Psiquiatria Biologica最新文献

{"title":"El problema de la nosología psiquiátrica","authors":"Mauro Agustín Rolando López","doi":"10.1016/j.psiq.2025.100755","DOIUrl":"10.1016/j.psiq.2025.100755","url":null,"abstract":"<div><div>Current psychiatric nosology continues to be based on clinical manifestations without recourse to biological markers of pathology, which leads to a number of complications in clinical practice and research. Normally in medicine, diseases are defined by their biological alterations and not by their manifestations. This paper argues why traditional classifications should be abandoned, at least for the approval of biological therapies. It is proposed to create a new nosology based on psychobiology.</div></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 4","pages":"Article 100755"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Riesgo de suicidio en personas con enfermedad orgánica crónica sin contacto previo con salud mental: a propósito de un caso","authors":"Laura Prieto-Arenas,&nbsp;María Albors Rossi,&nbsp;Pablo De Fez Febré,&nbsp;Lucía Ros Pérez-Salamero","doi":"10.1016/j.psiq.2025.100754","DOIUrl":"10.1016/j.psiq.2025.100754","url":null,"abstract":"","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 4","pages":"Article 100754"},"PeriodicalIF":0.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the effectiveness of agomelatine, bupropion, and sertraline in the treatment of non-psychotic major depressive disorder: a double- blind, randomized clinical trial","authors":"Romina Hamzehpour ,&nbsp;Ashraf Ahangar ,&nbsp;Elham Motevalli Alamouti ,&nbsp;Farzan Khierkhah ,&nbsp;Mahboobeh Khoozan ,&nbsp;Hoda Shirafkan","doi":"10.1016/j.psiq.2025.100742","DOIUrl":"10.1016/j.psiq.2025.100742","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Major depression is a psychiatric disorder associated with a decrease in performance in personal and interpersonal relationships. Among the various treatment options for major depression, pharmacotherapy is the most common method. However, some patients do not respond adequately to first- or second-line antidepressants. Many patients discontinue their medications due to intolerable side effects, inadequate responses, and the persistence of symptoms. In this study, the efficacy of agomelatine was compared against sertraline and bupropion.</div></div><div><h3>Research method</h3><div>A double-blind, randomized clinical trial was conducted on 90 patients diagnosed with major depressive disorder according to DSM-5, who were referred to Shahid Yahiinejad Hospital in Babol, Iran. Patients were assigned to three groups using a random block design. The agomelatine group initially received 25 mg of the drug daily for two weeks. Patients who did not show improvement with 25 mg per day were increased to 50 mg per day. The sertraline group received 50 mg of the drug daily. The bupropion group received 75 mg of the drug per day. Initial drug response and side effects were assessed in the second week, while secondary responses and more complete responses to treatment were evaluated in weeks 4 and 8. The Hamilton Depression Rating Scale was used to measure response and remission in weeks 2, 4, and 8.</div></div><div><h3>Findings</h3><div>The average age of participants was 39.49 years, with a standard deviation of 10.55. Side effects in patients treated with agomelatine were generally fewer than in the other two groups. The association between different drugs and side effects such as decreased sexual desire, nausea, headache, anxiety, drowsiness, palpitations, and restlessness was significant (p &lt; 0.05). However, this relationship was not significant for other complications (p &gt; 0.05). The depression scores during the follow-up visits showed a decreasing trend across all patients, regardless of the drug group. There was a significant difference in the average depression scores between the agomelatine, sertraline, and bupropion groups in the second (p = 0.002), fourth (p = 0.004), and eighth (p = 0.003) weeks.</div></div><div><h3>Conclusion</h3><div>The results of the study demonstrated that the use of agomelatine in patients with non-psychotic major depressive disorder was as effective as sertraline and bupropion in reducing depression scores. Additionally, the side effects associated with agomelatine were less frequently reported compared to the other routine antidepressant drugs.