Early Puberty Trend during the COVID-19 Pandemic in Singapore: A Retrospective Review in a Single Tertiary Centre.

IF 0.6 Q4 ENDOCRINOLOGY & METABOLISM
Annie Leong, Rashida Farhad Vasanwala
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引用次数: 0

Abstract

Objectives: We aimed to study the trend of referrals for precocious puberty during the COVID-19 pandemic compared to pre-COVID years, explore the differences in the demographic and clinical features, and evaluate the contributing factors.

Methodology: The cases referred for assessment of PP from 2018-2021 to our endocrine centre were grouped into pre-COVID (2018-2019) and COVID (2020-2021) years. Cases fulfilling the diagnosis of PP included the onset of thelarche <8 years in females and 4 ml testicular volume <9 years in males. The PP was further differentiated as Isolated Thelarche (IST) and Central Precocious Puberty (CPP). Early menarche was defined as menarche <10 years old.

Results: There were more referrals for PP and more diagnosed as CPP during the COVID-19 pandemic, predominantly among females. There were more endocrine tests done and more cases received treatment. None of the abnormal magnetic resonance imaging (MRI) pituitary findings required surgical intervention. The body mass index (BMI) was found to be positively associated with the risk of getting CPP with a crude-odd ratio (COR) of 1.8, P <0.001, and early menarche (COR 2.1, P <0.001).

Conclusion: We found a significant increase in the referrals of PP and diagnosis of CPP during the COVID-19 pandemic. Higher BMI was found to be associated with CPP and early menarche.

新加坡 COVID-19 大流行期间的性早熟趋势:一家三级医疗中心的回顾性研究。
目的:我们旨在研究COVID-19大流行期间与COVID前相比转诊性早熟的趋势,探讨人口统计学和临床特征的差异,并评估诱因:将2018-2021年转诊至我院内分泌中心评估PP的病例分为COVID前(2018-2019年)和COVID(2020-2021年)两组。符合 PP 诊断的病例包括月经初潮:在COVID-19大流行期间,转诊为PP和确诊为CPP的病例较多,主要是女性。做内分泌检查的人数和接受治疗的人数都有所增加。在磁共振成像(MRI)发现的异常垂体病例中,没有一例需要进行手术治疗。研究发现,体重指数(BMI)与罹患 CPP 的风险呈正相关,粗略多德比(COR)为 1.8,P P 结论:我们发现,在 COVID-19 大流行期间,转诊 PP 和确诊 CPP 的人数明显增加。发现较高的体重指数与 CPP 和月经初潮过早有关。
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来源期刊
CiteScore
1.20
自引率
0.00%
发文量
22
审稿时长
8 weeks
期刊介绍: The Journal of the ASEAN Federation of Endocrine Societies (JAFES) is an OPEN ACCESS, internationally peer-reviewed, English language, medical and health science journal that is published in print two times a year by the ASEAN Federation of Endocrine Societies. It shall serve as the endocrine window between the ASEAN region and the world, featuring original papers and publishing key findings from specialists and experts of endocrinology.
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