{"title":"[Incidence of acquired morbidity and its impact on patients in a pediatric intensive care unit based on the functional status scale]","authors":"Judith Frydman, Mara Inés López","doi":"10.31053/1853.0605.v82.n1.45328","DOIUrl":"10.31053/1853.0605.v82.n1.45328","url":null,"abstract":"<p><strong>Introduction: </strong>a significant number of children suffer cognitive, physical, mental and social limitations as a result of critical illnesses and their subsequent treatment. Pollack et al. developed the functional status scale with the purpose of measuring the change in functional status during hospitalization.</p><p><strong>Objectives: </strong>evaluate the acquired morbidity upon discharge from the Pediatric Intensive Care Unit (PICU). Specific objectives: compare mortality and acquired morbidity rates, analyze changes in functional status categories, identify the most affected domains, describe relationships between domain affection and admission diagnosis, between domain affection and age group, between morbidity and days in invasive mechanical ventilation (IMV), non-invasive ventilation and high-flow oxygen therapy.</p><p><strong>Methodology: </strong>observational, descriptive, prospective and longitudinal study. Patients between 1 and 180 months of age requiring ventilatory support for at least 48 hours, between February 2021 and February 2024, were included.</p><p><strong>Results: </strong>90.9% survived, and of these, 26.9% developed acquired morbidity. The 42% of patients changed their functional status at least one point. The most affected domains were motor and feeding. Those who died had fewer days of IMV and hospitalization.</p><p><strong>Conclusion: </strong>The incidence of acquired morbidity was higher than mortality in the analyzed period. Children who developed morbidity remained hospitalized for a longer period of time and had greater requirements and days of IMV. Increased survival makes mortality an insufficient outcome metric. More studies with longer follow-up are needed.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"41-60"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anyhely Yhoan Escudero Quispe, José Luis Vivanco Osorio
{"title":"[Advanced maternal age as a risk factor for adverse perinatal outcomes]","authors":"Anyhely Yhoan Escudero Quispe, José Luis Vivanco Osorio","doi":"10.31053/1853.0605.v82.n1.45349","DOIUrl":"10.31053/1853.0605.v82.n1.45349","url":null,"abstract":"<p><p>This study finds a gradual increase in women's age at first pregnancy, a situation that has been associated with an increased risk of adverse maternal and postpartum events. While in the mid-1970s there were 1.7 per thousand pregnant nulliparous women between 35 and 39 years old, in 2012 this figure increased to 11 per thousand pregnant women, a six-fold increase. The global prevalence of pregnant women over 35 years of age is estimated at 12.3%. Maternal and perinatal characteristics and outcomes of nulliparous women aged 40 years and older are described and compared with characteristics of nulliparous women younger than 40 years. During the time of said study, approximately 4095 nulliparous female patients who met the inclusion criteria were treated; however, a limitation was found because it was a closed population treated in a highly complex tertiary hospital, the majority with high level of schooling and middle class socioeconomic level. In conclusion, older women constitute a high-risk population whose management and follow-up would require a different approach aimed at improving maternal and postpartum outcomes.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"223-230"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[ Accumulation of hyaluronic acid in rhinoseptoplasty: intraoperative finding]","authors":"Sebastián Abad-Cuenca, Xavier Eduardo Abad-González","doi":"10.31053/1853.0605.v82.n1.45169","DOIUrl":"10.31053/1853.0605.v82.n1.45169","url":null,"abstract":"<p><p>Current beauty standards have influenced individuals to seek an aesthetically \"ideal\" nose, leading them to pursue non-surgical strategies like rhinomodeling using hyaluronic acid or surgical approaches such as rhinoplasty. The use of hyaluronic acid in the nose can complicate its manipulation in the event of subsequent surgical intervention and carries various risks if performed by unqualified personnel.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"215-222"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcelo A Rada, Paula Edit Cuffaro, María Celeste Szydlowicz, Verónica Andrea Peuchot, Margarita Susana Morales, Jorge Javier Janson, Ruben Micali, José Alfie, Carlos Rodolfo Galarza
{"title":"[Validation of a new impedance cardiography device for noninvasive hemodynamic measurement in outpatient hypertensive patients]","authors":"Marcelo A Rada, Paula Edit Cuffaro, María Celeste Szydlowicz, Verónica Andrea Peuchot, Margarita Susana Morales, Jorge Javier Janson, Ruben Micali, José Alfie, Carlos Rodolfo Galarza","doi":"10.31053/1853.0605.v82.n1.45253","DOIUrl":"10.31053/1853.0605.v82.n1.45253","url":null,"abstract":"<p><strong>Objective: </strong>To compare the new cardiograph ZLogic for non-invasive measurements of Stroke volume (SV) and Cardiac output (CO) against the Minnesota cardiograph.</p><p><strong>Methods: </strong>86 subjects from both genders, 18-80 years old, hypertensive and healthy volunteers were included. Three hemodynamic measurements performed with each device, in an alternate fashion, using the Bland-Altman method to determine the level of agreement. Percentage error was calculated for interchangeability of both methods.</p><p><strong>Results: </strong>Mean SV was 86.71±27.35 mL and mean CO 5.42±1.74 L/min. There was a strong correlation between measures of SV and CO obtained with both devices (r=0.99, p<0.001). Mean difference (MD) for SV was 0.65±3.08 mL (CI95%: -0.01-1.31) and 95% limits of agreement −5.39 to +6.69 mL. MD for CO was 0.05±0.17 L/min (CI95%: 0.01-0.09) and the 95% limits of agreement −0.28 to +0.38 L/min.</p><p><strong>Conclusion: </strong>ZLogic and Minnesota cardiographs provided equivalent SV and CO values in ambulatory hypertensive patients.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"95-109"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Elisa Rivas, Melania Ron, Fernando Martín Salierno, María Soledad Broggi, Lucas Bonamico
