diabetes Mellitus Knowledge Questionnaire (GDMKQ) among Filipino Patients in a Tertiary Medical Center.","authors":"Hanah Go, Florence Rochelle Gan","doi":"10.15605/jafes.039.01.10","DOIUrl":"10.15605/jafes.039.01.10","url":null,"abstract":"<p><strong>Objectives: </strong>Gestational diabetes mellitus (GDM) is a common pregnancy complication with adverse fetal and maternal outcomes. Currently, there are only a few validated tools available that address knowledge in GDM. Recognition of the inconsistencies will provide an effective learning program to achieve optimal results. This study aimed at validating the \"Gestational Diabetes Mellitus Knowledge Questionnaire\" (GDMKQ).</p><p><strong>Methodology: </strong>A cross-sectional validation study on GDMKQ among 51 GDM patients aged at least 18 years was conducted in the outpatient clinics of a tertiary hospital. Excluded were those with pre-existing diabetes. The questionnaire was submitted for peer review for translation to Filipino and back-translation. Concurrent validity, internal consistency and test-retest reliability of the questionnaire were undertaken as part of the validation process. Descriptive analysis was used for data elaboration by using SPSS v23.</p><p><strong>Results: </strong>The Filipino version of GDMKQ demonstrated sensible content and face validity. As measured, respondents obtained higher total and domain scores with better knowledge levels of GDM compared to its English version. Overall adequate knowledge was observed among those married and college subgroups as compared to single women and those with secondary levels of education. The reliability of the questionnaire was calculated at 0.632 using the Kuder-Richardson 20. The test-retest scores using the Filipino-translated questionnaire have a Pearson correlation coefficient of 0.853 with moderate to good level of agreement with each other, and Cohen's kappa of 0.564 with an intra-class correlation coefficient of 0.828.</p><p><strong>Conclusion: </strong>The Filipino-translated version of GDMKQ is a valid screening tool that assesses a patient's knowledge on gestational diabetes. Identifying the level of their understanding will enable clinicians to develop an individualized, effective learning program to improve pregnancy outcomes.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 1","pages":"18-25"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of American College of Radiology Thyroid Imaging Reporting Data System: A Single-center Cross-sectional Study.","authors":"Pamela Ann Aribon, Emmylou Teope, Anna Lyn Egwolf, Maria Patricia Maningat","doi":"10.15605/jafes.039.01.08","DOIUrl":"10.15605/jafes.039.01.08","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the diagnostic accuracy of the American College of Radiology Thyroid Imaging Reporting Data System (ACR TI-RADS) in identifying nodules that need to undergo fine-needle aspiration biopsy (FNAB) and identify specific thyroid ultrasound characteristics of nodules associated with thyroid malignancy in Filipinos in a single tertiary center.</p><p><strong>Methodology: </strong>One hundred seventy-six thyroid nodules from 130 patients who underwent FNAB from January 2018 to December 2018 were included. The sonographic features were described and scored using the ACR TI-RADS risk classification system, and the score was correlated to their final cytopathology results.</p><p><strong>Results: </strong>The calculated malignancy rates for TI-RADS 2 to TI-RADS 5 were 0%, 3.13%, 7.14%, and 38.23%, respectively, which were within the TI-RADS risk stratification thresholds. The ACR TI-RADS had a sensitivity of 89.5% and specificity of 54%, LR + of 1.95 and LR - of 0.194, NPV of 97.7%, PPV of 19.1%, and accuracy of 58%.</p><p><strong>Conclusion: </strong>The ACR TI-RADS may provide an effective malignancy risk stratification for thyroid nodules and may help guide the decision for FNAB among Filipino patients. The classification system may decrease the number of unnecessary FNABs for nodules with low-risk scores.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"39 1","pages":"61-68"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}