Emran-Ur-Rashid Chowdhury, Hurjahan Banu, Md Shahed Morshed, Iffat Ara Jahan, Subi Kharel, Muhammad Abdul Hasanat
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After a thorough clinical examination, fasting blood was collected in the follicular phase of the menstrual cycle to measure glucose, lipids, insulin, luteinizing hormone, folliclestimulating hormone, total testosterone, sex hormone binding globulin, dehydroepiandrosterone sulfate, and BPA. Glucose was measured by glucose oxidase, lipids by glycerol phosphate dehydrogenase-peroxidase, all hormones including SHBG by chemiluminescent immunoassay and BPA by sandwiched enzyme-linked immunosorbent assay. Insulin resistance was measured using homeostasis model assessment of insulin resistance.</p><p><strong>Result: </strong>Women with PCOS had significantly higher BPA levels (ng/mL) than the control group [27.30 (25.60, 33.40) vs. 24.0 (15.58, 28.70), median (IQR), <i>p</i> = 0.001]. Using the 75<sup>th</sup> percentile value of the control group, 15 (37.5%) women with PCOS had high BPA levels. Those with high BPA levels had a significantly higher frequency of menstrual regulation / abortion among women with PCOS [53.8% vs. 0%, <i>p</i>= 0.005]. Women with PCOS with a history of menstrual regulation / abortion [36.7 ± 4.9 vs. 28.5 ± 6.4, mean ± SD, <i>p</i> = 0.004] and subfertility [34.3 ± 6.8 vs. 28.5 ± 6.4, mean ± SD, <i>p</i> = 0.031] had higher levels of BPA than those without the histories. Serum BPA had no significant association or correlation with any androgenic and metabolic manifestations.</p><p><strong>Conclusion: </strong>Raised BPA level may be associated with adverse reproductive features in PCOS.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"40 1","pages":"26-31"},"PeriodicalIF":0.6000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097971/pdf/","citationCount":"0","resultStr":"{\"title\":\"Raised Bisphenol A has a Significant Association with Adverse Reproductive Manifestations Rather than Biochemical or Hormonal Aberrations in Women with Polycystic Ovary Syndrome.\",\"authors\":\"Emran-Ur-Rashid Chowdhury, Hurjahan Banu, Md Shahed Morshed, Iffat Ara Jahan, Subi Kharel, Muhammad Abdul Hasanat\",\"doi\":\"10.15605/jafes.040.01.14\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Bisphenol A (BPA) is a widely used industrial element. Recently it is suspected that BPA may disrupt the endocrine system to influence the manifestations of polycystic ovary syndrome (PCOS).</p><p><strong>Objective: </strong>This study aimed to assess serum BPA level and its association with manifestations of PCOS in women.</p><p><strong>Methodology: </strong>This cross-sectional study included 40 young adults with PCOS and 38 age-matched control women [23.0 (20.0, 29.0) vs. 25.0 (21.0, 29.0), years, median (IQR), <i>p</i> = 0.406]. After a thorough clinical examination, fasting blood was collected in the follicular phase of the menstrual cycle to measure glucose, lipids, insulin, luteinizing hormone, folliclestimulating hormone, total testosterone, sex hormone binding globulin, dehydroepiandrosterone sulfate, and BPA. Glucose was measured by glucose oxidase, lipids by glycerol phosphate dehydrogenase-peroxidase, all hormones including SHBG by chemiluminescent immunoassay and BPA by sandwiched enzyme-linked immunosorbent assay. Insulin resistance was measured using homeostasis model assessment of insulin resistance.</p><p><strong>Result: </strong>Women with PCOS had significantly higher BPA levels (ng/mL) than the control group [27.30 (25.60, 33.40) vs. 24.0 (15.58, 28.70), median (IQR), <i>p</i> = 0.001]. Using the 75<sup>th</sup> percentile value of the control group, 15 (37.5%) women with PCOS had high BPA levels. Those with high BPA levels had a significantly higher frequency of menstrual regulation / abortion among women with PCOS [53.8% vs. 0%, <i>p</i>= 0.005]. Women with PCOS with a history of menstrual regulation / abortion [36.7 ± 4.9 vs. 28.5 ± 6.4, mean ± SD, <i>p</i> = 0.004] and subfertility [34.3 ± 6.8 vs. 28.5 ± 6.4, mean ± SD, <i>p</i> = 0.031] had higher levels of BPA than those without the histories. 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引用次数: 0