{"title":"[Outcomes of a Transdisciplinary Rehabilitation Program for Patients with Consciousness Disorders (2006-2022, Argentina)]","authors":"Maria Elisa Rivas, Melania Ron, Fernando Martín Salierno, María Soledad Broggi, Lucas Bonamico","doi":"10.31053/1853.0605.v82.n1.42871","DOIUrl":"10.31053/1853.0605.v82.n1.42871","url":null,"abstract":"<p><strong>Introduction: </strong>After suffering brain damage with altered consciousness, clinically stable patients are referred to rehabilitation programs. The objective of this study is to describe the results of a transdisciplinary multisensory stimulation program in adults with altered consciousness admitted to a rehabilitation center in Argentina between 2006 and 2022.</p><p><strong>Methodology: </strong>A retrospective case series study was conducted that included 178 patients who completed the multisensory stimulation program. Consciousness was assessed with the Coma Recovery Scale – Revised (CRS-R), functional outcome with the Functional Independence Measure (FIM), and disability with the Disability Rating Scale (DRS).</p><p><strong>Results: </strong>The majority of patients (68%) were men with a diagnosis of unresponsive wakefulness syndrome (RSVS). The median time of injury to admission was 77 days, and the average length of stay was 127 days. The median CRS-R at admission was 6 and 10 at discharge (p = 0.01). The highest percentage (61.8%) of emergence was in traumatic injuries. Patients who emerged showed a significant functional improvement, with a median FIM = 44 and DRS = 11. The stay was significantly shorter in those who emerged (70 vs. 163 days; p = 0.001).</p><p><strong>Conclusion: </strong>These results highlight the benefit of a transdisciplinary multisensory stimulation program to improve diagnostic evaluation and promote recovery of consciousness in patients with severe brain injury.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"6-21"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis Angel Di Giuseppe, Juan Ignacio Appendino, María Del Carmen García, Karina Elena Alvarez, Gabriela Buela, Mariana Andrea Burgos, María Lourdes Posadas-Martínez, Maria Celeste Puga
{"title":"[Real-life study with pharmaceutical cannabidiol in refractory epilepsy]","authors":"Luis Angel Di Giuseppe, Juan Ignacio Appendino, María Del Carmen García, Karina Elena Alvarez, Gabriela Buela, Mariana Andrea Burgos, María Lourdes Posadas-Martínez, Maria Celeste Puga","doi":"10.31053/1853.0605.v82.n1.45350","DOIUrl":"10.31053/1853.0605.v82.n1.45350","url":null,"abstract":"<p><p>Pharmaceutical-grade cannabidiol (CBD) is an alternative treatment for patients with drug-resistant epilepsy (DRE). In 2022, the Italian Hospital of Buenos Aires implemented a non-medical change (NMC) of treatment, replacing one commercial pharmaceutical-grade CBD product with another, the latter also being the initial option for new patients.</p><p><p>Our objective was to evaluate the clinical outcomes of the commercial product change in this population.</p><p><strong>Methods: </strong>Retrospective cohort of DRE patients who either switched from one commercial pharmaceutical-grade CBD product to another or started treatment with the new product. The clinical response was evaluated by changes in seizure frequency, perception of change with the Patient Global Impression of Change (PGIC) scale, and safety considering discontinuation and/or the presence of adverse effects.</p><p><strong>Results: </strong>Nineteen patients were included, 12 in the change group and 7 in the new start group (7 pediatric and 12 adults). One patient discontinued treatment due to lack of response. Among those who completed follow-up, 8 (44%) reduced seizure frequency, 6 (33%) showed no change, and 4 (22%) increased seizure frequency. According to the PGIC scale, 9 (50%) remained unchanged, 5 (28%) reported barely noticeable changes, and 4 (22%) reported improvement. Adverse events were mild and transient.</p><p><strong>Conclusion: </strong>The new commercial pharmaceutical-grade CBD product is a safe and valid option both for substitution and initial treatment in patients with DRE. During the treatment period, patients perceived stability or improvement according to the PGIC scale.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"110-126"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Belén Ginetti, Pablo Oyhamburu, Martín Bosio, Fernando Di Tullio
