Journal of the ASEAN Federation of Endocrine Societies最新文献

{"title":"Before Explaining Depression Solely Caused by Diabetes, All Other Causes Must Have Been Ruled Out.","authors":"Josef Finsterer","doi":"10.15605/jafes.040.01.12","DOIUrl":"10.15605/jafes.040.01.12","url":null,"abstract":"","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"40 1","pages":"134-135"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Glycaemia: Socioeconomic Factors and Diabetes Distress are Associated with Health-Related Quality of Life in People with Type 2 Diabetes.","authors":"Suresh Rama Chandran, Gilbert Soh Keng Keat, Nur Nasyitah Binte Mohamed Salim, Xiaohui Xin, Gek Hsiang Lim, Daphne Gardner, Su-Yen Goh","doi":"10.15605/jafes.040.01.19","DOIUrl":"10.15605/jafes.040.01.19","url":null,"abstract":"<p><strong>Background: </strong>Diabetes is a complex multifactorial disease. Therapy focused only on managing glycaemia does not yield optimal health outcomes. Health-related Quality of Life (HRQOL) is a broad, subjective, and multidimensional concept gaining significance in diabetes care. The complex interplay of HRQOL and other factors must be addressed to achieve optimal health outcomes.</p><p><strong>Objective: </strong>We aim to describe the factors associated with HRQOL in type 2 diabetes.</p><p><strong>Methodology: </strong>A single-center cross-sectional short messaging service (SMS) survey invited adults with type 2 diabetes (T2D) with ≥1 clinic attendance in the past year. Participants completed the Problem Areas in Diabetes-5 (PAID-5), Diabetes Distress Scale-17 (DDS17), and European Quality of Life Score (EQ-5D-5L). Demographic and diabetes-related data were retrieved from electronic medical records. Multiple regression models were created with EQ-5D-5L Index score (HRQOL) as the dependent variable.</p><p><strong>Result: </strong>A total of 1406 people with T2D participated, 46.4% women, mean (SD) age 61.1 (13.4) years, BMI 27.1 (5.4) kg/ m², and HbA1c 8.0 (1.4)%. Of these, 60.9% had ≥1 microvascular and 23.8% had ≥1 macrovascular complication. Mean (SD) of EQ-5D-5L Index score was 0.81 (0.27), EQ5D Visual Analog Score (VAS) was 77.4 (23.8), total mean DDS17 score was 1.87 (0.93) and PAID-5 score was 5.04 (4.5). 26.9% and 11.3% had significant diabetes distress (DD) based on PAID-5 ≥8 and DDS17 ≥3. Multiple regression models revealed diabetes distress, a lower class of housing type, presence of macrovascular complication, higher BMI, older age, and female sex to be associated with a poorer EQ-5D-5L Index Score.</p><p><strong>Conclusion: </strong>Multiple non-glycemic factors like sociodemographic, socioeconomic, diabetes distress, impact health-related QoL in people with type 2 diabetes.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"40 1","pages":"72-79"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ROHHAD-NET Syndrome: A Case Series.","authors":"Dhanya Soodhana, Manjula Subramaniya Iyer, Joe George, Vimal Mavila Veetil, Preetha Remesh, Kesavan Melarcode Ramanan, Binesh Arayullathil, Abraham Mammen","doi":"10.15605/jafes.040.01.10","DOIUrl":"10.15605/jafes.040.01.10","url":null,"abstract":"<p><p>Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation and neural crest tumor (ROHHAD-NET) though a rare disease, is potentially fatal. It is of utmost importance to be understood and urgently diagnosed. We hereby report a series of three cases, the first of its kind from India. Children older than 18 months old usually exhibit rapid weight growth as a presenting symptom. Hypothalamic dysfunction could lead to endocrine issues, respiratory dysfunction and autonomic dysregulation. Over the years, with variable timing, one or more signs of hypothalamic dysfunction appear: hyperprolactinemia, growth hormone deficiency, central hypothyroidism, central adrenal insufficiency or Cushing syndrome, early or delayed puberty, water-electrolyte balance disorders. The diagnosis is difficult because there is no reliable test, and the treatment is mainly supportive. All the three children who were thriving well, presented with rapid weight gain and then developed symptoms of hypothalamic dysfunction. While in one a neural crest tumor was incidentally detected, the second had persistent hypernatremia and the third child presented with intestinal obstruction. The varied presentation and vague symptom spectrum exhibit a diagnostic challenge to the clinician and underscores the importance of creating awareness. An individualized strategic approach is needed as it is clinically difficult to distinguish ROHHAD syndrome from other obesity syndromes of genetic origin.