Journal of the ASEAN Federation of Endocrine Societies最新文献

{"title":"Genetic Variants Associated with Poor Responsiveness to Sulfonylureas in Filipinos with Type 2 Diabetes Mellitus.","authors":"Elizabeth Paz-Pacheco,&nbsp;Jose Nevado,&nbsp;Eva Maria Cutiongco-De La Paz,&nbsp;Gabriel Jasul,&nbsp;Aimee Yvonne Criselle Aman,&nbsp;Elizabeth Laurize Alejandro-Ribaya,&nbsp;Mark David Francisco,&nbsp;Ma Luz Vicenta Guanzon,&nbsp;May Uyking-Naranjo,&nbsp;Cecille Añonuevo-Cruz,&nbsp;Maria Patricia Deanna Maningat,&nbsp;Cristina Jaring,&nbsp;Paulette Nacpil-Dominguez,&nbsp;Aniza Pala-Mohamad,&nbsp;Abigail Uy-Canto,&nbsp;John Paul Quisumbing,&nbsp;Annabelle Marie Lat,&nbsp;Diane Carla Bernardo,&nbsp;Noemie Marie Mansibang,&nbsp;Vincent Sean Ribaya,&nbsp;Karell Jo Angelique Calpito,&nbsp;Julius Patrick Ferrer,&nbsp;Jessica Biwang,&nbsp;Jodelyn Melegrito,&nbsp;Christian Deo Deguit,&nbsp;Carlos Emmanuel Panerio","doi":"10.15605/jafes.037.S8","DOIUrl":"https://doi.org/10.15605/jafes.037.S8","url":null,"abstract":"<p><strong>Introduction: </strong>Sulfonylureas (SUs) are commonly used drugs for type 2 diabetes mellitus (T2DM) in the Philippines. This study aimed to associate genetic variants with poor response to gliclazide and glimepiride among Filipinos.</p><p><strong>Methodology: </strong>Two independent, dichotomous longitudinal substudies enrolled 139 and 113 participants in the gliclazide and glimepiride substudies, respectively. DNA from blood samples underwent customized genotyping for candidate genes using microarray. Allelic and genotypic features and clinical associations were determined using exact statistical methods.</p><p><strong>Results: </strong>Three months after sulfonylurea monotherapy, 18 (13%) were found to be poorly responsive to gliclazide, while 7 (6%) had poor response to glimepiride. Seven genetic variants were nominally associated (<i>p</i><0.05) with poor gliclazide response, while three variants were nominally associated with poor glimepiride response. For gliclazide response, 3 carboxypeptidase-associated variants (rs319952 and rs393994 of <i>AGBL4</i> and rs2229437 of <i>PRCP</i>) had the highest genotypic association; other variants include rs9806699, rs7119, rs6465084 and rs1234315. For glimepiride response, 2 variants were nominally associated: <i>CLCN6-NPPA-MTHFR</i> gene cluster - rs5063 and rs17367504 - and rs2299267 from the <i>PON2</i> loci.</p><p><strong>Conclusion: </strong>Genetic variants were found to have a nominal association with sulfonylurea response among Filipinos. These findings can guide for future study directions on pharmacotherapeutic applications for sulfonylurea treatment in this population.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"38 1","pages":"31-40"},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/70/JAFES-38-S1-31.PMC10207869.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9598993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Langerhans Cell Histiocytosis Presenting as Anterior Neck Mass in a Child: A Case Report.","authors":"Kristine Mae Betansos, Melissa Joyanne Cachero, Caridad Santos, Eve Fernandez, Marichu Mabulac, Lorna Abad","doi":"10.15605/jafes.038.02.15","DOIUrl":"10.15605/jafes.038.02.15","url":null,"abstract":"<p><p>Thyroid involvement in Langerhans Cell Histiocytosis (LCH) is rare. We report a 10-year-old Filipino male who presented with a rapidly enlarging goiter. Computed tomography scan showed thyroid and bilateral submandibular masses with malignant features, pulmonary blebs and hepatic cysts. Ultrasound-guided core needle biopsy findings were consistent with LCH and chemotherapy was initiated. This case demonstrates that LCH should be considered in patients with goiter. Multidisciplinary management is warranted to achieve proper diagnosis and institute timely treatment.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"38 2","pages":"149-153"},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138478861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignancy in Thyroid Nodules with Bethesda III Category on Repeat Fine Needle Aspiration Biopsy.","authors":"Jennifer Lourdes Ng, Luz Margaret Escueta, Oliver Allan Dampil","doi":"10.15605/jafes.038.02.19","DOIUrl":"10.15605/jafes.038.02.19","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the risk of malignancy for nodules repeatedly classified as Bethesda category III on fine needle aspiration biopsy (FNAB).</p><p><strong>Methodology: </strong>A chart review on a series of 59 patients seen with thyroid nodules who underwent both initial and repeat FNAB at the Diabetes, Thyroid and Endocrine Center of St. Luke's Medical Center, Quezon City was conducted. The Thyroid Registry was utilized to collect each patient's demographic and clinical characteristics, ultrasonographic features of thyroid nodules along with the cytopathologic and histopathologic results. The subclassification of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) were retrieved from the cytopathology reports using the institution's electronic Healthcare-Results Management System.