摘要
背景：双酚A （BPA）是一种应用广泛的工业原料。近年来，人们怀疑双酚a可能干扰内分泌系统，从而影响多囊卵巢综合征（PCOS）的表现。目的：探讨血清BPA水平及其与PCOS临床表现的关系。方法：本横断面研究纳入40名年轻PCOS成年患者和38名年龄匹配的对照女性[23.0 (20.0,29.0)vs. 25.0(21.0, 29.0)，年龄，中位数（IQR）， p = 0.406]。经全面临床检查后，于月经周期卵泡期采集空腹血，测定血糖、血脂、胰岛素、促黄体生成素、促卵泡激素、总睾酮、性激素结合球蛋白、硫酸脱氢表雄酮和双酚a。葡萄糖氧化酶法测定葡萄糖，甘油磷酸脱氢酶-过氧化物酶法测定脂质，化学发光免疫法测定SHBG等激素，夹心酶联免疫吸附法测定BPA。胰岛素抵抗采用稳态模型评估。结果：PCOS女性双酚a水平（ng/mL）明显高于对照组[27.30（25.60,33.40）比24.0(15.58,28.70)，中位数（IQR）， p = 0.001]。使用对照组的第75百分位值，15名（37.5%）多囊卵巢综合征妇女双酚a水平高。BPA水平高的PCOS患者月经调节/流产频率显著高于对照组（53.8% vs. 0%, p= 0.005）。有月经调节/流产史的PCOS患者（36.7±4.9比28.5±6.4，平均±SD， p = 0.004）和生育能力低下的PCOS患者（34.3±6.8比28.5±6.4，平均±SD， p = 0.031） BPA水平高于无月经调节/流产史的PCOS患者。血清BPA与任何雄激素和代谢表现无显著关联或相关。结论：双酚a水平升高可能与PCOS患者的不良生殖特征有关。
Raised Bisphenol A has a Significant Association with Adverse Reproductive Manifestations Rather than Biochemical or Hormonal Aberrations in Women with Polycystic Ovary Syndrome.
Background: Bisphenol A (BPA) is a widely used industrial element. Recently it is suspected that BPA may disrupt the endocrine system to influence the manifestations of polycystic ovary syndrome (PCOS).
Objective: This study aimed to assess serum BPA level and its association with manifestations of PCOS in women.
Methodology: This cross-sectional study included 40 young adults with PCOS and 38 age-matched control women [23.0 (20.0, 29.0) vs. 25.0 (21.0, 29.0), years, median (IQR), p = 0.406]. After a thorough clinical examination, fasting blood was collected in the follicular phase of the menstrual cycle to measure glucose, lipids, insulin, luteinizing hormone, folliclestimulating hormone, total testosterone, sex hormone binding globulin, dehydroepiandrosterone sulfate, and BPA. Glucose was measured by glucose oxidase, lipids by glycerol phosphate dehydrogenase-peroxidase, all hormones including SHBG by chemiluminescent immunoassay and BPA by sandwiched enzyme-linked immunosorbent assay. Insulin resistance was measured using homeostasis model assessment of insulin resistance.
Result: Women with PCOS had significantly higher BPA levels (ng/mL) than the control group [27.30 (25.60, 33.40) vs. 24.0 (15.58, 28.70), median (IQR), p = 0.001]. Using the 75th percentile value of the control group, 15 (37.5%) women with PCOS had high BPA levels. Those with high BPA levels had a significantly higher frequency of menstrual regulation / abortion among women with PCOS [53.8% vs. 0%, p= 0.005]. Women with PCOS with a history of menstrual regulation / abortion [36.7 ± 4.9 vs. 28.5 ± 6.4, mean ± SD, p = 0.004] and subfertility [34.3 ± 6.8 vs. 28.5 ± 6.4, mean ± SD, p = 0.031] had higher levels of BPA than those without the histories. Serum BPA had no significant association or correlation with any androgenic and metabolic manifestations.
Conclusion: Raised BPA level may be associated with adverse reproductive features in PCOS.
期刊介绍：
The Journal of the ASEAN Federation of Endocrine Societies (JAFES) is an OPEN ACCESS, internationally peer-reviewed, English language, medical and health science journal that is published in print two times a year by the ASEAN Federation of Endocrine Societies. It shall serve as the endocrine window between the ASEAN region and the world, featuring original papers and publishing key findings from specialists and experts of endocrinology.
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