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"40 1","pages":"126-132"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Catecholamine-Secreting Adrenal Myelolipoma.","authors":"Veenu Jain, Anshita Aggarwal, Bindu Kulshreshtha, Preeti Singh, Hemant Goel","doi":"10.15605/jafes.040.01.15","DOIUrl":"10.15605/jafes.040.01.15","url":null,"abstract":"<p><p>Adrenal myelolipoma (AML) is a rare, benign, asymptomatic, nonfunctioning tumor of the adrenal cortex detected incidentally. AML can be accompanied by several other endocrine disorders simultaneously. Here, we report a case of a 36-year-old female with primary hypothyroidism and metabolic syndrome accompanied by severe hypertension and pheochromocytoma. However, the histopathological examination of the excised adrenal gland confirmed myelolipoma. Following surgery, her plasma nor-metanephrine levels decreased to normal values and the patient became normotensive, which suggested that the mass was functioning.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"40 1","pages":"104-107"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Nutritional Status using the Short Nutritional Assessment Questionnaire (SNAQ) and Malnutrition Risk using the Malnutrition Screening Tool (MST) with In-Hospital Mortality and Intensive Care Unit Admission Among Non-Critically-Ill Patients: A Single Center, Prospective Cohort Study.","authors":"Karl Homer Nievera, Mark Henry Joven","doi":"10.15605/jafes.040.01.20","DOIUrl":"10.15605/jafes.040.01.20","url":null,"abstract":"<p><strong>Background and objective: </strong>Although nutritional assessment tools have been available internationally, local data for their use in foreseeing adverse outcomes among admitted patients are currently unavailable. The primary objective of this study was to determine the association of nutritional status using Short Nutritional Assessment Questionnaire (SNAQ) and malnutrition risk using the Malnutrition Screening Tool (MST) with intensive care unit (ICU) admission and in-hospital mortality.</p><p><strong>Methodology: </strong>This was a prospective-cohort study which included 122 purposively-selected adult participants who were non-intubated, admitted for medical and surgical management, stayed for at least 24 hours, had no COVID-19 infection, and were not admitted in any critical care unit. The SNAQ and MST questionnaires, which are validated tools and consists of two to three easy-to-answer questions, were used among the participants and their scores were tallied in order to get their nutritional status and malnutrition risk. Primary endpoints measured were the length of hospital stay, incidence of mortality, and ICU admission rate. Comorbidities were taken into account using the Charlson Comorbidity Index.</p><p><strong>Results: </strong>Categorizing the SNAQ scores showed 33.61% were severely malnourished, which was similar when using the MST classification, wherein 34.43% were at risk of malnutrition. None of the participants were admitted to the ICU. Malnutrition risk and nutritional status was not significantly associated with 30-day in-hospital mortality (p >0.05). On the other hand, results of the Cox proportional hazards showed that SNAQ and MST significantly predicted the hazard of 30-day in-hospital mortality, increasing the hazard of mortality by 2.58 times and 3.67 times, respectively, for every 1-unit increase in SNAQ and MST scores. Similarly, nutritional status using the SNAQ classification indicated the severely malnourished category significantly predicted the hazard of mortality, increasing it by 9.22 times for those who are severely malnourished. Also, malnutrition risk using the MST classification indicated that those who were at risk of malnutrition were 9.80 times greater hazard of mortality than those who were not at risk of malnutrition.</p><p><strong>Conclusion: </strong>The MST and SNAQ classification are screening tools for nutritional status (SNAQ) and malnutrition risk (MST) that can be administered at the onset of the patient's hospital course and have been demonstrated in this study to predict 30-day in-hospital mortality. It is important to note that none of the patients included in this study required intensive care unit admission.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"40 1","pages":"80-88"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Tumultuous Journey of Metastatic Pancreatic Neuroendocrine Tumor with Carcinoid Syndrome.","authors":"Somdatta Giri, Sadishkumar Kamalanathan, Kalayarasan Raja, Nandini Pandit, Dukhabandhu Naik, Jayaprakash Sahoo","doi":"10.15605/jafes.040.01.04","DOIUrl":"10.15605/jafes.040.01.04","url":null,"abstract":"<p><p>A 25-year-old woman presented with metastatic pancreatic neuroendocrine tumor with carcinoid syndrome. She was refractory to octreotide and did not respond well to chemotherapy. Although surgical debulking remains the primary approach for managing these tumours, it entails inherent risks, including potentially exacerbating carcinoid syndrome. We strategically delivered the one Peptide Receptor Radionuclide Therapy cycle before tumor debulking, a decision that yielded a remarkable response, stabilizing her condition.