</p><p><strong>Results: </strong>A total of 59 adult patients with thyroid nodules were included. Nodules which were initially AUS/FLUS turned out to be malignant on repeat FNAB in 38 patients with a prevalence of 64.41% (95% CI: 50.87-76.45%). There was no significant difference with regards to clinical, ultrasonographic and cytopathologic features of malignancy between benign and malignant nodules.</p><p><strong>Conclusion: </strong>Findings of this study support surgical intervention as a reasonable option after a repeat Bethesda III classification on FNAB. However, the small sample size warrants confirmation in future studies with a representative sample of patients.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"38 2","pages":"86-93"},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138478863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Inpatient Hypoglycemia in a Tertiary Care Hospital in Indonesia.","authors":"Chici Pratiwi,&nbsp;Martin Rumende,&nbsp;Ida Ayu Made Kshanti,&nbsp;Pradana Soewondo","doi":"10.15605/jafes.037.02.06","DOIUrl":"https://doi.org/10.15605/jafes.037.02.06","url":null,"abstract":"<p><strong>Introduction: </strong>Hypoglycemia is an important and harmful complication that often occurs in inpatient and outpatient settings. This study aims to assess the incidence of inpatient hypoglycemia and its related factors. We also assessed mortality and length of hospital stay.</p><p><strong>Methodology: </strong>We performed a retrospective cohort study among patients with type 2 diabetes mellitus admitted to a tertiary hospital in Indonesia. Using multivariate regression, we analyzed age, sex, body mass index, comorbidities, history of hypoglycemia, hyperglycemia treatment administered, nutritional intake, and medical instruction as the related risk factors for inpatient hypoglycemia.</p><p><strong>Results: </strong>From 475 subjects, 80 (16.8%) had inpatient hypoglycemia, of which, 7.4% experienced severe hypoglycemia. We found that patients with a history of hypoglycemia (RR: 4.6; 95% CI: 2.8-7.6), insulin and/or sulfonylurea treatment (RR 6.4; 95% CI: 1.6-26.5), and inadequate nutritional intake (RR 2.6; 95% CI: 1.5-4.3) were more likely to have hypoglycemic events compared to those who did not. The length of hospital stay for patients in the hypoglycemic group is significantly longer than those in the non-hypoglycemic group (13 vs 7 days, <i>p</i><0.001), but their mortality rates did not differ (16% vs 10.9%, <i>p</i>=0.18).</p><p><strong>Conclusion: </strong>Inpatient hypoglycemia may be affected by a history of hypoglycemia and inadequate nutritional intake. Patients who had inpatient hypoglycemia tend to have a longer median length of hospital stay.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"37 2","pages":"28-33"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/39/81/JAFES-37-2-28.PMC9758546.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10472505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Profile of People Living with HIV in a Treatment Hub in Manila, Philippines: A Pre- and Post-Antiretroviral Analysis.","authors":"Christian Francisco, Eddieson Gonzales, Marc Gregory Yu, Edsel Maurice Salvaña, Cybele Abad, Paul Ferdinand Reganit, Patricia Maningat, Olivia Sison, Marissa Alejandria","doi":"10.15605/jafes.037.01.17","DOIUrl":"10.15605/jafes.037.01.17","url":null,"abstract":"<p><strong>Objectives: </strong>People living with HIV (PLHIV) are susceptible to develop dyslipidemia and hyperglycemia. This study aims to determine the prevalence of these metabolic derangements among Filipino PLHIV.</p><p><strong>Methodology: </strong>We reviewed 635 medical records in a treatment hub in Manila, Philippines from January 2004 to July 2016. Logistic regression analysis was done to determine factors associated with dyslipidemia and hyperglycemia pre- and post-ART.</p><p><strong>Results: </strong>Among 635 PLHIV, 97.3% were males with mean age of 30 years and median CD4 count of 207 cells/mm³. Pre-ART, prevalence of dyslipidemia was 65.4% and hyperglycemia was 10.4%. Risk factors for dyslipidemia include hyperglycemia (AOR 3.8, <i>p</i> 0.001) and >320 days delay in ART initiation from HIV confirmation (AOR 1.5, <i>p</i> 0.032), while dyslipidemia was associated with hyperglycemia (AOR 3.1, <i>p</i> 0.001). Post-ART, prevalence of dyslipidemia was 48.6% and hyperglycemia was 15.6%. Risk factors for post-ART dyslipidemia include being WHO stage 4 (AOR 2.1, <i>p</i> 0.021), hyperglycemia (AOR 16.1, <i>p</i><0.001), >36 months ART duration (AOR 8.7, <i>p</i><0.001) and efavirenz-based ART (AOR 2.8, <i>p</i><0.001). Low CD4 count post-ART had a negative correlation with dyslipidemia (AOR 0.5, <i>p</i> 0.005). Post-ART hyperglycemia was associated with age >30 years (AOR 2.1, <i>p</i> 0.004), being overweight (AOR 1.8, <i>p</i> 0.023), dyslipidemia (AOR 17.8, <i>p</i><0.001) and zidovudine-based ART (AOR 1.4, <i>p</i> 0.051).