{"title":"[Long-term Titanium mesh cage implant failure after total en bloc spondylectomy due to spinal chondrosarcoma: case report and literature review]","authors":"María Belén Ginetti, Pablo Oyhamburu, Martín Bosio, Fernando Di Tullio","doi":"10.31053/1853.0605.v82.n1.44999","DOIUrl":"10.31053/1853.0605.v82.n1.44999","url":null,"abstract":"<p><strong>Objective: </strong>To report an unusual titanium mesh cage failure after ten years of follow-up.</p><p><strong>Clinical case: </strong>A 40-year-old woman diagnosed with low-grade spinal chondrosarcoma underwent a total en-bloc spondylenctomy (TES) surgery. This technique required a wide resection, anterior reconstruction with a titanium mesh cage (TMC), and posterior stabilization. For several years a favorable clinical outcome was achieved. After 10 years of follow-up, the patient developed acute non-traumatic low back pain without neurological repercussions. The images confirmed a rupture of the titanium cage. After ruling out tumor recurrence, the patient went through spinal instrumentation revision.</p><p><strong>Conclusion: </strong>Isolated TMC rupture is a rare event scarcely reported in the literature. There is a strong recommendation to instrument two levels proximal and distal to the bone defect in 360° reconstructions after a TES. Stability had likely been lost over the years due to the slow resorption of the bone graft. We consider necessary studies with a higher casuistry and level of evidence to analyze the contributing factors for the event of TMC rupture.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"154-164"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The implications of Argentina's withdrawal from the world health organization]","authors":"Eduardo Cuestas","doi":"10.31053/1853.0605.v82.n1.48157","DOIUrl":"10.31053/1853.0605.v82.n1.48157","url":null,"abstract":"<p><p>The implications of Argentina's withdrawal from the world health organization</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julia Inés Simonassi, María Tatiana Canzobre, Victoria Eleonora Lopez Fiorito, Cinthia Giselle Perez, Solana Pellegrini
{"title":"[Liberation of mechanical ventilation in tracheostomized pediatric patients during their stay in the intensive care unit]","authors":"Julia Inés Simonassi, María Tatiana Canzobre, Victoria Eleonora Lopez Fiorito, Cinthia Giselle Perez, Solana Pellegrini","doi":"10.31053/1853.0605.v82.n1.45243","DOIUrl":"10.31053/1853.0605.v82.n1.45243","url":null,"abstract":"<p><strong>Introduction: </strong>Tracheostomy in pediatric intensive care has a prevalence between 5% and 10% of patients on mechanical ventilation.</p><p><strong>Objective: </strong>The objective of this study was to determine the duration and outcome of the weaning process from mechanical ventilation (MV) and the behavior according to the reason for the tracheostomy.</p><p><strong>Methodology: </strong>Data from 59 patients under 18 years of age who received MV and underwent tracheostomy between January 2018 and March 2023 at the Juan P. Garrahan National Pediatric Hospital, Argentina, were retrospectively examined. Demographic variables, reasons for admission to the unit, days on MV, tracheostomy characteristics, and the weaning process from MV were recorded.</p><p><strong>Results: </strong>The main reasons for tracheostomy were airway disorders (50.8%) and prolonged MV (30.5%). Notable variability was observed in the duration and success of the weaning process among different groups of patients. Patients with airway disorders showed a faster weaning (median: 1.5 days) and higher success in this process, while those with prolonged MV and neurological disorders experienced longer processes (medians: 25.5 and 28 days, respectively) and more patients required partial or total mechanical ventilation at the end of this process. The presence of diaphragmatic dysfunction was more common in those who took longer to wean.</p><p><strong>Conclusion: </strong>The weaning from MV is a complex process, and the reason for the tracheostomy influences its progression.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"78-94"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-term Titanium mesh cage implant failure after total en bloc spondylectomy due to spinal chondrosarcoma","authors":"Ezequiel Martinez, Matias Pereira Duarte, Gonzalo Kido, Gaston Camino-Willhuber, Julio Bassani, Marcelo Gruenberg, Matias Petracchi","doi":"10.31053/1853.0605.v82.n1.44961","DOIUrl":"10.31053/1853.0605.v82.n1.44961","url":null,"abstract":"<p><strong>Objective: </strong>To report an unusual titanium mesh cage failure after ten years of follow-up.</p><p><strong>Clinical case: </strong>A 40-year-old woman diagnosed with low-grade spinal chondrosarcoma underwent a total en-bloc spondylenctomy (TES) surgery. This technique required a wide resection, anterior reconstruction with a titanium mesh cage (TMC), and posterior stabilization. For several years a favorable clinical outcome was achieved. After 10 years of follow-up, the patient developed acute non-traumatic low back pain without neurological repercussions. The images confirmed a rupture of the titanium cage. After ruling out tumor recurrence, the patient went through spinal instrumentation revision.</p><p><strong>Conclusion: </strong>Isolated TMC rupture is a rare event scarcely reported in the literature. There is a strong recommendation to instrument two levels proximal and distal to the bone defect in 360° reconstructions after a TES. Stability had likely been lost over the years due to the slow resorption of the bone graft. We consider necessary studies with a higher casuistry and level of evidence to analyze the contributing factors for the event of TMC rupture.</p>","PeriodicalId":38814,"journal":{"name":"Revista de la Facultad de Ciencias Medicas de Cordoba","volume":"82 1","pages":"140-153"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}