Journal of the ASEAN Federation of Endocrine Societies最新文献

{"title":"Adrenocortical Carcinoma with Suspected Dual Cortisol and Aldosterone Secretion: A Case Report.","authors":"Ciara Fatima Jaime, Florence Rochelle Gan","doi":"10.15605/jafes.041.02.5875","DOIUrl":"10.15605/jafes.041.02.5875","url":null,"abstract":"<p><p>Adrenocortical carcinoma (ACC) is a rare malignancy, accounting for 0.05-2% of all malignant tumors. Most cases are sporadic and asymptomatic, often discovered incidentally via imaging. However, 50-60% present with autonomous hormonal secretion, with 45% producing excess cortisol, and only 1% exhibiting mineralocorticoid excess. We report a 43-year-old Filipino female with a 6-month history of abdominal bloating, proximal muscle weakness, edema, and hypertension. Laboratory tests showed hypokalemia (serum potassium 2.5-3.05 mmol/L; normal 3.3-5.0 mmol/L). Imaging revealed a neoplastic right suprarenal mass (adrenal origin vs confluent lymphadenopathy) described as an incidental, lipid-poor right adrenal mass measuring 4.7 x 3.6 x 6.1 cm, with contrast-enhanced Hounsfield units of 40, along with periportal and paraaortic lymphadenopathies. Biochemical evaluation indicated an intermediate probability of primary aldosteronism: suppressed plasma renin at 0.97 ug/L/hr (0.97 ng/mL/hr), normal plasma aldosterone 599.46 pmol/L (21.61 ng/dl), and aldosterone-renin ratio of 618 (pmol/L)/(ng/L/hr) (22.27 ng/dl/ng/mL/hr). Ideally, confirmatory testing with an aldosterone suppression test prior to imaging and adrenal vein sampling (AVS) should be performed to lateralize the lesion before surgery; however, the patient opted to proceed with surgery. The patient also had overt hypercortisolism, with non-suppressed serum cortisol of 31.88 µg/dL (reference <1.8 µg/dL) on a low-dose dexamethasone suppression test, suppressed ACTH at 2.81 pg/mL (reference 7.7-63.6 pg/mL) (Table 1), and clinical features of Cushing syndrome, including facial plethora, and proximal muscle weakness. While these findings support the diagnosis of an ACTH-independent hypercortisolism, current guidelines recommend confirmatory testing, including 24-hour urinary free cortisol or late-night salivary cortisol, before definitive evaluation to distinguish ACTH-dependent from ACTH-independent disease. Concomitant catecholamine and androgen excess were excluded with normal 24-hour urine metanephrines and serum DHEAS. Surgical removal via open adrenalectomy was performed. Histopathology confirmed ACC, supported by immunohistochemistry. Postoperative treatment included radiotherapy and planned adjuvant mitotane therapy. During follow-up, the patient's blood glucose and blood pressure worsened, requiring medication adjustments. Unfortunately, the patient succumbed to the disease seven months post-surgery. This case highlights the difficulties in assessing adrenal tumors that concurrently secrete cortisol and aldosterone, especially when biochemical results are inconclusive, emphasizing the need for careful assessment and prompt intervention in this rare coexistence.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"41 2","pages":"124-130"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging Gaps in Newborn Screening: A Comparative Study of Point-of-Care Testing Versus Traditional Reference Laboratory Method for Congenital Hypothyroidism.","authors":"Endah Indriastuti, Rahmah Yasinta Rangkuti, Fatimah Nur Fitriani, Putri Alief Siswanto, Edwin Nugroho Njoto, Muhammad Nazhif Haykal, Fauqa Arinil Aulia","doi":"10.15605/jafes.041.02.6233","DOIUrl":"10.15605/jafes.041.02.6233","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare the reliability, agreement, and practical application (turnaround time) of a point-of-care testing (POCT) device using two different reagents versus the traditional reference laboratory method for thyroid-stimulating hormone (TSH) measurement in newborn congenital hypothyroidism screening.</p><p><strong>Methodology: </strong>This prospective cross-sectional method-comparison study included 122 term newborns at a mother and child hospital in Surabaya, Indonesia. Heel-prick capillary blood samples were simultaneously analyzed using the Standard F-200 POCT device with two reagents (Group 1: n = 62, Standard™ F TSH-II; Group 2: n = 60, FastClear F TSHII) and compared to the standard dried blood spot method (GSP^® Neonatal hTSH, PerkinElmer) as reference. Analyses included Pearson and Spearman correlations, linear regression, Bland-Altman plots, intraclass correlation coefficient (ICC), Cohen's Kappa, and mean difference tests.