</div></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 4","pages":"Article 100742"},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144863431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bipolar i disorder in a patient with selective IgA deficiency and iatrogenic hepatitis C infection. A complex neuroimmunological and affective intersection","authors":"Alicia Alemañ Prats ,&nbsp;Sergio Cardona Bejarano ,&nbsp;Lorena García-Fernández","doi":"10.1016/j.psiq.2025.100743","DOIUrl":"10.1016/j.psiq.2025.100743","url":null,"abstract":"<div><div>Bipolar I Disorder (BD-I) is a severe, recurrent psychiatric condition arising from intricate interactions between genetic, environmental, and biological factors. Immune dysfunction and neuroinflammation are increasingly recognized as contributors to its pathogenesis. We present the case of a 51-year-old male with BD-I, selective immunoglobulin A deficiency (SIgAD), and iatrogenic hepatitis C infection, whose clinical course highlights the complex neuroimmune and affective interplay underlying mood disorders. His psychiatric history includes recurrent manic episodes with psychotic features, initially triggered by interferon-alpha therapy, a known immune activator. Early life adversity, including paternal loss and the psychosocial burden of premature caregiving, intersected with chronic immune dysregulation from SIgAD and iatrogenic hepatitis C, potentially fostering neuroinflammatory priming. The trajectory of his illness is consistent with the affective sensitization (kindling) model, where initial episodes were stress-linked, but subsequent recurrences emerged autonomously. Additionally, a traumatic brain injury during a manic state likely added neuroanatomical vulnerability without altering the primary affective phenotype. This case underscores the relevance of immune-inflammatory mechanisms in BD-I and highlights the importance of integrative, biopsychosocial approaches to both diagnosis and management, especially in medically complex patients.</div></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 4","pages":"Article 100743"},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fiabilidad interjueces en el contexto clínico: aplicación del método DOMENIC (Detección de Múltiples Examinadores No Consensuados) en la evaluación de la manía","authors":"Carmen Vidal-Mariño ,&nbsp;Irene Caro-Cañizares ,&nbsp;María Luisa Barrigón Estévez ,&nbsp;Enrique Baca-García","doi":"10.1016/j.psiq.2025.100741","DOIUrl":"10.1016/j.psiq.2025.100741","url":null,"abstract":"<div><h3>Objective</h3><div>The diagnosis of bipolar disorder generates discrepancies among clinicians, impacting its treatment. We explored the inter-rater reliability of the Young Mania Rating Scale (YMRS) in a clinical setting, using the Detection of Multiple Examiners with No Consensus (DOMENIC) method, to determine whether there were differences in the level of agreement obtained by raters trained in the use of the YMRS versus untrained raters with greater clinical experience.</div></div><div><h3>Method</h3><div>Forty-four raters (12 trained in the scale and 32 untrained) viewed an interview with a patient diagnosed with bipolar disorder and completed the YMRS. We used the DOMENIC method to obtain the level of agreement.</div></div><div><h3>Results</h3><div>The average inter-rater agreement ranged from 47% to 100%. Trained raters showed agreement ≥<!--> <!-->79% on 7 of the 11 items, while untrained raters only achieved agreement on 3 of the 11 items.</div></div><div><h3>Conclusions</h3><div>Specific training in the use of the YMRS is key to achieving optimal levels of inter-rater reliability, regardless of clinical experience. The DOMENIC method allows for identifying the percentage of inter-rater agreement and comparing each rater with the rest of the group, facilitating rater training.</div></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 4","pages":"Article 100741"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144880026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidio sin previo aviso: a propósito de un caso","authors":"Laura Prieto-Arenas,&nbsp;María Albors Rossi,&nbsp;Lucía Ros Pérez-Salamero,&nbsp;Pablo de Fez Febré","doi":"10.1016/j.psiq.2025.100740","DOIUrl":"10.1016/j.psiq.2025.100740","url":null,"abstract":"","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 4","pages":"Article 100740"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factores de riesgo de ansiedad y depresión en adolescentes embarazadas atendidas en un programa de control prenatal en Atlántico, Colombia","authors":"María Arana-Baquero ,&nbsp;Valery Bernal-Ceballos ,&nbsp;Ivanna Castro-Lozano ,&nbsp;Sofía Jiménez- de la Ossa ,&nbsp;Rachel Sefair-Ceballos ,&nbsp;Tania Acosta-Vergara ,&nbsp;Victor Florez-García ,&nbsp;Ana Gutiérrez-Polo","doi":"10.1016/j.psiq.2025.100735","DOIUrl":"10.1016/j.psiq.2025.100735","url":null,"abstract":"<div><h3>Introduction</h3><div>Adolescent pregnancy is a prevalent social issue in our context and entails significant mental health risks, with high rates of anxiety and depression in this vulnerable group. Given the scarcity of studies in Colombia, it is essential to identify factors associated with these disorders.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional observational study with 103 pregnant adolescents between the ages of 15 and 19 enrolled in a prenatal care program in Atlántico, Colombia. Data collection included a structured telephone survey comprising a sociodemographic and clinical questionnaire, the Patient Health Questionnaire (PHQ-9), and the Generalized Anxiety Disorder Scale (GAD-7).