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"40 1","pages":"112-116"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aplasia Cutis Congenita on the Scalp.","authors":"Supasuta Wongdama, Chutintorn Sriphrapradang","doi":"10.15605/jafes.040.01.11","DOIUrl":"10.15605/jafes.040.01.11","url":null,"abstract":"","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"40 1","pages":"136-137"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic and Lifestyle Factors Associated with Undiagnosed Diabetes in Indonesia: Findings from the Basic Health Research Work of Riskesdas 2018.","authors":"Ayunina Rizky Ferdina, Juhairiyah, Windy Tri Yuana, Budi Setyawati, Dhita Elsha Pangestika","doi":"10.15605/jafes.040.01.21","DOIUrl":"10.15605/jafes.040.01.21","url":null,"abstract":"<p><strong>Background: </strong>As a developing nation, there has been an increasing trend in non-communicable diseases, including diabetes mellitus (DM) in Indonesia. However, a remarkable proportion of DM cases in this archipelagic country is likely undiagnosed.</p><p><strong>Objective: </strong>This study assessed the sociodemographic and lifestyle factors related to undiagnosed DM in Indonesians.</p><p><strong>Methodology: </strong>This cross-sectional study analyzed secondary data from the 2018 Indonesian Basic Health Research (Riskesdas). It involved 3,755 study subjects, 3,619 individuals with high blood glucose levels meeting the DM criteria and 136 individuals with controlled DM. Multivariable regression analysis examined the associations between sociodemographic and lifestyle factors and undiagnosed diabetes.</p><p><strong>Results: </strong>The study revealed that 80% of the DM cases among the subjects were undiagnosed. Multivariable analysis confirmed that age group, area of residence, employment, wealth quintiles and physical activity were significantly associated with higher odds of undiagnosed diabetes. Notably, sex, smoking status and vegetable consumption did not show any association with the diagnosis status of diabetes.</p><p><strong>Conclusion: </strong>A significant portion of DM cases in Indonesia remain undiagnosed, especially among young adults, rural residents, agricultural workers and lower socioeconomic groups. Improved healthcare access, targeted screening and enhanced health education are essential to ensure early diagnosis and effective management of diabetes.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"40 1","pages":"53-60"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Editor-in-Chief's Reflections on a 15-Year Journey.","authors":"Elizabeth Paz-Pacheco","doi":"10.15605/jafes.040.01.01","DOIUrl":"https://doi.org/10.15605/jafes.040.01.01","url":null,"abstract":"","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"40 1","pages":"4-5"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raised Bisphenol A has a Significant Association with Adverse Reproductive Manifestations Rather than Biochemical or Hormonal Aberrations in Women with Polycystic Ovary Syndrome.","authors":"Emran-Ur-Rashid Chowdhury, Hurjahan Banu, Md Shahed Morshed, Iffat Ara Jahan, Subi Kharel, Muhammad Abdul Hasanat","doi":"10.15605/jafes.040.01.14","DOIUrl":"10.15605/jafes.040.01.14","url":null,"abstract":"<p><strong>Background: </strong>Bisphenol A (BPA) is a widely used industrial element. Recently it is suspected that BPA may disrupt the endocrine system to influence the manifestations of polycystic ovary syndrome (PCOS).</p><p><strong>Objective: </strong>This study aimed to assess serum BPA level and its association with manifestations of PCOS in women.</p><p><strong>Methodology: </strong>This cross-sectional study included 40 young adults with PCOS and 38 age-matched control women [23.0 (20.0, 29.0) vs. 25.0 (21.0, 29.0), years, median (IQR), <i>p</i> = 0.406]. After a thorough clinical examination, fasting blood was collected in the follicular phase of the menstrual cycle to measure glucose, lipids, insulin, luteinizing hormone, folliclestimulating hormone, total testosterone, sex hormone binding globulin, dehydroepiandrosterone sulfate, and BPA. Glucose was measured by glucose oxidase, lipids by glycerol phosphate dehydrogenase-peroxidase, all hormones including SHBG by chemiluminescent immunoassay and BPA by sandwiched enzyme-linked immunosorbent assay. Insulin resistance was measured using homeostasis model assessment of insulin resistance.</p><p><strong>Result: </strong>Women with PCOS had significantly higher BPA levels (ng/mL) than the control group [27.30 (25.60, 33.40) vs. 24.0 (15.58, 28.70), median (IQR), <i>p</i> = 0.001]. Using the 75^th percentile value of the control group, 15 (37.5%) women with PCOS had high BPA levels. Those with high BPA levels had a significantly higher frequency of menstrual regulation / abortion among women with PCOS [53.8% vs. 0%, <i>p</i>= 0.005]. Women with PCOS with a history of menstrual regulation / abortion [36.7 ± 4.9 vs. 28.5 ± 6.4, mean ± SD, <i>p</i> = 0.004] and subfertility [34.3 ± 6.8 vs. 28.5 ± 6.4, mean ± SD, <i>p</i> = 0.031] had higher levels of BPA than those without the histories. Serum BPA had no significant association or correlation with any androgenic and metabolic manifestations.</p><p><strong>Conclusion: </strong>Raised BPA level may be associated with adverse reproductive features in PCOS.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"40 1","pages":"26-31"},"PeriodicalIF":0.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}