</p><p><strong>Results: </strong>Strong positive correlations were observed in both Group 1 (Pearson's r = 0.87, Spearman's ρ = 0.85; <i>p</i> <0.001) and Group 2 (Pearson's r = 0.88, Spearman's ρ = 0.91; <i>p</i> <0.001). Bland-Altman analysis showed minimal systematic bias with acceptable agreement between the two techniques. The ICC values indicated excellent reliability (Group 1: 0.89; Group 2: 0.91). High categorical agreement was confirmed by Cohen's Kappa values of 0.85 and 0.87 (<i>p</i> <0.001). No significant differences in mean TSH levels were found between the POCT and reference methods. The POCT turnaround time was 30 minutes, significantly shorter than the 15-22 days required for the traditional method.</p><p><strong>Conclusion: </strong>POCT devices present a promising alternative to traditional reference screening method for congenital hypothyroidism.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"41 2","pages":"16-23"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VIPoma Presenting With Obstructive Jaundice: A Case Report.","authors":"Sim Yin Ng, Ken Seng Chiew","doi":"10.15605/jafes.041.02.6165","DOIUrl":"10.15605/jafes.041.02.6165","url":null,"abstract":"<p><p>VIPoma is a rare pancreatic neuroendocrine tumor characterized by the overproduction of vasoactive intestinal peptide (VIP), typically manifesting as watery diarrhea, hypokalaemia and metabolic acidosis. Its presentation can be atypical, complicating diagnosis. We report the case of a 30-year-old male who initially presented with obstructive jaundice and fatigue, with imaging revealing a pancreatic head mass and liver metastases. Histopathological analysis confirmed a lowgrade pancreatic neuroendocrine tumor. The clinical course was complicated by portal vein thrombosis and metastatic spread. Six months later, the patient developed persistent, refractory watery diarrhea with associated hypokalaemia. Elevated serum VIP levels and Gallium-68 DOTATATE positron-emission tomography and computed tomography (PET-CT) supported the diagnosis of VIPoma. Symptom resolution was achieved with subcutaneous octreotide, followed by transition to monthly long-acting release (LAR) octreotide. Approximately 60% of VIPoma cases are metastatic at the time of diagnosis, as demonstrated in this patient. The case highlighted the diagnostic challenges of VIPoma in the presence of atypical symptoms such as jaundice and absence of initial diarrhea. It also underscores the need for close multidisciplinary collaboration to determine the best course of action and to optimize patient outcomes.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"41 2","pages":"131-134"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Syncope, Behavioral Changes and Weight Gain in an Elderly Filipino Woman: Successful Diagnosis and Management of Insulinoma With 13-Year Disease-Free Follow-up.","authors":"Edwin Canete, Mark Anthony Sandoval","doi":"10.15605/jafes.041.02.6285","DOIUrl":"10.15605/jafes.041.02.6285","url":null,"abstract":"<p><p>Recurrent syncope and behavioral changes in the older population may suggest several disease entities associated with aging. Hypoglycemia is an often-missed potentially correctable underlying cause that should also be considered in the differential diagnosis. We present a case of a 62-year-old Filipino female who presented with recurrent syncopal attacks, behavioral changes and unintentional weight gain, associated with endogenous hyperinsulinemic hypoglycemia with no pancreatic mass seen on abdominal CT scan. A pancreatic head tumor was visualized through endoscopic ultrasound. Surgical removal of the mass resulted in resolution of her symptoms and restoration of her physical and functional wellbeing. This case is being reported to highlight that surgery cured her of the disease and she remains asymptomatic and well 13 years after her surgery.