</div></div><div><h3>Results</h3><div>The prevalence of anxiety and depression symptoms was 8.7 and 14.5%, respectively. Factors associated with depression included having an academic title (OR = 3.16; 95% CI: 1.41–7.09) and being in the 17 to 19 age group (OR = 2.50; 95% CI: 1.10–5.66). For anxiety, the identified factors were education level, age, and planned pregnancy, although these were not statistically significant.</div></div><div><h3>Conclusions</h3><div>Symptoms of anxiety and depression show significant variability among pregnant adolescents in Atlántico and are associated with specific sociodemographic factors. Comprehensive preventive interventions are recommended to improve mental health in this population.</div></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 3","pages":"Article 100735"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compilation of animal-assisted therapy studies: A narrative review of clinical evidence","authors":"Vanessa Herrera ,&nbsp;Luis Gutierrez-Rojas ,&nbsp;Miguel Angel Alvarez-Mon","doi":"10.1016/j.psiq.2025.100738","DOIUrl":"10.1016/j.psiq.2025.100738","url":null,"abstract":"<div><div>Animal-assisted interventions are classified into animal-assisted therapy, animal-assisted activities, and animal-assisted programs. These interventions aim to improve emotional, cognitive, social, and physical functioning. Animal-assisted therapy is defined as an intervention in which animals play an active role in improving health and well-being. It involves interactions between individuals and animals, facilitated by a trained therapist or healthcare professional, to achieve specific therapeutic goals. This therapy encompasses emotional, psychological, and physical dimensions and involves not only the individuals participating in the therapy but also the animals and the environment in which interactions take place. Animal-assisted therapy is based on the fundamental principle of facilitating human-animal interactions to promote therapeutic outcomes. This therapy is formed by a team of trained animals, therapeutic interactions, and positive results associated with rehab goals. The use of dogs, as the most common animal in these interventions, is associated with significant benefits, including stress reduction, mood improvement, and the strengthening of social skills, highlighting their transformative impact on participants' quality of life. Additionally, this review underscores that animal-assisted therapy is not only effective in clinical contexts but also has the potential to humanize healthcare and foster deep emotional connections. This makes it a valuable and underutilized strategy that could revolutionize conventional therapeutic approaches. Despite these contributions, the article emphasizes the need to standardize practices and develop more rigorous studies to maximize its effectiveness, ensuring its sustainable and evidence-based implementation.</div></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 3","pages":"Article 100738"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La mente en violencia: trastorno delirante en víctimas de violencia de género. A propósito de un caso","authors":"Carlota Duro de la Merced,&nbsp;Ana Blanco Barrón,&nbsp;Ana del Cuvillo Yges,&nbsp;Lourdes Johnson Redondo,&nbsp;Mónica Fernández Rodríguez,&nbsp;Olga Méndez González","doi":"10.1016/j.psiq.2025.100739","DOIUrl":"10.1016/j.psiq.2025.100739","url":null,"abstract":"<div><div>Gender-based violence is not only a social and legal problem, but also a significant public health issue that can have devastating consequences for the physical and mental health of its victims. The following is a case of a patient who develops a delusional disorder after years of continued marital abuse. This is not an isolated case, as previous studies have shown that women who suffer gender violence can experience a variety of mental disorders, including depression, anxiety and psychotic disorders.</div><div>This case illustrates how prolonged exposure to violence can lead to the breakdown of mental health, resulting in the emergence of delusional symptoms. Understanding this relationship is crucial for developing effective interventions and supporting victims of gender-based violence.</div></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 3","pages":"Article 100739"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deterioro cognitivo vascular: a propósito de un caso","authors":"Jesús Ángel Monforte Porto ,&nbsp;Alberto de Vega Martín ,&nbsp;Marisol Asperilla Gallardo","doi":"10.1016/j.psiq.2025.100737","DOIUrl":"10.1016/j.psiq.2025.100737","url":null,"abstract":"","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 4","pages":"Article 100737"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144880025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}