</p><p><strong>Conclusion: </strong>Dyslipidemia and hyperglycemia prevalence was high in Filipino PLHIV. Traditional, HIV and treatment related factors contributed to its development. Intensive monitoring and initiation of appropriate treatment is recommended.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"37 1","pages":"53-61"},"PeriodicalIF":0.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9b/7f/JAFES-37-1-53.PMC9242666.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10395181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Modified Rose Method of Thyroid Palpation Versus Other Methods for the Detection of Retrosternal and Nodular Goitre.","authors":"Santosha Kumar Pattashanee,&nbsp;Gopal Puri,&nbsp;Kamal Kataria,&nbsp;Piyush Ranjan,&nbsp;Anita Dhar,&nbsp;Anurag Srivastava,&nbsp;Surabhi Vyas,&nbsp;Yashdeep Gupta,&nbsp;R M Pandey","doi":"10.15605/jafes.037.01.02","DOIUrl":"https://doi.org/10.15605/jafes.037.01.02","url":null,"abstract":"<p><strong>Objectives: </strong>This is a diagnostic test research study to evaluate the various existing methods of thyroid examination and their comparison with the novel modified Rose method. It also aims to measure inter-examiner variation in clinical findings based on the level of education and training, as compared to ultrasonography.</p><p><strong>Methodology: </strong>This cross-sectional study was conducted at a tertiary care hospital with 83 patients presenting to surgery OPD with neck swelling. Each patient was examined by one trained Junior Resident and a Surgery Consultant with all the four methods and with ultrasonography. Data was analysed by Stata-14, agreement between the two categorical variables was assessed by Kappa. In case of continuous variable agreement was assessed by Intra class correlation and Bland-Altman plot.</p><p><strong>Results: </strong>Modified Rose method by the consultant has the highest sensitivity (98%) and diagnostic odds (210) as compared to others but its specificity ranges from 46.7-91.1% to diagnose retro-sternal extension of a goiter. It has 93.98% agreement for identification of nodules. It has a high specificity (Consultant - 100%, Resident - 95.5%) with relatively lower sensitivity (Consultant - 94%, Resident - 86.8%) to diagnose solitary thyroid nodule (STN) but the sensitivity and specificity for diagnosing a multinodular goitre (MNG) was high. However, the highest sensitivity to diagnose STN was highest with Crile's method, but specificity was low. Lahey's method was a better clinical method to palpate lymph nodes compared to the other three.</p><p><strong>Conclusion: </strong>Examination in modified Rose's position is a better method of clinical examination of thyroid especially in patients with occult substernal extension. Lahey's method is a better method to examine cervical lymph nodes.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"37 1","pages":"4-13"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/f8/JAFES-37-1-4.PMC9242661.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10395183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Outcome of a β-hCG Secreting Intracranial Germ Cell Tumor in an Adult Filipino Using Definitive Chemotherapy Followed by Radiotherapy: A Case Report.","authors":"Florence Rochelle Gan,&nbsp;Maria Honolina Gomez,&nbsp;Julie Ann Tapispisan","doi":"10.15605/jafes.037.01.12","DOIUrl":"https://doi.org/10.15605/jafes.037.01.12","url":null,"abstract":"<p><p>We report a case of a 24-year-old Filipino male who complained of general weakness, polydipsia, weight loss, bitemporal headaches, loss of libido and behavioral changes. Endocrine work-up revealed neurogenic diabetes insipidus and panhypopituitarism. Brain MRI showed multiple intracranial tumors in the left frontal lobe, pineal and suprasellar region with moderate non-communicating hydrocephalus. Intracranial mass biopsy with ventriculo-peritoneal shunting was done. Histopathology of the mass and CSF revealed a germinoma. He underwent chemoradiotherapy while on maintenance hormone replacement.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"37 1","pages":"97-102"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/f7/JAFES-37-1-97.PMC9242662.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10386842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Eruptive Xanthoma: A Condition Confused With Monkeypox Rash.","authors":"Yotsapon Thewjitcharoen, Natthakan Saiwaew, Soontaree Nakasatien, Thep Himathongkam","doi":"10.15605/jafes.037.02.18","DOIUrl":"10.15605/jafes.037.02.18","url":null,"abstract":"","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"37 2","pages":"114-115"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/47/JAFES-37-2-114.PMC9758557.