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"41 2","pages":"135-140"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the European Renal Function Consortium Equation With Chronic Kidney Disease - Epidemiology Collaboration 2021 for Estimating Glomerular Filtration Rate Among Algerian Population With Type 2 Diabetes Mellitus.","authors":"Zohra Sedoud, Feriel Yasmine Baghdali, Arzour Hind, Ouzriat Massinissa, Deghima Sabrine, Haddoum Farid, Djenouhat Kamel","doi":"10.15605/jafes.041.02.6337","DOIUrl":"10.15605/jafes.041.02.6337","url":null,"abstract":"<p><strong>Introduction: </strong>Type 2 diabetes mellitus (T2D) is the leading cause of end stage renal disease. Screening for chronic kidney disease is recommended for early diagnosis and intervention. This requires assessment of renal function by computing for estimated glomerular filtration rate (eGFR) and urine albumin-creatine ratio. Several formulas have been proposed for computation of eGFR. The European Renal Function Consortium (EKFC) equation, obtained by combining the full age spectrum (FAS) and Chronic Kidney Disease - Epidemiology Collaboration 2021 (CKD-EPI) equations, has been proposed as a more universal formula for eGFR. It has the advantage of eliminating correction for ethnicity and covers a wide age range. The aim of this study is to compare the EKFC and CKD-EPI 2021 equations to assess eGFR among Algerian population with T2D.</p><p><strong>Methodology: </strong>This is an observational, cross-sectional, analytical study. Serum creatinine levels were measured using the Cobas integra 400 Roche diagnostic device. The results were used to estimate GFR using the two formulas: CKD-EPI 2021 and EKFC.</p><p><strong>Results: </strong>There was a statistically significant difference between the performance of the CKD-EPI 2021 and EKFC equations (<i>p</i> <0.001). However, there was a very good correlation (r = 0.99) even though the EKFC underestimates eGFR compared to CKD-EPI 2021 (bias: -8 ml/min/1.73 m²).</p><p><strong>Conclusions: </strong>The main value of the EKFC lies in its ability to provide a detailed stratification in the early stages of chronic kidney disease. Our study also represents the first attempt to establish the q-value in the Algerian population.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"41 2","pages":"52-59"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Perception of Reproductive Health, Mental Health, and Quality of Life in Females With Classical Congenital Adrenal Hyperplasia: A Systematic Review.","authors":"Whitney Joycelyn Tenaya, Mozza Nugraha, Jesslyn Vianesa Susanto, Audrey Faustina Liu, Shannon Rency Wijaya, Laurentius Aswin Pramono","doi":"10.15605/jafes.041.02.6237","DOIUrl":"10.15605/jafes.041.02.6237","url":null,"abstract":"<p><strong>Background: </strong>Classical Congenital Adrenal Hyperplasia (C-CAH) is a congenital disorder characterized by a loss of 21-hydroxylase enzymes. Consequently, androgen levels increase, resulting in varying degrees of psychological and physiological masculinization. This systematic review aims to examine existing research on females with C-CAH and identify challenges related to reproductive self-perception, mental health, and overall quality of life.</p><p><strong>Methodology: </strong>This systematic review was conducted based on the PRISMA 2020 guidelines, studies were retrieved from PubMed, EBSCO, Science Direct, and ProQuest, and screened according to predefined eligibility criteria. Quality assessments of included studies were done using the Newcastle-Ottawa Scale (NOS) for case-control studies, adapted NOS for cross-sectional studies, and Risk of Bias in Non-randomized Studies of Intervention (ROBINS-I).</p><p><strong>Results: </strong>Eleven studies determined to have low risk of bias involving 523 participants were included. All 11 studies addressed self-perception of reproductive health, evaluating gender and sexual-related issues, with outcomes such as atypical gender identity and sexual orientation, gender dysphoria, and sexual satisfaction impairment. Adverse perceptions and experiences related to virilized genitalia were commonly reported. Four studies examined mental health issues, comprising anxiety, social phobia, ADHD, sexual distress, and signs of depression. Finally, females with C-CAH have reduced QoL compared to healthy females, mainly due to impacted general health and pain.</p><p><strong>Conclusion: </strong>Females with C-CAH demonstrated impaired reproductive self-perception, including sexual satisfaction and gender-related difficulties, alongside psychological concerns including anxiety, social phobia, and maladaptive coping behaviors, with reduced quality of life related to general health and pain.