Psiquiatria Biologica最新文献

{"title":"Schizophrenia in 22q11.2 deletion syndrome: A case report","authors":"Sergio Cardona Bejarano MD ,&nbsp;Lorena García-Fernández PhD MD","doi":"10.1016/j.psiq.2025.100714","DOIUrl":"10.1016/j.psiq.2025.100714","url":null,"abstract":"<div><div>22q11.2 deletion syndrome (22q11.2DS), also known as velocardiofacial syndrome (VCFS) or DiGeorge syndrome, is a common autosomal dominant disorder caused by a microdeletion on chromosome 22, leading to a spectrum of congenital defects and neuropsychiatric manifestations, including a significantly increased risk of schizophrenia. This case report details a 23-year-old male with confirmed 22q11.2DS who presented with acute psychosis, following a history of developmental delays, attention deficit hyperactivity disorder, obsessive-compulsive disorder, and cognitive impairments. The neuropsychiatric symptoms are attributed to genetic disruptions in dopamine and glutamate pathways, notably involving the COMT and PRODH genes, which contribute to dopaminergic dysregulation and NMDA receptor dysfunction. Neuroimaging supports these findings, with structural anomalies in the prefrontal cortex and thalamus. The case exemplifies the complex interaction of genetic predisposition and environmental stressors in the onset of schizophrenia in 22q11.2DS. Early intervention targeting both genetic factors and environmental stressors is critical in managing the neuropsychiatric burden in this population, emphasizing the need for comprehensive, multidisciplinary care.</div></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 2","pages":"Article 100714"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conversion disorder in adolescence: Detailed report of a clinical case","authors":"Mateo Andrade ,&nbsp;Dennis Olmedo","doi":"10.1016/j.psiq.2025.100713","DOIUrl":"10.1016/j.psiq.2025.100713","url":null,"abstract":"<div><h3>Introduction</h3><div>Conversion disorder, or functional neurological disorder, is a complex condition characterized by neurological symptoms without an underlying organic medical cause. This paper presents a clinical case analysis of a 15-year-old female adolescent diagnosed with conversion disorder.</div></div><div><h3>Objective</h3><div>To detail the psychobiological, social, and environmental factors that contribute to the appearance of symptoms, as well as to describe the diagnostic and therapeutic strategies applied.</div></div><div><h3>Method</h3><div>This is an observational study focused on the case report of a female teenager hospitalized in Quito, Ecuador. The inclusion criteria were a confirmed diagnosis of conversion disorder and informed consent and assent from the patient and her parents. Data were collected through medical history recording. No statistical analysis was required due to the descriptive nature of the study.</div></div><div><h3>Results</h3><div>The patient was evaluated for hyporexia, insomnia, anhedonia, suicidal ideation, and significant psychomotor regression. During her hospitalization, she exhibited sporadic and violent movements of her upper extremities, along with episodes of disconnection from her surroundings. The examinations performed, including electroencephalogram, computed tomography, and brain MRI, did not reveal structural abnormalities or epileptiform activity. The diagnosis of conversion disorder was confirmed according to DSM-5 criteria, ruling out other neurological and psychiatric conditions. Treatment included pharmacological therapy along with behavioral and family therapy. The inclusion of the mother in therapy sessions contributed to significant improvement, reflected in the decrease in suicidal risk and the reduction of behavioral alterations.</div></div><div><h3>Discussion and conclusion</h3><div>This case highlights the importance of thorough evaluation and comprehensive management in the treatment of conversion disorder in adolescents, the value of multidisciplinary intervention, and the crucial role of family involvement in recovery.</div></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 2","pages":"Article 100713"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevenir en suicidio, ¿oportunidad o utopía? Revisión pragmática sobre el estado de la cuestión","authors":"Íñigo Alberdi-Páramo ,&nbsp;Irene Rodrigo-Holgado","doi":"10.1016/j.psiq.2025.100712","DOIUrl":"10.1016/j.psiq.2025.100712","url":null,"abstract":"<div><h3>Background</h3><div>Suicide is one of the leading causes of death worldwide, representing a significant challenge for public health and psychiatry. This article pragmatically reviews the current state of suicide prevention strategies, identifying both achieved progress and persistent challenges.