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10472509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal Case of Possible Thyroid Crisis Induced by SARS-CoV-2 Infection: A Case Report.","authors":"Febriyani Hamzah,&nbsp;Andi Makbul Aman,&nbsp;Harun Iskandar","doi":"10.15605/jafes.037.02.19","DOIUrl":"https://doi.org/10.15605/jafes.037.02.19","url":null,"abstract":"<p><p>Thyroid crisis is an emergency due to impaired thyroid function caused by various conditions, particularly infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that result in the dysfunction of various vital organs. We report a case of a 31-year-old Indonesian female with a 2-year history of hyperthyroidism with elevated thyroid-stimulating hormone (TSH) receptor antibodies. (TRAb) who developed thyroid crisis possibly in association with SARS-CoV-2 pneumonia, sepsis, and disseminated intravascular coagulation (DIC). Prior to admission, she was treated for her hyperthyroidism with propylthiouracil and had been in stable remission for a year. She was admitted to the Emergency Room with complaints of watery stools, icteric sclerae, jaundice, coughing, and shortness of breath. The physical examination showed a World Health Organization (WHO) performance score of 4, delirium, blood pressure within normal limits, tachycardia, tachypnea, axillary temperature of 36.7°C, icteric sclerae, jaundice, and exophthalmos. There was a 3 cm palpable nodule on the right side of the neck. Auscultation of the lungs revealed bilateral pulmonary rales. Abdominal examination noted a palpable liver and enlarged spleen. Laboratory tests showed thrombocytopenia, electrolyte imbalance, hypoalbuminemia and elevated transaminases. The thyroid function tests showed a suppressed TSH level with an elevated free thyroxine (FT4) level. The SARS-CoV-2 polymerase chain reaction (PCR) swab test was positive. Initial patient management was with supportive therapy that included favipiravir and anti-hyperthyroidism medication; however, despite these interventions, her condition continued to deteriorate and she died after a few hours. This case demonstrates no difference in therapy between patients with thyroid crises and COVID-19 or other infections. Proper and timely treatment is important for reducing mortality rates.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"37 2","pages":"101-105"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/59/68/JAFES-37-2-101.PMC9758544.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10537162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Hemostasis Abnormalities in Type 2 Diabetes Mellitus Using Thromboelastography.","authors":"Putu Moda Arsana,&nbsp;Novi Khila Firani,&nbsp;Siti Fatonah,&nbsp;Affa Kiysa Waafi,&nbsp;Adinda Dian Novitasari","doi":"10.15605/jafes.037.02.12","DOIUrl":"https://doi.org/10.15605/jafes.037.02.12","url":null,"abstract":"<p><strong>Introduction: </strong>Type 2 DM (T2DM) is associated with inflammation and vascular dysfunction which impact hemostasis. Thromboelastography (TEG) as a hemostasis assessment method, is not routinely applied in T2DM. We aimed to detect hemostasis abnormalities by using the TEG method in association with glycemic levels and type of therapy among T2DM patients.</p><p><strong>Methodology: </strong>A cross-sectional study was conducted among T2DM patients attending the Endocrinology Clinic of Saiful Anwar Hospital, Indonesia. Glycemic profiles were determined using fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPPG), and glycosylated hemoglobin (HbA1c). Therapy for T2DM was classified into insulin and non-insulin regimens. The primary and secondary hemostasis profile were examined using TEG and was classified as hypo- hyper- and normo-coagulable states.</p><p><strong>Result: </strong>A total of 57 T2DM patients were included. Kruskal-Wallis test did not reveal a significant association between glycemic profiles and groups of hemostasis. However, the median HbA1c was higher in the hypercoagulable group of primary hemostasis and fibrinolysis. The median FPG and 2hPPG were higher in the normo-coagulable group of secondary hemostasis. Logistic regression did not indicate a significant association between type of therapy for diabetes and hemostasis profile.</p><p><strong>Conclusion: </strong>This study did not find significant associations between glycemic levels and type of DM therapy with hemostasis profiles using the TEG method in patients with T2DM.</p>","PeriodicalId":41792,"journal":{"name":"Journal of the ASEAN Federation of Endocrine Societies","volume":"37 2","pages":"42-48"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/08/60/JAFES-37-2-42.PMC9758559.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10830867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}