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"41 2","pages":"109-117"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hirata's Disease: A Case Report.","authors":"Quynh Thuy Luu, Thuy Thi Nguyen, Loan Thi Vu, Nhan Bich Le, Nhung Hong Thi Pham, Manh Van Nguyen, Linh Thuy Thi Nguyen","doi":"10.15605/jafes.041.02.6357","DOIUrl":"10.15605/jafes.041.02.6357","url":null,"abstract":"<p><p>Insulin Autoimmune Syndrome (IAS), also known as Hirata's disease, is a rare endocrine disorder characterized by recurrent hypoglycemia due to endogenous hyperinsulinemia and the presence of insulin autoantibodies (IAAs). We report a case of IAS successfully treated with corticosteroid therapy. Notably, the definitive diagnosis was established only during the second hospitalization, after multiple recurrent hypoglycemic episodes. The delayed diagnosis reflects the nonspecific presentation and the low initial suspicion for autoimmune hypoglycemia. In the first admission, although insulinoma had been excluded, the patient was discharged without a confirmed diagnosis. This case highlights the importance of early insulin autoantibody testing in patients with unexplained endogenous hyperinsulinemic hypoglycemia to prevent diagnostic delay and unnecessary investigations. Initial evaluation prioritized exclusion of insulinoma, the most common cause of endogenous hyperinsulinemic hypoglycemia, before autoimmune testing was pursued.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"41 2","pages":"147-150"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13622023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Adrenal Insufficiency in Clinically Stable Adults Living with HIV Attending Outpatient Clinics in Malaysia.","authors":"Qing Ci Goh, Subashini Rajoo, Norlaila Mustafa, Chin Voon Tong","doi":"10.15605/jafes.041.02.6383","DOIUrl":"10.15605/jafes.041.02.6383","url":null,"abstract":"<p><strong>Background: </strong>Adrenal insufficiency (AI) is a potentially life-threatening condition in people living with HIV/AIDS. Data on this topic are scarce and estimates of its prevalence vary.</p><p><strong>Objective: </strong>To determine the prevalence of AI among people living with HIV and to guide the management strategies.</p><p><strong>Methodology: </strong>This is a cross-sectional study conducted at the Infectious Diseases Clinics of two tertiary centres. Clinical and laboratory data were collected, and Synacthen (cosyntropin) stimulation tests were performed. Adrenal antibodies and Adrenocorticotropic Hormone (ACTH) levels were analysed in those who had an inadequate Synacthen response. The data were analysed using SPSS (version 28.0).</p><p><strong>Results: </strong>A total of 110 stable outpatient adults living with HIV, aged 18 to 80 years, were recruited. The mean age of the studied population was 37.5 ± 10.6 years, 81.8% were male, 23.6% had a normal BMI and 64.5% were either overweight or obese. The median disease duration was 4.5 years and all subjects had been on HAART for a median duration of 3.8 years. Treatment failure occurred in 20% of participants, 41.8% had a history of opportunistic infections and 4.5% had autoimmune diseases. The mean nadir CD4 count was 202 cells/mm³ ± 200 with 60.6% below 200 cells/mm³. At the time of the Synacthen tests, 88.2% had a viral load of <40 copies/ml while 89.1% had a CD4 count >200 cells/mm³. AI was identified in 2 participants (1.8%; 95% CI 0.2-6.4%). Their adrenal antibodies were negative, and ACTH levels were 4.5 ± 5.9 pmol/L. Both had significantly lower nadir CD4 counts (<i>p</i> <0.001), a history of treatment failure (<i>p</i> = 0.039) and symptoms suggestive of AI (<i>p</i> = 0.004).</p><p><strong>Conclusion: </strong>This study revealed a low prevalence of AI (1.8%) among stable HIV patients on HAART. Significant associations with AI were found in participants with lower nadir CD4 counts, a history of treatment failure, and symptoms suggestive of AI.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"41 2","pages":"92-97"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Glycemic Control Among Prospective Hajj Pilgrims With Type 2 Diabetes Mellitus in Tangerang City, Indonesia.","authors":"Muniroh Muniroh, Mustika Putri Hanifa A, Dwi Tyastuti, Yusran Tamsyi Sopian, Arif Sumantri","doi":"10.15605/jafes.041.02.6347","DOIUrl":"10.15605/jafes.041.02.6347","url":null,"abstract":"<p><strong>Background: </strong>Diabetes Mellitus Type 2 (T2DM) is a significant health concern for Hajj pilgrims, with glycaemic control crucial for their well-being during the pilgrimage. Physical health is key to determining <i>istithaah</i>, including HbA1c and fasting blood glucose tests for prospective Hajj pilgrims with type 2 diabetes mellitus.