</div></div><div><h3>Methods</h3><div>A review of the literature was conducted, including recent and relevant studies published in major academic databases. Studies were selected and analyzed based on their relevance to suicide prevention, methodological approaches, and key findings.</div></div><div><h3>Results</h3><div>The review revealed that while significant progress has been made in identifying risk factors and developing preventive interventions, major challenges persist. Multifaceted interventions, including educational, psychological, and pharmacological components, show the most promising results. However, effective implementation and accessibility of these interventions remain problematic in many regions.</div></div><div><h3>Conclusions</h3><div>Suicide prevention presents both opportunities and challenges. Continued research and improved implementation of evidence-based strategies are crucial to reduce suicide rates. Interdisciplinary collaboration and the adaptation of interventions to specific contexts are essential for progress in this field.</div></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 2","pages":"Article 100712"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repatriation of refugees in the post-conflict era: Implications for mental health","authors":"Agustín Bermejo Pastor ,&nbsp;Jesús Enrique Ibáñez Vizoso","doi":"10.1016/j.psiq.2025.100711","DOIUrl":"10.1016/j.psiq.2025.100711","url":null,"abstract":"<div><div>refugees, repatriation, PTSD, trauma.</div></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 2","pages":"Article 100711"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Un cordobés con mucho acento… hindú","authors":"Onorina Stoicev Stefoglo,&nbsp;Teresa Jimeno Beltrán,&nbsp;Maria Antònia Martí Femenias,&nbsp;Francisco Jesús Cámara Aguilera,&nbsp;Guillermo Momparler Lázaro,&nbsp;Maria Antònia Miquel Ribot","doi":"10.1016/j.psiq.2024.100542","DOIUrl":"10.1016/j.psiq.2024.100542","url":null,"abstract":"","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 1","pages":"Article 100542"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vulnerabilidad del paciente psiquiátrico ante el fraude romántico vía digital","authors":"Miguel Jiménez Blázquez ,&nbsp;María Parrondo Pérez-Olivares","doi":"10.1016/j.psiq.2024.100526","DOIUrl":"10.1016/j.psiq.2024.100526","url":null,"abstract":"","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 1","pages":"Article 100526"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observational, cross-sectional study to describe the efficacy and safety of Esketamine Nasal Spray treatment in real clinical practice: INtegrate study","authors":"Pilar Alejandra Sáiz ,&nbsp;Jose Luis Hernández ,&nbsp;Verónica Gálvez ,&nbsp;Nagore Iriarte ,&nbsp;Paola López ,&nbsp;Patricio Molero","doi":"10.1016/j.psiq.2024.100517","DOIUrl":"10.1016/j.psiq.2024.100517","url":null,"abstract":"","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 1","pages":"Article 100517"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conducta suicida, policonsumo de sustancias y patología dual en la adolescencia. Un desafío para los servicios de psiquiatría infantil y pediatría en un hospital general. A propósito de un caso","authors":"María Rosario Pérez Moreno,&nbsp;Clara María Martín Gozalo,&nbsp;Adrián García Ron,&nbsp;Idir Mesián Pérez","doi":"10.1016/j.psiq.2024.100527","DOIUrl":"10.1016/j.psiq.2024.100527","url":null,"abstract":"","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 1","pages":"Article 100527"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sin queso no hay suicidio","authors":"Onorina Stoicev Stefoglo,&nbsp;Júlia Rodríguez Martín,&nbsp;Lucianna Ifarraguirre Mello,&nbsp;Maria Antònia Ribot Miquel,&nbsp;Francisco Jesús Cámara Aguilera,&nbsp;Jaume Andreu Garcias Trullols","doi":"10.1016/j.psiq.2024.100540","DOIUrl":"10.1016/j.psiq.2024.100540","url":null,"abstract":"","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 1","pages":"Article 100540"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoso escolar y suicidio","authors":"Ana Jiménez Bidón","doi":"10.1016/j.psiq.2024.100521","DOIUrl":"10.1016/j.psiq.2024.100521","url":null,"abstract":"<div><div>Bullying is an adverse event that can have serious consequences for victims, which can even lead to suicidal behavior. In this article, a study is carried out on adolescents who are psychiatric inpatients in the Hospital 12 de Octubre in Madrid. The bullying is examined in the inpatient adolescents and the reasons for admission to a psychiatric hospital. The results obtained are discussed and the importance of establishing preventive measures and protection against bullying is emphasized.</div></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 1","pages":"Article 100521"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}