</p><p><strong>Objective: </strong>This study describes HbA1c and fasting blood glucose levels as indicators of glycaemic control among Indonesian prospective Hajj pilgrims diagnosed with T2DM based on laboratory results from medical check-ups for the 2024 departure in Tangerang City, and assesses their association with demographic factors.</p><p><strong>Methodology: </strong>A cross-sectional study analyzed HbA1c from 125 pre-departure medical check-ups of 75 female and 50 male prospective Hajj pilgrims. Data were collected from medical records at a public hospital in Tangerang City and from the Hajj Integrated Computer Health System (SISKOHATKES) application in 2024. Statistical analysis was performed using the Chi-square test or Fisher's exact test, as appropriate.</p><p><strong>Results: </strong>This study showed that most subjects were female, with the most common age group being 18-59 years (adult). The most prevalent health eligibility (istitaah) status was eligible with assistance. More than 50% of Hajj pilgrims with T2DM had comorbid conditions such as hypertension, cardiomegaly, and hyperlipidaemia. The mean HbA1c level was 9.82 ± 2.2%, with most participants exhibiting uncontrolled glycaemic status (HbA1c >7.5%). Similarly, the mean fasting blood glucose level was 197.0 ± 67.8 mg/dL, with the majority also falling within the uncontrolled range (fasting blood glucose >126 mg/dL). There was no significant correlation between HbA1c levels and age or sex.</p><p><strong>Conclusion: </strong>The majority of prospective Hajj pilgrims with T2DM are uncontrolled in terms of glycaemic status. These findings require comprehensive assessment and management strategies before, during, and after the Hajj pilgrimage to minimize risk and prevent complications.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"41 2","pages":"85-91"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13622024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization and Impact of Diabetes Technology Among Type 1 Diabetes Patients at a Tertiary Hospital in Thailand.","authors":"Jirawan Pongrujikorn, Jutipond Jitchana, Nitchakarn Laichuthai","doi":"10.15605/jafes.041.02.6355","DOIUrl":"10.15605/jafes.041.02.6355","url":null,"abstract":"<p><strong>Background: </strong>While diabetes technologies such as insulin pumps, continuous glucose monitoring (CGM), and automated insulin delivery (AID) systems have demonstrated potential to improve glycemic control and reduce hypoglycemia, their utilization and effectiveness in Thailand remain underdocumented. This study aimed to assess the use and impact of diabetes technologies on glycemic outcomes at King Chulalongkorn Memorial Hospital (KCMH), a tertiary care center in Bangkok, Thailand.</p><p><strong>Methodology: </strong>A cross-sectional study was conducted among T1D patients receiving care at the endocrinology clinic of KCMH between August 2023 and July 2024. Data were collected at each patient's most recent follow-up visit, and participants were classified into technology users and non-technology users. Data collection focused on demographics, diabetes technology use, and clinical parameters, including HbA1c, hypoglycemia events, and CGM metrics (Time in Range (TIR), Time Above Range (TAR), Time Below Range (TBR)).</p><p><strong>Results: </strong>A total of 61 patients with T1D were included, of whom 49% were technology users (6% insulin pumps, 57% CGM, 37% AID). Technology users had a significantly higher mean HbA1c (8.1% ± 1.6) than non-technology users (7.2% ± 1.2, p = 0.011). AID users achieved a higher mean TIR (67.6% ± 16%) compared to CGM users (54.0% ± 23.8%), but the difference was not statistically significant. Both AID and CGM users maintained a low incidence of hypoglycemia (<54 mg/dL).</p><p><strong>Conclusion: </strong>This study found a relatively high rate of diabetes technology adoption at our center compared to other Asian countries, highlighting its potential to reduce the risk of hypoglycemia and improve glycemic stability. However, technology users also had higher HbA1c levels, suggesting that diabetes technology is often prescribed to high-risk patients with poor glycemic control. Future research should focus on longitudinal studies to better understand and address barriers to optimal glycemic outcomes among diabetes technology users.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"41 2","pages":"162-166"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}